Leukotriene b4

Leukotriene b4 is a lipid of Fatty Acyls (FA) class. The involved functions are known as Chemotaxis, release of sequestered calcium ion into cytoplasm and Polymerization. Leukotriene b4 often locates in Protoplasm. The associated genes with Leukotriene b4 are phallacidin.

Cross Reference

Introduction

To understand associated biological information of Leukotriene b4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Leukotriene b4?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Leukotriene b4

MeSH term MeSH ID Detail
Dermatitis, Contact D003877 59 associated lipids
Bacterial Infections D001424 21 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Alveolitis, Extrinsic Allergic D000542 6 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Mycobacterium Infections D009164 7 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Per page 10 20 50 100 | Total 265

PubChem Associated disorders and diseases

What pathways are associated with Leukotriene b4

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Leukotriene b4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Leukotriene b4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Leukotriene b4?

There are no associated biomedical information in the current reference collection.

What genes are associated with Leukotriene b4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Leukotriene b4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Leukotriene b4

Download all related citations
Per page 10 20 50 100 | Total 5221
Authors Title Published Journal PubMed Link
Csupor D et al. Anti-inflammatory activities of eleven Centaurea species occurring in the Carpathian Basin. 2013 Phytother Res pmid:22674731
Xu GL et al. Inhibition of inflammatory mediators contributes to the anti-inflammatory activity of KYKZL-1 via MAPK and NF-κB pathway. 2013 Toxicol. Appl. Pharmacol. pmid:23732080
Rosiak M et al. Lack of effect of common single nucleotide polymorphisms in leukotriene pathway genes on platelet reactivity in patients with diabetes. 2013 Mol Med Rep pmid:23828562
Ikeno Y et al. Wasp venom allergy: effect of anti-IgE antibody on wasp venom anaphylaxis in a mouse model. 2013 Asian Pac. J. Allergy Immunol. pmid:23859410
Ochkur SI et al. Cys-leukotrienes promote fibrosis in a mouse model of eosinophil-mediated respiratory inflammation. 2013 Am. J. Respir. Cell Mol. Biol. pmid:23859654
Kazani S et al. Exhaled breath condensate eicosanoid levels associate with asthma and its severity. 2013 J. Allergy Clin. Immunol. pmid:23608729
Roversi P et al. Bifunctional lipocalin ameliorates murine immune complex-induced acute lung injury. 2013 J. Biol. Chem. pmid:23625922
Murata N et al. Effect of allergen sensitization on external root resorption. 2013 J. Dent. Res. pmid:23648742
Lefèvre L et al. The C-type lectin receptors dectin-1, MR, and SIGNR3 contribute both positively and negatively to the macrophage response to Leishmania infantum. 2013 Immunity pmid:23684988
Cabral M et al. Role of arachidonic acid metabolites on the control of non-differentiated intestinal epithelial cell growth. 2013 Int. J. Biochem. Cell Biol. pmid:23685077
Dalli J et al. Heterogeneity in neutrophil microparticles reveals distinct proteome and functional properties. 2013 Mol. Cell Proteomics pmid:23660474
Sydlik U et al. Recovery of neutrophil apoptosis by ectoine: a new strategy against lung inflammation. 2013 Eur. Respir. J. pmid:23100492
Jian F et al. The change of LTB4 and 5-LO during pregnancy. 2013 Arch. Gynecol. Obstet. pmid:23572152
Balderramas HA et al. The role of leukotriene B4 in early stages of experimental paracoccidioidomycosis induced in phenotypically selected mouse strains. 2013 Med. Mycol. pmid:23534453
Lin W et al. A highly sensitive and selective method for the determination of leukotriene B4 (LTB4) in ex vivo stimulated human plasma by ultra fast liquid chromatography-tandem mass spectrometry. 2013 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:23523878
Ferreira RG et al. Niacin inhibits carrageenan-induced neutrophil migration in mice. 2013 Naunyn Schmiedebergs Arch. Pharmacol. pmid:23525501
Nisar A et al. Atropa acuminata Royle Ex Lindl. blunts production of pro-inflammatory mediators eicosanoids., leukotrienes, cytokines in vitro and in vivo models of acute inflammatory responses. 2013 J Ethnopharmacol pmid:23528361
Li Y et al. Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer. 2013 Toxicol. Appl. Pharmacol. pmid:23747687
Lämmermann T et al. Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo. 2013 Nature pmid:23708969
