Leukotriene b4

Leukotriene b4 is a lipid of Fatty Acyls (FA) class. The involved functions are known as Chemotaxis, release of sequestered calcium ion into cytoplasm and Polymerization. Leukotriene b4 often locates in Protoplasm. The associated genes with Leukotriene b4 are phallacidin.

Cross Reference


To understand associated biological information of Leukotriene b4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Leukotriene b4?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Leukotriene b4

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Airway Obstruction D000402 13 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Hypoxia D000860 23 associated lipids
Adenocarcinoma D000230 166 associated lipids
Enterocolitis D004760 3 associated lipids
Breast Neoplasms D001943 24 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Bacterial Infections D001424 21 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Alveolitis, Extrinsic Allergic D000542 6 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Mycobacterium Infections D009164 7 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Sarcoidosis D012507 13 associated lipids
Wounds and Injuries D014947 20 associated lipids
Pleurisy D010998 20 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Fatty Liver D005234 48 associated lipids
Cataract D002386 34 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Body Weight D001835 333 associated lipids
Intestinal Diseases D007410 6 associated lipids
Edema D004487 152 associated lipids
Esophageal Neoplasms D004938 20 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Carcinoma D002277 18 associated lipids
Gastritis D005756 27 associated lipids
Pulmonary Edema D011654 23 associated lipids
Joint Dislocations D004204 2 associated lipids
Ureteral Obstruction D014517 10 associated lipids
Coronary Disease D003327 70 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Acne Vulgaris D000152 35 associated lipids
Osteoarthritis, Hip D015207 4 associated lipids
Pain, Postoperative D010149 13 associated lipids
Asthma D001249 52 associated lipids
Weight Gain D015430 101 associated lipids
Cadmium Poisoning D002105 6 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Ulcer D014456 16 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Peritonitis D010538 38 associated lipids
Hemorrhage D006470 15 associated lipids
Proteinuria D011507 30 associated lipids
Spasm D013035 5 associated lipids
Prostatic Hyperplasia D011470 20 associated lipids
Lymphoma D008223 18 associated lipids
Anti-Glomerular Basement Membrane Disease D019867 2 associated lipids
Arteriosclerosis D001161 86 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Respiratory Distress Syndrome, Newborn D012127 5 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Cholestasis D002779 23 associated lipids
Carcinoma, Ductal, Breast D018270 19 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Leukocytosis D007964 9 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Glomerulonephritis D005921 35 associated lipids
Cerebral Hemorrhage D002543 13 associated lipids
Psoriasis D011565 47 associated lipids
Leukopenia D007970 9 associated lipids
Gingivitis D005891 3 associated lipids
Periodontal Pocket D010514 9 associated lipids
Liver Cirrhosis, Alcoholic D008104 17 associated lipids
Brain Ischemia D002545 89 associated lipids
Leukemia, Myeloid D007951 52 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Seizures D012640 87 associated lipids
Leukemia, Basophilic, Acute D015471 9 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Cytomegalovirus Infections D003586 7 associated lipids
Dermatitis D003872 30 associated lipids
Nasal Polyps D009298 26 associated lipids
Gastrointestinal Diseases D005767 20 associated lipids
Per page 10 20 50 100 | Total 265

PubChem Associated disorders and diseases

What pathways are associated with Leukotriene b4

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Leukotriene b4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Leukotriene b4?

Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Leukotriene b4?

There are no associated biomedical information in the current reference collection.

What genes are associated with Leukotriene b4?

Related references are published most in these journals:

Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Leukotriene b4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Leukotriene b4

Download all related citations
Per page 10 20 50 100 | Total 5221
Authors Title Published Journal PubMed Link
Bitto A et al. Effects of COX1-2/5-LOX blockade in Alzheimer transgenic 3xTg-AD mice. 2017 Inflamm. Res. pmid:28238167
Sasaki F et al. Biochemical and immunological characterization of a novel monoclonal antibody against mouse leukotriene B4 receptor 1. 2017 PLoS ONE pmid:28922396
Pazos MA et al. Pseudomonas aeruginosa ExoU augments neutrophil transepithelial migration. 2017 PLoS Pathog. pmid:28771621
Heineke MH et al. Peptide mimetics of immunoglobulin A (IgA) and FcαRI block IgA-induced human neutrophil activation and migration. 2017 Eur. J. Immunol. pmid:28736835
Vincent WJB et al. Neutrophil derived LTB4 induces macrophage aggregation in response to encapsulated Streptococcus iniae infection. 2017 PLoS ONE pmid:28658259
Tu ZL et al. LTB4 and montelukast in transplantation-related bronchiolitis obliterans in rats. 2017 J Cardiothorac Surg pmid:28545478
Yu XH et al. Biomarkers of unstable angina pectoris and yangxin decoction intervention: An exploratory metabonomics study of blood plasma. 2017 Medicine (Baltimore) pmid:28538412
Hamilton KD et al. Natural products isolated from Tetragonula carbonaria cerumen modulate free radical-scavenging and 5-lipoxygenase activities in vitro. 2017 BMC Complement Altern Med pmid:28446157
Al-Roujayee AS Naringenin improves the healing process of thermally-induced skin damage in rats. 2017 J. Int. Med. Res. pmid:28415935
Ying W et al. Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling. 2017 J. Clin. Invest. pmid:28192375
Archambault AS et al. Leukotriene B₄ Metabolism and p70S6 Kinase 1 Inhibitors: PF-4708671 but Not LY2584702 Inhibits CYP4F3A and the ω-Oxidation of Leukotriene B₄ In Vitro and In Cellulo. 2017 PLoS ONE pmid:28068410
Min A et al. SNAP23-Dependent Surface Translocation of Leukotriene B4 (LTB4) Receptor 1 Is Essential for NOX2-Mediated Exocytotic Degranulation in Human Mast Cells Induced by Trichomonas vaginalis-Secreted LTB4. 2017 Infect. Immun. pmid:27795355
Spilker ME et al. Leveraging model-based study designs and serial micro-sampling techniques to understand the oral pharmacokinetics of the potent LTB4 inhibitor, CP-105696, for mouse pharmacology studies. 2017 Xenobiotica pmid:27435693
Zhou X et al. Erythromycin attenuates metalloprotease/anti-metalloprotease imbalance in cigarette smoke-induced emphysema in rats via the mitogen-activated protein kinase/nuclear factor-κB activation pathway. 2017 Mol Med Rep pmid:28358431
Singh A et al. Lipoxin A4, a 5-lipoxygenase pathway metabolite, modulates immune response during acute respiratory tularemia. 2017 J. Leukoc. Biol. pmid:27630217
Pruzanski W et al. Hydrolysis of lipoproteins by sPLA2's enhances mitogenesis and eicosanoid release from vascular smooth muscle cells: Diverse activity of sPLA2's IIA, V and X. 2016 Prostaglandins Other Lipid Mediat. pmid:26711221
Sun D and Shi M Neutrophil swarming toward Cryptococcus neoformans is mediated by complement and leukotriene B4. 2016 Biochem. Biophys. Res. Commun. pmid:27402276
Ee MT et al. Leukotriene B4 mediates macrophage influx and pulmonary hypertension in bleomycin-induced chronic neonatal lung injury. 2016 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:27317685
Maddipati KR et al. Lipidomic analysis of patients with microbial invasion of the amniotic cavity reveals up-regulation of leukotriene B4. 2016 FASEB J. pmid:27312808
Siddiqui F et al. Opuntia dillenii cladode: Opuntiol and opuntioside attenuated cytokines and eicosanoids mediated inflammation. 2016 J Ethnopharmacol pmid:26900126