| MeSH term | MeSH ID | Detail |
|---|---|---|
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Urination Disorders | D014555 | 9 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
| Brain Ischemia | D002545 | 89 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
Galangin
Galangin is a lipid of Polyketides (PK) class. Galangin is associated with abnormalities such as Morphologically altered structure and Wiskott-Aldrich Syndrome. The involved functions are known as Apoptosis, Metabolic Inhibition, Cell Proliferation, Process and Proliferation (morphologic abnormality). Galangin often locates in Microsomes, Liver, Cytoplasmic matrix, Microsomes, Protoplasm and Tissue membrane. The associated genes with Galangin are CYP1A1 gene, CYP1A2 gene, WNT3A gene, ALPP gene and TCF7L2 gene. The related lipids are Promega.
Cross Reference
Introduction
To understand associated biological information of Galangin, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Galangin?
Galangin is suspected in Morphologically altered structure and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Galangin
PubChem Associated disorders and diseases
What pathways are associated with Galangin
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Galangin?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Galangin?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Galangin?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Galangin?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Galangin?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Galangin
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sun L et al. | Potential Antinociceptive Effects of Chinese Propolis and Identification on Its Active Compounds. | 2018 | J Immunol Res | pmid:30356413 |
| Elgazar AA et al. | Isolates from Alpinia officinarum Hance attenuate LPS-induced inflammation in HepG2: Evidence from in silico and in vitro studies. | 2018 | Phytother Res | pmid:29468851 |
| Chung KW et al. | Evaluation of Antimelanogenic Activity and Mechanism of Galangin in Silico and in Vivo. | 2018 | Biol. Pharm. Bull. | pmid:29311485 |
| Zou WW and Xu SP | Galangin inhibits the cell progression and induces cell apoptosis through activating PTEN and Caspase-3 pathways in retinoblastoma. | 2018 | Biomed. Pharmacother. | pmid:29136761 |
| Lei D et al. | Galangin increases ERK1/2 phosphorylation to decrease ADAM9 expression and prevents invasion in A172 glioma cells. | 2018 | Mol Med Rep | pmid:29115634 |
| Yu S et al. | Galangin (GG) combined with cisplatin (DDP) to suppress human lung cancer by inhibition of STAT3-regulated NF-κB and Bcl-2/Bax signaling pathways. | 2018 | Biomed. Pharmacother. | pmid:29091869 |
| Aloud AA et al. | Galangin, a natural flavonoid reduces mitochondrial oxidative damage in streptozotocin-induced diabetic rats. | 2018 | Redox Rep. | pmid:28813209 |
| Devadoss D et al. | Galangin, a dietary flavonol inhibits tumor initiation during experimental pulmonary tumorigenesis by modulating xenobiotic enzymes and antioxidant status. | 2018 | Arch. Pharm. Res. | pmid:24497035 |
| Lee HN et al. | Anti‑inflammatory effect of quercetin and galangin in LPS‑stimulated RAW264.7 macrophages and DNCB‑induced atopic dermatitis animal models. | 2018 | Int. J. Mol. Med. | pmid:29207037 |
| Fu Q et al. | Galangin protects human rheumatoid arthritis fibroblast‑like synoviocytes via suppression of the NF‑κB/NLRP3 pathway. | 2018 | Mol Med Rep | pmid:30152847 |
| Aloud AA et al. | Galangin, a dietary flavonoid, ameliorates hyperglycaemia and lipid abnormalities in rats with streptozotocin-induced hyperglycaemia. | 2018 | Pharm Biol | pmid:29952676 |
| Liu D et al. | Galangin Induces Apoptosis in MCF-7 Human Breast Cancer Cells Through Mitochondrial Pathway and Phosphatidylinositol 3-Kinase/Akt Inhibition. | 2018 | Pharmacology | pmid:29879712 |
