Leukotriene b4 is a lipid of Fatty Acyls (FA) class. The involved functions are known as Chemotaxis, release of sequestered calcium ion into cytoplasm and Polymerization. Leukotriene b4 often locates in Protoplasm. The associated genes with Leukotriene b4 are phallacidin.
To understand associated biological information of Leukotriene b4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with Leukotriene b4
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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There are no associated biomedical information in the current reference collection.
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Sasaki F et al. | Biochemical and immunological characterization of a novel monoclonal antibody against mouse leukotriene B4 receptor 1. | 2017 | PLoS ONE | pmid:28922396 |
Pazos MA et al. | Pseudomonas aeruginosa ExoU augments neutrophil transepithelial migration. | 2017 | PLoS Pathog. | pmid:28771621 |
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Vincent WJB et al. | Neutrophil derived LTB4 induces macrophage aggregation in response to encapsulated Streptococcus iniae infection. | 2017 | PLoS ONE | pmid:28658259 |
Tu ZL et al. | LTB4 and montelukast in transplantation-related bronchiolitis obliterans in rats. | 2017 | J Cardiothorac Surg | pmid:28545478 |
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Ying W et al. | Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling. | 2017 | J. Clin. Invest. | pmid:28192375 |
Archambault AS et al. | Leukotriene B₄ Metabolism and p70S6 Kinase 1 Inhibitors: PF-4708671 but Not LY2584702 Inhibits CYP4F3A and the ω-Oxidation of Leukotriene B₄ In Vitro and In Cellulo. | 2017 | PLoS ONE | pmid:28068410 |
Min A et al. | SNAP23-Dependent Surface Translocation of Leukotriene B4 (LTB4) Receptor 1 Is Essential for NOX2-Mediated Exocytotic Degranulation in Human Mast Cells Induced by Trichomonas vaginalis-Secreted LTB4. | 2017 | Infect. Immun. | pmid:27795355 |
Spilker ME et al. | Leveraging model-based study designs and serial micro-sampling techniques to understand the oral pharmacokinetics of the potent LTB4 inhibitor, CP-105696, for mouse pharmacology studies. | 2017 | Xenobiotica | pmid:27435693 |
Zhou X et al. | Erythromycin attenuates metalloprotease/anti-metalloprotease imbalance in cigarette smoke-induced emphysema in rats via the mitogen-activated protein kinase/nuclear factor-κB activation pathway. | 2017 | Mol Med Rep | pmid:28358431 |
Singh A et al. | Lipoxin A4, a 5-lipoxygenase pathway metabolite, modulates immune response during acute respiratory tularemia. | 2017 | J. Leukoc. Biol. | pmid:27630217 |
Pallio G et al. | Use of a balanced dual cyclooxygenase-1/2 and 5-lypoxygenase inhibitor in experimental colitis. | 2016 | Eur. J. Pharmacol. | pmid:27450484 |
Pruzanski W et al. | Hydrolysis of lipoproteins by sPLA2's enhances mitogenesis and eicosanoid release from vascular smooth muscle cells: Diverse activity of sPLA2's IIA, V and X. | 2016 | Prostaglandins Other Lipid Mediat. | pmid:26711221 |
Pontes AS et al. | p38 MAPK is involved in human neutrophil chemotaxis induced by L-amino acid oxidase from Calloselasma rhodosthoma. | 2016 | Toxicon | pmid:27242041 |
Pedruzzi G et al. | Understanding PGE2, LXA4 and LTB4 balance during Mycobacterium tuberculosis infection through mathematical model. | 2016 | J. Theor. Biol. | pmid:26551160 |
Jung KH et al. | Protective Effects of Intratracheally-Administered Bee Venom Phospholipase A2 on Ovalbumin-Induced Allergic Asthma in Mice. | 2016 | Toxins (Basel) | pmid:27669297 |
Yoshida S et al. | Treatment with DHA/EPA ameliorates atopic dermatitis-like skin disease by blocking LTB4 production. | 2016 | J. Med. Invest. | pmid:27644556 |
Chaves MM et al. | Crosstalk between purinergic receptors and lipid mediators in leishmaniasis. | 2016 | Parasit Vectors | pmid:27595742 |
Sun D and Shi M | Neutrophil swarming toward Cryptococcus neoformans is mediated by complement and leukotriene B4. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27402276 |
Ee MT et al. | Leukotriene B4 mediates macrophage influx and pulmonary hypertension in bleomycin-induced chronic neonatal lung injury. | 2016 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:27317685 |
