Tangeretin

Tangeretin is a lipid of Polyketides (PK) class. Tangeretin is associated with abnormalities such as Cardiovascular Diseases, Complex Regional Pain Syndromes, Blood Clot, Hypercholesterolemia and Restenosis. The involved functions are known as Thrombus, Platelet function, Localized desquamation, Platelet Activation and Signal. Tangeretin often locates in Protoplasm, Cytoplasmic Granules, Cytoplasmic matrix, Plasma membrane and Blood. The associated genes with Tangeretin are GP6 gene, CDK2 gene, CDK6 gene, Tumor Suppressor Genes and CDH1 gene. The related lipids are Lipopolysaccharides. The related experimental models are Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Tangeretin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Tangeretin?

Tangeretin is suspected in Complex Regional Pain Syndromes, Cardiovascular Diseases, Blood Clot, Hypercholesterolemia, Restenosis and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Tangeretin

MeSH term MeSH ID Detail
Diabetes Mellitus D003920 90 associated lipids
Lung Neoplasms D008175 171 associated lipids
Reperfusion Injury D015427 65 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Parkinson Disease D010300 53 associated lipids
Per page 10 20 | Total 13

PubChem Associated disorders and diseases

What pathways are associated with Tangeretin

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Tangeretin?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Tangeretin?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Tangeretin?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Tangeretin?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Tangeretin?

Mouse Model

Mouse Model are used in the study 'Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin.' (Takano K et al., 2007) and Mouse Model are used in the study 'Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer.' (Bracke ME et al., 1999).

Transgenic Model

Transgenic Model are used in the study 'Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?' (Walle T, 2007).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Tangeretin

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Per page 10 20 50 100 | Total 222
Authors Title Published Journal PubMed Link
Vanhoecke BW et al. A safety study of oral tangeretin and xanthohumol administration to laboratory mice. 2005 Jan-Feb In Vivo pmid:15796161
Park YJ et al. [6]-Gingerol induces cell cycle arrest and cell death of mutant p53-expressing pancreatic cancer cells. 2006 Yonsei Med. J. pmid:17066513
Ujiki MB et al. Apigenin inhibits pancreatic cancer cell proliferation through G2/M cell cycle arrest. 2006 Mol. Cancer pmid:17196098
Hamada M et al. TCDD-induced CYP1A1 expression, an index of dioxin toxicity, is suppressed by flavonoids permeating the human intestinal Caco-2 cell monolayers. 2006 J. Agric. Food Chem. pmid:17090139
Weber B et al. Liquid chromatography/mass spectrometry and liquid chromatography/nuclear magnetic resonance as complementary analytical techniques for unambiguous identification of polymethoxylated flavones in residues from molecular distillation of orange peel oils (Citrus sinensis). 2006 J. Agric. Food Chem. pmid:16417279
Li C et al. [Chemical constituents from roots of Ficus hirta]. 2006 Zhongguo Zhong Yao Za Zhi pmid:16570800
Li LJ et al. [Chemical constituents from roots of Platycodon grandiflorum]. 2006 Zhongguo Zhong Yao Za Zhi pmid:17144467
Abe S et al. Chemopreventive effects of orange peel extract (OPE). II: OPE inhibits atypical hyperplastic lesions in rodent mammary gland. 2007 J Med Food pmid:17472462
Fan K et al. Chemopreventive effects of orange peel extract (OPE). I: OPE inhibits intestinal tumor growth in ApcMin/+ mice. 2007 J Med Food pmid:17472461
Yi LZ et al. Quality control and discrimination of pericarpium citri reticulatae and pericarpium citri reticulatae viride based on high-performance liquid chromatographic fingerprints and multivariate statistical analysis. 2007 Anal. Chim. Acta pmid:17386812
Walle UK and Walle T Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones. 2007 Drug Metab. Dispos. pmid:17709371
Ohtani H et al. Effects of various methoxyflavones on vincristine uptake and multidrug resistance to vincristine in P-gp-overexpressing K562/ADM cells. 2007 Pharm. Res. pmid:17492365
Johann S et al. Antimicrobial activity of wax and hexane extracts from Citrus spp. peels. 2007 Mem. Inst. Oswaldo Cruz pmid:17923995
Nishimuta H et al. Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3. 2007 Biopharm Drug Dispos pmid:17876860
Malemud CJ Inhibitors of stress-activated protein/mitogen-activated protein kinase pathways. 2007 Curr Opin Pharmacol pmid:17398158
Buisson D et al. Biotransformation of polymethoxylated flavonoids: access to their 4'-O-demethylated metabolites. 2007 J. Nat. Prod. pmid:17559266
Walle T Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass? 2007 Semin. Cancer Biol. pmid:17574860
Choi SY et al. Correlation between flavonoid content and the NO production inhibitory activity of peel extracts from various citrus fruits. 2007 Biol. Pharm. Bull. pmid:17409518
Takano K et al. Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin. 2007 Am. J. Physiol., Cell Physiol. pmid:16971492
Chen KH et al. Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells. 2007 Biochem. Pharmacol. pmid:17067555