ISOVALERIC ACID

ISOVALERIC ACID is a lipid of Fatty Acyls (FA) class. Isovaleric acid is associated with abnormalities such as Infection, Lymphocele, Cyst, Abscess and Subgingival plaque. The involved functions are known as Biochemical Reaction, 5-(carboxyamino)imidazole ribonucleotide mutase activity, nitrate reductase activity, urease activity and colony morphology. Isovaleric acid often locates in Skeleton, Abdomen, Chromosomes, Tissue membrane and Microsomes. The associated genes with ISOVALERIC ACID are trypticase, Operon, KCNT1 gene, Genome and Reverse primer. The related lipids are Fatty Acids, Propionate, Fatty Acids, Unsaturated, Steroids and Promega. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of ISOVALERIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with ISOVALERIC ACID?

ISOVALERIC ACID is suspected in Exanthema, Isovaleryl-CoA dehydrogenase deficiency, Subgingival plaque, Dehydration, MAJOR DEPRESSIVE DISORDER 1, MAJOR DEPRESSIVE DISORDER 2 and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with ISOVALERIC ACID

MeSH term MeSH ID Detail
Inflammatory Bowel Diseases D015212 9 associated lipids
Occupational Diseases D009784 42 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Olfaction Disorders D000857 17 associated lipids
Maple Syrup Urine Disease D008375 5 associated lipids
Acidosis, Renal Tubular D000141 4 associated lipids
Fanconi Syndrome D005198 4 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Dwarfism D004392 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with ISOVALERIC ACID

Lipid pathways are not clear in current pathway databases. We organized associated pathways with ISOVALERIC ACID through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with ISOVALERIC ACID?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with ISOVALERIC ACID?


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Function Cross reference Weighted score Related literatures

What lipids are associated with ISOVALERIC ACID?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with ISOVALERIC ACID?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with ISOVALERIC ACID?

Knock-out

Knock-out are used in the study '3-Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase is involved in biosynthesis of isovaleryl-CoA in the myxobacterium Myxococcus xanthus during fruiting body formation.' (Bode HB et al., 2006) and Knock-out are used in the study 'Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.' (Ruan Y et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with ISOVALERIC ACID