Bischel LL et al. Zebrafish Entrapment By Restriction Array (ZEBRA) device: a low-cost, agarose-free zebrafish mounting technique for automated imaging. 2013 Lab Chip pmid:23503983
Fernandes ES et al. Superoxide generation and leukocyte accumulation: key elements in the mediation of leukotriene Bâ‚„-induced itch by transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1. 2013 FASEB J. pmid:23271050
Waki H et al. Excessive leukotriene B4 in nucleus tractus solitarii is prohypertensive in spontaneously hypertensive rats. 2013 Hypertension pmid:23172924
Kovarik JJ et al. Eicosanoid modulation by the short-chain fatty acid n-butyrate in human monocytes. 2013 Immunology pmid:23398566
Bitencourt CS et al. Cooperative role of endogenous leucotrienes and platelet-activating factor in ischaemia-reperfusion-mediated tissue injury. 2013 J. Cell. Mol. Med. pmid:24373549
Gomes A et al. Trihydroxyflavones with antioxidant and anti-inflammatory efficacy. 2012 Sep-Oct Biofactors pmid:22806885
Wang J et al. Superiority of a fish oil-enriched emulsion to medium-chain triacylglycerols/long-chain triacylglycerols in gastrointestinal surgery patients: a randomized clinical trial. 2012 Nutrition pmid:22113064
Park SW et al. The shunting of arachidonic acid metabolism to 5-lipoxygenase and cytochrome p450 epoxygenase antagonizes the anti-cancer effect of cyclooxygenase-2 inhibition in head and neck cancer cells. 2012 Cell Oncol (Dordr) pmid:21656078
Eun JC et al. The 5-lipoxygenase pathway is required for acute lung injury following hemorrhagic shock. 2012 Shock pmid:22392149
Pettipher R et al. Pharmacologic profile of OC000459, a potent, selective, and orally active D prostanoid receptor 2 antagonist that inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils. 2012 J. Pharmacol. Exp. Ther. pmid:22106101
Pineda-Peña EA et al. Docosahexaenoic acid, an omega-3 polyunsaturated acid protects against indomethacin-induced gastric injury. 2012 Eur. J. Pharmacol. pmid:23063544
Hanjalic-Beck A et al. Chlormadinone acetate suppresses prostaglandin biosynthesis in human endometrial explants. 2012 Fertil. Steril. pmid:22769735
Hoffmeyer F et al. Impact of different welding techniques on biological effect markers in exhaled breath condensate of 58 mild steel welders. 2012 J. Toxicol. Environ. Health Part A pmid:22686312
Biondo GA et al. Production of leukotriene B4 by Paracoccidioides brasiliensis. 2012 Yeast pmid:22628121
Afonso PV et al. LTB4 is a signal-relay molecule during neutrophil chemotaxis. 2012 Dev. Cell pmid:22542839
Ferreira RG et al. Neutrophil recruitment is inhibited by nicotinamide in experimental pleurisy in mice. 2012 Eur. J. Pharmacol. pmid:22543086
Auner B et al. Circulating leukotriene B4 identifies respiratory complications after trauma. 2012 Mediators Inflamm. pmid:22529525
Waldron MK et al. Plasma phospholipid fatty acid and ex vivo neutrophil responses are differentially altered in dogs fed fish- and linseed-oil containing diets at the same n-6:n-3 fatty acid ratio. 2012 Lipids pmid:22252853
Gonçalves de Albuquerque CF et al. Reduced plasma nonesterified fatty acid levels and the advent of an acute lung injury in mice after intravenous or enteral oleic acid administration. 2012 Mediators Inflamm. pmid:22529526
Wasfi YS et al. The efficacy and tolerability of MK-0633, a 5-lipoxygenase inhibitor, in chronic asthma. 2012 Respir Med pmid:21945511
Amaral FA et al. NLRP3 inflammasome-mediated neutrophil recruitment and hypernociception depend on leukotriene B(4) in a murine model of gout. 2012 Arthritis Rheum. pmid:21952942
Koskela H et al. The cough receptor TRPV1 agonists 15(S)-HETE and LTB4 in the cough response to hypertonicity. 2012 Inflamm Allergy Drug Targets pmid:22280233
Tobin DM et al. Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. 2012 Cell pmid:22304914
Wang B et al. [Expression of extracellular matrix metalloproteinase inducer in the unstable plaque of patients with acute coronary syndrome]. 2012 Zhonghua Xin Xue Guan Bing Za Zhi pmid:22883094
Dalli J and Serhan CN Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators. 2012 Blood pmid:22904297
Pandey A et al. Anti-arthritic activity of agnuside mediated through the down-regulation of inflammatory mediators and cytokines. 2012 Inflamm. Res. pmid:22228102
Jeanson L et al. Oxidative stress induces unfolding protein response and inflammation in nasal polyposis. 2012 Allergy pmid:22188019
Peroni DG et al. Markers of oxidative stress are increased in exhaled breath condensates of children with atopic dermatitis. 2012 Br. J. Dermatol. pmid:22175656