Maddipati KR et al. | Lipidomic analysis of patients with microbial invasion of the amniotic cavity reveals up-regulation of leukotriene B4. | 2016 | FASEB J. | pmid:27312808 |
Gall BJ et al. | Reduction of GPSM3 expression akin to the arthritis-protective SNP rs204989 differentially affects migration in a neutrophil model. | 2016 | Genes Immun. | pmid:27307211 |
Marvar PJ et al. | Systemic leukotriene B4 receptor antagonism lowers arterial blood pressure and improves autonomic function in the spontaneously hypertensive rat. | 2016 | J. Physiol. (Lond.) | pmid:27230966 |
Elias I et al. | ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance. | 2016 | Diabetes | pmid:27207555 |
Zoccal KF et al. | Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality. | 2016 | Nat Commun | pmid:26907476 |
Jiang J et al. | Effect of Marine-Derived n-3 Polyunsaturated Fatty Acids on Major Eicosanoids: A Systematic Review and Meta-Analysis from 18 Randomized Controlled Trials. | 2016 | PLoS ONE | pmid:26808318 |
Tavares N et al. | Degranulating Neutrophils Promote Leukotriene B4 Production by Infected Macrophages To Kill Leishmania amazonensis Parasites. | 2016 | J. Immunol. | pmid:26800873 |
Robinson R | To Attract Others, Immune Cells Release a Packet Which Releases a Signal. | 2016 | PLoS Biol. | pmid:26742021 |
Majumdar R et al. | Exosomes Mediate LTB4 Release during Neutrophil Chemotaxis. | 2016 | PLoS Biol. | pmid:26741884 |
Dong R et al. | Cigarette smoke-induced lung inflammation in COPD mediated via LTB4/BLT1/SOCS1 pathway. | 2016 | Int J Chron Obstruct Pulmon Dis | pmid:26730186 |
Havixbeck JJ et al. | Neutrophil contributions to the induction and regulation of the acute inflammatory response in teleost fish. | 2016 | J. Leukoc. Biol. | pmid:26292979 |
Su HH et al. | Aryl hydrocarbon receptor-ligand axis mediates pulmonary fibroblast migration and differentiation through increased arachidonic acid metabolism. | 2016 | Toxicology | pmid:27697457 |
Bellou A et al. | 4-Aminopyridine, A Blocker of Voltage-Dependent K+ Channels, Restores Blood Pressure and Improves Survival in the Wistar Rat Model of Anaphylactic Shock. | 2016 | Crit. Care Med. | pmid:27270180 |
Madrigales-Ahuatzi D and Perez-Gutierrez RM | Evaluation of Anti-inflammatory Activity of Seeds of Phalaris canariensis. | 2016 | Drug Res (Stuttg) | pmid:25830684 |
Siddiqui F et al. | Opuntia dillenii cladode: Opuntiol and opuntioside attenuated cytokines and eicosanoids mediated inflammation. | 2016 | J Ethnopharmacol | pmid:26900126 |
Kim HK et al. | Glutamine Prevents Late-Phase Anaphylaxis via MAPK Phosphatase 1-Dependent Cytosolic Phospholipase A2 Deactivation. | 2016 | Int. Arch. Allergy Immunol. | pmid:27838690 |
Tsen SY et al. | Relative Inhibitions of 5-Lipoxygenase and Myeloperoxidase and Free-Radical Scavenging Activities of Daidzein, Dihydrodaidzein, and Equol. | 2016 | J Med Food | pmid:27027338 |
Cossette C et al. | Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes. | 2015 | Biochem. Pharmacol. | pmid:26032638 |
Tang F et al. | Inhibitory effect of methyleugenol on IgE-mediated allergic inflammation in RBL-2H3 cells. | 2015 | Mediators Inflamm. | pmid:25960618 |
Jiang JX et al. | EETs Attenuate Ox-LDL-Induced LTB4 Production and Activity by Inhibiting p38 MAPK Phosphorylation and 5-LO/BLT1 Receptor Expression in Rat Pulmonary Arterial Endothelial Cells. | 2015 | PLoS ONE | pmid:26035589 |
Leliebre-Lara V et al. | Influence of Navisporus floccosus (Higher Basidiomycetes) n-Hexane Extract on Arachidonate Metabolism in Vitro. | 2015 | Int J Med Mushrooms | pmid:26082985 |
Pazos MA et al. | Distinct cellular sources of hepoxilin A3 and leukotriene B4 are used to coordinate bacterial-induced neutrophil transepithelial migration. | 2015 | J. Immunol. | pmid:25548217 |
Holen E et al. | Combining eicosapentaenoic acid, decosahexaenoic acid and arachidonic acid, using a fully crossed design, affect gene expression and eicosanoid secretion in salmon head kidney cells in vitro. | 2015 | Fish Shellfish Immunol. | pmid:26003739 |
