| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammatory Bowel Diseases | D015212 | 9 associated lipids |
| Occupational Diseases | D009784 | 42 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Amino Acid Metabolism, Inborn Errors | D000592 | 16 associated lipids |
| Olfaction Disorders | D000857 | 17 associated lipids |
| Maple Syrup Urine Disease | D008375 | 5 associated lipids |
| Acidosis, Renal Tubular | D000141 | 4 associated lipids |
| Fanconi Syndrome | D005198 | 4 associated lipids |
| Lipid Metabolism, Inborn Errors | D008052 | 26 associated lipids |
| Dwarfism | D004392 | 1 associated lipids |
ISOVALERIC ACID
ISOVALERIC ACID is a lipid of Fatty Acyls (FA) class. Isovaleric acid is associated with abnormalities such as Infection, Lymphocele, Cyst, Abscess and Subgingival plaque. The involved functions are known as Biochemical Reaction, 5-(carboxyamino)imidazole ribonucleotide mutase activity, nitrate reductase activity, urease activity and colony morphology. Isovaleric acid often locates in Skeleton, Abdomen, Chromosomes, Tissue membrane and Microsomes. The associated genes with ISOVALERIC ACID are trypticase, Operon, KCNT1 gene, Genome and Reverse primer. The related lipids are Fatty Acids, Propionate, Fatty Acids, Unsaturated, Steroids and Promega. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of ISOVALERIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ISOVALERIC ACID?
ISOVALERIC ACID is suspected in Exanthema, Isovaleryl-CoA dehydrogenase deficiency, Subgingival plaque, Dehydration, MAJOR DEPRESSIVE DISORDER 1, MAJOR DEPRESSIVE DISORDER 2 and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ISOVALERIC ACID
PubChem Associated disorders and diseases
What pathways are associated with ISOVALERIC ACID
Lipid pathways are not clear in current pathway databases. We organized associated pathways with ISOVALERIC ACID through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ISOVALERIC ACID?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with ISOVALERIC ACID?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with ISOVALERIC ACID?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with ISOVALERIC ACID?
Related references are published most in these journals:
- Appl. Environ. Microbiol. (4)
- Int. J. Syst. Evol. Microbiol. (3)
- Microbiology (Reading, Engl.) (2)
- Others (7)
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with ISOVALERIC ACID?
Knock-out
Knock-out are used in the study '3-Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase is involved in biosynthesis of isovaleryl-CoA in the myxobacterium Myxococcus xanthus during fruiting body formation.' (Bode HB et al., 2006) and Knock-out are used in the study 'Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.' (Ruan Y et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with ISOVALERIC ACID
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ensenauer R et al. | Newborn screening for isovaleric acidemia using tandem mass spectrometry: data from 1.6 million newborns. | 2011 | Clin. Chem. | pmid:21335445 |
| Weickert MO et al. | Changes in dominant groups of the gut microbiota do not explain cereal-fiber induced improvement of whole-body insulin sensitivity. | 2011 | Nutr Metab (Lond) | pmid:22177085 |
| Adams JB et al. | Gastrointestinal flora and gastrointestinal status in children with autism--comparisons to typical children and correlation with autism severity. | 2011 | BMC Gastroenterol | pmid:21410934 |
| Xiao W et al. | [Functional magnetic resonance imaging of brain activation in early period after olfactory adaptation]. | 2011 | Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi | pmid:22177038 |
| Johnson AJ | Cognitive facilitation following intentional odor exposure. | 2011 | Sensors (Basel) | pmid:22163909 |
| Jo YJ et al. | Comparison of fermented soybean paste (Doenjang) prepared by different methods based on profiling of volatile compounds. | 2011 | J. Food Sci. | pmid:21535802 |
| Ito N et al. | Antidepressant-like Effect of l-perillaldehyde in Stress-induced Depression-like Model Mice through Regulation of the Olfactory Nervous System. | 2011 | Evid Based Complement Alternat Med | pmid:18955354 |