| KuÅ› P et al. | Extraction of bioactive phenolics from black poplar (Populus nigra L.) buds by supercritical CO and its optimization by response surface methodology. | 2018 | J Pharm Biomed Anal | pmid:29414004 |
| Kumar R and Tiku AB | Galangin induces cell death by modulating the expression of glyoxalase-1 and Nrf-2 in HeLa cells. | 2018 | Chem. Biol. Interact. | pmid:29113808 |
| Lee CC et al. | Galangin Induces p53-independent S-phase Arrest and Apoptosis in Human Nasopharyngeal Carcinoma Cells Through Inhibiting PI3K-AKT Signaling Pathway. | 2018 | Anticancer Res. | pmid:29491062 |
| Upadhye AS et al. | Development and validation of HPTLC fingerprints of three species of Alpinia with biomarker Galangin. | 2018 | BMC Complement Altern Med | pmid:29338724 |
| Ouyang J et al. | Antimicrobial Activity of Galangin and Its Effects on Murein Hydrolases of Vancomycin-Intermediate Staphylococcus aureus (VISA) Strain Mu50. | 2018 | Chemotherapy | pmid:29145175 |
| Arif H et al. | Flavonoids-induced redox cycling of copper ions leads to generation of reactive oxygen species: A potential role in cancer chemoprevention. | 2018 | Int. J. Biol. Macromol. | pmid:28834706 |
| Bacanlı M et al. | The antioxidant, cytotoxic, and antigenotoxic effects of galangin, puerarin, and ursolic acid in mammalian cells. | 2017 | Drug Chem Toxicol | pmid:27461151 |
| Verma S et al. | Natural polyphenolic inhibitors against the antiapoptotic BCL-2. | 2017 | J. Recept. Signal Transduct. Res. | pmid:28264627 |
| Chen G et al. | Galangin Reduces the Loss of Dopaminergic Neurons in an LPS-Evoked Model of Parkinson's Disease in Rats. | 2017 | Int J Mol Sci | pmid:29267220 |
| Sadhana N et al. | Marker-based standardization and investigation of nutraceutical potential of Indian propolis. | 2017 | J Integr Med | pmid:29103419 |
| Wang Y et al. | Galangin suppresses hepatocellular carcinoma cell proliferation by reversing the Warburg effect. | 2017 | Biomed. Pharmacother. | pmid:28938520 |
| Ahmad SS et al. | Screening and Elucidation of Selected Natural Compounds for Anti- Alzheimer's Potential Targeting BACE-1 Enzyme: A Case Computational Study. | 2017 | Curr Comput Aided Drug Des | pmid:28413992 |
| Aloud AA et al. | Galangin, a dietary flavonoid, improves antioxidant status and reduces hyperglycemia-mediated oxidative stress in streptozotocin-induced diabetic rats. | 2017 | Redox Rep. | pmid:28030991 |
| Kwak MK et al. | Galangin enhances TGF-β1-mediated growth inhibition by suppressing phosphorylation of threonine 179 residue in Smad3 linker region. | 2017 | Biochem. Biophys. Res. Commun. | pmid:29097203 |
| Tomar A et al. | Galangin ameliorates cisplatin induced nephrotoxicity in vivo by modulation of oxidative stress, apoptosis and inflammation through interplay of MAPK signaling cascade. | 2017 | Phytomedicine | pmid:28899498 |
| Wen SY et al. | Galangin suppresses H O -induced aging in human dermal fibroblasts. | 2017 | Environ. Toxicol. | pmid:28834114 |
| Choi MJ et al. | Anti-inflammatory mechanism of galangin in lipopolysaccharide-stimulated microglia: Critical role of PPAR-γ signaling pathway. | 2017 | Biochem. Pharmacol. | pmid:28757373 |
| Huang YC et al. | Galangin ameliorates cisplatin-induced nephrotoxicity by attenuating oxidative stress, inflammation and cell death in mice through inhibition of ERK and NF-kappaB signaling. | 2017 | Toxicol. Appl. Pharmacol. | pmid:28558962 |
| Yang Z et al. | Galangin suppresses human osteosarcoma cells: An exploration of its underlying mechanism. | 2017 | Oncol. Rep. | pmid:27840963 |
| Wang HX and Tang C | Galangin suppresses human laryngeal carcinoma via modulation of caspase-3 and AKT signaling pathways. | 2017 | Oncol. Rep. | pmid:28677816 |
| Liu C et al. | Galangin inhibits human osteosarcoma cells growth by inducing transforming growth factor-β1-dependent osteogenic differentiation. | 2017 | Biomed. Pharmacother. | pmid:28340520 |