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Authors Title Published Journal PubMed Link
Huss AR et al. Mitigation of Salmonella on Pet Food Kibbles by Using Liquid and Powdered 3-Hydroxy-3-Methylbutyric Acid. 2017 J. Food Prot. pmid:28561638
Ryan PM et al. Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E mice. 2017 Microbiome pmid:28285599
Couce ML et al. Genotype and phenotype characterization in a Spanish cohort with isovaleric acidemia. 2017 J. Hum. Genet. pmid:27904153
Yuan J et al. Engineering the leucine biosynthetic pathway for isoamyl alcohol overproduction in Saccharomyces cerevisiae. 2017 J. Ind. Microbiol. Biotechnol. pmid:27826727
Nakazawa A et al. Evaluation of Adsorption Characteristics of a Fibrous Adsorbent Containing Zwitter-Ionic Functional Group, Targeting Organic Acids. 2017 J. UOEH pmid:28331124
Kalbe B et al. Olfactory signaling components and olfactory receptors are expressed in tubule cells of the human kidney. 2016 Arch. Biochem. Biophys. pmid:27693121
Szczesniak O et al. Isovaleric acid in stool correlates with human depression. 2016 Nutr Neurosci pmid:25710209
Malinin VV et al. Dipeptides Increase Functional Activity of Human Skin Fibroblasts. 2015 Bull. Exp. Biol. Med. pmid:26033609
Stevens D et al. Spatial variations in the microbial community structure and diversity of the human foot is associated with the production of odorous volatiles. 2015 FEMS Microbiol. Ecol. pmid:25764539
Lu R et al. Effect of non-surgical periodontal treatment on short chain fatty acid levels in gingival crevicular fluid of patients with generalized aggressive periodontitis. 2014 J. Periodont. Res. pmid:25340203
Takakura Y et al. Characterization of the key aroma compounds in beef extract using aroma extract dilution analysis. 2014 Meat Sci. pmid:24486684
Zhou XL et al. Dietary supplementation with soybean oligosaccharides increases short-chain fatty acids but decreases protein-derived catabolites in the intestinal luminal content of weaned Huanjiang mini-piglets. 2014 Nutr Res pmid:25236424
Blasioli S et al. Identification of volatile markers in potato brown rot and ring rot by combined GC-MS and PTR-MS techniques: study on in vitro and in vivo samples. 2014 J. Agric. Food Chem. pmid:24313381
Al-Qudah MA Chemical composition and antimicrobial activity of the essential oil of Linum pubescens growing wild in Jordan. 2013 Nat. Prod. Res. pmid:22913459
Kybert NJ et al. Differentiation of complex vapor mixtures using versatile DNA-carbon nanotube chemical sensor arrays. 2013 ACS Nano pmid:23442175
Jakobsdottir G et al. Fasting serum concentration of short-chain fatty acids in subjects with microscopic colitis and celiac disease: no difference compared with controls, but between genders. 2013 Scand. J. Gastroenterol. pmid:23600961
Müller LG et al. Effect of storage time and conditions on the diene valepotriates content of the extract of Valeriana glechomifolia obtained by supercritical carbon dioxide. 2012 May-Jun Phytochem Anal pmid:21953720
Parma V et al. Subliminally perceived odours modulate female intrasexual competition: an eye movement study. 2012 PLoS ONE pmid:22383968
Kang W et al. Characterization of aroma compounds in Chinese bayberry (Myrica rubra Sieb. et Zucc.) by gas chromatography mass spectrometry (GC-MS) and olfactometry (GC-O). 2012 J. Food Sci. pmid:23009608
Xiong H et al. Influences of volatile solid concentration, temperature and solid retention time for the hydrolysis of waste activated sludge to recover volatile fatty acids. 2012 Bioresour. Technol. pmid:22750494
Pais VF et al. An electronic nose based on coated piezoelectric quartz crystals to certify ewes' cheese and to discriminate between cheese varieties. 2012 Sensors (Basel) pmid:22438717
Qiqiang L et al. Longitudinal study of volatile fatty acids in the gingival crevicular fluid of patients with periodontitis before and after nonsurgical therapy. 2012 J. Periodont. Res. pmid:22594616
Moura AP et al. 3-Methylcrotonylglycine disrupts mitochondrial energy homeostasis and inhibits synaptic Na(+),K (+)-ATPase activity in brain of young rats. 2012 Cell. Mol. Neurobiol. pmid:21993987