| Thu TV et al. | Effects of liquid metabolite combinations produced by Lactobacillus plantarum on growth performance, faeces characteristics, intestinal morphology and diarrhoea incidence in postweaning piglets. | 2011 | Trop Anim Health Prod | pmid:20632092 |
| Potu RB et al. | The effect of lipid supplements on ruminal bacteria in continuous culture fermenters varies with the fatty acid composition. | 2011 | J. Microbiol. | pmid:21538241 |
| Kaster AK et al. | More than 200 genes required for methane formation from Hâ‚‚ and COâ‚‚ and energy conservation are present in Methanothermobacter marburgensis and Methanothermobacter thermautotrophicus. | 2011 | Archaea | pmid:21559116 |
| Daniotti M et al. | New developments in the treatment of hyperammonemia: emerging use of carglumic acid. | 2011 | Int J Gen Med | pmid:21403788 |
| Sentürk E et al. | Treatment efficiency and VFA composition of a thermophilic anaerobic contact reactor treating food industry wastewater. | 2010 | J. Hazard. Mater. | pmid:20022175 |
| Falentin H et al. | The complete genome of Propionibacterium freudenreichii CIRM-BIA1, a hardy actinobacterium with food and probiotic applications. | 2010 | PLoS ONE | pmid:20668525 |
| de Carvalho CC and Fernandes P | Production of metabolites as bacterial responses to the marine environment. | 2010 | Mar Drugs | pmid:20411122 |
| Berthiaume R et al. | Effects of nonstructural carbohydrate concentration in alfalfa on fermentation and microbial protein synthesis in continuous culture. | 2010 | J. Dairy Sci. | pmid:20105540 |
| Xu W et al. | Odorant-binding proteins of the malaria mosquito Anopheles funestus sensu stricto. | 2010 | PLoS ONE | pmid:21042539 |
| Gogerty DS and Bobik TA | Formation of isobutene from 3-hydroxy-3-methylbutyrate by diphosphomevalonate decarboxylase. | 2010 | Appl. Environ. Microbiol. | pmid:20971863 |
| Storm AC and Kristensen NB | Effects of particle size and dry matter content of a total mixed ration on intraruminal equilibration and net portal flux of volatile fatty acids in lactating dairy cows. | 2010 | J. Dairy Sci. | pmid:20723696 |
| Erdem E et al. | Chronic intermittent form of isovaleric acidemia mimicking diabetic ketoacidosis. | 2010 | J. Pediatr. Endocrinol. Metab. | pmid:20662350 |
| Lee HH et al. | A novel duplication at the putative DNA polymerase alpha arrest site and a founder mutation in Chinese in the IVD gene underlie isovaleric acidaemia. | 2010 | Hong Kong Med J | pmid:20519759 |
| Shirouchi B et al. | Physiological functions of iso-type short-chain fatty acid and omega 3 polyunsaturated fatty acids containing oil in obese OLETF rats. | 2010 | J Oleo Sci | pmid:20484835 |
| Ishida Y et al. | Polyprenylated benzoylphloroglucinol-type derivatives including novel cage compounds from Hypericum erectum. | 2010 | Chem. Pharm. Bull. | pmid:20190438 |
| Urano K et al. | Molecular defect of isovaleryl-CoA dehydrogenase in the skunk mutant of silkworm, Bombyx mori. | 2010 | FEBS J. | pmid:21040472 |
| Ren Y et al. | Geobacillus sp., a thermophilic soil bacterium producing volatile antibiotics. | 2010 | Microb. Ecol. | pmid:20091406 |
| Shen Q et al. | A comparative in vitro investigation into the effects of cooked meats on the human faecal microbiota. | 2010 | Anaerobe | pmid:20934523 |
| Connor SC et al. | Integration of metabolomics and transcriptomics data to aid biomarker discovery in type 2 diabetes. | 2010 | Mol Biosyst | pmid:20567778 |
| MartÃnez ME et al. | Comparison of fermentation of diets of variable composition and microbial populations in the rumen of sheep and Rusitec fermenters. I. Digestibility, fermentation parameters, and microbial growth. | 2010 | J. Dairy Sci. | pmid:20655438 |
| Jerković I and Marijanović Z | Volatile composition screening of Salix spp. nectar honey: benzenecarboxylic acids, norisoprenoids, terpenes, and others. | 2010 | Chem. Biodivers. | pmid:20860033 |
