Leukotriene b4 is a lipid of Fatty Acyls (FA) class. The involved functions are known as Chemotaxis, release of sequestered calcium ion into cytoplasm and Polymerization. Leukotriene b4 often locates in Protoplasm. The associated genes with Leukotriene b4 are phallacidin.
To understand associated biological information of Leukotriene b4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with Leukotriene b4
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Yamauchi A et al. | Systematic single cell analysis of migration and morphological changes of human neutrophils over stimulus concentration gradients. | 2014 | J. Immunol. Methods | pmid:24370750 |
Jänne PA et al. | Randomized, double-blind, phase II trial comparing gemcitabine-cisplatin plus the LTB4 antagonist LY293111 versus gemcitabine-cisplatin plus placebo in first-line non-small-cell lung cancer. | 2014 | J Thorac Oncol | pmid:24346102 |
Wang Z et al. | Leukotriene B4 enhances the generation of proinflammatory microRNAs to promote MyD88-dependent macrophage activation. | 2014 | J. Immunol. | pmid:24477912 |
Keijsers RR et al. | In vivo induction of cutaneous inflammation results in the accumulation of extracellular trap-forming neutrophils expressing RORγt and IL-17. | 2014 | J. Invest. Dermatol. | pmid:24317395 |
Stsiapanava A et al. | Product formation controlled by substrate dynamics in leukotriene A4 hydrolase. | 2014 | Biochim. Biophys. Acta | pmid:24333438 |
Sharma-Walia N et al. | The Kaposi's sarcoma-associated herpesvirus (KSHV)-induced 5-lipoxygenase-leukotriene B4 cascade plays key roles in KSHV latency, monocyte recruitment, and lipogenesis. | 2014 | J. Virol. | pmid:24335295 |
Guan WJ et al. | Exhaled breath condensate eicosanoid levels in asthma: still questioned. | 2014 | J. Allergy Clin. Immunol. | pmid:24530097 |
Paige M et al. | Role of leukotriene A4 hydrolase aminopeptidase in the pathogenesis of emphysema. | 2014 | J. Immunol. | pmid:24771855 |
Chaves MM et al. | Leukotriene B4 modulates P2X7 receptor-mediated Leishmania amazonensis elimination in murine macrophages. | 2014 | J. Immunol. | pmid:24729618 |
Wan M et al. | Cathelicidin LL-37 induces time-resolved release of LTB4 and TXA2 by human macrophages and triggers eicosanoid generation in vivo. | 2014 | FASEB J. | pmid:24736410 |
Galet C et al. | Effect of a low-fat fish oil diet on proinflammatory eicosanoids and cell-cycle progression score in men undergoing radical prostatectomy. | 2014 | Cancer Prev Res (Phila) | pmid:24169960 |
Secatto A et al. | The leukotriene Bâ‚„/BLTâ‚ axis is a key determinant in susceptibility and resistance to histoplasmosis. | 2014 | PLoS ONE | pmid:24465479 |
Wan M et al. | Oxidized but not native cardiolipin has pro-inflammatory effects, which are inhibited by Annexin A5. | 2014 | Atherosclerosis | pmid:24956533 |
Byrne MB et al. | Oscillatory behavior of neutrophils under opposing chemoattractant gradients supports a winner-take-all mechanism. | 2014 | PLoS ONE | pmid:24465668 |
Tavares NM et al. | Understanding the mechanisms controlling Leishmania amazonensis infection in vitro: the role of LTB4 derived from human neutrophils. | 2014 | J. Infect. Dis. | pmid:24634497 |
van den Borne P et al. | Leukotriene B4 levels in human atherosclerotic plaques and abdominal aortic aneurysms. | 2014 | PLoS ONE | pmid:24475136 |
Balderramas HA et al. | Human neutrophils produce IL-12, IL-10, PGE2 and LTB4 in response to Paracoccidioides brasiliensis. Involvement of TLR2, mannose receptor and dectin-1. | 2014 | Cytokine | pmid:24680480 |
