| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammatory Bowel Diseases | D015212 | 9 associated lipids |
| Occupational Diseases | D009784 | 42 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Amino Acid Metabolism, Inborn Errors | D000592 | 16 associated lipids |
| Olfaction Disorders | D000857 | 17 associated lipids |
| Maple Syrup Urine Disease | D008375 | 5 associated lipids |
| Acidosis, Renal Tubular | D000141 | 4 associated lipids |
| Fanconi Syndrome | D005198 | 4 associated lipids |
| Lipid Metabolism, Inborn Errors | D008052 | 26 associated lipids |
| Dwarfism | D004392 | 1 associated lipids |
ISOVALERIC ACID
ISOVALERIC ACID is a lipid of Fatty Acyls (FA) class. Isovaleric acid is associated with abnormalities such as Infection, Lymphocele, Cyst, Abscess and Subgingival plaque. The involved functions are known as Biochemical Reaction, 5-(carboxyamino)imidazole ribonucleotide mutase activity, nitrate reductase activity, urease activity and colony morphology. Isovaleric acid often locates in Skeleton, Abdomen, Chromosomes, Tissue membrane and Microsomes. The associated genes with ISOVALERIC ACID are trypticase, Operon, KCNT1 gene, Genome and Reverse primer. The related lipids are Fatty Acids, Propionate, Fatty Acids, Unsaturated, Steroids and Promega. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of ISOVALERIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ISOVALERIC ACID?
ISOVALERIC ACID is suspected in Exanthema, Isovaleryl-CoA dehydrogenase deficiency, Subgingival plaque, Dehydration, MAJOR DEPRESSIVE DISORDER 1, MAJOR DEPRESSIVE DISORDER 2 and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ISOVALERIC ACID
PubChem Associated disorders and diseases
What pathways are associated with ISOVALERIC ACID
Lipid pathways are not clear in current pathway databases. We organized associated pathways with ISOVALERIC ACID through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ISOVALERIC ACID?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ISOVALERIC ACID?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with ISOVALERIC ACID?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with ISOVALERIC ACID?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with ISOVALERIC ACID?
Knock-out
Knock-out are used in the study '3-Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase is involved in biosynthesis of isovaleryl-CoA in the myxobacterium Myxococcus xanthus during fruiting body formation.' (Bode HB et al., 2006) and Knock-out are used in the study 'Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.' (Ruan Y et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with ISOVALERIC ACID
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| González LA et al. | Increasing sodium bicarbonate level in high-concentrate diets for heifers. I. Effects on intake, water consumption and ruminal fermentation. | 2008 | Animal | pmid:22443595 |
| Hayashida-Soiza G et al. | Purification and characterization of antibacterial substances produced by a marine bacterium Pseudoalteromonas haloplanktis strain. | 2008 | J. Appl. Microbiol. | pmid:18828792 |
| Atsumi T et al. | Salivary free radical-scavenging activity is affected by physical and mental activities. | 2008 | Oral Dis | pmid:18826379 |
| Förster-Fromme K and Jendrossek D | Biochemical characterization of isovaleryl-CoA dehydrogenase (LiuA) of Pseudomonas aeruginosa and the importance of liu genes fora functional catabolic pathway of methyl-branched compounds. | 2008 | FEMS Microbiol. Lett. | pmid:18625020 |
| Lu RF et al. | [Analysis of short chain fatty acids in gingival crevicular fluid of patients with aggressive periodontitis]. | 2008 | Zhonghua Kou Qiang Yi Xue Za Zhi | pmid:19087639 |
| Downes J et al. | Prevotella histicola sp. nov., isolated from the human oral cavity. | 2008 | Int. J. Syst. Evol. Microbiol. | pmid:18676457 |
| Solano AF et al. | Induction of oxidative stress by the metabolites accumulating in isovaleric acidemia in brain cortex of young rats. | 2008 | Free Radic. Res. | pmid:18661426 |