| Molina-Alcaide E et al. | Ruminal fermentation, microbial growth and amino acid flow in single-flow continuous culture fermenters fed a diet containing olive leaves. | 2010 | J Anim Physiol Anim Nutr (Berl) | pmid:19175451 |
| Sun H et al. | Complete genome sequence of Desulfarculus baarsii type strain (2st14). | 2010 | Stand Genomic Sci | pmid:21304732 |
| Andriamihaja M et al. | Colon luminal content and epithelial cell morphology are markedly modified in rats fed with a high-protein diet. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20689060 |
| Cometto-Muñiz JE and Abraham MH | Structure-activity relationships on the odor detectability of homologous carboxylic acids by humans. | 2010 | Exp Brain Res | pmid:20931179 |
| Barry KA et al. | Dietary cellulose, fructooligosaccharides, and pectin modify fecal protein catabolites and microbial populations in adult cats. | 2010 | J. Anim. Sci. | pmid:20495116 |
| Rezanka T et al. | Pilot-plant cultivation of Streptomyces griseus producing homologues of nonactin by precursor-directed biosynthesis and their identification by LC/MS-ESI. | 2010 | J. Antibiot. | pmid:20664602 |
| Kumazawa K et al. | Identification and formation of volatile components responsible for the characteristic aroma of mat rush (igusa). | 2010 | Biosci. Biotechnol. Biochem. | pmid:20530899 |
| Biagia G et al. | Effect of tannins on growth performance and intestinal ecosystem in weaned piglets. | 2010 | Arch Anim Nutr | pmid:20481351 |
| Okumu FO et al. | Development and field evaluation of a synthetic mosquito lure that is more attractive than humans. | 2010 | PLoS ONE | pmid:20126628 |
| Olanga EA et al. | Attraction of Anopheles gambiae to odour baits augmented with heat and moisture. | 2010 | Malar. J. | pmid:20051143 |
| Karlsson C et al. | Probiotic therapy to men with incipient arteriosclerosis initiates increased bacterial diversity in colon: a randomized controlled trial. | 2010 | Atherosclerosis | pmid:19608185 |
| Thrash JC et al. | Description of the novel perchlorate-reducing bacteria Dechlorobacter hydrogenophilus gen. nov., sp. nov.and Propionivibrio militaris, sp. nov. | 2010 | Appl. Microbiol. Biotechnol. | pmid:19921177 |
| Marreddy RK et al. | Amino acid accumulation limits the overexpression of proteins in Lactococcus lactis. | 2010 | PLoS ONE | pmid:20436673 |
| Ibrahim MA et al. | Elevation of night-time temperature increases terpenoid emissions from Betula pendula and Populus tremula. | 2010 | J. Exp. Bot. | pmid:20181662 |
| Spring S et al. | Complete genome sequence of Thermosphaera aggregans type strain (M11TL). | 2010 | Stand Genomic Sci | pmid:21304709 |
| Pitluck S et al. | Complete genome sequence of Thermosediminibacter oceani type strain (JW/IW-1228P). | 2010 | Stand Genomic Sci | pmid:21304740 |
| Labutti K et al. | Permanent draft genome sequence of Dethiosulfovibrio peptidovorans type strain (SEBR 4207). | 2010 | Stand Genomic Sci | pmid:21304695 |
| Rey FE et al. | Dissecting the in vivo metabolic potential of two human gut acetogens. | 2010 | J. Biol. Chem. | pmid:20444704 |
| Benus RF et al. | Impact of digestive and oropharyngeal decontamination on the intestinal microbiota in ICU patients. | 2010 | Intensive Care Med | pmid:20232045 |
| Schilmiller A et al. | Mass spectrometry screening reveals widespread diversity in trichome specialized metabolites of tomato chromosomal substitution lines. | 2010 | Plant J. | pmid:20113441 |
| Parker DB et al. | Recovery of agricultural odors and odorous compounds from polyvinyl fluoride film bags. | 2010 | Sensors (Basel) | pmid:22163671 |
| Urriola PE and Stein HH | Effects of distillers dried grains with solubles on amino acid, energy, and fiber digestibility and on hindgut fermentation of dietary fiber in a corn-soybean meal diet fed to growing pigs. | 2010 | J. Anim. Sci. | pmid:20023135 |
| Corriher VA et al. | Pigeon peas as a supplement for lactating dairy cows fed corn silage-based diets. | 2010 | J. Dairy Sci. | pmid:20965347 |
| Tiihonen K et al. | The effect of feeding essential oils on broiler performance and gut microbiota. | 2010 | Br. Poult. Sci. | pmid:20680873 |