Shang E et al. | De novo design of multitarget ligands with an iterative fragment-growing strategy. | 2014 | J Chem Inf Model | pmid:24611712 |
Hester AG et al. | Relationship between a common variant in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans. | 2014 | J. Biol. Chem. | pmid:24962583 |
Kubala SA et al. | Pathogen induced chemo-attractant hepoxilin A3 drives neutrophils, but not eosinophils across epithelial barriers. | 2014 | Prostaglandins Other Lipid Mediat. | pmid:24315875 |
Cheung KL et al. | Nrf2 knockout enhances intestinal tumorigenesis in Apc(min/+) mice due to attenuation of anti-oxidative stress pathway while potentiates inflammation. | 2014 | Mol. Carcinog. | pmid:22911891 |
Kurtz M et al. | Peroxisome proliferator-activated receptor ligands regulate lipid content, metabolism, and composition in fetal lungs of diabetic rats. | 2014 | J. Endocrinol. | pmid:24389592 |
Sorensen LS et al. | Effects of perioperative supplementation with omega-3 fatty acids on leukotriene Bâ‚„ and leukotriene Bâ‚… production by stimulated neutrophils in patients with colorectal cancer: a randomized, placebo-controlled intervention trial. | 2014 | Nutrients | pmid:25268838 |
Bukiya AN et al. | Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4. | 2014 | J. Biol. Chem. | pmid:25371198 |
Leaker BR et al. | The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthma. | 2014 | BMC Pulm Med | pmid:25351474 |
Fredman G et al. | Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25246560 |
Lin HC et al. | 5-Lipoxygenase inhibitors attenuate TNF-α-induced inflammation in human synovial fibroblasts. | 2014 | PLoS ONE | pmid:25229347 |
He G et al. | Interrelationships between ALOX5AP polymorphisms, serum leukotriene B4 level and risk of acute coronary syndrome. | 2014 | PLoS ONE | pmid:25210744 |
Morato CI et al. | Essential role of leukotriene B4 on Leishmania (Viannia) braziliensis killing by human macrophages. | 2014 | Microbes Infect. | pmid:25195516 |
Boneschansker L et al. | Microfluidic platform for the quantitative analysis of leukocyte migration signatures. | 2014 | Nat Commun | pmid:25183261 |
McNeill E et al. | Contrasting in vitro vs. in vivo effects of a cell membrane-specific CC-chemokine binding protein on macrophage chemotaxis. | 2014 | J. Mol. Med. | pmid:25077938 |
Kaźmierczak M et al. | Correlation of inflammatory markers with echocardiographic parameters of left and right ventricular function in patients with chronic obstructive pulmonary disease and cardiovascular diseases. | 2014 | Pol. Arch. Med. Wewn. | pmid:24824617 |
Fischer CD et al. | Tulathromycin exerts proresolving effects in bovine neutrophils by inhibiting phospholipases and altering leukotriene B4, prostaglandin E2, and lipoxin A4 production. | 2014 | Antimicrob. Agents Chemother. | pmid:24820086 |
Anderson R et al. | The beta-2-adrenoreceptor agonists, formoterol and indacaterol, but not salbutamol, effectively suppress the reactivity of human neutrophils in vitro. | 2014 | Mediators Inflamm. | pmid:24733958 |
Drozdovszky O et al. | Sputum eicosanoid profiling in exacerbations of chronic obstructive pulmonary disease. | 2014 | Respiration | pmid:24714447 |
Mendes MT and Silveira PF | The interrelationship between leukotriene B4 and leukotriene-A4-hydrolase in collagen/adjuvant-induced arthritis in rats. | 2014 | Biomed Res Int | pmid:24701582 |
Ringholz FC et al. | Reduced 15-lipoxygenase 2 and lipoxin A4/leukotriene B4 ratio in children with cystic fibrosis. | 2014 | Eur. Respir. J. | pmid:24696116 |