| Martin FP et al. | Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model. | 2008 | Mol. Syst. Biol. | pmid:18197175 |
| Zuhainis Saad W et al. | Effects of phenolic monomers on the enzymes activities and volatile fatty acids production of Neocallimastix frontalis B9. | 2008 | Anaerobe | pmid:18083606 |
| Bal D et al. | Investigation of a wide spectrum of inherited metabolic disorders by 13C NMR spectroscopy. | 2008 | Acta Biochim. Pol. | pmid:18217108 |
| Yu AN et al. | Top note compounds of Chinese traditional bacteria-fermented soybean. | 2008 | Nat. Prod. Res. | pmid:19023819 |
| Kawata J et al. | Cyclooxygenase-2 inhibitory effects and composition of the volatile oil from the dried roots of Lithospermum erythrorhizon. | 2008 | J Nat Med | pmid:18404332 |
| Røjen BA et al. | Urea and short-chain fatty acids metabolism in Holstein cows fed a low-nitrogen grass-based diet. | 2008 | Animal | pmid:22443564 |
| Nilsson U et al. | Dietary supplementation with beta-glucan enriched oat bran increases faecal concentration of carboxylic acids in healthy subjects. | 2008 | Eur J Clin Nutr | pmid:17522598 |
| Castorina M et al. | Different outcome in isovaleric acidemia might be related to unsatisfactory diet compliance. | 2008 | Scand. J. Gastroenterol. | pmid:18569998 |
| Kimmoun A et al. | Acute decompensation of isovaleric acidemia induced by Graves' disease. | 2008 | Intensive Care Med | pmid:18607566 |
| Callejón RM et al. | Defining the typical aroma of sherry vinegar: sensory and chemical approach. | 2008 | J. Agric. Food Chem. | pmid:18651741 |
| Elefsiniotis P and Li W | Biodegradation behavior of agricultural pesticides in anaerobic batch reactors. | 2008 | J Environ Sci Health B | pmid:18246509 |
| Greene JL et al. | Characterization of volatile compounds contributing to naturally occurring fruity fermented flavor in peanuts. | 2008 | J. Agric. Food Chem. | pmid:18686969 |
| Wilson GJ et al. | Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review. | 2008 | Nutr Metab (Lond) | pmid:18173841 |
| Botelho G et al. | Differences in odor-active compounds of trincadeira wines obtained from five different clones. | 2008 | J. Agric. Food Chem. | pmid:18627166 |
| Graça G et al. | Metabolite profiling of human amniotic fluid by hyphenated nuclear magnetic resonance spectroscopy. | 2008 | Anal. Chem. | pmid:18564856 |
| Knaapila A et al. | Environmental effects exceed genetic effects on perceived intensity and pleasantness of several odors: a three-population twin study. | 2008 | Behav. Genet. | pmid:18543092 |
| Getachew G et al. | Influence of tannic acid application on alfalfa hay: in vitro rumen fermentation, serum metabolites and nitrogen balance in sheep. | 2008 | Animal | pmid:22445040 |
| Safaralie A et al. | Essential oil composition of Valeriana officinalis L. roots cultivated in Iran. Comparative analysis between supercritical CO2 extraction and hydrodistillation. | 2008 | J Chromatogr A | pmid:18164718 |
| Rotsatchakul P et al. | Identification of characteristic aroma components of Thai fried chili paste. | 2008 | J. Agric. Food Chem. | pmid:18163558 |
| Loh G et al. | The Toll-like receptors TLR2 and TLR4 do not affect the intestinal microbiota composition in mice. | 2008 | Environ. Microbiol. | pmid:18036181 |
| Shiratori H et al. | Lutispora thermophila gen. nov., sp. nov., a thermophilic, spore-forming bacterium isolated from a thermophilic methanogenic bioreactor digesting municipal solid wastes. | 2008 | Int. J. Syst. Evol. Microbiol. | pmid:18398203 |
| Rodrigues DF et al. | Architecture of thermal adaptation in an Exiguobacterium sibiricum strain isolated from 3 million year old permafrost: a genome and transcriptome approach. | 2008 | BMC Genomics | pmid:19019206 |
| Lapid H et al. | Prediction models for the pleasantness of binary mixtures in olfaction. | 2008 | Chem. Senses | pmid:18534998 |
| Varel VH et al. | Odorant production and persistence of Escherichia coli in manure slurries from cattle fed zero, twenty, forty, or sixty percent wet distillers grains with solubles. | 2008 | J. Anim. Sci. | pmid:18676716 |