| Anderson IJ et al. | The complete genome sequence of Staphylothermus marinus reveals differences in sulfur metabolism among heterotrophic Crenarchaeota. | 2009 | BMC Genomics | pmid:19341479 |
| Verhulst NO et al. | Cultured skin microbiota attracts malaria mosquitoes. | 2009 | Malar. J. | pmid:20017925 |
| Chung YH et al. | Ruminal and blood responses to propylene glycol during frequent feeding. | 2009 | J. Dairy Sci. | pmid:19700718 |
| Wongchoosuk C et al. | Detection and classification of human body odor using an electronic nose. | 2009 | Sensors (Basel) | pmid:22399995 |
| Karnati SK et al. | Investigating unsaturated fat, monensin, or bromoethanesulfonate in continuous cultures retaining ruminal protozoa. I. Fermentation, biohydrogenation, and microbial protein synthesis. | 2009 | J. Dairy Sci. | pmid:19620669 |
| Foroud NA and Eudes F | Trichothecenes in cereal grains. | 2009 | Int J Mol Sci | pmid:19333439 |
| Lapid H et al. | Odorant concentration dependence in electroolfactograms recorded from the human olfactory epithelium. | 2009 | J. Neurophysiol. | pmid:19657081 |
| Robin S et al. | Genetic diversity of canine olfactory receptors. | 2009 | BMC Genomics | pmid:19144169 |
| Bengtsson JM et al. | Field attractants for Pachnoda interrupta selected by means of GC-EAD and single sensillum screening. | 2009 | J. Chem. Ecol. | pmid:19768509 |
| Weng Y et al. | Isovaleric, methylmalonic, and propionic acid decrease anesthetic EC50 in tadpoles, modulate glycine receptor function, and interact with the lipid 1,2-dipalmitoyl-Sn-glycero-3-phosphocholine. | 2009 | Anesth. Analg. | pmid:19372333 |
| Ribeiro CA et al. | Creatine administration prevents Na+,K+-ATPase inhibition induced by intracerebroventricular administration of isovaleric acid in cerebral cortex of young rats. | 2009 | Brain Res. | pmid:19210957 |
| Zahorodny Duggan ZP et al. | Distribution and development of the highly specialized lipids in the sound reception systems of dolphins. | 2009 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:19373476 |
| Loots DT | Abnormal tricarboxylic acid cycle metabolites in isovaleric acidaemia. | 2009 | J. Inherit. Metab. Dis. | pmid:19343532 |
| Liu Q et al. | Effects of isovalerate on ruminal fermentation, urinary excretion of purine derivatives and digestibility in steers. | 2009 | J Anim Physiol Anim Nutr (Berl) | pmid:19138353 |
| Van den Velde S et al. | Detection of odorous compounds in breath. | 2009 | J. Dent. Res. | pmid:19329466 |
| Kobayashi E et al. | Functional optical hemodynamic imaging of the olfactory cortex in normosmia subjects and dysosmia subjects. | 2009 | Acta Otolaryngol Suppl | pmid:19848246 |
| Caroprese A et al. | HS-SPME-GC-MS analysis of body odor to test the efficacy of foot deodorant formulations. | 2009 | Skin Res Technol | pmid:19832965 |
| Wu H et al. | The effect of pH on anaerobic fermentation of primary sludge at room temperature. | 2009 | J. Hazard. Mater. | pmid:19643539 |
| MartÃnez ME et al. | Effects of dilution rate and retention time of concentrate on efficiency of microbial growth, methane production, and ruminal fermentation in Rusitec fermenters. | 2009 | J. Dairy Sci. | pmid:19620676 |
| Ye FX et al. | Deodorization of swine manure slurry using horseradish peroxidase and peroxides. | 2009 | J. Hazard. Mater. | pmid:19171425 |
| Illmer P and Gstraunthaler G | Effect of seasonal changes in quantities of biowaste on full scale anaerobic digester performance. | 2009 | Waste Manag | pmid:18400485 |
| Abstracts of the 2008 ISSOL Meeting. August 24-29, 2008. Florence, Italy. | 2009 | Orig Life Evol Biosph | pmid:19468860 | |
| Barbosa C et al. | Nitrogen addition influences formation of aroma compounds, volatile acidity and ethanol in nitrogen deficient media fermented by Saccharomyces cerevisiae wine strains. | 2009 | J. Biosci. Bioeng. | pmid:19619854 |
| Bailly S et al. | Fate of key odorants in Sauternes wines through aging. | 2009 | J. Agric. Food Chem. | pmid:19754174 |
| May ML et al. | Effects of dry-rolled or steam-flaked corn finishing diets with or without twenty-five percent dried distillers grains on ruminal fermentation and apparent total tract digestion. | 2009 | J. Anim. Sci. | pmid:19648506 |
