ISOVALERIC ACID

ISOVALERIC ACID is a lipid of Fatty Acyls (FA) class. Isovaleric acid is associated with abnormalities such as Infection, Lymphocele, Cyst, Abscess and Subgingival plaque. The involved functions are known as Biochemical Reaction, 5-(carboxyamino)imidazole ribonucleotide mutase activity, nitrate reductase activity, urease activity and colony morphology. Isovaleric acid often locates in Skeleton, Abdomen, Chromosomes, Tissue membrane and Microsomes. The associated genes with ISOVALERIC ACID are trypticase, Operon, KCNT1 gene, Genome and Reverse primer. The related lipids are Fatty Acids, Propionate, Fatty Acids, Unsaturated, Steroids and Promega. The related experimental models are Knock-out.

Cross Reference

Introduction

To understand associated biological information of ISOVALERIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with ISOVALERIC ACID?

ISOVALERIC ACID is suspected in Exanthema, Isovaleryl-CoA dehydrogenase deficiency, Subgingival plaque, Dehydration, MAJOR DEPRESSIVE DISORDER 1, MAJOR DEPRESSIVE DISORDER 2 and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with ISOVALERIC ACID

MeSH term MeSH ID Detail
Inflammatory Bowel Diseases D015212 9 associated lipids
Occupational Diseases D009784 42 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Amino Acid Metabolism, Inborn Errors D000592 16 associated lipids
Olfaction Disorders D000857 17 associated lipids
Maple Syrup Urine Disease D008375 5 associated lipids
Acidosis, Renal Tubular D000141 4 associated lipids
Fanconi Syndrome D005198 4 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Dwarfism D004392 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with ISOVALERIC ACID

Lipid pathways are not clear in current pathway databases. We organized associated pathways with ISOVALERIC ACID through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with ISOVALERIC ACID?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with ISOVALERIC ACID?


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Function Cross reference Weighted score Related literatures

What lipids are associated with ISOVALERIC ACID?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with ISOVALERIC ACID?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with ISOVALERIC ACID?

Knock-out

Knock-out are used in the study '3-Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase is involved in biosynthesis of isovaleryl-CoA in the myxobacterium Myxococcus xanthus during fruiting body formation.' (Bode HB et al., 2006) and Knock-out are used in the study 'Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.' (Ruan Y et al., 2001).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with ISOVALERIC ACID