Wang M et al. | Differential Contribution of BLT1 and BLT2 to Leukotriene B4-Induced Human NK Cell Cytotoxicity and Migration. | 2015 | Mediators Inflamm. | pmid:26696753 |
Vaivoda R et al. | CYP4F18-Deficient Neutrophils Exhibit Increased Chemotaxis to Complement Component C5a. | 2015 | J Immunol Res | pmid:26613087 |
Homann J et al. | In Vivo Availability of Pro-Resolving Lipid Mediators in Oxazolone Induced Dermal Inflammation in the Mouse. | 2015 | PLoS ONE | pmid:26599340 |
Liu X et al. | Leukotriene B4 Inhibits L-Type Calcium Channels via p38 Signaling Pathway in Vascular Smooth Muscle Cells. | 2015 | Cell. Physiol. Biochem. | pmid:26584289 |
Qian J et al. | Leukotriene B4 Activates Pulmonary Artery Adventitial Fibroblasts in Pulmonary Hypertension. | 2015 | Hypertension | pmid:26558820 |
Rodrigues IA et al. | Natural Products: Insights into Leishmaniasis Inflammatory Response. | 2015 | Mediators Inflamm. | pmid:26538837 |
Jeon WK et al. | The proinflammatory LTB4/BLT1 signal axis confers resistance to TGF-β1-induced growth inhibition by targeting Smad3 linker region. | 2015 | Oncotarget | pmid:26497676 |
Li J and Pan JH | [Clinical efficacy of montelukast for the treatment of bronchiolitis in infants]. | 2015 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:26483224 |
Le Bel M and Gosselin J | Leukotriene B4 Enhances NOD2-Dependent Innate Response against Influenza Virus Infection. | 2015 | PLoS ONE | pmid:26444420 |
Sawada Y et al. | Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses. | 2015 | J. Exp. Med. | pmid:26438363 |
Akthar S et al. | Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection. | 2015 | Nat Commun | pmid:26400771 |
O'Dwyer CA et al. | The BLT1 Inhibitory Function of α-1 Antitrypsin Augmentation Therapy Disrupts Leukotriene B4 Neutrophil Signaling. | 2015 | J. Immunol. | pmid:26371243 |
Kiyoyuki Y et al. | Leukotriene enhances NMDA-induced inward currents in dorsal horn neurons of the rat spinal cord after peripheral nerve injury. | 2015 | Mol Pain | pmid:26353783 |
Colom B et al. | Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo. | 2015 | Immunity | pmid:26047922 |
Khan M et al. | Oral administration of cytosolic PLA2 inhibitor arachidonyl trifluoromethyl ketone ameliorates cauda equina compression injury in rats. | 2015 | J Neuroinflammation | pmid:25971887 |
Lv J et al. | Leukotriene B₄-leukotriene B₄ receptor axis promotes oxazolone-induced contact dermatitis by directing skin homing of neutrophils and CD8⺠T cells. | 2015 | Immunology | pmid:25959240 |
Kuraishi Y | Methods for preclinical assessment of antipruritic agents and itch mechanisms independent of mast-cell histamine. | 2015 | Biol. Pharm. Bull. | pmid:25947907 |
Satpathy SR et al. | Crystalline silica-induced leukotriene B4-dependent inflammation promotes lung tumour growth. | 2015 | Nat Commun | pmid:25923988 |
Zhang C et al. | Growth inhibitory effect of polyunsaturated fatty acids (PUFAs) on colon cancer cells via their growth inhibitory metabolites and fatty acid composition changes. | 2015 | PLoS ONE | pmid:25886460 |
Pardo V et al. | Opposite cross-talk by oleate and palmitate on insulin signaling in hepatocytes through macrophage activation. | 2015 | J. Biol. Chem. | pmid:25792746 |
Li P et al. | LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes. | 2015 | Nat. Med. | pmid:25706874 |
Filgueiras LR et al. | Leukotriene B4-mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes. | 2015 | Sci Signal | pmid:25628460 |
Tateishi N et al. | Dietary supplementation with arachidonic acid increases arachidonic acid content in paw, but does not affect arthritis severity or prostaglandin E2 content in rat adjuvant-induced arthritis model. | 2015 | Lipids Health Dis | pmid:25595700 |
Fahel JS et al. | 5-Lipoxygenase negatively regulates Th1 response during Brucella abortus infection in mice. | 2015 | Infect. Immun. | pmid:25583526 |
Liu M and Yokomizo T | The role of leukotrienes in allergic diseases. | 2015 | Allergol Int | pmid:25572555 |
Dalli J et al. | The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:25568926 |