Wang Y et al. | DanQi Pill protects against heart failure through the arachidonic acid metabolism pathway by attenuating different cyclooxygenases and leukotrienes B4. | 2014 | BMC Complement Altern Med | pmid:24555740 |
Wan GH et al. | Using high-performance liquid chromatography with UV detector to quantify exhaled leukotriene B4 level in nonatopic adults. | 2014 | J. Formos. Med. Assoc. | pmid:24491995 |
O'Sullivan A et al. | Habitual diets rich in dark-green vegetables are associated with an increased response to ω-3 fatty acid supplementation in Americans of African ancestry. | 2014 | J. Nutr. | pmid:24259553 |
Liu YH et al. | Hydrogen sulfide prevents heart failure development via inhibition of renin release from mast cells in isoproterenol-treated rats. | 2014 | Antioxid. Redox Signal. | pmid:23581627 |
Di Gennaro A and Haeggström JZ | Targeting leukotriene B4 in inflammation. | 2014 | Expert Opin. Ther. Targets | pmid:24090264 |
Joshi YB et al. | Modulation of amyloid-β production by leukotriene B4 via the γ-secretase pathway. | 2014 | J. Alzheimers Dis. | pmid:24008686 |
Estevão-Silva CF et al. | Anethole and eugenol reduce in vitro and in vivo leukocyte migration induced by fMLP, LTB4, and carrageenan. | 2014 | J Nat Med | pmid:24789168 |
Patnode ML et al. | Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. | 2014 | J. Exp. Med. | pmid:24889202 |
Finsterbusch M et al. | Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF. | 2014 | J. Exp. Med. | pmid:24913232 |
Winslow V et al. | Altered leukotriene B4 metabolism in CYP4F18-deficient mice does not impact inflammation following renal ischemia. | 2014 | Biochim. Biophys. Acta | pmid:24632148 |
Moshkovits I et al. | CMRF35-like molecule 1 (CLM-1) regulates eosinophil homeostasis by suppressing cellular chemotaxis. | 2014 | Mucosal Immunol | pmid:23820751 |
John F et al. | Elevated levels of leukotriene B4 and thromboxane B2 distinguish chest pain of cardiac and non cardiac origin. | 2013 May-Jun | Indian Heart J | pmid:23809385 |
McFarland AJ et al. | Paradoxical role of 3-methyladenine in pyocyanin-induced toxicity in 1321N1 astrocytoma and SH-SY5Y neuroblastoma cells. | 2013 May-Jun | Int. J. Toxicol. | pmid:23525265 |
Inada T et al. | Intravenous anesthetic propofol suppresses leukotriene production in murine dendritic cells. | 2013 Jul-Sep | J Immunotoxicol | pmid:22953970 |
Kochtebane N et al. | Release of leukotriene B4, transforming growth factor-beta1 and microparticles in relation to aortic valve calcification. | 2013 | J. Heart Valve Dis. | pmid:24597398 |
Xu S et al. | Clinical significance of leukotriene b4 and extracellular matrix metalloproteinase inducer in acute coronary syndrome. | 2013 | Clin Invest Med | pmid:24309224 |
Beck I et al. | High environmental ozone levels lead to enhanced allergenicity of birch pollen. | 2013 | PLoS ONE | pmid:24278250 |
Dave M and Amin AR | Yin-Yang regulation of prostaglandins and nitric oxide by PGD2 in human arthritis: reversal by celecoxib. | 2013 | Immunol. Lett. | pmid:23603366 |
Dalli J et al. | The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype. | 2013 | FASEB J. | pmid:23504711 |
Loell I et al. | Activated LTB4 pathway in muscle tissue of patients with polymyositis or dermatomyositis. | 2013 | Ann. Rheum. Dis. | pmid:22736094 |
Bain G et al. | Pharmacodynamics, pharmacokinetics and safety of GSK2190915, a novel oral anti-inflammatory 5-lipoxygenase-activating protein inhibitor. | 2013 | Br J Clin Pharmacol | pmid:22803688 |