| Song W et al. | Galangin potentiates human breast cancer to apoptosis induced by TRAIL through activating AMPK. | 2017 | Biomed. Pharmacother. | pmid:28282786 |
| Salazar-Aguilar S et al. | Sechium edule (Jacq.) Swartz, a New Cultivar with Antiproliferative Potential in a Human Cervical Cancer HeLa Cell Line. | 2017 | Nutrients | pmid:28757593 |
| Brown A et al. | Attenuation of airway smooth muscle contractility via flavonol-mediated inhibition of phospholipase-Cβ. | 2016 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26773068 |
| Verma S et al. | Hydrophobic Interactions Are a Key to MDM2 Inhibition by Polyphenols as Revealed by Molecular Dynamics Simulations and MM/PBSA Free Energy Calculations. | 2016 | PLoS ONE | pmid:26863418 |
| Zheng YZ et al. | A theoretical study on the hydrogen-bonding interactions between flavonoids and ethanol/water. | 2016 | J Mol Model | pmid:27029620 |
| Zou QY et al. | A new labdane diterpene from the rhizomes of Alpinia officinarum. | 2016 | Nat. Prod. Res. | pmid:26189919 |
| Bugel SM et al. | Comparative Developmental Toxicity of Flavonoids Using an Integrative Zebrafish System. | 2016 | Toxicol. Sci. | pmid:27492224 |
| Yang R et al. | Analysis of Potential Amino Acid Biomarkers in Brain Tissue and the Effect of Galangin on Cerebral Ischemia. | 2016 | Molecules | pmid:27058522 |
| Cao J et al. | Galangin inhibits cell invasion by suppressing the epithelial-mesenchymal transition and inducing apoptosis in renal cell carcinoma. | 2016 | Mol Med Rep | pmid:27035542 |
| Han MA et al. | Galangin sensitizes TRAIL-induced apoptosis through down-regulation of anti-apoptotic proteins in renal carcinoma Caki cells. | 2016 | Sci Rep | pmid:26725939 |
| Kim YR et al. | Galangin prevents aminoglycoside-induced ototoxicity by decreasing mitochondrial production of reactive oxygen species in mouse cochlear cultures. | 2016 | Toxicol. Lett. | pmid:26778349 |
| Ren K et al. | Synergistic anti-cancer effects of galangin and berberine through apoptosis induction and proliferation inhibition in oesophageal carcinoma cells. | 2016 | Biomed. Pharmacother. | pmid:27876206 |
| Benguedouar L et al. | Ethanolic Extract of Algerian Propolis and Galangin Decreased Murine Melanoma T. | 2016 | Anticancer Agents Med Chem | pmid:26863880 |
| Honmore VS et al. | Isolates of Alpinia officinarum Hance as COX-2 inhibitors: Evidence from anti-inflammatory, antioxidant and molecular docking studies. | 2016 | Int. Immunopharmacol. | pmid:26849772 |
| Zhang Y et al. | Galangin inhibits hypertrophic scar formation via ALK5/Smad2/3 signaling pathway. | 2016 | Mol. Cell. Biochem. | pmid:26728998 |
| Li X et al. | Galangin Induces Autophagy via Deacetylation of LC3 by SIRT1 in HepG2 Cells. | 2016 | Sci Rep | pmid:27460655 |
| Lau AJ et al. | Cell-based and in silico evidence against quercetin and structurally-related flavonols as activators of vitamin D receptor. | 2016 | J. Steroid Biochem. Mol. Biol. | pmid:27041117 |
| Maini S et al. | Flavonols Protect Against UV Radiation-Induced Thymine Dimer Formation in an Artificial Skin Mimic. | 2015 | J Pharm Pharm Sci | pmid:26626251 |
| Lau AJ and Chang TK | 3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease. | 2015 | Pharmacol. Res. | pmid:26238175 |
| Choi YJ et al. | Galangin and kaempferol suppress phorbol-12-myristate-13-acetate-induced matrix metalloproteinase-9 expression in human fibrosarcoma HT-1080 cells. | 2015 | Mol. Cells | pmid:25518925 |
| Kerimi A et al. | Modulation of cellular glucose metabolism in human HepG2 cells by combinations of structurally related flavonoids. | 2015 | Mol Nutr Food Res | pmid:25712349 |
| Wu C et al. | Wnt/β-catenin coupled with HIF-1α/VEGF signaling pathways involved in galangin neurovascular unit protection from focal cerebral ischemia. | 2015 | Sci Rep | pmid:26537366 |
| Liu YN et al. | Galangin attenuates airway remodelling by inhibiting TGF-β1-mediated ROS generation and MAPK/Akt phosphorylation in asthma. | 2015 | Sci Rep | pmid:26156213 |