Grégoire P et al. Desulfosoma profundi sp. nov., a thermophilic sulfate-reducing bacterium isolated from a deep terrestrial geothermal spring in France. 2012 Antonie Van Leeuwenhoek pmid:22120904
Gutsche KA et al. Production of volatile compounds by Lactobacillus sakei from branched chain α-keto acids. 2012 Food Microbiol. pmid:22202876
Curtin CD et al. De-novo assembly and analysis of the heterozygous triploid genome of the wine spoilage yeast Dekkera bruxellensis AWRI1499. 2012 PLoS ONE pmid:22470482
Can Güven S and Laska M Olfactory sensitivity and odor structure-activity relationships for aliphatic carboxylic acids in CD-1 mice. 2012 PLoS ONE pmid:22479594
Bai G et al. Comparison of storage conditions for human vaginal microbiome studies. 2012 PLoS ONE pmid:22655031
Dalmasso M et al. A temporal-omic study of Propionibacterium freudenreichii CIRM-BIA1 adaptation strategies in conditions mimicking cheese ripening in the cold. 2012 PLoS ONE pmid:22253706
Kerr KR et al. Apparent total tract energy and macronutrient digestibility and fecal fermentative end-product concentrations of domestic cats fed extruded, raw beef-based, and cooked beef-based diets. 2012 J. Anim. Sci. pmid:22003235
Dadamio J et al. Clinical utility of a novel colorimetric chair side test for oral malodour. 2012 J. Clin. Periodontol. pmid:22612797
Mukabana WR et al. A novel synthetic odorant blend for trapping of malaria and other African mosquito species. 2012 J. Chem. Ecol. pmid:22426893
Sharp MD et al. Rapid discrimination and characterization of vanilla bean extracts by attenuated total reflection infrared spectroscopy and selected ion flow tube mass spectrometry. 2012 J. Food Sci. pmid:22384952
Seo YS et al. Removal of off-flavors from sea tangle (Laminaria japonica) extract by fermentation with Aspergillus oryzae. 2012 Bioresour. Technol. pmid:22840201
Sato J et al. [An attempt to degradation of anticancer drug and odor in the medical environment by photocatalyst]. 2012 Yakugaku Zasshi pmid:23037705
Sabbia JA et al. Soybean meal substitution with a yeast-derived microbial protein source in dairy cow diets. 2012 J. Dairy Sci. pmid:22863090
Xu J et al. Isolation, structural elucidation, and neuroprotective effects of iridoids from Valeriana jatamansi. 2012 Biosci. Biotechnol. Biochem. pmid:22785467
Liu XG et al. In vivo antidepressant activity of sesquiterpenes from the roots of Valeriana fauriei Briq. 2012 Fitoterapia pmid:22285939
Welke JE et al. Characterization of the volatile profile of Brazilian Merlot wines through comprehensive two dimensional gas chromatography time-of-flight mass spectrometric detection. 2012 J Chromatogr A pmid:22277184
Kim YH and Kim KH Novel approach to test the relative recovery of liquid-phase standard in sorbent-tube analysis of gaseous volatile organic compounds. 2012 Anal. Chem. pmid:22468653
Badenhorst CP et al. Enzymatic characterization and elucidation of the catalytic mechanism of a recombinant bovine glycine N-acyltransferase. 2012 Drug Metab. Dispos. pmid:22071172
Bloomer RJ et al. Effects of 2-nitrooxy ethyl 2-amino 3-methylbutanoate gel on resistance exercise performance and blood nitrate/nitrite in resistance trained men. 2012 J Strength Cond Res pmid:21921823
Min BR et al. Effects of pine bark supplementation on performance, rumen fermentation, and carcass characteristics of Kiko crossbred male goats. 2012 J. Anim. Sci. pmid:22851241
Fang JJ et al. Odor compounds from different sources of landfill: characterization and source identification. 2012 Waste Manag pmid:22480726
Mohamed HN et al. Tentative identification of volatile flavor compounds in commercial Budu, a Malaysian fish sauce, using GC-MS. 2012 Molecules pmid:22555296
Rughoonundun H et al. Influence of carbon-to-nitrogen ratio on the mixed-acid fermentation of wastewater sludge and pretreated bagasse. 2012 Bioresour. Technol. pmid:22425518
Filipiak W et al. Molecular analysis of volatile metabolites released specifically by Staphylococcus aureus and Pseudomonas aeruginosa. 2012 BMC Microbiol. pmid:22716902
van Leeuwen BN et al. Fermentative production of isobutene. 2012 Appl. Microbiol. Biotechnol. pmid:22234536
