ISOVALERIC ACID is a lipid of Fatty Acyls (FA) class. Isovaleric acid is associated with abnormalities such as Infection, Lymphocele, Cyst, Abscess and Subgingival plaque. The involved functions are known as Biochemical Reaction, 5-(carboxyamino)imidazole ribonucleotide mutase activity, nitrate reductase activity, urease activity and colony morphology. Isovaleric acid often locates in Skeleton, Abdomen, Chromosomes, Tissue membrane and Microsomes. The associated genes with ISOVALERIC ACID are trypticase, Operon, KCNT1 gene, Genome and Reverse primer. The related lipids are Fatty Acids, Propionate, Fatty Acids, Unsaturated, Steroids and Promega. The related experimental models are Knock-out.
To understand associated biological information of ISOVALERIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
ISOVALERIC ACID is suspected in Exanthema, Isovaleryl-CoA dehydrogenase deficiency, Subgingival plaque, Dehydration, MAJOR DEPRESSIVE DISORDER 1, MAJOR DEPRESSIVE DISORDER 2 and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with ISOVALERIC ACID
Lipid pathways are not clear in current pathway databases. We organized associated pathways with ISOVALERIC ACID through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study '3-Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase is involved in biosynthesis of isovaleryl-CoA in the myxobacterium Myxococcus xanthus during fruiting body formation.' (Bode HB et al., 2006) and Knock-out are used in the study 'Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.' (Ruan Y et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
Kybert NJ et al. | Differentiation of complex vapor mixtures using versatile DNA-carbon nanotube chemical sensor arrays. | 2013 | ACS Nano | pmid:23442175 |
Bal D et al. | Investigation of a wide spectrum of inherited metabolic disorders by 13C NMR spectroscopy. | 2008 | Acta Biochim. Pol. | pmid:18217108 |
Parvez M et al. | 3-Germyl-3,3-dimethylpropionic acid derivatives. | 2005 | Acta Crystallogr C | pmid:15640578 |
Yamin BM and Othman EA | 3-Methyl-2-propionamido-butanoic acid. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21582407 |
Zaccara G et al. | Treatment of epileptic patients with valproic acid does not modify plasma and urine short-chain-fatty acids. | 1983 | Acta Neurol. Scand. | pmid:6419536 |
Kobayashi E et al. | Functional optical hemodynamic imaging of the olfactory cortex in normosmia subjects and dysosmia subjects. | 2009 | Acta Otolaryngol Suppl | pmid:19848246 |
Ishimaru T et al. | Near-infrared spectroscopy of the adult human olfactory cortex. | 2004 | Acta Otolaryngol Suppl | pmid:15277045 |
Papierkowski A et al. | Serum concentrations of individual monocarboxylic short-chain fatty acids C2-C6 in underweight children. | 1976 | Acta Paediatr Acad Sci Hung | pmid:1032869 |
Elsas LJ and Naglak M | Acute and chronic-intermittent isovaleric acidemia: diagnosis and glycine therapy. | 1988 | Acta Paediatr Jpn | pmid:3150234 |