| Martin FP et al. | Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model. | 2008 | Mol. Syst. Biol. | pmid:18628745 |
| Westermann CM et al. | Acquired multiple Acyl-CoA dehydrogenase deficiency in 10 horses with atypical myopathy. | 2008 | Neuromuscul. Disord. | pmid:18406615 |
| Boeckaert C et al. | Effect of dietary starch or micro algae supplementation on rumen fermentation and milk fatty acid composition of dairy cows. | 2008 | J. Dairy Sci. | pmid:19038948 |
| Heil M et al. | Defense-inducing volatiles: in search of the active motif. | 2008 | J. Chem. Ecol. | pmid:18408973 |
| Strobel GA et al. | Synergism among volatile organic compounds resulting in increased antibiosis in Oidium sp. | 2008 | FEMS Microbiol. Lett. | pmid:18422630 |
| Kim J et al. | An allylic ketyl radical intermediate in clostridial amino-acid fermentation. | 2008 | Nature | pmid:18337824 |
| Song H and Cadwallader KR | Aroma components of American country ham. | 2008 | J. Food Sci. | pmid:18211346 |
| Lee YW et al. | Different spectrum of mutations of isovaleryl-CoA dehydrogenase (IVD) gene in Korean patients with isovaleric acidemia. | 2007 Sep-Oct | Mol. Genet. Metab. | pmid:17576084 |
| Shigematsu Y et al. | Stable-isotope dilution measurement of isovalerylglycine by tandem mass spectrometry in newborn screening for isovaleric acidemia. | 2007 Nov-Dec | Clin. Chim. Acta | pmid:17850781 |
| Zhao G et al. | Determination of short-chain fatty acids in serum by hollow fiber supported liquid membrane extraction coupled with gas chromatography. | 2007 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:17070116 |
| Zhang X and Firestein S | Nose thyself: individuality in the human olfactory genome. | 2007 | Genome Biol. | pmid:18086317 |
| Gross L | A genetic basis for hypersensitivity to "sweaty" odors in humans. | 2007 | PLoS Biol. | pmid:20076651 |
| Chung TC et al. | A sensitive liquid chromatographic method for the analysis of isovaleric and valeric acids in urine as fluorescent derivatives. | 2007 | J Chromatogr A | pmid:17374376 |
| Lynch MB et al. | Effects of increasing the intake of dietary β-glucans by exchanging wheat for barley on nutrient digestibility, nitrogen excretion, intestinal microflora, volatile fatty acid concentration and manure ammonia emissions in finishing pigs. | 2007 | Animal | pmid:22444744 |
| Ma B et al. | Cytotoxicity of a Quinone-containing Cockroach Sex Pheromone in Human Lung Adenocarcinoma Cells. | 2007 | Chem. Res. Toxicol. | pmid:17226928 |
| Menashe I et al. | Genetic elucidation of human hyperosmia to isovaleric acid. | 2007 | PLoS Biol. | pmid:17973576 |
| Kobayashi E et al. | Functional optical hemodynamic imaging of the olfactory cortex. | 2007 | Laryngoscope | pmid:17334319 |
| Loots DT et al. | Amino-acid depletion induced by abnormal amino-acid conjugation and protein restriction in isovaleric acidemia. | 2007 | Eur J Clin Nutr | pmid:17299485 |
| Jiang S et al. | Biological short-chain fatty acids (SCFAs) production from waste-activated sludge affected by surfactant. | 2007 | Water Res. | pmid:17499838 |
| Ribeiro CA et al. | Isovaleric acid reduces Na+, K+-ATPase activity in synaptic membranes from cerebral cortex of young rats. | 2007 | Cell. Mol. Neurobiol. | pmid:17394058 |
| DÃaz C et al. | Aminiphilus circumscriptus gen. nov., sp. nov., an anaerobic amino-acid-degrading bacterium from an upflow anaerobic sludge reactor. | 2007 | Int. J. Syst. Evol. Microbiol. | pmid:17684281 |
| Maxia C et al. | A morphological and 13C NMR study of the extramandibular fat bodies of the striped dolphin (Stenella coeruleoalba). | 2007 | Anat Rec (Hoboken) | pmid:17516451 |
| Murata Y et al. | Effects of olfactory stimulation with isovaleric acid on brain activation in informed and naïve conditions: a functional MRI study. | 2007 | Auris Nasus Larynx | pmid:17481839 |
| Man O et al. | A framework for exploring functional variability in olfactory receptor genes. | 2007 | PLoS ONE | pmid:17668060 |
| Jumas-Bilak E et al. | Jonquetella anthropi gen. nov., sp. nov., the first member of the candidate phylum 'Synergistetes' isolated from man. | 2007 | Int. J. Syst. Evol. Microbiol. | pmid:18048718 |