| Luo Q et al. | Protective effect of galangin in Concanavalin A-induced hepatitis in mice. | 2015 | Drug Des Devel Ther | pmid:26089647 |
| Zhao X and Zhang J | [Inhibitory effect of galangin on DNA topoisomerases in lung cancer cells]. | 2015 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:26032076 |
| Arif H et al. | Mobilization of Copper ions by Flavonoids in Human Peripheral Lymphocytes Leads to Oxidative DNA Breakage: A Structure Activity Study. | 2015 | Int J Mol Sci | pmid:26569217 |
| Tsai MS et al. | Galangin Prevents Acute Hepatorenal Toxicity in Novel Propacetamol-Induced Acetaminophen-Overdosed Mice. | 2015 | J Med Food | pmid:26501381 |
| Chernetsova ES and Morlock GE | Aspects of surface scanning by direct analysis in real time mass spectrometry employing plasma glow visualization. | 2015 | Rapid Commun. Mass Spectrom. | pmid:26395608 |
| Feng WH et al. | Determination of galangin in rat plasma by UPLC and pharmacokinetic study. | 2015 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:26149247 |
| Zeng H et al. | Galangin-induced down-regulation of BACE1 by epigenetic mechanisms in SH-SY5Y cells. | 2015 | Neuroscience | pmid:25779965 |
| Li L et al. | A novel system of galangin-potassium permanganate-polyphosphoric acid for the determination of tryptophan and its chemiluminescence mechanism. | 2015 | Luminescence | pmid:25271024 |
| Carazo Fernández A et al. | Chrysin, baicalein and galangin are indirect activators of the human constitutive androstane receptor (CAR). | 2015 | Toxicol. Lett. | pmid:25625231 |
| Ogunbayo OA and Michelangeli F | Related flavonoids cause cooperative inhibition of the sarcoplasmic reticulum Ca²⺠ATPase by multimode mechanisms. | 2014 | FEBS J. | pmid:24238016 |
| Santos EO et al. | Flavonols modulate the effector functions of healthy individuals' immune complex-stimulated neutrophils: a therapeutic perspective for rheumatoid arthritis. | 2014 | Int. Immunopharmacol. | pmid:24797916 |
| Xu L et al. | Identification of luteolin as enterovirus 71 and coxsackievirus A16 inhibitors through reporter viruses and cell viability-based screening. | 2014 | Viruses | pmid:25036464 |
| Gómez-Florit M et al. | Identification of quercitrin as a potential therapeutic agent for periodontal applications. | 2014 | J. Periodontol. | pmid:24548116 |
| Jailani F and Williamson G | Effect of edible oils on quercetin, kaempferol and galangin transport and conjugation in the intestinal Caco-2/HT29-MTX co-culture model. | 2014 | Food Funct | pmid:24525490 |
| Sinha R et al. | In-vitro anti-proliferative and anti-oxidant activity of galangin, fisetin and quercetin: role of localization and intermolecular interaction in model membrane. | 2014 | Eur J Med Chem | pmid:24727463 |
| Zhu L et al. | Galangin inhibits growth of human head and neck squamous carcinoma cells in vitro and in vivo. | 2014 | Chem. Biol. Interact. | pmid:25450235 |
| Wang Y et al. | Galangin suppresses HepG2 cell proliferation by activating the TGF-β receptor/Smad pathway. | 2014 | Toxicology | pmid:25268046 |
| Jung YC et al. | Anti-inflammatory effects of galangin on lipopolysaccharide-activated macrophages via ERK and NF-κB pathway regulation. | 2014 | Immunopharmacol Immunotoxicol | pmid:25270721 |
| Huo SX et al. | The effects of galangin on a mouse model of vitiligo induced by hydroquinone. | 2014 | Phytother Res | pmid:24820380 |
| Shu YS et al. | Galangin dampens mice lipopolysaccharide-induced acute lung injury. | 2014 | Inflammation | pmid:24743919 |
| Choi JK and Kim SH | Inhibitory effect of galangin on atopic dermatitis-like skin lesions. | 2014 | Food Chem. Toxicol. | pmid:24675422 |
| Forbes AM et al. | Structure-activity relationship studies of flavonol analogues on pollen germination. | 2014 | J. Agric. Food Chem. | pmid:24524670 |
