| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cerebellar Diseases | D002526 | 2 associated lipids |
| Cerebral Hemorrhage | D002543 | 13 associated lipids |
| Hypoglycemia | D007003 | 13 associated lipids |
| Bacteroides Infections | D001442 | 1 associated lipids |
| Clostridium Infections | D003015 | 5 associated lipids |
| Fusobacterium Infections | D005674 | 3 associated lipids |
| Sepsis | D018805 | 11 associated lipids |
| Thiamine Deficiency | D013832 | 4 associated lipids |
| Pancytopenia | D010198 | 6 associated lipids |
| Nervous System Diseases | D009422 | 37 associated lipids |
ISOVALERIC ACID
ISOVALERIC ACID is a lipid of Fatty Acyls (FA) class. Isovaleric acid is associated with abnormalities such as Infection, Lymphocele, Cyst, Abscess and Subgingival plaque. The involved functions are known as Biochemical Reaction, 5-(carboxyamino)imidazole ribonucleotide mutase activity, nitrate reductase activity, urease activity and colony morphology. Isovaleric acid often locates in Skeleton, Abdomen, Chromosomes, Tissue membrane and Microsomes. The associated genes with ISOVALERIC ACID are trypticase, Operon, KCNT1 gene, Genome and Reverse primer. The related lipids are Fatty Acids, Propionate, Fatty Acids, Unsaturated, Steroids and Promega. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of ISOVALERIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ISOVALERIC ACID?
ISOVALERIC ACID is suspected in Exanthema, Isovaleryl-CoA dehydrogenase deficiency, Subgingival plaque, Dehydration, MAJOR DEPRESSIVE DISORDER 1, MAJOR DEPRESSIVE DISORDER 2 and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ISOVALERIC ACID
PubChem Associated disorders and diseases
What pathways are associated with ISOVALERIC ACID
Lipid pathways are not clear in current pathway databases. We organized associated pathways with ISOVALERIC ACID through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ISOVALERIC ACID?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ISOVALERIC ACID?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with ISOVALERIC ACID?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with ISOVALERIC ACID?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with ISOVALERIC ACID?
Knock-out
Knock-out are used in the study '3-Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase is involved in biosynthesis of isovaleryl-CoA in the myxobacterium Myxococcus xanthus during fruiting body formation.' (Bode HB et al., 2006) and Knock-out are used in the study 'Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.' (Ruan Y et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with ISOVALERIC ACID
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Huss AR et al. | Mitigation of Salmonella on Pet Food Kibbles by Using Liquid and Powdered 3-Hydroxy-3-Methylbutyric Acid. | 2017 | J. Food Prot. | pmid:28561638 |
| Ryan PM et al. | Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E mice. | 2017 | Microbiome | pmid:28285599 |
| Couce ML et al. | Genotype and phenotype characterization in a Spanish cohort with isovaleric acidemia. | 2017 | J. Hum. Genet. | pmid:27904153 |
| Yuan J et al. | Engineering the leucine biosynthetic pathway for isoamyl alcohol overproduction in Saccharomyces cerevisiae. | 2017 | J. Ind. Microbiol. Biotechnol. | pmid:27826727 |
| Nakazawa A et al. | Evaluation of Adsorption Characteristics of a Fibrous Adsorbent Containing Zwitter-Ionic Functional Group, Targeting Organic Acids. | 2017 | J. UOEH | pmid:28331124 |
| Kalbe B et al. | Olfactory signaling components and olfactory receptors are expressed in tubule cells of the human kidney. | 2016 | Arch. Biochem. Biophys. | pmid:27693121 |
| Szczesniak O et al. | Isovaleric acid in stool correlates with human depression. | 2016 | Nutr Neurosci | pmid:25710209 |
| Malinin VV et al. | Dipeptides Increase Functional Activity of Human Skin Fibroblasts. | 2015 | Bull. Exp. Biol. Med. | pmid:26033609 |
| Stevens D et al. | Spatial variations in the microbial community structure and diversity of the human foot is associated with the production of odorous volatiles. | 2015 | FEMS Microbiol. Ecol. | pmid:25764539 |
| Lu R et al. | Effect of non-surgical periodontal treatment on short chain fatty acid levels in gingival crevicular fluid of patients with generalized aggressive periodontitis. | 2014 | J. Periodont. Res. | pmid:25340203 |
| Takakura Y et al. | Characterization of the key aroma compounds in beef extract using aroma extract dilution analysis. | 2014 | Meat Sci. | pmid:24486684 |
| Zhou XL et al. | Dietary supplementation with soybean oligosaccharides increases short-chain fatty acids but decreases protein-derived catabolites in the intestinal luminal content of weaned Huanjiang mini-piglets. | 2014 | Nutr Res | pmid:25236424 |
| Blasioli S et al. | Identification of volatile markers in potato brown rot and ring rot by combined GC-MS and PTR-MS techniques: study on in vitro and in vivo samples. | 2014 | J. Agric. Food Chem. | pmid:24313381 |
| Al-Qudah MA | Chemical composition and antimicrobial activity of the essential oil of Linum pubescens growing wild in Jordan. | 2013 | Nat. Prod. Res. | pmid:22913459 |
| Kybert NJ et al. | Differentiation of complex vapor mixtures using versatile DNA-carbon nanotube chemical sensor arrays. | 2013 | ACS Nano | pmid:23442175 |
| Jakobsdottir G et al. | Fasting serum concentration of short-chain fatty acids in subjects with microscopic colitis and celiac disease: no difference compared with controls, but between genders. | 2013 | Scand. J. Gastroenterol. | pmid:23600961 |
| Müller LG et al. | Effect of storage time and conditions on the diene valepotriates content of the extract of Valeriana glechomifolia obtained by supercritical carbon dioxide. | 2012 May-Jun | Phytochem Anal | pmid:21953720 |
| Dadamio J et al. | Clinical utility of a novel colorimetric chair side test for oral malodour. | 2012 | J. Clin. Periodontol. | pmid:22612797 |
| Mukabana WR et al. | A novel synthetic odorant blend for trapping of malaria and other African mosquito species. | 2012 | J. Chem. Ecol. | pmid:22426893 |
| Liu XG et al. | In vivo antidepressant activity of sesquiterpenes from the roots of Valeriana fauriei Briq. | 2012 | Fitoterapia | pmid:22285939 |