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Battaglia L et al. Solid lipid nanoparticles formed by solvent-in-water emulsion-diffusion technique: development and influence on insulin stability. 2007 J Microencapsul pmid:17763060
Shigematsu Y et al. Prenatal diagnosis of isovaleric acidemia by fast atom bombardment and tandem mass spectrometry. 1991 Clin. Chim. Acta pmid:1777996
Müller-Schwarze D et al. Mammalian pheromone: identification of active component in the subauricular scent of the male pronghorn. 1974 Science pmid:17780773
Htoo JK et al. Effect of dietary protein content on ileal amino acid digestibility, growth performance, and formation of microbial metabolites in ileal and cecal digesta of early-weaned pigs. 2007 J. Anim. Sci. pmid:17785591
Shigematsu Y et al. Stable-isotope dilution measurement of isovalerylglycine by tandem mass spectrometry in newborn screening for isovaleric acidemia. 2007 Nov-Dec Clin. Chim. Acta pmid:17850781
Krizsan SJ et al. Effect of alfalfa silage storage structure and roasting corn on production and ruminal metabolism of lactating dairy cows. 2007 J. Dairy Sci. pmid:17881702
Kambere MB and Lane RP Co-regulation of a large and rapidly evolving repertoire of odorant receptor genes. 2007 BMC Neurosci pmid:17903278
Menashe I et al. Genetic elucidation of human hyperosmia to isovaleric acid. 2007 PLoS Biol. pmid:17973576
Loh G et al. The Toll-like receptors TLR2 and TLR4 do not affect the intestinal microbiota composition in mice. 2008 Environ. Microbiol. pmid:18036181
Qiu YT et al. Attractiveness of MM-X traps baited with human or synthetic odor to mosquitoes (Diptera: Culicidae) in The Gambia. 2007 J. Med. Entomol. pmid:18047195
Jumas-Bilak E et al. Jonquetella anthropi gen. nov., sp. nov., the first member of the candidate phylum 'Synergistetes' isolated from man. 2007 Int. J. Syst. Evol. Microbiol. pmid:18048718
Zuhainis Saad W et al. Effects of phenolic monomers on the enzymes activities and volatile fatty acids production of Neocallimastix frontalis B9. 2008 Anaerobe pmid:18083606
Jacobs DM et al. (1)H NMR metabolite profiling of feces as a tool to assess the impact of nutrition on the human microbiome. 2008 NMR Biomed pmid:18085514
Zhang X and Firestein S Nose thyself: individuality in the human olfactory genome. 2007 Genome Biol. pmid:18086317
Bramley E et al. The definition of acidosis in dairy herds predominantly fed on pasture and concentrates. 2008 J. Dairy Sci. pmid:18096953
Rotsatchakul P et al. Identification of characteristic aroma components of Thai fried chili paste. 2008 J. Agric. Food Chem. pmid:18163558
Safaralie A et al. Essential oil composition of Valeriana officinalis L. roots cultivated in Iran. Comparative analysis between supercritical CO2 extraction and hydrodistillation. 2008 J Chromatogr A pmid:18164718
Wilson GJ et al. Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review. 2008 Nutr Metab (Lond) pmid:18173841
Martin FP et al. Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model. 2008 Mol. Syst. Biol. pmid:18197175
Song H and Cadwallader KR Aroma components of American country ham. 2008 J. Food Sci. pmid:18211346
Bal D et al. Investigation of a wide spectrum of inherited metabolic disorders by 13C NMR spectroscopy. 2008 Acta Biochim. Pol. pmid:18217108
Elefsiniotis P and Li W Biodegradation behavior of agricultural pesticides in anaerobic batch reactors. 2008 J Environ Sci Health B pmid:18246509
Förster-Fromme K et al. Biochemical characterization of AtuD from Pseudomonas aeruginosa, the first member of a new subgroup of acyl-CoA dehydrogenases with specificity for citronellyl-CoA. 2008 Microbiology (Reading, Engl.) pmid:18310025
Kim J et al. An allylic ketyl radical intermediate in clostridial amino-acid fermentation. 2008 Nature pmid:18337824
Shiratori H et al. Lutispora thermophila gen. nov., sp. nov., a thermophilic, spore-forming bacterium isolated from a thermophilic methanogenic bioreactor digesting municipal solid wastes. 2008 Int. J. Syst. Evol. Microbiol. pmid:18398203
