| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Carcinoma, Ductal, Breast | D018270 | 19 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
Tangeretin
Tangeretin is a lipid of Polyketides (PK) class. Tangeretin is associated with abnormalities such as Cardiovascular Diseases, Complex Regional Pain Syndromes, Blood Clot, Hypercholesterolemia and Restenosis. The involved functions are known as Thrombus, Platelet function, Localized desquamation, Platelet Activation and Signal. Tangeretin often locates in Protoplasm, Cytoplasmic Granules, Cytoplasmic matrix, Plasma membrane and Blood. The associated genes with Tangeretin are GP6 gene, CDK2 gene, CDK6 gene, Tumor Suppressor Genes and CDH1 gene. The related lipids are Lipopolysaccharides. The related experimental models are Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Tangeretin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Tangeretin?
Tangeretin is suspected in Complex Regional Pain Syndromes, Cardiovascular Diseases, Blood Clot, Hypercholesterolemia, Restenosis and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Tangeretin
PubChem Associated disorders and diseases
What pathways are associated with Tangeretin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Tangeretin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Tangeretin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Tangeretin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Tangeretin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Tangeretin?
Mouse Model
Mouse Model are used in the study 'Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin.' (Takano K et al., 2007) and Mouse Model are used in the study 'Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer.' (Bracke ME et al., 1999).
Transgenic Model
Transgenic Model are used in the study 'Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?' (Walle T, 2007).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Tangeretin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Wang MS et al. | Inhibition of 11beta-hydroxysteroid dehydrogenase in guinea pig kidney by three bioflavonoids and their interactions with gossypol. | 2002 | Acta Pharmacol. Sin. | pmid:11860745 |
| Guo XQ et al. | Tangeretin alters neuronal apoptosis and ameliorates the severity of seizures in experimental epilepsy-induced rats by modulating apoptotic protein expressions, regulating matrix metalloproteinases, and activating the PI3K/Akt cell survival pathway. | 2017 | Adv Med Sci | pmid:28501723 |
| Brack ME et al. | The citrus methoxyflavone tangeretin affects human cell-cell interactions. | 2002 | Adv. Exp. Med. Biol. | pmid:12083457 |
| Takano K et al. | Methoxyflavones protect cells against endoplasmic reticulum stress and neurotoxin. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:16971492 |
| Yi LZ et al. | Quality control and discrimination of pericarpium citri reticulatae and pericarpium citri reticulatae viride based on high-performance liquid chromatographic fingerprints and multivariate statistical analysis. | 2007 | Anal. Chim. Acta | pmid:17386812 |
| Yi LZ et al. | Fingerprinting alterations of secondary metabolites of tangerine peels during growth by HPLC-DAD and chemometric methods. | 2009 | Anal. Chim. Acta | pmid:19664461 |
| Tistaert C et al. | Quality control of Citri reticulatae pericarpium: exploratory analysis and discrimination. | 2011 | Anal. Chim. Acta | pmid:21962354 |
| Rooprai HK et al. | Influence of putative antiinvasive agents on matrix metalloproteinase secretion by human neoplastic glia in vitro. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10415799 |
| Bracke ME et al. | Plant polyphenolics as anti-invasive cancer agents. | 2008 | Anticancer Agents Med Chem | pmid:18288920 |
| Kandaswami C et al. | Differential inhibition of proliferation of human squamous cell carcinoma, gliosarcoma and embryonic fibroblast-like lung cells in culture by plant flavonoids. | 1992 | Anticancer Drugs | pmid:1450447 |
| Vaiyapuri S et al. | Tangeretin regulates platelet function through inhibition of phosphoinositide 3-kinase and cyclic nucleotide signaling. | 2013 | Arterioscler. Thromb. Vasc. Biol. | pmid:24135020 |
| Meiyanto E et al. | Natural products for cancer-targeted therapy: citrus flavonoids as potent chemopreventive agents. | 2012 | Asian Pac. J. Cancer Prev. | pmid:22524801 |
| Whitman SC et al. | Nobiletin, a citrus flavonoid isolated from tangerines, selectively inhibits class A scavenger receptor-mediated metabolism of acetylated LDL by mouse macrophages. | 2005 | Atherosclerosis | pmid:15585197 |
| Nagase H et al. | Nobiletin and its related flavonoids with CRE-dependent transcription-stimulating and neuritegenic activities. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16253614 |
| Quintieri L et al. | Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes. | 2008 | Biochem. Pharmacol. | pmid:18191104 |
| Chen KH et al. | Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells. | 2007 | Biochem. Pharmacol. | pmid:17067555 |
| Lakshmi A and Subramanian S | Chemotherapeutic effect of tangeretin, a polymethoxylated flavone studied in 7, 12-dimethylbenz(a)anthracene induced mammary carcinoma in experimental rats. | 2014 | Biochimie | pmid:24299963 |
| Eguchi A et al. | Suppressive effects of demethylated metabolites of nobiletin on phorbol ester-induced expression of scavenger receptor genes in THP-1 human monocytic cells. | 2007 | Biofactors | pmid:18806314 |