Rehman A et al. Effects of probiotics and antibiotics on the intestinal homeostasis in a computer controlled model of the large intestine. 2012 BMC Microbiol. pmid:22452835
Xiong M et al. A bio-catalytic approach to aliphatic ketones. 2012 Sci Rep pmid:22416247
Sun JL et al. Metabolic profiling of Staphylococcus aureus cultivated under aerobic and anaerobic conditions with (1)H NMR-based nontargeted analysis. 2012 Can. J. Microbiol. pmid:22571732
Grünert SC et al. Clinical and neurocognitive outcome in symptomatic isovaleric acidemia. 2012 Orphanet J Rare Dis pmid:22277694
Walton GE et al. A randomised, double-blind, placebo controlled cross-over study to determine the gastrointestinal effects of consumption of arabinoxylan-oligosaccharides enriched bread in healthy volunteers. 2012 Nutr J pmid:22657950
Davis CK et al. Isolation and survey of novel fluoroacetate-degrading bacteria belonging to the phylum Synergistetes. 2012 FEMS Microbiol. Ecol. pmid:22372434
Chang P et al. The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium. 2012 Dis Model Mech pmid:21876211
French EA et al. Rumen and milk odd- and branched-chain fatty acid proportions are minimally influenced by ruminal volatile fatty acid infusions. 2012 J. Dairy Sci. pmid:22459847
Ni JQ et al. Volatile organic compounds at swine facilities: a critical review. 2012 Chemosphere pmid:22682363
Paczkowski S and Schütz S Post-mortem volatiles of vertebrate tissue. 2011 Appl. Microbiol. Biotechnol. pmid:21720824
Kumar PA et al. Identification of fruity aroma-producing compounds from Chryseobacterium sp. isolated from the Western Ghats, India. 2011 Curr. Microbiol. pmid:21667308
Serrazanetti DI et al. Acid stress-mediated metabolic shift in Lactobacillus sanfranciscensis LSCE1. 2011 Appl. Environ. Microbiol. pmid:21335381
Shank RA et al. Current and future experimental strategies for structural analysis of trichothecene mycotoxins--a prospectus. 2011 Toxins (Basel) pmid:22295175
Schmidt J et al. Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3. 2011 J. Biol. Chem. pmid:21220428
Pelchat ML et al. Excretion and perception of a characteristic odor in urine after asparagus ingestion: a psychophysical and genetic study. 2011 Chem. Senses pmid:20876394
Pati A et al. Non-contiguous finished genome sequence of the opportunistic oral pathogen Prevotella multisaccharivorax type strain (PPPA20). 2011 Stand Genomic Sci pmid:22180809
Arora R et al. Potential of Complementary and Alternative Medicine in Preventive Management of Novel H1N1 Flu (Swine Flu) Pandemic: Thwarting Potential Disasters in the Bud. 2011 Evid Based Complement Alternat Med pmid:20976081
Nes WD Biosynthesis of cholesterol and other sterols. 2011 Chem. Rev. pmid:21902244
Wroblewska M et al. Physiological properties of beetroot crisps applied in standard and dyslipidaemic diets of rats. 2011 Lipids Health Dis pmid:21995671
Ukhanov K et al. Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor neurons. 2011 J. Neurosci. pmid:21209212
Ensenauer R et al. Newborn screening for isovaleric acidemia using tandem mass spectrometry: data from 1.6 million newborns. 2011 Clin. Chem. pmid:21335445
Dinarvand R et al. Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents. 2011 Int J Nanomedicine pmid:21720501
Downes J and Wade WG Prevotella fusca sp. nov. and Prevotella scopos sp. nov., isolated from the human oral cavity. 2011 Int. J. Syst. Evol. Microbiol. pmid:20495041
Holzmann I et al. Evaluation of Behavioral and Pharmacological Effects of Hydroalcoholic Extract of Valeriana prionophylla Standl. from Guatemala. 2011 Evid Based Complement Alternat Med pmid:21754942
Gronow S et al. Complete genome sequence of Bacteroides salanitronis type strain (BL78). 2011 Stand Genomic Sci pmid:21677856
Zasloff M Observations on the remarkable (and mysterious) wound-healing process of the bottlenose dolphin. 2011 J. Invest. Dermatol. pmid:21776005
Hansen CF et al. A high dietary concentration of inulin is necessary to reduce the incidence of swine dysentery in pigs experimentally challenged with Brachyspira hyodysenteriae. 2011 Br. J. Nutr. pmid:21736788
