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Inflamm. Res. |
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Oxidative stress induces unfolding protein response and inflammation in nasal polyposis. |
2012 |
Allergy |
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Lipoxin A4 inhibits 5-lipoxygenase translocation and leukotrienes biosynthesis to exert a neuroprotective effect in cerebral ischemia/reperfusion injury. |
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Ly6G ligation blocks recruitment of neutrophils via a β2-integrin-dependent mechanism. |
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Blood |
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Intrapulmonary administration of leukotriene B(4) augments neutrophil accumulation and responses in the lung to Klebsiella infection in CXCL1 knockout mice. |
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Atherosclerosis |
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Nitroxide derivatives of non-steroidal anti-inflammatory drugs exert anti-inflammatory and superoxide dismutase scavenging properties in A459 cells. |
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News & views in ... Immunotherapy. |
2012 |
Immunotherapy |
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Epinephrine, cortisol, endotoxin, nutrition, and the neutrophil. |
2012 |
Surg Infect (Larchmt) |
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Montelukast therapy and psychological distress in chronic obstructive pulmonary disease (COPD): a preliminary report. |
2011 Jan-Feb |
Arch Gerontol Geriatr |
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Monocyte chemoattractant protein 1 regulates pulmonary host defense via neutrophil recruitment during Escherichia coli infection. |
2011 |
Infect. Immun. |
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Impaired phagocytosis in localized aggressive periodontitis: rescue by Resolvin E1. |
2011 |
PLoS ONE |
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Oxidative stress suppresses cysteinyl leukotriene generation by mouse bone marrow-derived mast cells. |
2011 |
J. Biol. Chem. |
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Characterization of the interactions of the pneumolysoid, Δ6 PLY, with human neutrophils in vitro. |
2011 |
Vaccine |
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Biodegradable microspheres containing leukotriene B(4) and cell-free antigens from Histoplasma capsulatum activate murine bone marrow-derived macrophages. |
2011 |
Eur J Pharm Sci |
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Effect of sulindac sulfide on metallohydrolases in the human colon cancer cell line HT-29. |
2011 |
PLoS ONE |
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A phase II randomized placebo-controlled trial of omega-3 fatty acids for the treatment of acute lung injury. |
2011 |
Crit. Care Med. |
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Mechanisms for anti-inflammatory effects of 1-[15(S)-hydroxyeicosapentaenoyl] lysophosphatidylcholine, administered intraperitoneally, in zymosan A-induced peritonitis. |
2011 |
Br. J. Pharmacol. |
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Role of nitric oxide-synthase and cyclooxygenase/lipooxygenase systems in development of experimental ulcerative colitis. |
2011 |
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Macrophage-produced IL-12p70 mediates hemorrhage-induced damage in a complement-dependent manner. |
2011 |
Shock |
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Blockade of LTB(4) /BLT(1) pathway improves CD8(+) T-cell-mediated colitis. |
2011 |
Inflamm. Bowel Dis. |
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Eicosanoid-induced store-operated calcium entry in dendritic cells. |
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Semisynthesis and pharmacological investigation of lipo-alkaloids prepared from aconitine. |
2011 |
Fitoterapia |
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Leukotriene B4 receptors: novel roles in immunological regulations. |
2011 |
Adv. Enzyme Regul. |
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Dietary fish oil and flaxseed oil suppress inflammation and immunity in cats. |
2011 |
Vet. Immunol. Immunopathol. |
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Gastroprotective and ulcer-healing mechanisms of ellagic acid in experimental rats. |
2011 |
J. Agric. Food Chem. |
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Neutrophilic airways inflammation in lung cancer: the role of exhaled LTB-4 and IL-8. |
2011 |
BMC Cancer |
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Anti-inflammatory effects of chronic aspirin on brain arachidonic acid metabolites. |
2011 |
Neurochem. Res. |
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Leukotriene biosynthesis inhibition ameliorates acute lung injury following hemorrhagic shock in rats. |
2011 |