| Siess MH et al. | Mechanisms involved in the chemoprevention of flavonoids. | 2000 | Biofactors | pmid:11216486 |
| Yamanishi Y et al. | Drug-target interaction prediction from chemical, genomic and pharmacological data in an integrated framework. | 2010 | Bioinformatics | pmid:20529913 |
| Yamaguchi M et al. | Effects of Cultivation Month and Genetic Background on Phenolic Content of Citrus tachibana Peel. | 2018 | Biol. Pharm. Bull. | pmid:30068877 |
| Choi SY et al. | Correlation between flavonoid content and the NO production inhibitory activity of peel extracts from various citrus fruits. | 2007 | Biol. Pharm. Bull. | pmid:17409518 |
| Green CO et al. | Determination of polymethoxylated flavones in peels of selected Jamaican and Mexican citrus (Citrus spp.) cultivars by high-performance liquid chromatography. | 2007 | Biomed. Chromatogr. | pmid:17080505 |
| Ma LL et al. | Tangeretin induces cell cycle arrest and apoptosis through upregulation of PTEN expression in glioma cells. | 2016 | Biomed. Pharmacother. | pmid:27261630 |
| Chen F et al. | Tangeretin inhibits high glucose-induced extracellular matrix accumulation in human glomerular mesangial cells. | 2018 | Biomed. Pharmacother. | pmid:29710524 |
| Akao Y et al. | Interactive effects of polymethoxy flavones from Citrus on cell growth inhibition in human neuroblastoma SH-SY5Y cells. | 2008 | Bioorg. Med. Chem. | pmid:18282757 |
| Oshitari T et al. | B-Ring-modified and/or 5-demethylated nobiletin congeners: inhibitory activity against pro-MMP-9 production. | 2011 | Bioorg. Med. Chem. | pmid:22047798 |
| Quintin J et al. | Synthesis and biological evaluation of a series of tangeretin-derived chalcones. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19013795 |
| Quintin J et al. | Semisynthesis and antiproliferative evaluation of a series of 3'-aminoflavones. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19457664 |
| Johnson EJ et al. | Prioritizing pharmacokinetic drug interaction precipitants in natural products: application to OATP inhibitors in grapefruit juice. | 2017 | Biopharm Drug Dispos | pmid:28032362 |
| Nishimuta H et al. | Inhibitory effects of various beverages on human recombinant sulfotransferase isoforms SULT1A1 and SULT1A3. | 2007 | Biopharm Drug Dispos | pmid:17876860 |
| Kuroda Y et al. | Activation of human bitter taste receptors by polymethoxylated flavonoids. | 2016 | Biosci. Biotechnol. Biochem. | pmid:27379685 |
| Androutsopoulos VP et al. | Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention. | 2009 | BMC Cancer | pmid:19531241 |
| Kim GS et al. | Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells. | 2012 | BMC Complement Altern Med | pmid:22471389 |
| Asami Y et al. | Use of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources. | 2010 | BMC Pharmacol. | pmid:20537191 |
| Hirano T et al. | Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes. | 1995 | Br. J. Cancer | pmid:8519648 |
| Cheng Z et al. | Tangeretin and its metabolite 4'-hydroxytetramethoxyflavone attenuate EGF-stimulated cell cycle progression in hepatocytes; role of inhibition at the level of mTOR/p70S6K. | 2011 | Br. J. Pharmacol. | pmid:21198542 |
| Honda Y et al. | Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux. | 2004 | Br. J. Pharmacol. | pmid:15504753 |
| Liu LL et al. | Tangeretin has anti-asthmatic effects via regulating PI3K and Notch signaling and modulating Th1/Th2/Th17 cytokine balance in neonatal asthmatic mice. | 2017 | Braz. J. Med. Biol. Res. | pmid:28746467 |
| Li YR et al. | Tangeretin derivative, 5-acetyloxy-6,7,8,4'-tetramethoxyflavone induces G2/M arrest, apoptosis and autophagy in human non-small cell lung cancer cells in vitro and in vivo. | 2016 | Cancer Biol. Ther. | pmid:26569090 |
| Ionta M et al. | Exogenous Cx43 expression decrease cell proliferation rate in rat hepatocarcinoma cells independently of functional gap junction. | 2009 | Cancer Cell Int. | pmid:19678939 |
| Periyasamy K et al. | Antitumor efficacy of tangeretin by targeting the oxidative stress mediated on 7,12-dimethylbenz(a) anthracene-induced proliferative breast cancer in Sprague-Dawley rats. | 2015 | Cancer Chemother. Pharmacol. | pmid:25431347 |
| Ishii K et al. | Effects of naturally occurring polymethyoxyflavonoids on cell growth, p-glycoprotein function, cell cycle, and apoptosis of daunorubicin-resistant T lymphoblastoid leukemia cells. | 2010 | Cancer Invest. | pmid:19863351 |
| Chaumontet C et al. | Flavonoids (apigenin, tangeretin) counteract tumor promoter-induced inhibition of intercellular communication of rat liver epithelial cells. | 1997 | Cancer Lett. | pmid:9103293 |
| Kandaswami C et al. | Antiproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro. | 1991 | Cancer Lett. | pmid:1998943 |
| Ikegawa T et al. | Inhibition of P-glycoprotein by orange juice components, polymethoxyflavones in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells. | 2000 | Cancer Lett. | pmid:11098080 |
| Morley KL et al. | Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells. | 2007 | Cancer Lett. | pmid:17197076 |
| Weng CJ and Yen GC | Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities. | 2012 | Cancer Metastasis Rev. | pmid:22314287 |
| Arafa el-SA et al. | Tangeretin sensitizes cisplatin-resistant human ovarian cancer cells through downregulation of phosphoinositide 3-kinase/Akt signaling pathway. | 2009 | Cancer Res. | pmid:19903849 |