| MeSH term | MeSH ID | Detail |
|---|---|---|
| Inflammatory Bowel Diseases | D015212 | 9 associated lipids |
| Occupational Diseases | D009784 | 42 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Amino Acid Metabolism, Inborn Errors | D000592 | 16 associated lipids |
| Olfaction Disorders | D000857 | 17 associated lipids |
| Maple Syrup Urine Disease | D008375 | 5 associated lipids |
| Acidosis, Renal Tubular | D000141 | 4 associated lipids |
| Fanconi Syndrome | D005198 | 4 associated lipids |
| Lipid Metabolism, Inborn Errors | D008052 | 26 associated lipids |
| Dwarfism | D004392 | 1 associated lipids |
ISOVALERIC ACID
ISOVALERIC ACID is a lipid of Fatty Acyls (FA) class. Isovaleric acid is associated with abnormalities such as Infection, Lymphocele, Cyst, Abscess and Subgingival plaque. The involved functions are known as Biochemical Reaction, 5-(carboxyamino)imidazole ribonucleotide mutase activity, nitrate reductase activity, urease activity and colony morphology. Isovaleric acid often locates in Skeleton, Abdomen, Chromosomes, Tissue membrane and Microsomes. The associated genes with ISOVALERIC ACID are trypticase, Operon, KCNT1 gene, Genome and Reverse primer. The related lipids are Fatty Acids, Propionate, Fatty Acids, Unsaturated, Steroids and Promega. The related experimental models are Knock-out.
Cross Reference
Introduction
To understand associated biological information of ISOVALERIC ACID, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with ISOVALERIC ACID?
ISOVALERIC ACID is suspected in Exanthema, Isovaleryl-CoA dehydrogenase deficiency, Subgingival plaque, Dehydration, MAJOR DEPRESSIVE DISORDER 1, MAJOR DEPRESSIVE DISORDER 2 and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with ISOVALERIC ACID
PubChem Associated disorders and diseases
What pathways are associated with ISOVALERIC ACID
Lipid pathways are not clear in current pathway databases. We organized associated pathways with ISOVALERIC ACID through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with ISOVALERIC ACID?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with ISOVALERIC ACID?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with ISOVALERIC ACID?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with ISOVALERIC ACID?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with ISOVALERIC ACID?
Knock-out
Knock-out are used in the study '3-Hydroxy-3-methylglutaryl-coenzyme A (CoA) synthase is involved in biosynthesis of isovaleryl-CoA in the myxobacterium Myxococcus xanthus during fruiting body formation.' (Bode HB et al., 2006) and Knock-out are used in the study 'Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.' (Ruan Y et al., 2001).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with ISOVALERIC ACID
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Morales B et al. | Inhibitory K+ current activated by odorants in toad olfactory neurons. | 1994 | Proc. Biol. Sci. | pmid:7991632 |
| Salamino F et al. | Involvement of erythrocyte calpain in glycine- and carnitine-treated isovaleric acidemia. | 1994 | Pediatr. Res. | pmid:7970932 |
| Vague P et al. | Kinetics of the early insulin response of the perfused rat pancreas to various metabolites and tolbutamide. | 1975 | Diabete Metab | pmid:791726 |
| Jaworsky DE et al. | Calcium modulates the rapid kinetics of the odorant-induced cyclic AMP signal in rat olfactory cilia. | 1995 | J. Neurosci. | pmid:7823137 |
| Orban T et al. | Severe CNS bleeding followed by a good clinical outcome in the acute neonatal form of isovaleric acidaemia. | 1994 | J. Inherit. Metab. Dis. | pmid:7707703 |
| Kleijer WJ et al. | Prenatal diagnosis of isovaleric acidaemia by enzyme and metabolite assay in the first and second trimesters. | 1995 | Prenat. Diagn. | pmid:7659686 |
| Kelleher JF et al. | The pancytopenia of isovaleric acidemia. | 1980 | Pediatrics | pmid:7367115 |
| Schuberth J and Dahlberg L | Antagonistic effects of isovalerate and glycine on plasma choline levels in rabbits. | 1980 | Life Sci. | pmid:7354706 |
| Watanabe S and Fukuchi Y | [Occupational impairment of the olfactory sense of chromate producing workers (author's transl)]. | 1981 | Sangyo Igaku | pmid:7334695 |
| Al-Bassam SS and Sherratt HS | The antagonism of the toxicity of hypoglycin by glycine. | 1981 | Biochem. Pharmacol. | pmid:7317076 |