ISOVALERIC ACID is a lipid of Fatty Acyls (FA) class. Isovaleric acid is associated with abnormalities such as Infection, Lymphocele, Cyst, Abscess and Subgingival plaque. The involved functions are known as Biochemical Reaction, 5-(carboxyamino)imidazole ribonucleotide mutase activity, nitrate reductase activity, urease activity and colony morphology. Isovaleric acid often locates in Skeleton, Abdomen, Chromosomes, Tissue membrane and Microsomes. The associated genes with ISOVALERIC ACID are trypticase, Operon, KCNT1 gene, Genome and Reverse primer. The related lipids are Fatty Acids, Propionate, Fatty Acids, Unsaturated, Steroids and Promega. The related experimental models are Knock-out.
To understand associated biological information of ISOVALERIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
ISOVALERIC ACID is suspected in Exanthema, Isovaleryl-CoA dehydrogenase deficiency, Subgingival plaque, Dehydration, MAJOR DEPRESSIVE DISORDER 1, MAJOR DEPRESSIVE DISORDER 2 and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with ISOVALERIC ACID
Lipid pathways are not clear in current pathway databases. We organized associated pathways with ISOVALERIC ACID through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study '3-Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase is involved in biosynthesis of isovaleryl-CoA in the myxobacterium Myxococcus xanthus during fruiting body formation.' (Bode HB et al., 2006) and Knock-out are used in the study 'Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.' (Ruan Y et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wei CC et al. | Isovaleric acidemia diagnosed promptly by tandem mass spectrometry: report of one case. | 2004 Jul-Aug | Acta Paediatr Taiwan | pmid:15624372 |
Tanaka K et al. | Molecular basis of isovaleric acidemia and the study of the acyl-CoA dehydrogenase family. | 1988 | Adv Neurol | pmid:3275439 |
Saudubray JM et al. | Hyperammonemia secondary to hereditary organic acidurias: a study of 29 cases. | 1982 | Adv. Exp. Med. Biol. | pmid:7164893 |
Yoshino M et al. | Neonatal isovaleric acidemia associated with hyperammonemia. | 1982 | Adv. Exp. Med. Biol. | pmid:6897695 |
Fulbright RK et al. | Functional MR imaging of regional brain responses to pleasant and unpleasant odors. | 1998 | AJNR Am J Neuroradiol | pmid:9802496 |
Vockley J and Ensenauer R | Isovaleric acidemia: new aspects of genetic and phenotypic heterogeneity. | 2006 | Am J Med Genet C Semin Med Genet | pmid:16602101 |
Williams KM et al. | Isovalericacidemia appearing as diabetic ketoacidosis. | 1981 | Am. J. Dis. Child. | pmid:6794359 |
Tjellström B et al. | Gut microflora associated characteristics in children with celiac disease. | 2005 | Am. J. Gastroenterol. | pmid:16393236 |
Ensenauer R et al. | A common mutation is associated with a mild, potentially asymptomatic phenotype in patients with isovaleric acidemia diagnosed by newborn screening. | 2004 | Am. J. Hum. Genet. | pmid:15486829 |
Vockley J et al. | Molecular characterization of four different classes of mutations in the isovaleryl-CoA dehydrogenase gene responsible for isovaleric acidemia. | 1991 | Am. J. Hum. Genet. | pmid:2063866 |