Nam YH et al. Leukotriene B(4) receptors BLT1 and BLT2 are involved in interleukin-8 production in human neutrophils induced by Trichomonas vaginalis-derived secretory products. 2012 Inflamm. Res. pmid:22215047
Guan F et al. Deleterious effects of high concentrations of (-)-epigallocatechin-3-gallate and atorvastatin in mice with colon inflammation. 2012 Nutr Cancer pmid:22716294
Pelclová D et al. Leukotrienes B4, C4, D4 and E4 in the exhaled breath condensate (EBC), blood and urine in patients with pneumoconiosis. 2012 Ind Health pmid:22785421
Sorgi CA et al. GM-CSF priming drives bone marrow-derived macrophages to a pro-inflammatory pattern and downmodulates PGE2 in response to TLR2 ligands. 2012 PLoS ONE pmid:22808181
Stanke-Labesque F et al. Leukotriene B4 pathway activation and atherosclerosis in obstructive sleep apnea. 2012 J. Lipid Res. pmid:22761257
Hung SL et al. Effects of herpes simplex virus type 1 infection on immune functions of human neutrophils. 2012 J. Periodont. Res. pmid:22471246
Altavilla D et al. Effects of flavocoxid, a dual inhibitor of COX and 5-lipoxygenase enzymes, on benign prostatic hyperplasia. 2012 Br. J. Pharmacol. pmid:22471974
Bertin J et al. Leukotrienes inhibit early stages of HIV-1 infection in monocyte-derived microglia-like cells. 2012 J Neuroinflammation pmid:22424294
Saito Y et al. Disruption of group IVA cytosolic phospholipase A(2) attenuates myocardial ischemia-reperfusion injury partly through inhibition of TNF-α-mediated pathway. 2012 Am. J. Physiol. Heart Circ. Physiol. pmid:22427514
Andoh T et al. Involvement of leukotriene B4 in itching in a mouse model of ocular allergy. 2012 Exp. Eye Res. pmid:22504036
He C et al. Dynamic eicosanoid responses upon different inhibitor and combination treatments on the arachidonic acid metabolic network. 2012 Mol Biosyst pmid:22446875
Secatto A et al. 5-Lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection. 2012 PLoS ONE pmid:22448213
Blidberg K et al. Increased neutrophil migration in smokers with or without chronic obstructive pulmonary disease. 2012 Respirology pmid:22509802
Sehgal N et al. Fenofibrate reduces mortality and precludes neurological deficits in survivors in murine model of Japanese encephalitis viral infection. 2012 PLoS ONE pmid:22514742
Barberà-Cremades M et al. P2X7 receptor-stimulation causes fever via PGE2 and IL-1β release. 2012 FASEB J. pmid:22490780
Loke WM et al. Products of 5-lipoxygenase and myeloperoxidase activities are increased in young male cigarette smokers. 2012 Free Radic. Res. pmid:22690830
Serezani CH et al. Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis. 2012 J. Immunol. pmid:22696442
Kurtz M et al. Increased nitric oxide production and gender-dependent changes in PPARα expression and signaling in the fetal lung from diabetic rats. 2012 Mol. Cell. Endocrinol. pmid:22687882
Stone H et al. Variability of sputum inflammatory mediators in COPD and α1-antitrypsin deficiency. 2012 Eur. Respir. J. pmid:22700846
Wang JX et al. Ly6G ligation blocks recruitment of neutrophils via a β2-integrin-dependent mechanism. 2012 Blood pmid:22661700
Batra S et al. Intrapulmonary administration of leukotriene B(4) augments neutrophil accumulation and responses in the lung to Klebsiella infection in CXCL1 knockout mice. 2012 J. Immunol. pmid:22379035
Wu Y et al. Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors. 2012 J. Med. Chem. pmid:22380511
Camacho M et al. Genetic determinants of 5-lipoxygenase pathway in a Spanish population and their relationship with cardiovascular risk. 2012 Atherosclerosis pmid:22835628
Gaudreault É et al. TAK1 contributes to the enhanced responsiveness of LTB(4)-treated neutrophils to Toll-like receptor ligands. 2012 Int. Immunol. pmid:22843747
Choi Y et al. Inhibitory effects of panduratin A on allergy-related mediator production in rat basophilic leukemia mast cells. 2012 Inflammation pmid:22864999
Sahin A et al. Regulation of leukotriene B4 secretion by human corneal, conjunctival, and meibomian gland epithelial cells. 2012 Arch. Ophthalmol. pmid:22893071
Li L et al. The different inhibitory effects of Huang-Lian-Jie-Du-Tang on cyclooxygenase 2 and 5-lipoxygenase. 2012 J Ethnopharmacol pmid:22884869
Barcellos-de-Souza P et al. Leukotriene B(4) inhibits neutrophil apoptosis via NADPH oxidase activity: redox control of NF-κB pathway and mitochondrial stability. 2012 Biochim. Biophys. Acta pmid:22884975
