| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abetalipoproteinemia | D000012 | 7 associated lipids |
| Acne Vulgaris | D000152 | 35 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Agranulocytosis | D000380 | 7 associated lipids |
| Agricultural Workers' Diseases | D000382 | 1 associated lipids |
| Airway Obstruction | D000402 | 13 associated lipids |
| Alveolitis, Extrinsic Allergic | D000542 | 6 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
Leukotriene b4
Leukotriene b4 is a lipid of Fatty Acyls (FA) class. The involved functions are known as Chemotaxis, release of sequestered calcium ion into cytoplasm and Polymerization. Leukotriene b4 often locates in Protoplasm. The associated genes with Leukotriene b4 are phallacidin.
Cross Reference
Introduction
To understand associated biological information of Leukotriene b4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Leukotriene b4?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Leukotriene b4
PubChem Associated disorders and diseases
What pathways are associated with Leukotriene b4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Leukotriene b4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Leukotriene b4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Leukotriene b4?
There are no associated biomedical information in the current reference collection.
What genes are associated with Leukotriene b4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Leukotriene b4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Leukotriene b4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cossette C et al. | Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes. | 2015 | Biochem. Pharmacol. | pmid:26032638 |
| Tang F et al. | Inhibitory effect of methyleugenol on IgE-mediated allergic inflammation in RBL-2H3 cells. | 2015 | Mediators Inflamm. | pmid:25960618 |
| Jiang JX et al. | EETs Attenuate Ox-LDL-Induced LTB4 Production and Activity by Inhibiting p38 MAPK Phosphorylation and 5-LO/BLT1 Receptor Expression in Rat Pulmonary Arterial Endothelial Cells. | 2015 | PLoS ONE | pmid:26035589 |
| Leliebre-Lara V et al. | Influence of Navisporus floccosus (Higher Basidiomycetes) n-Hexane Extract on Arachidonate Metabolism in Vitro. | 2015 | Int J Med Mushrooms | pmid:26082985 |
| Pazos MA et al. | Distinct cellular sources of hepoxilin A3 and leukotriene B4 are used to coordinate bacterial-induced neutrophil transepithelial migration. | 2015 | J. Immunol. | pmid:25548217 |
| Holen E et al. | Combining eicosapentaenoic acid, decosahexaenoic acid and arachidonic acid, using a fully crossed design, affect gene expression and eicosanoid secretion in salmon head kidney cells in vitro. | 2015 | Fish Shellfish Immunol. | pmid:26003739 |
| Wang M et al. | Differential Contribution of BLT1 and BLT2 to Leukotriene B4-Induced Human NK Cell Cytotoxicity and Migration. | 2015 | Mediators Inflamm. | pmid:26696753 |
| Vaivoda R et al. | CYP4F18-Deficient Neutrophils Exhibit Increased Chemotaxis to Complement Component C5a. | 2015 | J Immunol Res | pmid:26613087 |
| Homann J et al. | In Vivo Availability of Pro-Resolving Lipid Mediators in Oxazolone Induced Dermal Inflammation in the Mouse. | 2015 | PLoS ONE | pmid:26599340 |
| Liu X et al. | Leukotriene B4 Inhibits L-Type Calcium Channels via p38 Signaling Pathway in Vascular Smooth Muscle Cells. | 2015 | Cell. Physiol. Biochem. | pmid:26584289 |
| Qian J et al. | Leukotriene B4 Activates Pulmonary Artery Adventitial Fibroblasts in Pulmonary Hypertension. | 2015 | Hypertension | pmid:26558820 |
| Rodrigues IA et al. | Natural Products: Insights into Leishmaniasis Inflammatory Response. | 2015 | Mediators Inflamm. | pmid:26538837 |
| Jeon WK et al. | The proinflammatory LTB4/BLT1 signal axis confers resistance to TGF-β1-induced growth inhibition by targeting Smad3 linker region. | 2015 | Oncotarget | pmid:26497676 |
| Colom B et al. | Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo. | 2015 | Immunity | pmid:26047922 |
| Khan M et al. | Oral administration of cytosolic PLA2 inhibitor arachidonyl trifluoromethyl ketone ameliorates cauda equina compression injury in rats. | 2015 | J Neuroinflammation | pmid:25971887 |
| Lv J et al. | Leukotriene B₄-leukotriene B₄ receptor axis promotes oxazolone-induced contact dermatitis by directing skin homing of neutrophils and CD8⺠T cells. | 2015 | Immunology | pmid:25959240 |
| Kuraishi Y | Methods for preclinical assessment of antipruritic agents and itch mechanisms independent of mast-cell histamine. | 2015 | Biol. Pharm. Bull. | pmid:25947907 |
| Satpathy SR et al. | Crystalline silica-induced leukotriene B4-dependent inflammation promotes lung tumour growth. | 2015 | Nat Commun | pmid:25923988 |
| Zhang C et al. | Growth inhibitory effect of polyunsaturated fatty acids (PUFAs) on colon cancer cells via their growth inhibitory metabolites and fatty acid composition changes. | 2015 | PLoS ONE | pmid:25886460 |
| Pardo V et al. | Opposite cross-talk by oleate and palmitate on insulin signaling in hepatocytes through macrophage activation. | 2015 | J. Biol. Chem. | pmid:25792746 |
