| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammatory Bowel Diseases | D015212 | 9 associated lipids |
| Occupational Diseases | D009784 | 42 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Amino Acid Metabolism, Inborn Errors | D000592 | 16 associated lipids |
| Olfaction Disorders | D000857 | 17 associated lipids |
| Maple Syrup Urine Disease | D008375 | 5 associated lipids |
| Acidosis, Renal Tubular | D000141 | 4 associated lipids |
| Fanconi Syndrome | D005198 | 4 associated lipids |
| Lipid Metabolism, Inborn Errors | D008052 | 26 associated lipids |
| Dwarfism | D004392 | 1 associated lipids |
ISOVALERIC ACID
ISOVALERIC ACID is a lipid of Fatty Acyls (FA) class. Isovaleric acid is associated with abnormalities such as Infection, Lymphocele, Cyst, Abscess and Subgingival plaque. The involved functions are known as Biochemical Reaction, 5-(carboxyamino)imidazole ribonucleotide mutase activity, nitrate reductase activity, urease activity and colony morphology. Isovaleric acid often locates in Skeleton, Abdomen, Chromosomes, Tissue membrane and Microsomes. The associated genes with ISOVALERIC ACID are trypticase, Operon, KCNT1 gene, Genome and Reverse primer. The related lipids are Fatty Acids, Propionate, Fatty Acids, Unsaturated, Steroids and Promega. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of ISOVALERIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ISOVALERIC ACID?
ISOVALERIC ACID is suspected in Exanthema, Isovaleryl-CoA dehydrogenase deficiency, Subgingival plaque, Dehydration, MAJOR DEPRESSIVE DISORDER 1, MAJOR DEPRESSIVE DISORDER 2 and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ISOVALERIC ACID
PubChem Associated disorders and diseases
What pathways are associated with ISOVALERIC ACID
Lipid pathways are not clear in current pathway databases. We organized associated pathways with ISOVALERIC ACID through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ISOVALERIC ACID?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with ISOVALERIC ACID?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with ISOVALERIC ACID?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with ISOVALERIC ACID?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with ISOVALERIC ACID?
Knock-out
Knock-out are used in the study '3-Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase is involved in biosynthesis of isovaleryl-CoA in the myxobacterium Myxococcus xanthus during fruiting body formation.' (Bode HB et al., 2006) and Knock-out are used in the study 'Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.' (Ruan Y et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with ISOVALERIC ACID
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Shukla S et al. | Determination of non-volatile and volatile organic acids in Korean traditional fermented soybean paste (Doenjang). | Food Chem. Toxicol. | pmid:20434502 | |
| Cai L et al. | Evaluation of zeolite for control of odorants emissions from simulated poultry manure storage. | J. Environ. Qual. | pmid:17215226 | |
| Varel VH et al. | Manure odor potential and Escherichia coli concentrations in manure slurries of feedlot steers fed 40% corn wet distillers grains. | J. Environ. Qual. | pmid:20830936 | |
| pmid: | ||||
| Fang HH et al. | Effects of Mo(VI) on phototrophic hydrogen production by Rhodobacter sphaeroides. | Environ Technol | pmid:21970170 | |
| ZABIN I and BLOCH K | The formation of ketone bodies from isovaleric acid. | 1950 | J. Biol. Chem. | pmid:15436482 |
| ZABIN I and BLOCH K | The utilization of isovaleric acid for the synthesis of cholesterol. | 1950 | J. Biol. Chem. | pmid:15436483 |
| ZABIN I and BLOCH K | Studies on the utilization of isovaleric acid in cholesterol synthesis. | 1951 | J. Biol. Chem. | pmid:14917674 |
| WOOLF LI | The hypoglycaemic effect of leucine and isovaleric acid. | 1960 | Clin. Chim. Acta | pmid:13845932 |
| Blank ML et al. | Isolation and identification of an alkyldiacylglycerol containing isovaleric acid. | 1972 | J. Lipid Res. | pmid:5025469 |
| Varanasi U and Malins DC | Triacylglycerols characteristic of porpoise acoustic tissues: molecular structures of diisovaleroylglycerides. | 1972 | Science | pmid:5033637 |
| Lipid biosynthesis and increase in isovaleric acid of plasma. | 1972 | Science | pmid:5034554 | |
| Malins DC et al. | Biosynthesis of triacylglycerols containing isovaleric acid. | 1972 | Biochem. Biophys. Res. Commun. | pmid:5043185 |
| Ando T et al. | Isovaleric acidemia: identification of isovalerate, isovalerylglycine, and 3-hydroxyisovalerate in urine of a patient previously reported as having butyric and hexanoic acidemia. | 1973 | J. Pediatr. | pmid:4684367 |
| Litchfield C and Ackman RG | Chromatographic analysis of isomeric isovalerate and isoamyl wax esters. | 1973 | J. Chromatogr. | pmid:4685182 |
| Müller-Schwarze D et al. | Mammalian pheromone: identification of active component in the subauricular scent of the male pronghorn. | 1974 | Science | pmid:17780773 |
| Conner RL et al. | Isovaleric acid as a precursor of odd numbered iso fatty acids in Tetrahymena. | 1974 | Lipids | pmid:4370638 |