Nielsen MS et al. | Adipose tissue arachidonic acid content is associated with the expression of 5-lipoxygenase in atherosclerotic plaques. | 2013 | Lipids Health Dis | pmid:23351835 |
Raulf-Heimsoth M et al. | Comparison of different non-invasive methods for detection of allergic asthma. | 2013 | Adv. Exp. Med. Biol. | pmid:22826049 |
Sánchez GA et al. | Relationship between salivary leukotriene B4 levels and salivary mucin or alveolar bone resorption, in subjects with periodontal health and disease. | 2013 | J. Periodont. Res. | pmid:23488687 |
Abdel-Aziz H et al. | Novel effects of ectoine, a bacteria-derived natural tetrahydropyrimidine, in experimental colitis. | 2013 | Phytomedicine | pmid:23453305 |
Tufvesson E et al. | Inflammatory biomarkers in sputum predict COPD exacerbations. | 2013 | Lung | pmid:23689877 |
Das R et al. | Macrophage gene expression and foam cell formation are regulated by plasminogen. | 2013 | Circulation | pmid:23401155 |
Jian W et al. | Quantitation of leukotriene B(4) in human sputum as a biomarker using UPLC-MS/MS. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23831697 |
Tobin DM et al. | An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection. | 2013 | PLoS ONE | pmid:23874453 |
Kang KH et al. | Protection of dopaminergic neurons by 5-lipoxygenase inhibitor. | 2013 | Neuropharmacology | pmid:23800665 |
Pereira PA et al. | Celecoxib improves host defense through prostaglandin inhibition during Histoplasma capsulatum infection. | 2013 | Mediators Inflamm. | pmid:23818746 |
Hoobler EK et al. | Discovery of a novel dual fungal CYP51/human 5-lipoxygenase inhibitor: implications for anti-fungal therapy. | 2013 | PLoS ONE | pmid:23826084 |
Xu GL et al. | Inhibition of inflammatory mediators contributes to the anti-inflammatory activity of KYKZL-1 via MAPK and NF-κB pathway. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23732080 |
Rosiak M et al. | Lack of effect of common single nucleotide polymorphisms in leukotriene pathway genes on platelet reactivity in patients with diabetes. | 2013 | Mol Med Rep | pmid:23828562 |
Ikeno Y et al. | Wasp venom allergy: effect of anti-IgE antibody on wasp venom anaphylaxis in a mouse model. | 2013 | Asian Pac. J. Allergy Immunol. | pmid:23859410 |
Ochkur SI et al. | Cys-leukotrienes promote fibrosis in a mouse model of eosinophil-mediated respiratory inflammation. | 2013 | Am. J. Respir. Cell Mol. Biol. | pmid:23859654 |
Matsunaga Y et al. | Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia. | 2013 | FASEB J. | pmid:23603839 |
Kazani S et al. | Exhaled breath condensate eicosanoid levels associate with asthma and its severity. | 2013 | J. Allergy Clin. Immunol. | pmid:23608729 |
Roversi P et al. | Bifunctional lipocalin ameliorates murine immune complex-induced acute lung injury. | 2013 | J. Biol. Chem. | pmid:23625922 |
Labat C et al. | Inflammatory mediators in saliva associated with arterial stiffness and subclinical atherosclerosis. | 2013 | J. Hypertens. | pmid:23868086 |
Khajah M et al. | Fer kinase limits neutrophil chemotaxis toward end target chemoattractants. | 2013 | J. Immunol. | pmid:23355730 |
Soares EM et al. | Leukotriene B4 enhances innate immune defense against the puerperal sepsis agent Streptococcus pyogenes. | 2013 | J. Immunol. | pmid:23325886 |
Kent SE et al. | The 5-lipoxygenase-activating protein inhibitor, GSK2190915, attenuates the early and late responses to inhaled allergen in mild asthma. | 2013 | Clin. Exp. Allergy | pmid:23331559 |