| Ferreira G et al. | Changes in measures of biotin status do not reflect milk yield responses when dairy cows are fed supplemental biotin. | 2007 | J. Dairy Sci. | pmid:17297118 |
| Pluske JR et al. | Feeding different types of cooked white rice to piglets after weaning influences starch digestion, digesta and fermentation characteristics and the faecal shedding of beta-haemolytic Escherichia coli. | 2007 | Br. J. Nutr. | pmid:17298698 |
| Lin WD et al. | Genetic mutation profile of isovaleric acidemia patients in Taiwan. | 2007 | Mol. Genet. Metab. | pmid:17027310 |
| Qiu YT et al. | Attractiveness of MM-X traps baited with human or synthetic odor to mosquitoes (Diptera: Culicidae) in The Gambia. | 2007 | J. Med. Entomol. | pmid:18047195 |
| Kambere MB and Lane RP | Co-regulation of a large and rapidly evolving repertoire of odorant receptor genes. | 2007 | BMC Neurosci | pmid:17903278 |
| Krizsan SJ et al. | Effect of alfalfa silage storage structure and roasting corn on production and ruminal metabolism of lactating dairy cows. | 2007 | J. Dairy Sci. | pmid:17881702 |
| Battaglia L et al. | Solid lipid nanoparticles formed by solvent-in-water emulsion-diffusion technique: development and influence on insulin stability. | 2007 | J Microencapsul | pmid:17763060 |
| Randazzo CL et al. | Preliminary characterization of wild lactic acid bacteria and their abilities to produce flavour compounds in ripened model cheese system. | 2007 | J. Appl. Microbiol. | pmid:17650203 |
| Maone E et al. | Functional analysis of the translation factor aIF2/5B in the thermophilic archaeon Sulfolobus solfataricus. | 2007 | Mol. Microbiol. | pmid:17608795 |
| Scheidig C et al. | Changes in key odorants of raw coffee beans during storage under defined conditions. | 2007 | J. Agric. Food Chem. | pmid:17571898 |
| Queenan KM et al. | Concentrated oat beta-glucan, a fermentable fiber, lowers serum cholesterol in hypercholesterolemic adults in a randomized controlled trial. | 2007 | Nutr J | pmid:17386092 |
| Kristensen NB et al. | Metabolism of silage alcohols in lactating dairy cows. | 2007 | J. Dairy Sci. | pmid:17297111 |
| Leisner JJ et al. | Carnobacterium: positive and negative effects in the environment and in foods. | 2007 | FEMS Microbiol. Rev. | pmid:17696886 |
| Htoo JK et al. | Effect of dietary protein content on ileal amino acid digestibility, growth performance, and formation of microbial metabolites in ileal and cecal digesta of early-weaned pigs. | 2007 | J. Anim. Sci. | pmid:17785591 |
| Martin FP et al. | A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model. | 2007 | Mol. Syst. Biol. | pmid:17515922 |
| Piao SJ et al. | The organic acid profiles in the feces of pigs at Brachyspira hyodysenteriae- or B. pilosicoli-positive farms. | 2007 | J. Vet. Med. Sci. | pmid:17485934 |
| Dunkley KD et al. | Comparison of in vitro fermentation and molecular microbial profiles of high-fiber feed substrates incubated with chicken cecal inocula. | 2007 | Poult. Sci. | pmid:17435012 |
| Gokcay G et al. | Breast feeding in organic acidaemias. | 2006 Apr-Jun | J. Inherit. Metab. Dis. | pmid:16763892 |
| Dionisi-Vici C et al. | 'Classical' organic acidurias, propionic aciduria, methylmalonic aciduria and isovaleric aciduria: long-term outcome and effects of expanded newborn screening using tandem mass spectrometry. | 2006 Apr-Jun | J. Inherit. Metab. Dis. | pmid:16763906 |
| Irokawa Y et al. | Photodegradation of toluene over TiO(2-x)N(x) under visible light irradiation. | 2006 | Phys Chem Chem Phys | pmid:16633593 |
| Zhao G et al. | Rapid determination of short-chain fatty acids in colonic contents and faeces of humans and rats by acidified water-extraction and direct-injection gas chromatography. | 2006 | Biomed. Chromatogr. | pmid:16206138 |
| Klocke M et al. | Monitoring Lactobacillus plantarum in grass silages with the aid of 16S rDNA-based quantitative real-time PCR assays. | 2006 | Syst. Appl. Microbiol. | pmid:16423656 |