| Kawabata K et al. | Flavonols enhanced production of anti-inflammatory substance(s) by Bifidobacterium adolescentis: prebiotic actions of galangin, quercetin, and fisetin. | 2013 Jul-Aug | Biofactors | pmid:23554103 |
| Satué M et al. | Quercitrin and taxifolin stimulate osteoblast differentiation in MC3T3-E1 cells and inhibit osteoclastogenesis in RAW 264.7 cells. | 2013 | Biochem. Pharmacol. | pmid:24060614 |
| Huh JE et al. | The natural flavonoid galangin inhibits osteoclastic bone destruction and osteoclastogenesis by suppressing NF-κB in collagen-induced arthritis and bone marrow-derived macrophages. | 2013 | Eur. J. Pharmacol. | pmid:22985747 |
| Zhang W et al. | Galangin inhibits tumor growth and metastasis of B16F10 melanoma. | 2013 | J. Cell. Biochem. | pmid:22887049 |
| Kumar S and Alagawadi KR | Anti-obesity effects of galangin, a pancreatic lipase inhibitor in cafeteria diet fed female rats. | 2013 | Pharm Biol | pmid:23363068 |
| Gao J et al. | Analysis of serum metabolites for the discovery of amino acid biomarkers and the effect of galangin on cerebral ischemia. | 2013 | Mol Biosyst | pmid:23793526 |
| Wang X et al. | Antifibrotic activity of galangin, a novel function evaluated in animal liver fibrosis model. | 2013 | Environ. Toxicol. Pharmacol. | pmid:23686009 |
| Navarro-Navarro M et al. | Antibacterial activity of Sonoran propolis and some of its constituents against clinically significant Vibrio species. | 2013 | Foodborne Pathog. Dis. | pmid:23351031 |
| Kim HH et al. | Galangin attenuates mast cell-mediated allergic inflammation. | 2013 | Food Chem. Toxicol. | pmid:23535185 |
| Ha TK et al. | Galangin induces human colon cancer cell death via the mitochondrial dysfunction and caspase-dependent pathway. | 2013 | Exp. Biol. Med. (Maywood) | pmid:23925650 |
| Descamps O et al. | AβPP-selective BACE inhibitors (ASBI): novel class of therapeutic agents for alzheimer's disease. | 2013 | J. Alzheimers Dis. | pmid:23948888 |
| Zhang H et al. | Galangin inhibits proliferation of HepG2 cells by activating AMPK via increasing the AMP/TAN ratio in a LKB1-independent manner. | 2013 | Eur. J. Pharmacol. | pmid:24028940 |
| Su L et al. | Galangin inhibits proliferation of hepatocellular carcinoma cells by inducing endoplasmic reticulum stress. | 2013 | Food Chem. Toxicol. | pmid:24161691 |
| Pavlović AV et al. | Chemical composition of two different extracts of berries harvested in Serbia. | 2013 | J. Agric. Food Chem. | pmid:23600608 |
| Nie P et al. | Application of visible and near infrared spectroscopy for rapid analysis of chrysin and galangin in Chinese propolis. | 2013 | Sensors (Basel) | pmid:23945741 |
| Gomes A et al. | Trihydroxyflavones with antioxidant and anti-inflammatory efficacy. | 2012 Sep-Oct | Biofactors | pmid:22806885 |
| Bertelli D et al. | ¹H-NMR simultaneous identification of health-relevant compounds in propolis extracts. | 2012 May-Jun | Phytochem Anal | pmid:21853496 |
| Bisogni S et al. | Influence of oxidative stress on inducing micturition dysfunction following chronic infravesical obstruction and the protective role of an antioxidant diet - association of in vivo and in vitro studies in rats. | 2012 Jul-Aug | Int Braz J Urol | pmid:22951166 |
| Lin HH and Huang CY | Characterization of flavonol inhibition of DnaB helicase: real-time monitoring, structural modeling, and proposed mechanism. | 2012 | J. Biomed. Biotechnol. | pmid:23091356 |
| Kim DA et al. | Galangin induces apoptosis in gastric cancer cells via regulation of ubiquitin carboxy-terminal hydrolase isozyme L1 and glutathione S-transferase P. | 2012 | Food Chem. Toxicol. | pmid:22142694 |
| Zhong L et al. | Antimicrobial flavonoids from the twigs of Populus nigra x Populus deltoides. | 2012 | Nat. Prod. Res. | pmid:21416454 |
| Tsai YC et al. | Induction of oxidative DNA damage by flavonoids of propolis: its mechanism and implication about antioxidant capacity. | 2012 | Chem. Res. Toxicol. | pmid:22148389 |