Illmer P and Gstraunthaler G Effect of seasonal changes in quantities of biowaste on full scale anaerobic digester performance. 2009 Waste Manag pmid:18400485
Kawata J et al. Cyclooxygenase-2 inhibitory effects and composition of the volatile oil from the dried roots of Lithospermum erythrorhizon. 2008 J Nat Med pmid:18404332
Westermann CM et al. Acquired multiple Acyl-CoA dehydrogenase deficiency in 10 horses with atypical myopathy. 2008 Neuromuscul. Disord. pmid:18406615
Heil M et al. Defense-inducing volatiles: in search of the active motif. 2008 J. Chem. Ecol. pmid:18408973
Strobel GA et al. Synergism among volatile organic compounds resulting in increased antibiosis in Oidium sp. 2008 FEMS Microbiol. Lett. pmid:18422630
James AG et al. Generation of volatile fatty acids by axillary bacteria. 2004 Int J Cosmet Sci pmid:18494871
Lapid H et al. Prediction models for the pleasantness of binary mixtures in olfaction. 2008 Chem. Senses pmid:18534998
Knaapila A et al. Environmental effects exceed genetic effects on perceived intensity and pleasantness of several odors: a three-population twin study. 2008 Behav. Genet. pmid:18543092
Graça G et al. Metabolite profiling of human amniotic fluid by hyphenated nuclear magnetic resonance spectroscopy. 2008 Anal. Chem. pmid:18564856
Castorina M et al. Different outcome in isovaleric acidemia might be related to unsatisfactory diet compliance. 2008 Scand. J. Gastroenterol. pmid:18569998
Kimmoun A et al. Acute decompensation of isovaleric acidemia induced by Graves' disease. 2008 Intensive Care Med pmid:18607566
Pesce F et al. Acute neonatal isovaleric acidaemia presented without acidosis or ketonuria. 1991 J. Inherit. Metab. Dis. pmid:1861451
Förster-Fromme K and Jendrossek D Biochemical characterization of isovaleryl-CoA dehydrogenase (LiuA) of Pseudomonas aeruginosa and the importance of liu genes fora functional catabolic pathway of methyl-branched compounds. 2008 FEMS Microbiol. Lett. pmid:18625020
Botelho G et al. Differences in odor-active compounds of trincadeira wines obtained from five different clones. 2008 J. Agric. Food Chem. pmid:18627166
Martin FP et al. Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model. 2008 Mol. Syst. Biol. pmid:18628745
Callejón RM et al. Defining the typical aroma of sherry vinegar: sensory and chemical approach. 2008 J. Agric. Food Chem. pmid:18651741
Solano AF et al. Induction of oxidative stress by the metabolites accumulating in isovaleric acidemia in brain cortex of young rats. 2008 Free Radic. Res. pmid:18661426
Downes J et al. Prevotella histicola sp. nov., isolated from the human oral cavity. 2008 Int. J. Syst. Evol. Microbiol. pmid:18676457
Varel VH et al. Odorant production and persistence of Escherichia coli in manure slurries from cattle fed zero, twenty, forty, or sixty percent wet distillers grains with solubles. 2008 J. Anim. Sci. pmid:18676716
Greene JL et al. Characterization of volatile compounds contributing to naturally occurring fruity fermented flavor in peanuts. 2008 J. Agric. Food Chem. pmid:18686969
Atsumi T et al. Salivary free radical-scavenging activity is affected by physical and mental activities. 2008 Oral Dis pmid:18826379
Hayashida-Soiza G et al. Purification and characterization of antibacterial substances produced by a marine bacterium Pseudoalteromonas haloplanktis strain. 2008 J. Appl. Microbiol. pmid:18828792
Frauendorfer F and Schieberle P Changes in key aroma compounds of Criollo cocoa beans during roasting. 2008 J. Agric. Food Chem. pmid:18925740
Ito N et al. Antidepressant-like Effect of l-perillaldehyde in Stress-induced Depression-like Model Mice through Regulation of the Olfactory Nervous System. 2011 Evid Based Complement Alternat Med pmid:18955354
Hasin Y et al. High-resolution copy-number variation map reflects human olfactory receptor diversity and evolution. 2008 PLoS Genet. pmid:18989455
Rossouw D et al. Linking gene regulation and the exo-metabolome: a comparative transcriptomics approach to identify genes that impact on the production of volatile aroma compounds in yeast. 2008 BMC Genomics pmid:18990252