Dulin JN et al. | Licofelone modulates neuroinflammation and attenuates mechanical hypersensitivity in the chronic phase of spinal cord injury. | 2013 | J. Neurosci. | pmid:23303944 |
Arab HH and El-Sawalhi MM | Carvedilol alleviates adjuvant-induced arthritis and subcutaneous air pouch edema: modulation of oxidative stress and inflammatory mediators. | 2013 | Toxicol. Appl. Pharmacol. | pmid:23360886 |
Guerrero AT et al. | The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia. | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23187752 |
Hiroi T et al. | Neutrophil TRPM2 channels are implicated in the exacerbation of myocardial ischaemia/reperfusion injury. | 2013 | Cardiovasc. Res. | pmid:23129587 |
Liu HP et al. | Chemoprevention of intestinal adenomatous polyposis by acetyl-11-keto-beta-boswellic acid in APC(Min/+) mice. | 2013 | Int. J. Cancer | pmid:23132636 |
Sydlik U et al. | Recovery of neutrophil apoptosis by ectoine: a new strategy against lung inflammation. | 2013 | Eur. Respir. J. | pmid:23100492 |
Jian F et al. | The change of LTB4 and 5-LO during pregnancy. | 2013 | Arch. Gynecol. Obstet. | pmid:23572152 |
Balderramas HA et al. | The role of leukotriene B4 in early stages of experimental paracoccidioidomycosis induced in phenotypically selected mouse strains. | 2013 | Med. Mycol. | pmid:23534453 |
Lin W et al. | A highly sensitive and selective method for the determination of leukotriene B4 (LTB4) in ex vivo stimulated human plasma by ultra fast liquid chromatography-tandem mass spectrometry. | 2013 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:23523878 |
Hirata K et al. | Critical role of leukotriene B4 receptor signaling in mouse 3T3-L1 preadipocyte differentiation. | 2013 | Lipids Health Dis | pmid:23937951 |
Sánchez-Vidaurre S et al. | Sputum inflammatory profile before and after specific inhalation challenge in individuals with suspected occupational asthma. | 2013 | PLoS ONE | pmid:24236015 |
Yin Y et al. | Regulation of cigarette smoke-induced toll-like receptor 4 expression by peroxisome proliferator-activated receptor-gamma agonists in bronchial epithelial cells. | 2013 | Respirology | pmid:24188201 |
Andrade EB et al. | TLR2-induced IL-10 production impairs neutrophil recruitment to infected tissues during neonatal bacterial sepsis. | 2013 | J. Immunol. | pmid:24078699 |
Santos PC et al. | The pivotal role of 5-lipoxygenase-derived LTB4 in controlling pulmonary paracoccidioidomycosis. | 2013 | PLoS Negl Trop Dis | pmid:23991239 |
Lino-dos-Santos-Franco A et al. | Formaldehyde inhalation reduces respiratory mechanics in a rat model with allergic lung inflammation by altering the nitric oxide/cyclooxygenase-derived products relationship. | 2013 | Food Chem. Toxicol. | pmid:23871789 |
Loke WM et al. | Augmentation of 5-lipoxygenase activity and expression during dengue serotype-2 infection. | 2013 | Virol. J. | pmid:24168271 |
Sadik CD et al. | Leukotrienes orchestrating allergic skin inflammation. | 2013 | Exp. Dermatol. | pmid:24433180 |
Landa P et al. | Inhibition of in vitro leukotriene B4 biosynthesis in human neutrophil granulocytes and docking studies of natural quinones. | 2013 | Nat Prod Commun | pmid:23472470 |
Bischel LL et al. | Zebrafish Entrapment By Restriction Array (ZEBRA) device: a low-cost, agarose-free zebrafish mounting technique for automated imaging. | 2013 | Lab Chip | pmid:23503983 |
Fernandes ES et al. | Superoxide generation and leukocyte accumulation: key elements in the mediation of leukotriene Bâ‚„-induced itch by transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1. | 2013 | FASEB J. | pmid:23271050 |