| Li P et al. | LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes. | 2015 | Nat. Med. | pmid:25706874 |
| Filgueiras LR et al. | Leukotriene B4-mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes. | 2015 | Sci Signal | pmid:25628460 |
| Tateishi N et al. | Dietary supplementation with arachidonic acid increases arachidonic acid content in paw, but does not affect arthritis severity or prostaglandin E2 content in rat adjuvant-induced arthritis model. | 2015 | Lipids Health Dis | pmid:25595700 |
| Fahel JS et al. | 5-Lipoxygenase negatively regulates Th1 response during Brucella abortus infection in mice. | 2015 | Infect. Immun. | pmid:25583526 |
| Liu M and Yokomizo T | The role of leukotrienes in allergic diseases. | 2015 | Allergol Int | pmid:25572555 |
| Dalli J et al. | The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:25568926 |
| Piotrowska-Tomala KK et al. | Lipopolysaccharides, cytokines, and nitric oxide affect secretion of prostaglandins and leukotrienes by bovine mammary gland during experimentally induced mastitis in vivo and in vitro. | 2015 | Domest. Anim. Endocrinol. | pmid:25935895 |
| Knab LM et al. | Ablation of 5-lipoxygenase mitigates pancreatic lesion development. | 2015 | J. Surg. Res. | pmid:25454978 |
| Zoccal KF et al. | PPAR-γ activation by Tityus serrulatus venom regulates lipid body formation and lipid mediator production. | 2015 | Toxicon | pmid:25450800 |
| Alvarellos ML et al. | PharmGKB summary: very important pharmacogene information for CYP4F2. | 2015 | Pharmacogenet. Genomics | pmid:25370453 |
| Jensen GS et al. | Anti-inflammatory properties of a dried fermentate in vitro and in vivo. | 2015 | J Med Food | pmid:25105458 |
| Vizmanos-Lamotte G et al. | [Determining asthma treatment in children by monitoring fractional exhaled nitric oxide, sputum eosinophils and leukotriene Bâ‚„]. | 2015 | An Pediatr (Barc) | pmid:24857428 |
| Minutoli L et al. | A dual inhibitor of cyclooxygenase and 5-lipoxygenase protects against kainic acid-induced brain injury. | 2015 | Neuromolecular Med. | pmid:25893744 |
| Voon PT et al. | Virgin olive oil, palm olein and coconut oil diets do not raise cell adhesion molecules and thrombogenicity indices in healthy Malaysian adults. | 2015 | Eur J Clin Nutr | pmid:25804278 |
| Gendelman O et al. | A randomized double-blind placebo-controlled study adding high dose vitamin D to analgesic regimens in patients with musculoskeletal pain. | 2015 | Lupus | pmid:25801891 |
| Hoffmeyer F et al. | Evaluation of Airway Inflammation in Compost Workers Exposed to Bioaerosols Using Exhaled Breath Condensate and Fractional Exhaled Nitric Oxide. | 2015 | Adv. Exp. Med. Biol. | pmid:25786401 |
| Carceller MC et al. | Paracrine in vivo inhibitory effects of adipose tissue-derived mesenchymal stromal cells in the early stages of the acute inflammatory response. | 2015 | Cytotherapy | pmid:26276006 |
| de Cássia Campos MR et al. | Differential effects of chemoattractants on mast cell recruitment in vivo. | 2014 May-Jun | Cell. Immunol. | pmid:24736098 |
| Breganó JW et al. | Comparison of selective and non selective cyclo-oxygenase 2 inhibitors in experimental colitis exacerbation: role of leukotriene B4 and superoxide dismutase. | 2014 Jul-Sep | Arq Gastroenterol | pmid:25296084 |
| Sharma-Walia N et al. | The Kaposi's sarcoma-associated herpesvirus (KSHV)-induced 5-lipoxygenase-leukotriene B4 cascade plays key roles in KSHV latency, monocyte recruitment, and lipogenesis. | 2014 | J. Virol. | pmid:24335295 |
| Guan WJ et al. | Exhaled breath condensate eicosanoid levels in asthma: still questioned. | 2014 | J. Allergy Clin. Immunol. | pmid:24530097 |
| Paige M et al. | Role of leukotriene A4 hydrolase aminopeptidase in the pathogenesis of emphysema. | 2014 | J. Immunol. | pmid:24771855 |
| Chaves MM et al. | Leukotriene B4 modulates P2X7 receptor-mediated Leishmania amazonensis elimination in murine macrophages. | 2014 | J. Immunol. | pmid:24729618 |
| Sorensen LS et al. | Effects of perioperative supplementation with omega-3 fatty acids on leukotriene Bâ‚„ and leukotriene Bâ‚… production by stimulated neutrophils in patients with colorectal cancer: a randomized, placebo-controlled intervention trial. | 2014 | Nutrients | pmid:25268838 |
| Leaker BR et al. | The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthma. | 2014 | BMC Pulm Med | pmid:25351474 |
| Fredman G et al. | Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25246560 |
| Joshi YB et al. | Modulation of amyloid-β production by leukotriene B4 via the γ-secretase pathway. | 2014 | J. Alzheimers Dis. | pmid:24008686 |
| Estevão-Silva CF et al. | Anethole and eugenol reduce in vitro and in vivo leukocyte migration induced by fMLP, LTB4, and carrageenan. | 2014 | J Nat Med | pmid:24789168 |
| Patnode ML et al. | Leukotriene B4 amplifies eosinophil accumulation in response to nematodes. | 2014 | J. Exp. Med. | pmid:24889202 |
| Finsterbusch M et al. | Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF. | 2014 | J. Exp. Med. | pmid:24913232 |