ISOVALERIC ACID is a lipid of Fatty Acyls (FA) class. Isovaleric acid is associated with abnormalities such as Infection, Lymphocele, Cyst, Abscess and Subgingival plaque. The involved functions are known as Biochemical Reaction, 5-(carboxyamino)imidazole ribonucleotide mutase activity, nitrate reductase activity, urease activity and colony morphology. Isovaleric acid often locates in Skeleton, Abdomen, Chromosomes, Tissue membrane and Microsomes. The associated genes with ISOVALERIC ACID are trypticase, Operon, KCNT1 gene, Genome and Reverse primer. The related lipids are Fatty Acids, Propionate, Fatty Acids, Unsaturated, Steroids and Promega. The related experimental models are Knock-out.
To understand associated biological information of ISOVALERIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
ISOVALERIC ACID is suspected in Exanthema, Isovaleryl-CoA dehydrogenase deficiency, Subgingival plaque, Dehydration, MAJOR DEPRESSIVE DISORDER 1, MAJOR DEPRESSIVE DISORDER 2 and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with ISOVALERIC ACID
Lipid pathways are not clear in current pathway databases. We organized associated pathways with ISOVALERIC ACID through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study '3-Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase is involved in biosynthesis of isovaleryl-CoA in the myxobacterium Myxococcus xanthus during fruiting body formation.' (Bode HB et al., 2006) and Knock-out are used in the study 'Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.' (Ruan Y et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Huss AR et al. | Mitigation of Salmonella on Pet Food Kibbles by Using Liquid and Powdered 3-Hydroxy-3-Methylbutyric Acid. | 2017 | J. Food Prot. | pmid:28561638 |
Ryan PM et al. | Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E mice. | 2017 | Microbiome | pmid:28285599 |
Couce ML et al. | Genotype and phenotype characterization in a Spanish cohort with isovaleric acidemia. | 2017 | J. Hum. Genet. | pmid:27904153 |
Yuan J et al. | Engineering the leucine biosynthetic pathway for isoamyl alcohol overproduction in Saccharomyces cerevisiae. | 2017 | J. Ind. Microbiol. Biotechnol. | pmid:27826727 |
Nakazawa A et al. | Evaluation of Adsorption Characteristics of a Fibrous Adsorbent Containing Zwitter-Ionic Functional Group, Targeting Organic Acids. | 2017 | J. UOEH | pmid:28331124 |
Kalbe B et al. | Olfactory signaling components and olfactory receptors are expressed in tubule cells of the human kidney. | 2016 | Arch. Biochem. Biophys. | pmid:27693121 |
Szczesniak O et al. | Isovaleric acid in stool correlates with human depression. | 2016 | Nutr Neurosci | pmid:25710209 |
Malinin VV et al. | Dipeptides Increase Functional Activity of Human Skin Fibroblasts. | 2015 | Bull. Exp. Biol. Med. | pmid:26033609 |
Stevens D et al. | Spatial variations in the microbial community structure and diversity of the human foot is associated with the production of odorous volatiles. | 2015 | FEMS Microbiol. Ecol. | pmid:25764539 |
Takakura Y et al. | Characterization of the key aroma compounds in beef extract using aroma extract dilution analysis. | 2014 | Meat Sci. | pmid:24486684 |