ISOVALERIC ACID is a lipid of Fatty Acyls (FA) class. Isovaleric acid is associated with abnormalities such as Infection, Lymphocele, Cyst, Abscess and Subgingival plaque. The involved functions are known as Biochemical Reaction, 5-(carboxyamino)imidazole ribonucleotide mutase activity, nitrate reductase activity, urease activity and colony morphology. Isovaleric acid often locates in Skeleton, Abdomen, Chromosomes, Tissue membrane and Microsomes. The associated genes with ISOVALERIC ACID are trypticase, Operon, KCNT1 gene, Genome and Reverse primer. The related lipids are Fatty Acids, Propionate, Fatty Acids, Unsaturated, Steroids and Promega. The related experimental models are Knock-out.
To understand associated biological information of ISOVALERIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
ISOVALERIC ACID is suspected in Exanthema, Isovaleryl-CoA dehydrogenase deficiency, Subgingival plaque, Dehydration, MAJOR DEPRESSIVE DISORDER 1, MAJOR DEPRESSIVE DISORDER 2 and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with ISOVALERIC ACID
Lipid pathways are not clear in current pathway databases. We organized associated pathways with ISOVALERIC ACID through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study '3-Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase is involved in biosynthesis of isovaleryl-CoA in the myxobacterium Myxococcus xanthus during fruiting body formation.' (Bode HB et al., 2006) and Knock-out are used in the study 'Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.' (Ruan Y et al., 2001).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Ackman RG et al. | Lipids of freshwater Dolphin Sotalia fluviatilis: comparison of odontocete bioacoustic lipids and habitat. | 1975 | Lipids | pmid:1123975 |
Vague P et al. | Kinetics of the early insulin response of the perfused rat pancreas to various metabolites and tolbutamide. | 1975 | Diabete Metab | pmid:791726 |
Tanaka K et al. | Metabolism of [1-(14)C] and [2-(14)C] leucine in cultured skin fibroblasts from patients with isovaleric acidemia. Characterization of metabolic defects. | 1976 | J. Clin. Invest. | pmid:932204 |
Papierkowski A et al. | Serum concentrations of individual monocarboxylic short-chain fatty acids C2-C6 in underweight children. | 1976 | Acta Paediatr Acad Sci Hung | pmid:1032869 |
Krieger I and Tanaka K | Therapeutic effects of glycine in isovaleric acidemia. | 1976 | Pediatr. Res. | pmid:1246461 |
Blomberg J | Variations in lipid composition and sound velocity in melon from the North Atlantic Pilot whale, globicephala melaena melaena. | 1976 | Lipids | pmid:1250078 |
Powers SG and Snell EE | Ketopantoate hydroxymethyltransferase. II. Physical, catalytic, and regulatory properties. | 1976 | J. Biol. Chem. | pmid:6463 |
Wedmid Y and Litchfield C | Positional analysis of isovaleroyl triglycerides using proton magnetic resonance with Eu(fod)3 and Pr(fod)3 shift reagents: II. Cetacean triglycerides. | 1976 | Lipids | pmid:1263761 |
Wysocki CJ et al. | Specific anosmia in the laboratory mouse. | 1977 | Behav. Genet. | pmid:869857 |
Sharaf DM et al. | Skin surface lipids of the dog. | 1977 | Lipids | pmid:916820 |