J Cardiothorac Surg |
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CXCL8 attenuates chemoattractant-induced equine neutrophil migration. |
2011 |
Vet. Immunol. Immunopathol. |
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Cigarette smoke extract activates human bronchial epithelial cells affecting non-neuronal cholinergic system signalling in vitro. |
2011 |
Life Sci. |
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Leukotrienes target F-actin/cofilin-1 to enhance alveolar macrophage anti-fungal activity. |
2011 |
J. Biol. Chem. |
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5-(4-Hydroxy-2,3,5-trimethylbenzylidene) thiazolidine-2,4-dione attenuates atherosclerosis possibly by reducing monocyte recruitment to the lesion. |
2011 |
Exp. Mol. Med. |
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Modulatory effect of α-linolenic acid-rich garden cress (Lepidium sativum L.) seed oil on inflammatory mediators in adult albino rats. |
2011 |
Br. J. Nutr. |
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The effects of dietary fish oil on inflammation, fibrosis and oxidative stress associated with obstructive renal injury in rats. |
2011 |
Mol Nutr Food Res |
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Changes in cysteinyl leukotrienes during and after cardiac surgery with cardiopulmonary bypass in patients with and without chronic obstructive pulmonary disease. |
2011 |
J. Thorac. Cardiovasc. Surg. |
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Extra domain A of fibronectin primes leukotriene biosynthesis and stimulates neutrophil migration through activation of Toll-like receptor 4. |
2011 |
Arthritis Rheum. |
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Role of leukotriene B4 in accelerated hyperlipidaemic renal injury. |
2011 |
Nephrology (Carlton) |
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Bioactive lipoxygenase metabolites stimulation of NADPH oxidases and reactive oxygen species. |
2011 |
Mol. Cells |
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Effect of walnut-enriched meat on the relationship between VCAM, ICAM, and LTB4 levels and PON-1 activity in ApoA4 360 and PON-1 allele carriers at increased cardiovascular risk. |
2011 |
Eur J Clin Nutr |
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The measurement of leukotrienes in urine as diagnostic option in systemic mastocytosis. |
2011 |
J. Physiol. Pharmacol. |
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Photohardening restores the impaired neutrophil responsiveness to chemoattractants leukotriene B4 and formyl-methionyl-leucyl-phenylalanin in patients with polymorphic light eruption. |
2011 |
Exp. Dermatol. |
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Impaired neonatal macrophage phagocytosis is not explained by overproduction of prostaglandin E2. |
2011 |
Respir. Res. |
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PPARα agonists regulate lipid metabolism and nitric oxide production and prevent placental overgrowth in term placentas from diabetic rats. |
2011 |
J. Mol. Endocrinol. |
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Leukotriene B4 mediates neutrophil migration induced by heme. |
2011 |
J. Immunol. |
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Role of 5-lipoxygenase in resveratrol mediated suppression of 7,12-dimethylbenz(α)anthracene-induced mammary carcinogenesis in rats. |
2011 |
Eur. J. Pharmacol. |
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Arsenic trioxide inhibits invasion/migration in SGC-7901 cells by activating the reactive oxygen species-dependent cyclooxygenase-2/matrix metalloproteinase-2 pathway. |
2011 |
Exp. Biol. Med. (Maywood) |
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Genome-wide gene expression study indicates the anti-inflammatory effect of polarized light in recurrent childhood respiratory disease. |
2011 |
Inflamm. Res. |
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2-(4-(Biphenyl-4-ylamino)-6-chloropyrimidin-2-ylthio)octanoic acid (HZ52)--a novel type of 5-lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivo. |
2011 |
Br. J. Pharmacol. |
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Battu GR et al. |
In vivo and in vitro pharmacological activity of Aristolochia tagala (syn: Aristolochia acuminata) root extracts. |
2011 |
Pharm Biol |
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Ethanol promotes chemically induced oral cancer in mice through activation of the 5-lipoxygenase pathway of arachidonic acid metabolism. |
2011 |
Cancer Prev Res (Phila) |
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Evidence for eosinophil recruitment, leukotriene B4 production and mast cell hyperplasia following Toxocara canis infection in rats. |
2011 |
Braz. J. Med. Biol. Res. |
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Genetic variants in the promoter region of the ALOX5AP gene and susceptibility of ischemic stroke. |