Rodrigues DF et al. Architecture of thermal adaptation in an Exiguobacterium sibiricum strain isolated from 3 million year old permafrost: a genome and transcriptome approach. 2008 BMC Genomics pmid:19019206
Yu AN et al. Top note compounds of Chinese traditional bacteria-fermented soybean. 2008 Nat. Prod. Res. pmid:19023819
Boeckaert C et al. Effect of dietary starch or micro algae supplementation on rumen fermentation and milk fatty acid composition of dairy cows. 2008 J. Dairy Sci. pmid:19038948
Gonçalves B et al. Effects of elevated CO2 on grapevine (Vitis vinifera L.): volatile composition, phenolic content, and in vitro antioxidant activity of red wine. 2009 J. Agric. Food Chem. pmid:19072054
Lu RF et al. [Analysis of short chain fatty acids in gingival crevicular fluid of patients with aggressive periodontitis]. 2008 Zhonghua Kou Qiang Yi Xue Za Zhi pmid:19087639
Liu Q et al. Effects of isovalerate on ruminal fermentation, urinary excretion of purine derivatives and digestibility in steers. 2009 J Anim Physiol Anim Nutr (Berl) pmid:19138353
Ntaikou I et al. Exploitation of olive oil mill wastewater for combined biohydrogen and biopolymers production. 2009 Bioresour. Technol. pmid:19138844
Robin S et al. Genetic diversity of canine olfactory receptors. 2009 BMC Genomics pmid:19144169
Ye FX et al. Deodorization of swine manure slurry using horseradish peroxidase and peroxides. 2009 J. Hazard. Mater. pmid:19171425
Molina-Alcaide E et al. Ruminal fermentation, microbial growth and amino acid flow in single-flow continuous culture fermenters fed a diet containing olive leaves. 2010 J Anim Physiol Anim Nutr (Berl) pmid:19175451
Ribeiro CA et al. Creatine administration prevents Na+,K+-ATPase inhibition induced by intracerebroventricular administration of isovaleric acid in cerebral cortex of young rats. 2009 Brain Res. pmid:19210957
Bell JA et al. Ecological characterization of the colonic microbiota of normal and diarrheic dogs. 2008 Interdiscip Perspect Infect Dis pmid:19282974
Van den Velde S et al. Detection of odorous compounds in breath. 2009 J. Dent. Res. pmid:19329466
Foroud NA and Eudes F Trichothecenes in cereal grains. 2009 Int J Mol Sci pmid:19333439
Anderson IJ et al. The complete genome sequence of Staphylothermus marinus reveals differences in sulfur metabolism among heterotrophic Crenarchaeota. 2009 BMC Genomics pmid:19341479
Loots DT Abnormal tricarboxylic acid cycle metabolites in isovaleric acidaemia. 2009 J. Inherit. Metab. Dis. pmid:19343532
Zanor MI et al. Metabolic characterization of loci affecting sensory attributes in tomato allows an assessment of the influence of the levels of primary metabolites and volatile organic contents. 2009 J. Exp. Bot. pmid:19346240
German DP Do herbivorous minnows have "plug-flow reactor" guts? Evidence from digestive enzyme activities, gastrointestinal fermentation, and luminal nutrient concentrations. 2009 J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. pmid:19363616
Weng Y et al. Isovaleric, methylmalonic, and propionic acid decrease anesthetic EC50 in tadpoles, modulate glycine receptor function, and interact with the lipid 1,2-dipalmitoyl-Sn-glycero-3-phosphocholine. 2009 Anesth. Analg. pmid:19372333
Zahorodny Duggan ZP et al. Distribution and development of the highly specialized lipids in the sound reception systems of dolphins. 2009 J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. pmid:19373476
Abstracts of the 2008 ISSOL Meeting. August 24-29, 2008. Florence, Italy. 2009 Orig Life Evol Biosph pmid:19468860
Aklujkar M et al. The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens. 2009 BMC Microbiol. pmid:19473543
Spiehs MJ and Varel VH Nutrient excretion and odorant production in manure from cattle fed corn wet distillers grains with solubles. 2009 J. Anim. Sci. pmid:19502500
Akdeniz N et al. Air sampling and analysis method for volatile organic compounds (VOCs) related to field-scale mortality composting operations. 2009 J. Agric. Food Chem. pmid:19514732