Chin ST et al. Identification of potent odourants in wine and brewed coffee using gas chromatography-olfactometry and comprehensive two-dimensional gas chromatography. 2011 J Chromatogr A pmid:21741655
Kappers IF et al. Variation in herbivory-induced volatiles among cucumber (Cucumis sativus L.) varieties has consequences for the attraction of carnivorous natural enemies. 2011 J. Chem. Ecol. pmid:21249432
Baena S et al. Desulfosoma caldarium gen. nov., sp. nov., a thermophilic sulfate-reducing bacterium from a terrestrial hot spring. 2011 Int. J. Syst. Evol. Microbiol. pmid:20418410
Weickert MO et al. Changes in dominant groups of the gut microbiota do not explain cereal-fiber induced improvement of whole-body insulin sensitivity. 2011 Nutr Metab (Lond) pmid:22177085
Kashima Y et al. Insecticidal effect and chemical composition of the volatile oil from Bergenia ligulata. 2011 J. Agric. Food Chem. pmid:21639116
Aguerre MJ et al. Effect of forage-to-concentrate ratio in dairy cow diets on emission of methane, carbon dioxide, and ammonia, lactation performance, and manure excretion. 2011 J. Dairy Sci. pmid:21605777
Prakash S et al. Gut microbiota: next frontier in understanding human health and development of biotherapeutics. 2011 Biologics pmid:21847343
Jawara M et al. Field testing of different chemical combinations as odour baits for trapping wild mosquitoes in The Gambia. 2011 PLoS ONE pmid:21637337
AbuGhazaleh AA et al. The effect of replacing corn with glycerol on ruminal bacteria in continuous culture fermenters. 2011 J Anim Physiol Anim Nutr (Berl) pmid:20880288
Verhulst NO et al. Improvement of a synthetic lure for Anopheles gambiae using compounds produced by human skin microbiota. 2011 Malar. J. pmid:21303496
Adams JB et al. Gastrointestinal flora and gastrointestinal status in children with autism--comparisons to typical children and correlation with autism severity. 2011 BMC Gastroenterol pmid:21410934
Hong SM et al. Relationship between the Korean Version of the Sniffin' Stick Test and the T&T Olfactometer in the Korean Population. 2011 Clin Exp Otorhinolaryngol pmid:22232713
Keller A Attention and olfactory consciousness. 2011 Front Psychol pmid:22203813
Xiao W et al. [Functional magnetic resonance imaging of brain activation in early period after olfactory adaptation]. 2011 Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi pmid:22177038
Johnson AJ Cognitive facilitation following intentional odor exposure. 2011 Sensors (Basel) pmid:22163909
Busman M et al. Observation of T-2 toxin and HT-2 toxin glucosides from Fusarium sporotrichioides by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). 2011 Toxins (Basel) pmid:22295176
Jo YJ et al. Comparison of fermented soybean paste (Doenjang) prepared by different methods based on profiling of volatile compounds. 2011 J. Food Sci. pmid:21535802
Scadding G et al. Diagnostic tools in Rhinology EAACI position paper. 2011 Clin Transl Allergy pmid:22410181
Ito N et al. Antidepressant-like Effect of l-perillaldehyde in Stress-induced Depression-like Model Mice through Regulation of the Olfactory Nervous System. 2011 Evid Based Complement Alternat Med pmid:18955354
Thu TV et al. Effects of liquid metabolite combinations produced by Lactobacillus plantarum on growth performance, faeces characteristics, intestinal morphology and diarrhoea incidence in postweaning piglets. 2011 Trop Anim Health Prod pmid:20632092
Potu RB et al. The effect of lipid supplements on ruminal bacteria in continuous culture fermenters varies with the fatty acid composition. 2011 J. Microbiol. pmid:21538241
Göker M et al. Complete genome sequence of Odoribacter splanchnicus type strain (1651/6). 2011 Stand Genomic Sci pmid:21677857
Kaster AK et al. More than 200 genes required for methane formation from Hâ‚‚ and COâ‚‚ and energy conservation are present in Methanothermobacter marburgensis and Methanothermobacter thermautotrophicus. 2011 Archaea pmid:21559116
Rolls ET Chemosensory learning in the cortex. 2011 Front Syst Neurosci pmid:21954379
Wilson AD and Baietto M Advances in electronic-nose technologies developed for biomedical applications. 2011 Sensors (Basel) pmid:22346620