Piotrowska-Tomala KK et al. | Lipopolysaccharides, cytokines, and nitric oxide affect secretion of prostaglandins and leukotrienes by bovine mammary gland during experimentally induced mastitis in vivo and in vitro. | 2015 | Domest. Anim. Endocrinol. | pmid:25935895 |
Knab LM et al. | Ablation of 5-lipoxygenase mitigates pancreatic lesion development. | 2015 | J. Surg. Res. | pmid:25454978 |
Zoccal KF et al. | PPAR-γ activation by Tityus serrulatus venom regulates lipid body formation and lipid mediator production. | 2015 | Toxicon | pmid:25450800 |
Alvarellos ML et al. | PharmGKB summary: very important pharmacogene information for CYP4F2. | 2015 | Pharmacogenet. Genomics | pmid:25370453 |
Zhang J et al. | Exhaled Hydrogen Sulfide Predicts Airway Inflammation Phenotype in COPD. | 2015 | Respir Care | pmid:25336529 |
Jensen GS et al. | Anti-inflammatory properties of a dried fermentate in vitro and in vivo. | 2015 | J Med Food | pmid:25105458 |
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Voon PT et al. | Virgin olive oil, palm olein and coconut oil diets do not raise cell adhesion molecules and thrombogenicity indices in healthy Malaysian adults. | 2015 | Eur J Clin Nutr | pmid:25804278 |
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Gendelman O et al. | A randomized double-blind placebo-controlled study adding high dose vitamin D to analgesic regimens in patients with musculoskeletal pain. | 2015 | Lupus | pmid:25801891 |
Hoffmeyer F et al. | Evaluation of Airway Inflammation in Compost Workers Exposed to Bioaerosols Using Exhaled Breath Condensate and Fractional Exhaled Nitric Oxide. | 2015 | Adv. Exp. Med. Biol. | pmid:25786401 |
Carceller MC et al. | Paracrine in vivo inhibitory effects of adipose tissue-derived mesenchymal stromal cells in the early stages of the acute inflammatory response. | 2015 | Cytotherapy | pmid:26276006 |
Wang FY et al. | Potential protective effects of Clostridium butyricum on experimental gastric ulcers in mice. | 2015 | World J. Gastroenterol. | pmid:26217085 |
de Cássia Campos MR et al. | Differential effects of chemoattractants on mast cell recruitment in vivo. | 2014 May-Jun | Cell. Immunol. | pmid:24736098 |
Breganó JW et al. | Comparison of selective and non selective cyclo-oxygenase 2 inhibitors in experimental colitis exacerbation: role of leukotriene B4 and superoxide dismutase. | 2014 Jul-Sep | Arq Gastroenterol | pmid:25296084 |
Wang Z et al. | Leukotriene B4 enhances the generation of proinflammatory microRNAs to promote MyD88-dependent macrophage activation. | 2014 | J. Immunol. | pmid:24477912 |
Laidlaw TM et al. | Prostaglandin E2 resistance in granulocytes from patients with aspirin-exacerbated respiratory disease. | 2014 | J. Allergy Clin. Immunol. | pmid:24486071 |
Yoo JM et al. | Anti-allergic action of aged black garlic extract in RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice. | 2014 | J Med Food | pmid:24456359 |
Cho H et al. | On-demand, competing gradient arrays for neutrophil chemotaxis. | 2014 | Lab Chip | pmid:24430002 |
Hendriks AG et al. | Cutaneous application of leukotriene B4 as an in vivo model of psoriasis-like skin inflammation: an immunohistological study. | 2014 | Skin Pharmacol Physiol | pmid:24401330 |
Wan M et al. | Oxidized but not native cardiolipin has pro-inflammatory effects, which are inhibited by Annexin A5. | 2014 | Atherosclerosis | pmid:24956533 |
Kubala SA et al. | Pathogen induced chemo-attractant hepoxilin A3 drives neutrophils, but not eosinophils across epithelial barriers. | 2014 | Prostaglandins Other Lipid Mediat. | pmid:24315875 |
Araújo-Santos T et al. | Prostaglandin E2/leukotriene B4 balance induced by Lutzomyia longipalpis saliva favors Leishmania infantum infection. | 2014 | Parasit Vectors | pmid:25526785 |
Dixit N et al. | Leukotriene B4 activates intracellular calcium and augments human osteoclastogenesis. | 2014 | Arthritis Res. Ther. | pmid:25443625 |
O'Sullivan A et al. | Habitual diets rich in dark-green vegetables are associated with an increased response to ω-3 fatty acid supplementation in Americans of African ancestry. | 2014 | J. Nutr. | pmid:24259553 |
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