2011 |
Cerebrovasc. Dis. |
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Dumitru AF et al. |
Petasol butenoate complex (Ze 339) relieves allergic rhinitis-induced nasal obstruction more effectively than desloratadine. |
2011 |
J. Allergy Clin. Immunol. |
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Glycyrrhetinic acid prevents cutaneous scratching behavior in mice elicited by substance P or PAR-2 agonist. |
2011 |
Eur. J. Pharmacol. |
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Basselin M et al. |
Imaging upregulated brain arachidonic acid metabolism in HIV-1 transgenic rats. |
2011 |
J. Cereb. Blood Flow Metab. |
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Mechanistic basis for the chemopreventive effects of black raspberries at a late stage of rat esophageal carcinogenesis. |
2011 |
Mol. Carcinog. |
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Andoh T et al. |
Involvement of leukotriene B4 in spontaneous itch-related behaviour in NC mice with atopic dermatitis-like skin lesions. |
2011 |
Exp. Dermatol. |
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Maaløe T et al. |
The effect of n-3 polyunsaturated fatty acids on leukotriene Bâ‚„ and leukotriene Bâ‚… production from stimulated neutrophil granulocytes in patients with chronic kidney disease. |
2011 |
Prostaglandins Leukot. Essent. Fatty Acids |
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Nam YH et al. |
Leukotriene B4 receptor BLT-mediated phosphorylation of NF-κB and CREB is involved in IL-8 production in human mast cells induced by Trichomonas vaginalis-derived secretory products. |
2011 |
Microbes Infect. |
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Chandrasekaran CV et al. |
Dual inhibitory effect of Glycyrrhiza glabra (GutGardâ„¢) on COX and LOX products. |
2011 |
Phytomedicine |
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Leukotriene b4 and its metabolites prime the neutrophil oxidase and induce proinflammatory activation of human pulmonary microvascular endothelial cells. |
2011 |
Shock |
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Arakeri G and Brennan PA |
Povidone-iodine: an anti-oedematous agent? |
2011 |
Int J Oral Maxillofac Surg |
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Fischer CD et al. |
Anti-Inflammatory benefits of antibiotic-induced neutrophil apoptosis: tulathromycin induces caspase-3-dependent neutrophil programmed cell death and inhibits NF-kappaB signaling and CXCL8 transcription. |
2011 |
Antimicrob. Agents Chemother. |
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Woodruff PG et al. |
Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization. |
2011 |
COPD |
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Widegren H et al. |
LTB4 increases nasal neutrophil activity and conditions neutrophils to exert antiviral effects. |
2011 |
Respir Med |
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Bioactive xanthones from the roots of Hypericum perforatum (common St John's wort). |
2011 |
J. Sci. Food Agric. |
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MartÃnez N et al. |
Activation of the nuclear receptor PPARα regulates lipid metabolism in foetal liver from diabetic rats: implications in diabetes-induced foetal overgrowth. |
2011 |
Diabetes Metab. Res. Rev. |
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Balistreri CR et al. |
LPS-mediated production of pro/anti-inflammatory cytokines and eicosanoids in whole blood samples: biological effects of +896A/G TLR4 polymorphism in a Sicilian population of healthy subjects. |
2011 |
Mech. Ageing Dev. |
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Quercetin reduces neutrophil recruitment induced by CXCL8, LTB4, and fMLP: inhibition of actin polymerization. |
2011 |
J. Nat. Prod. |
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Park MY et al. |
Dietary aloin, aloesin, or aloe-gel exerts anti-inflammatory activity in a rat colitis model. |
2011 |
Life Sci. |
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The endocannabinoid 2-arachidonoyl-glycerol activates human neutrophils: critical role of its hydrolysis and de novo leukotriene B4 biosynthesis. |
2011 |
J. Immunol. |
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Assessment of synovial fluid biomarkers in healthy foals and in foals with tarsocrural osteochondrosis. |
2011 |
Vet. J. |
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Leukotriene B4 amplifies NF-κB activation in mouse macrophages by reducing SOCS1 inhibition of MyD88 expression. |
2011 |
J. Clin. Invest. |
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Formyl peptide receptor 1 and 2 dual agonist inhibits human neutrophil chemotaxis by the induction of chemoattractant receptor cross-desensitization. |
2011 |
J. Pharmacol. Sci. |
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Differential chemokine receptor expression regulates functional specialization of endothelial progenitor cell subpopulations. |