| Serres MH et al. | Evolution by leaps: gene duplication in bacteria. | 2009 | Biol. Direct | pmid:19930658 |
| Gonçalves B et al. | Effects of elevated CO2 on grapevine (Vitis vinifera L.): volatile composition, phenolic content, and in vitro antioxidant activity of red wine. | 2009 | J. Agric. Food Chem. | pmid:19072054 |
| Berna AZ et al. | Bio-benchmarking of electronic nose sensors. | 2009 | PLoS ONE | pmid:19641604 |
| Smallegange RC et al. | The effect of aliphatic carboxylic acids on olfaction-based host-seeking of the malaria mosquito Anopheles gambiae sensu stricto. | 2009 | J. Chem. Ecol. | pmid:19626371 |
| Aklujkar M et al. | The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens. | 2009 | BMC Microbiol. | pmid:19473543 |
| German DP | Do herbivorous minnows have "plug-flow reactor" guts? Evidence from digestive enzyme activities, gastrointestinal fermentation, and luminal nutrient concentrations. | 2009 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:19363616 |
| Breme K et al. | Identification of odor impact compounds of Tagetes minuta L. essential oil: comparison of two GC-olfactometry methods. | 2009 | J. Agric. Food Chem. | pmid:19694437 |
| Zanor MI et al. | Metabolic characterization of loci affecting sensory attributes in tomato allows an assessment of the influence of the levels of primary metabolites and volatile organic contents. | 2009 | J. Exp. Bot. | pmid:19346240 |
| Wu XH et al. | Characterization of Chinese liquor starter, "Daqu", by flavor type with 1H NMR-based nontargeted analysis. | 2009 | J. Agric. Food Chem. | pmid:19886664 |
| Baughn AD et al. | An anaerobic-type alpha-ketoglutarate ferredoxin oxidoreductase completes the oxidative tricarboxylic acid cycle of Mycobacterium tuberculosis. | 2009 | PLoS Pathog. | pmid:19936047 |
| Yamin BM and Othman EA | 3-Methyl-2-propionamido-butanoic acid. | 2009 | Acta Crystallogr Sect E Struct Rep Online | pmid:21582407 |
| Pukall R et al. | Complete genome sequence of Slackia heliotrinireducens type strain (RHS 1). | 2009 | Stand Genomic Sci | pmid:21304663 |
| Anderson IJ et al. | Complete genome sequence of Staphylothermus marinus Stetter and Fiala 1986 type strain F1. | 2009 | Stand Genomic Sci | pmid:21304655 |
| Akdeniz N et al. | Air sampling and analysis method for volatile organic compounds (VOCs) related to field-scale mortality composting operations. | 2009 | J. Agric. Food Chem. | pmid:19514732 |
| Ntaikou I et al. | Exploitation of olive oil mill wastewater for combined biohydrogen and biopolymers production. | 2009 | Bioresour. Technol. | pmid:19138844 |
| Spiehs MJ and Varel VH | Nutrient excretion and odorant production in manure from cattle fed corn wet distillers grains with solubles. | 2009 | J. Anim. Sci. | pmid:19502500 |
| Hayashida-Soiza G et al. | Purification and characterization of antibacterial substances produced by a marine bacterium Pseudoalteromonas haloplanktis strain. | 2008 | J. Appl. Microbiol. | pmid:18828792 |
| Atsumi T et al. | Salivary free radical-scavenging activity is affected by physical and mental activities. | 2008 | Oral Dis | pmid:18826379 |
| Downes J et al. | Prevotella histicola sp. nov., isolated from the human oral cavity. | 2008 | Int. J. Syst. Evol. Microbiol. | pmid:18676457 |
| Callejón RM et al. | Defining the typical aroma of sherry vinegar: sensory and chemical approach. | 2008 | J. Agric. Food Chem. | pmid:18651741 |
| Greene JL et al. | Characterization of volatile compounds contributing to naturally occurring fruity fermented flavor in peanuts. | 2008 | J. Agric. Food Chem. | pmid:18686969 |
| Loh G et al. | The Toll-like receptors TLR2 and TLR4 do not affect the intestinal microbiota composition in mice. | 2008 | Environ. Microbiol. | pmid:18036181 |
| Varel VH et al. | Odorant production and persistence of Escherichia coli in manure slurries from cattle fed zero, twenty, forty, or sixty percent wet distillers grains with solubles. | 2008 | J. Anim. Sci. | pmid:18676716 |