ISOVALERIC ACID

ISOVALERIC ACID is a lipid of Fatty Acyls (FA) class. Isovaleric acid is associated with abnormalities such as Infection, Lymphocele, Cyst, Abscess and Subgingival plaque. The involved functions are known as Biochemical Reaction, 5-(carboxyamino)imidazole ribonucleotide mutase activity, nitrate reductase activity, urease activity and colony morphology. Isovaleric acid often locates in Skeleton, Abdomen, Chromosomes, Tissue membrane and Microsomes. The associated genes with ISOVALERIC ACID are trypticase, Operon, KCNT1 gene, Genome and Reverse primer. The related lipids are Fatty Acids, Propionate, Fatty Acids, Unsaturated, Steroids and Promega. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of ISOVALERIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with ISOVALERIC ACID?

ISOVALERIC ACID is suspected in Exanthema, Isovaleryl-CoA dehydrogenase deficiency, Subgingival plaque, Dehydration, MAJOR DEPRESSIVE DISORDER 1, MAJOR DEPRESSIVE DISORDER 2 and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with ISOVALERIC ACID

MeSH term MeSH ID Detail
Inflammatory Bowel Diseases D015212 9 associated lipids
Occupational Diseases D009784 42 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Olfaction Disorders D000857 17 associated lipids
Maple Syrup Urine Disease D008375 5 associated lipids
Acidosis, Renal Tubular D000141 4 associated lipids
Fanconi Syndrome D005198 4 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Dwarfism D004392 1 associated lipids
Cerebellar Diseases D002526 2 associated lipids
Cerebral Hemorrhage D002543 13 associated lipids
Hypoglycemia D007003 13 associated lipids
Bacteroides Infections D001442 1 associated lipids
Clostridium Infections D003015 5 associated lipids
Fusobacterium Infections D005674 3 associated lipids
Sepsis D018805 11 associated lipids
Thiamine Deficiency D013832 4 associated lipids
Pancytopenia D010198 6 associated lipids
Nervous System Diseases D009422 37 associated lipids
Phenylketonurias D010661 7 associated lipids
Enterocolitis, Pseudomembranous D004761 8 associated lipids
Ventricular Dysfunction D018754 1 associated lipids
Leukemia, Promyelocytic, Acute D015473 3 associated lipids
Ataxia D001259 20 associated lipids
Urinary Tract Infections D014552 11 associated lipids
Halitosis D006209 3 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Gram-Negative Bacterial Infections D016905 16 associated lipids
Canavan Disease D017825 2 associated lipids
Metabolic Diseases D008659 12 associated lipids
Tyrosinemias D020176 2 associated lipids
Propionic Acidemia D056693 3 associated lipids
Gingivitis D005891 3 associated lipids
Periodontal Pocket D010514 9 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with ISOVALERIC ACID

Lipid pathways are not clear in current pathway databases. We organized associated pathways with ISOVALERIC ACID through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with ISOVALERIC ACID?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with ISOVALERIC ACID?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with ISOVALERIC ACID?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with ISOVALERIC ACID?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with ISOVALERIC ACID?

Knock-out

Knock-out are used in the study '3-Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase is involved in biosynthesis of isovaleryl-CoA in the myxobacterium Myxococcus xanthus during fruiting body formation.' (Bode HB et al., 2006) and Knock-out are used in the study 'Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.' (Ruan Y et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with ISOVALERIC ACID

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Authors Title Published Journal PubMed Link
Qiqiang L et al. Longitudinal study of volatile fatty acids in the gingival crevicular fluid of patients with periodontitis before and after nonsurgical therapy. 2012 J. Periodont. Res. pmid:22594616
Grégoire P et al. Desulfosoma profundi sp. nov., a thermophilic sulfate-reducing bacterium isolated from a deep terrestrial geothermal spring in France. 2012 Antonie Van Leeuwenhoek pmid:22120904
Bai G et al. Comparison of storage conditions for human vaginal microbiome studies. 2012 PLoS ONE pmid:22655031
Badenhorst CP et al. Enzymatic characterization and elucidation of the catalytic mechanism of a recombinant bovine glycine N-acyltransferase. 2012 Drug Metab. Dispos. pmid:22071172
Fang JJ et al. Odor compounds from different sources of landfill: characterization and source identification. 2012 Waste Manag pmid:22480726
Mohamed HN et al. Tentative identification of volatile flavor compounds in commercial Budu, a Malaysian fish sauce, using GC-MS. 2012 Molecules pmid:22555296
Filipiak W et al. Molecular analysis of volatile metabolites released specifically by Staphylococcus aureus and Pseudomonas aeruginosa. 2012 BMC Microbiol. pmid:22716902
Sun JL et al. Metabolic profiling of Staphylococcus aureus cultivated under aerobic and anaerobic conditions with (1)H NMR-based nontargeted analysis. 2012 Can. J. Microbiol. pmid:22571732
Walton GE et al. A randomised, double-blind, placebo controlled cross-over study to determine the gastrointestinal effects of consumption of arabinoxylan-oligosaccharides enriched bread in healthy volunteers. 2012 Nutr J pmid:22657950
Ni JQ et al. Volatile organic compounds at swine facilities: a critical review. 2012 Chemosphere pmid:22682363