2011 |
Basic Res. Cardiol. |
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Erdosteine affects eicosanoid production in COPD. |
2011 |
Int J Clin Pharmacol Ther |
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Cho YS et al. |
Discovery of (2-fluoro-benzyl)-(2-methyl-2-phenethyl-2H-chromen-6-yl)-amine (KRH-102140) as an orally active 5-lipoxygenase inhibitor with activity in murine inflammation models. |
2011 |
Pharmacology |
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Davicino R et al. |
Leukotrienes antagonize the antiproliferative effect of Larrea divaricata Cav. on a lymphoma cell line interfering with cAMP intracellular level and PKC activity. |
2011 |
Cancer Invest. |
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Yano T et al. |
Group V secretory phospholipase A2 plays a pathogenic role in myocardial ischaemia-reperfusion injury. |
2011 |
Cardiovasc. Res. |
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CD97 antibody depletes granulocytes in mice under conditions of acute inflammation via a Fc receptor-dependent mechanism. |
2011 |
J. Leukoc. Biol. |
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Natural forms of vitamin E and 13'-carboxychromanol, a long-chain vitamin E metabolite, inhibit leukotriene generation from stimulated neutrophils by blocking calcium influx and suppressing 5-lipoxygenase activity, respectively. |
2011 |
J. Immunol. |
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Yang H et al. |
Chemopreventive effects of early-stage and late-stage supplementation of vitamin E and selenium on esophageal carcinogenesis in rats maintained on a low vitamin E/selenium diet. |
2011 |
Carcinogenesis |
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Bastin AJ et al. |
Biomarkers of lung injury after one-lung ventilation for lung resection. |
2011 |
Respirology |
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Saini A et al. |
Sea-cod oil supplementation alters the course of Streptococcus pneumoniae infection in BALB/c mice. |
2011 |
Eur. J. Clin. Microbiol. Infect. Dis. |
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Wang B et al. |
An inhibitor of arachidonate 5-lipoxygenase, Nordy, induces differentiation and inhibits self-renewal of glioma stem-like cells. |
2011 |
Stem Cell Rev |
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Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats. |
2011 |
Pancreas |
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Cooperative and redundant signaling of leukotriene B4 and leukotriene D4 in human monocytes. |
2011 |
Allergy |
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Hirayama M et al. |
Concentration dependence of 5-aminosalicylic acid pharmacological actions in intestinal mucosa after oral administration of a pH-dependent formulation. |
2011 |
Mol. Pharm. |
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Leukotriene B4/antimicrobial peptide LL-37 proinflammatory circuits are mediated by BLT1 and FPR2/ALX and are counterregulated by lipoxin A4 and resolvin E1. |
2011 |
FASEB J. |
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A novel positive feedback loop involving FASN/p-ERK1/2/5-LOX/LTB4/FASN sustains high growth of breast cancer cells. |
2011 |
Acta Pharmacol. Sin. |
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Profita M et al. |
Novel perspectives in the detection of oral and nasal oxidative stress and inflammation in pediatric united airway diseases. |
2010 Oct-Dec |
Int J Immunopathol Pharmacol |
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Hagi A et al. |
Effects of the omega-6:omega-3 fatty acid ratio of fat emulsions on the fatty acid composition in cell membranes and the anti-inflammatory action. |
2010 May-Jun |
JPEN J Parenter Enteral Nutr |
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Participation of 5-lipoxygenase-derived LTB(4) in 4-hydroxynonenal-enhanced MMP-2 production in vascular smooth muscle cells. |
2010 |
Atherosclerosis |
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RAGE and ICAM-1 cooperate in mediating leukocyte recruitment during acute inflammation in vivo. |
2010 |
Blood |
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Gomes AC et al. |
Mineral trioxide aggregate stimulates macrophages and mast cells to release neutrophil chemotactic factors: role of IL-1beta, MIP-2 and LTB(4). |
2010 |
Oral Surg Oral Med Oral Pathol Oral Radiol Endod |
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Inhibition of secretory phospholipase A2 activity attenuates acute cardiogenic pulmonary edema induced by isoproterenol infusion in mice after myocardial infarction. |
2010 |
J. Cardiovasc. Pharmacol. |
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Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide. |
2010 |
Toxicol. Appl. Pharmacol. |
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