Balode L et al. Lipoxygenase-derived arachidonic acid metabolites in chronic obstructive pulmonary disease. 2012 Medicina (Kaunas) pmid:22885362
Fan SY et al. The anti-inflammatory activities of an extract and compounds isolated from Platycladus orientalis (Linnaeus) Franco in vitro and ex vivo. 2012 J Ethnopharmacol pmid:21619922
Flores-Santana W et al. Nitroxide derivatives of non-steroidal anti-inflammatory drugs exert anti-inflammatory and superoxide dismutase scavenging properties in A459 cells. 2012 Br. J. Pharmacol. pmid:21658022
Kogut MH et al. Bacterial toll-like receptor agonists induce sequential NF-κB-mediated leukotriene B4 and prostaglandin E2 production in chicken heterophils. 2012 Vet. Immunol. Immunopathol. pmid:22119018
Sadik CD and Luster AD Lipid-cytokine-chemokine cascades orchestrate leukocyte recruitment in inflammation. 2012 J. Leukoc. Biol. pmid:22058421
Juchem G et al. Regulation of coronary venular barrier function by blood borne inflammatory mediators and pharmacological tools: insights from novel microvascular wall models. 2012 Am. J. Physiol. Heart Circ. Physiol. pmid:22081707
Koarai A et al. Expression of muscarinic receptors by human macrophages. 2012 Eur. Respir. J. pmid:21885397
Bitto A et al. Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis. 2012 Crit Care pmid:22356547
Fredman G et al. Self-limited versus delayed resolution of acute inflammation: temporal regulation of pro-resolving mediators and microRNA. 2012 Sci Rep pmid:22957142
Ishino Y and Harada T Novel computational methodologies for structural modeling of spacious ligand binding sites of G-protein-coupled receptors: development and application to human leukotriene B4 receptor. 2012 ScientificWorldJournal pmid:23304088
Nielsen MS et al. The effect of low-dose marine n-3 fatty acids on the biosynthesis of pro-inflammatory 5-lipoxygenase pathway metabolites in overweight subjects: a randomized controlled trial. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22748976
Lee CH et al. Glutamine suppresses airway neutrophilia by blocking cytosolic phospholipase A(2) via an induction of MAPK phosphatase-1. 2012 J. Immunol. pmid:23109722
Sadik CD et al. Neutrophils orchestrate their own recruitment in murine arthritis through C5aR and FcγR signaling. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:23112187
Yamada-Kato T et al. Inhibitory effects of wasabi isothiocyanates on chemical mediator release in RBL-2H3 rat basophilic leukemia cells. 2012 J. Nutr. Sci. Vitaminol. pmid:23132316
Chen X et al. Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster cheek pouch carcinogenesis by a 5-lipoxygenase inhibitor, garcinol. 2012 Nutr Cancer pmid:23137051
Piotrowska-Tomala KK et al. Lipopolysaccharides, cytokines, and nitric oxide affect secretion of prostaglandins and leukotrienes by bovine mammary gland epithelial cells. 2012 Domest. Anim. Endocrinol. pmid:22608768
Tulah AS et al. Leukotriene B4 receptor locus gene characterisation and association studies in asthma. 2012 BMC Med. Genet. pmid:23167751
Lysgaard C et al. No effect of high-dose atorvastatin on leukotriene Bâ‚„ formation from neutrophils in patients treated with coronary bypass surgery: a randomized placebo-controlled double-blinded trial with a crossover design. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:23063168
Oyoshi MK et al. Leukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation. 2012 Immunity pmid:23063331
Ganesh R et al. Cyclooxygenase/lipoxygenase shunting lowers the anti-cancer effect of cyclooxygenase-2 inhibition in colorectal cancer cells. 2012 World J Surg Oncol pmid:23013454
Park MK et al. Novel involvement of leukotriene Bâ‚„ receptor 2 through ERK activation by PP2A down-regulation in leukotriene Bâ‚„-induced keratin phosphorylation and reorganization of pancreatic cancer cells. 2012 Biochim. Biophys. Acta pmid:23017243
Komoda T and Nishikawa M 6'-Hydroxyoxosorbicillinol, a new lipoxygenase inhibitor and PGD2/LTB4 release suppressor from Penicillium sp. 2012 Biosci. Biotechnol. Biochem. pmid:22785490
Panicker S et al. Impact of selenium on the leukotriene B4 synthesis pathway during isoproterenol-induced myocardial infarction in experimental rats. 2012 Inflammation pmid:21274744
Parks KR and Davis JM Epinephrine, cortisol, endotoxin, nutrition, and the neutrophil. 2012 Surg Infect (Larchmt) pmid:23163310
Chandrasekaran CV et al. In vitro comparative evaluation of non-leaves and leaves extracts of Andrographis paniculata on modulation of inflammatory mediators. 2012 Antiinflamm Antiallergy Agents Med Chem pmid:22882083