Karlsson C et al. Probiotic therapy to men with incipient arteriosclerosis initiates increased bacterial diversity in colon: a randomized controlled trial. 2010 Atherosclerosis pmid:19608185
Barbosa C et al. Nitrogen addition influences formation of aroma compounds, volatile acidity and ethanol in nitrogen deficient media fermented by Saccharomyces cerevisiae wine strains. 2009 J. Biosci. Bioeng. pmid:19619854
Karnati SK et al. Investigating unsaturated fat, monensin, or bromoethanesulfonate in continuous cultures retaining ruminal protozoa. I. Fermentation, biohydrogenation, and microbial protein synthesis. 2009 J. Dairy Sci. pmid:19620669
Martínez ME et al. Effects of dilution rate and retention time of concentrate on efficiency of microbial growth, methane production, and ruminal fermentation in Rusitec fermenters. 2009 J. Dairy Sci. pmid:19620676
Smallegange RC et al. The effect of aliphatic carboxylic acids on olfaction-based host-seeking of the malaria mosquito Anopheles gambiae sensu stricto. 2009 J. Chem. Ecol. pmid:19626371
Berna AZ et al. Bio-benchmarking of electronic nose sensors. 2009 PLoS ONE pmid:19641604
Wu H et al. The effect of pH on anaerobic fermentation of primary sludge at room temperature. 2009 J. Hazard. Mater. pmid:19643539
May ML et al. Effects of dry-rolled or steam-flaked corn finishing diets with or without twenty-five percent dried distillers grains on ruminal fermentation and apparent total tract digestion. 2009 J. Anim. Sci. pmid:19648506
Lapid H et al. Odorant concentration dependence in electroolfactograms recorded from the human olfactory epithelium. 2009 J. Neurophysiol. pmid:19657081
Breme K et al. Identification of odor impact compounds of Tagetes minuta L. essential oil: comparison of two GC-olfactometry methods. 2009 J. Agric. Food Chem. pmid:19694437
Chung YH et al. Ruminal and blood responses to propylene glycol during frequent feeding. 2009 J. Dairy Sci. pmid:19700718
Bailly S et al. Fate of key odorants in Sauternes wines through aging. 2009 J. Agric. Food Chem. pmid:19754174
Bengtsson JM et al. Field attractants for Pachnoda interrupta selected by means of GC-EAD and single sensillum screening. 2009 J. Chem. Ecol. pmid:19768509
Caroprese A et al. HS-SPME-GC-MS analysis of body odor to test the efficacy of foot deodorant formulations. 2009 Skin Res Technol pmid:19832965
Kobayashi E et al. Functional optical hemodynamic imaging of the olfactory cortex in normosmia subjects and dysosmia subjects. 2009 Acta Otolaryngol Suppl pmid:19848246
Wu XH et al. Characterization of Chinese liquor starter, "Daqu", by flavor type with 1H NMR-based nontargeted analysis. 2009 J. Agric. Food Chem. pmid:19886664
Thrash JC et al. Description of the novel perchlorate-reducing bacteria Dechlorobacter hydrogenophilus gen. nov., sp. nov.and Propionivibrio militaris, sp. nov. 2010 Appl. Microbiol. Biotechnol. pmid:19921177
Serres MH et al. Evolution by leaps: gene duplication in bacteria. 2009 Biol. Direct pmid:19930658
Baughn AD et al. An anaerobic-type alpha-ketoglutarate ferredoxin oxidoreductase completes the oxidative tricarboxylic acid cycle of Mycobacterium tuberculosis. 2009 PLoS Pathog. pmid:19936047
Verhulst NO et al. Cultured skin microbiota attracts malaria mosquitoes. 2009 Malar. J. pmid:20017925
Sentürk E et al. Treatment efficiency and VFA composition of a thermophilic anaerobic contact reactor treating food industry wastewater. 2010 J. Hazard. Mater. pmid:20022175
Urriola PE and Stein HH Effects of distillers dried grains with solubles on amino acid, energy, and fiber digestibility and on hindgut fermentation of dietary fiber in a corn-soybean meal diet fed to growing pigs. 2010 J. Anim. Sci. pmid:20023135
Olanga EA et al. Attraction of Anopheles gambiae to odour baits augmented with heat and moisture. 2010 Malar. J. pmid:20051143
Ronnett GV et al. Odorant-sensitive adenylate cyclase: rapid, potent activation and desensitization in primary olfactory neuronal cultures. 1991 Proc. Natl. Acad. Sci. U.S.A. pmid:2006174
Gross L A genetic basis for hypersensitivity to "sweaty" odors in humans. 2007 PLoS Biol. pmid:20076651