| Conner RL and Reilly AE | The effects of isovalerate supplementation on growth and fatty acid composition of Tetrahymena pyriformis W. | 1975 | Biochim. Biophys. Acta | pmid:810159 |
| Varanasi U and Malins DC | Brain lipids from the porpoise (Delphinus delphis). Phosphoglycerides rich in isovaleric acid and long-chain iso-acids. | 1975 | Biochim. Biophys. Acta | pmid:1203247 |
| Rock CO and Snyder F | A short-chain acyl-CoA: 1-alkyl-2-acyl-sn-glycerol acyltrasnferase from a microsomal fraction of the rabbit Harderian gland. | 1975 | Biochim. Biophys. Acta | pmid:1138897 |
| Ackman RG et al. | Lipids of freshwater Dolphin Sotalia fluviatilis: comparison of odontocete bioacoustic lipids and habitat. | 1975 | Lipids | pmid:1123975 |
| Vague P et al. | Kinetics of the early insulin response of the perfused rat pancreas to various metabolites and tolbutamide. | 1975 | Diabete Metab | pmid:791726 |
| Tanaka K et al. | Metabolism of [1-(14)C] and [2-(14)C] leucine in cultured skin fibroblasts from patients with isovaleric acidemia. Characterization of metabolic defects. | 1976 | J. Clin. Invest. | pmid:932204 |
| Papierkowski A et al. | Serum concentrations of individual monocarboxylic short-chain fatty acids C2-C6 in underweight children. | 1976 | Acta Paediatr Acad Sci Hung | pmid:1032869 |
| Krieger I and Tanaka K | Therapeutic effects of glycine in isovaleric acidemia. | 1976 | Pediatr. Res. | pmid:1246461 |
| Blomberg J | Variations in lipid composition and sound velocity in melon from the North Atlantic Pilot whale, globicephala melaena melaena. | 1976 | Lipids | pmid:1250078 |
| Powers SG and Snell EE | Ketopantoate hydroxymethyltransferase. II. Physical, catalytic, and regulatory properties. | 1976 | J. Biol. Chem. | pmid:6463 |
| Wedmid Y and Litchfield C | Positional analysis of isovaleroyl triglycerides using proton magnetic resonance with Eu(fod)3 and Pr(fod)3 shift reagents: II. Cetacean triglycerides. | 1976 | Lipids | pmid:1263761 |
| Wysocki CJ et al. | Specific anosmia in the laboratory mouse. | 1977 | Behav. Genet. | pmid:869857 |
| Sharaf DM et al. | Skin surface lipids of the dog. | 1977 | Lipids | pmid:916820 |
| Niederhoff H et al. | [Serum isovaleric acid in a young infant]. | 1977 Jul-Aug | Pediatrie | pmid:896389 |
| Yudkoff M et al. | Glycine therapy in isovaleric acidemia. | 1978 | J. Pediatr. | pmid:641635 |
| Mantagos S et al. | Ethylmalonic-adipic aciduria. In vivo and in vitro studies indicating deficiency of activities of multiple acyl-CoA dehydrogenases. | 1979 | J. Clin. Invest. | pmid:500826 |
| Birr C et al. | Preparative merits of the mixed anhydride (MA) method in the excess use of DDZ-amino acids in the peptide synthesis of biologically active new antamanide analogues. | 1979 | Int. J. Pept. Protein Res. | pmid:581869 |
| Kodama H and Uasa S | Isotachophoretic analysis of isovalerylglycine in urine of a patient with isovaleric acidemia. | 1979 | J. Chromatogr. | pmid:541385 |
| Holze S and Panten U | Studies on the role of beta-cell metabolism in the insulinotropic effect of alpha-ketoisocaproic acid. | 1979 | Biochim. Biophys. Acta | pmid:389294 |
| Ohisa N et al. | Lindane degradation by cell-free extracts of Clostridium rectum. | 1980 | Arch. Microbiol. | pmid:6155109 |
| Picard B et al. | [Comparative study of the biochemical characteristics of hemolytic treponemes isolated from pigs]. | 1980 | Can. J. Microbiol. | pmid:7193071 |
| Takeda S et al. | Pharmacological studies on iridoid compounds. II. Relationship between structures and choleretic actions of iridoid compound. | 1980 | J. Pharmacobio-dyn. | pmid:7205532 |
| Schuberth J and Dahlberg L | Antagonistic effects of isovalerate and glycine on plasma choline levels in rabbits. | 1980 | Life Sci. | pmid:7354706 |
| Kelleher JF et al. | The pancytopenia of isovaleric acidemia. | 1980 | Pediatrics | pmid:7367115 |
| Hutton JC et al. | Fuel and signal function of 2-keto acids in insulin secretion. | 1980 | Horm. Metab. Res. Suppl. | pmid:7005062 |
| Larsson L et al. | Characterization of Clostridium difficile and its differentiation from Clostridium sporogenes by automatic head-space gas chromatography. | 1980 | Scand J Infect Dis Suppl | pmid:6937946 |
| Lehnert W | 3-Hydroxyisoheptanoic acid: a new metabolite in isovaleric acidemia. | 1981 | Clin. Chim. Acta | pmid:7237839 |
| Leyden JJ et al. | The microbiology of the human axilla and its relationship to axillary odor. | 1981 | J. Invest. Dermatol. | pmid:7288207 |
| Lehnert W | Excretion of N-isovalerylglutamic acid in isovaleric acidemia. | 1981 | Clin. Chim. Acta | pmid:7296890 |
| Al-Bassam SS and Sherratt HS | The antagonism of the toxicity of hypoglycin by glycine. | 1981 | Biochem. Pharmacol. | pmid:7317076 |
| Watanabe S and Fukuchi Y | [Occupational impairment of the olfactory sense of chromate producing workers (author's transl)]. | 1981 | Sangyo Igaku | pmid:7334695 |
| Truscott RJ et al. | New metabolites in isovaleric acidemia. | 1981 | Clin. Chim. Acta | pmid:6452974 |
| Sylvester SR et al. | In vitro conversion of leucine to valine: configurational assignment of [5-13C]leucines. | 1981 | Biochemistry | pmid:7028107 |