| Hu ZH et al. | Application of response surface methodology for optimization of acidogenesis of cattail by rumen cultures. | 2006 | Bioresour. Technol. | pmid:16289873 |
| Wierda RL et al. | Analysis of volatile compounds as spoilage indicators in fresh king salmon (Oncorhynchus tshawytscha) during storage using SPME-GC-MS. | 2006 | J. Agric. Food Chem. | pmid:17061824 |
| Kaler G et al. | Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions. | 2006 | Biochem. Biophys. Res. Commun. | pmid:17094945 |
| Larreta J et al. | Experimental design to optimise the analysis of organic volatile compounds in cow slurry by headspace solid-phase microextraction-gas chromatography-mass spectrometry. | 2006 | J Chromatogr A | pmid:17049541 |
| Frauendorfer F and Schieberle P | Identification of the key aroma compounds in cocoa powder based on molecular sensory correlations. | 2006 | J. Agric. Food Chem. | pmid:16848541 |
| Ring MW et al. | Novel iso-branched ether lipids as specific markers of developmental sporulation in the myxobacterium Myxococcus xanthus. | 2006 | J. Biol. Chem. | pmid:16990257 |
| Alam SI et al. | Clostridium schirmacherense sp. nov., an obligately anaerobic, proteolytic, psychrophilic bacterium isolated from lake sediment of Schirmacher Oasis, Antarctica. | 2006 | Int. J. Syst. Evol. Microbiol. | pmid:16585682 |
| Aguilar JA et al. | The atu and liu clusters are involved in the catabolic pathways for acyclic monoterpenes and leucine in Pseudomonas aeruginosa. | 2006 | Appl. Environ. Microbiol. | pmid:16517656 |
| Bode HB et al. | 3-Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase is involved in biosynthesis of isovaleryl-CoA in the myxobacterium Myxococcus xanthus during fruiting body formation. | 2006 | J. Bacteriol. | pmid:16952943 |
| Oka Y et al. | Odorant receptor map in the mouse olfactory bulb: in vivo sensitivity and specificity of receptor-defined glomeruli. | 2006 | Neuron | pmid:17145506 |
| Förster-Fromme K et al. | Identification of genes and proteins necessary for catabolism of acyclic terpenes and leucine/isovalerate in Pseudomonas aeruginosa. | 2006 | Appl. Environ. Microbiol. | pmid:16820476 |
| Ara K et al. | Foot odor due to microbial metabolism and its control. | 2006 | Can. J. Microbiol. | pmid:16699586 |
| Vockley J and Ensenauer R | Isovaleric acidemia: new aspects of genetic and phenotypic heterogeneity. | 2006 | Am J Med Genet C Semin Med Genet | pmid:16602101 |
| Seeling K et al. | On the effects of Fusarium toxin contaminated wheat and wheat chaff on nutrient utilisation and turnover of deoxynivalenol and zearalenone in vitro (Rusitec). | 2006 | Toxicol In Vitro | pmid:16321500 |
| Mehta AS et al. | Synthesis and antigenic analysis of the BclA glycoprotein oligosaccharide from the Bacillus anthracis exosporium. | 2006 | Chemistry | pmid:17133642 |
| Aloni R et al. | Ancient genomic architecture for mammalian olfactory receptor clusters. | 2006 | Genome Biol. | pmid:17010214 |
| King BM et al. | Orthonasal and retronasal perception of some green leaf volatiles used in beverage flavors. | 2006 | J. Agric. Food Chem. | pmid:16569059 |
| Mack M et al. | 3-Methylglutaconyl-CoA hydratase from Acinetobacter sp. | 2006 | Arch. Microbiol. | pmid:16482430 |
| Masaki K et al. | First-pass hydrolysis of a propranolol ester derivative in rat small intestine. | 2006 | Drug Metab. Dispos. | pmid:16326813 |
| Reed JJ et al. | Effects of season and inclusion of corn distillers dried grains with solubles in creep feed on intake, microbial protein synthesis and efficiency, ruminal fermentation, digestion, and performance of nursing calves grazing native range in southeastern North Dakota. | 2006 | J. Anim. Sci. | pmid:16864882 |
| Chung HY et al. | Aroma impact components in commercial plain sufu. | 2005 | J. Agric. Food Chem. | pmid:15740059 |
| Zhu K et al. | Precursor and temperature modulation of fatty acid composition and growth of Listeria monocytogenes cold-sensitive mutants with transposon-interrupted branched-chain alpha-keto acid dehydrogenase. | 2005 | Microbiology (Reading, Engl.) | pmid:15699210 |