ISOVALERIC ACID

ISOVALERIC ACID is a lipid of Fatty Acyls (FA) class. Isovaleric acid is associated with abnormalities such as Infection, Lymphocele, Cyst, Abscess and Subgingival plaque. The involved functions are known as Biochemical Reaction, 5-(carboxyamino)imidazole ribonucleotide mutase activity, nitrate reductase activity, urease activity and colony morphology. Isovaleric acid often locates in Skeleton, Abdomen, Chromosomes, Tissue membrane and Microsomes. The associated genes with ISOVALERIC ACID are trypticase, Operon, KCNT1 gene, Genome and Reverse primer. The related lipids are Fatty Acids, Propionate, Fatty Acids, Unsaturated, Steroids and Promega. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of ISOVALERIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with ISOVALERIC ACID?

ISOVALERIC ACID is suspected in Exanthema, Isovaleryl-CoA dehydrogenase deficiency, Subgingival plaque, Dehydration, MAJOR DEPRESSIVE DISORDER 1, MAJOR DEPRESSIVE DISORDER 2 and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with ISOVALERIC ACID

MeSH term MeSH ID Detail
Inflammatory Bowel Diseases D015212 9 associated lipids
Occupational Diseases D009784 42 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Olfaction Disorders D000857 17 associated lipids
Maple Syrup Urine Disease D008375 5 associated lipids
Acidosis, Renal Tubular D000141 4 associated lipids
Fanconi Syndrome D005198 4 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Dwarfism D004392 1 associated lipids
Per page 10 20 50 | Total 35

PubChem Associated disorders and diseases

What pathways are associated with ISOVALERIC ACID

Lipid pathways are not clear in current pathway databases. We organized associated pathways with ISOVALERIC ACID through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with ISOVALERIC ACID?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with ISOVALERIC ACID?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with ISOVALERIC ACID?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with ISOVALERIC ACID?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with ISOVALERIC ACID?

Knock-out

Knock-out are used in the study '3-Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase is involved in biosynthesis of isovaleryl-CoA in the myxobacterium Myxococcus xanthus during fruiting body formation.' (Bode HB et al., 2006) and Knock-out are used in the study 'Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.' (Ruan Y et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with ISOVALERIC ACID

Download all related citations
Per page 10 20 50 100 | Total 615
Authors Title Published Journal PubMed Link
pmid:
Halket JM et al. Deconvolution gas chromatography/mass spectrometry of urinary organic acids--potential for pattern recognition and automated identification of metabolic disorders. 1999 Rapid Commun. Mass Spectrom. pmid:10097403
Gilbert-Barness E and Barness LA Isovaleric acidemia with promyelocytic myeloproliferative syndrome. 1999 May-Jun Pediatr. Dev. Pathol. pmid:10191353
Papierkowski A et al. Serum concentrations of individual monocarboxylic short-chain fatty acids C2-C6 in underweight children. 1976 Acta Paediatr Acad Sci Hung pmid:1032869
Sakata T et al. Probiotic preparations dose-dependently increase net production rates of organic acids and decrease that of ammonia by pig cecal bacteria in batch culture. 1999 Dig. Dis. Sci. pmid:10489936
Vockley J et al. Exon skipping in IVD RNA processing in isovaleric acidemia caused by point mutations in the coding region of the IVD gene. 2000 Am. J. Hum. Genet. pmid:10677295
Volchenboum SL and Vockley J Mitochondrial import and processing of wild type and type III mutant isovaleryl-CoA dehydrogenase. 2000 J. Biol. Chem. pmid:10713113
Pophof B et al. Decyl-thio-trifluoropropanone, a competitive inhibitor of moth pheromone receptors. 2000 J. Comp. Physiol. A pmid:10757247
Bonafé L et al. Evaluation of urinary acylglycines by electrospray tandem mass spectrometry in mitochondrial energy metabolism defects and organic acidurias. 2000 Mol. Genet. Metab. pmid:10870848
Johnson BA and Leon M Odorant molecular length: one aspect of the olfactory code. 2000 J. Comp. Neurol. pmid:10982472
Yamada H and Nakatani K Odorant-induced hyperpolarization and suppression of cAMP-activated current in newt olfactory receptor neurons. 2001 Chem. Senses pmid:11124212
Snyder SE et al. Radiolabeled cholinesterase substrates: in vitro methods for determining structure-activity relationships and identification of a positron emission tomography radiopharmaceutical for in vivo measurement of butyrylcholinesterase activity. 2001 J. Cereb. Blood Flow Metab. pmid:11176278
Bandyk CA et al. Effect of ruminal vs postruminal administration of degradable protein on utilization of low-quality forage by beef steers. 2001 J. Anim. Sci. pmid:11204704
Ackman RG et al. Lipids of freshwater Dolphin Sotalia fluviatilis: comparison of odontocete bioacoustic lipids and habitat. 1975 Lipids pmid:1123975
Leskey TC et al. Evaluation of individual components of plum odor as potential attractants for adult plum curculios. 2001 J. Chem. Ecol. pmid:11382056
Rock CO and Snyder F A short-chain acyl-CoA: 1-alkyl-2-acyl-sn-glycerol acyltrasnferase from a microsomal fraction of the rabbit Harderian gland. 1975 Biochim. Biophys. Acta pmid:1138897
Kaylor JJ and Risley JM Synthesis of N4-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-asparagine analogues. n-Butyramide, 3-chloropropionamide, 3-aminopropionamide, and isovaleramide analogues. 2001 Carbohydr. Res. pmid:11398986
Wasant P et al. Detection of inherited metabolic disorders via tandem mass spectrometry in Thai infants. 1999 Southeast Asian J. Trop. Med. Public Health pmid:11400758
Obata K et al. Human biotin-containing subunit of 3-methylcrotonyl-CoA carboxylase gene (MCCA): cDNA sequence, genomic organization, localization to chromosomal band 3q27, and expression. 2001 Genomics pmid:11401427
Fournier D et al. Porphyromonas gulae sp. nov., an anaerobic, gram-negative coccobacillus from the gingival sulcus of various animal hosts. 2001 Int. J. Syst. Evol. Microbiol. pmid:11411686