| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Airway Obstruction | D000402 | 13 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Enterocolitis | D004760 | 3 associated lipids |
| Breast Neoplasms | D001943 | 24 associated lipids |
Leukotriene b4
Leukotriene b4 is a lipid of Fatty Acyls (FA) class. The involved functions are known as Chemotaxis, release of sequestered calcium ion into cytoplasm and Polymerization. Leukotriene b4 often locates in Protoplasm. The associated genes with Leukotriene b4 are phallacidin.
Cross Reference
Introduction
To understand associated biological information of Leukotriene b4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Leukotriene b4?
There are no associated biomedical information in the current reference collection.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Leukotriene b4
PubChem Associated disorders and diseases
What pathways are associated with Leukotriene b4
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Leukotriene b4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Leukotriene b4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Leukotriene b4?
There are no associated biomedical information in the current reference collection.
What genes are associated with Leukotriene b4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Leukotriene b4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Leukotriene b4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang B et al. | [Expression of extracellular matrix metalloproteinase inducer in the unstable plaque of patients with acute coronary syndrome]. | 2012 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:22883094 |
| Tsai JJ et al. | The identification of PAF-release-enhancing activity in culture supernatant of mononuclear cells from asthmatics. Correlation between lymphocyte responses and immediate type hypersensitivity. | 1991 | Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi | pmid:1667990 |
| Ding YL et al. | [Changes of leukotriene B4 in induced sputum and plasma of patients with chronic obstructive pulmonary disease and the effects of theophylline]. | 2005 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:16115390 |
| Jin SH et al. | [Effect of Cryptoporus volvatus (Peck) Schear on leukotriene production from polymorphonuclear leukocytes in rats]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15139113 |
| Liu YG et al. | [Effects of compositions of Mahuang decoction on chemotaxis and leukotriene production from neutrophils in rats]. | 2005 | Zhongguo Zhong Yao Za Zhi | pmid:16110872 |
| Wang W et al. | [The effect of glucoprotein component of musk on arachidonic acid metabolizing enzymes in rat polymorphonuclear leukocytes]. | 1997 | Zhongguo Zhong Yao Za Zhi | pmid:11038968 |
| Yang ZH et al. | [Effect of shuanglong capsule on content of leukotrienes compound of lung tissues in asthmatic rats]. | 2006 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:17569344 |
| Yue TL and Tong L | [Effects of dauricine on the metabolism of arachidonic acid in rat pleural neutrophils]. | 1989 | Zhongguo Yao Li Xue Bao | pmid:2558500 |
| Li J et al. | [Inhibition of release of prostaglandins and leukotrienes from calcimycin-induced mouse peritoneal macrophages and bovine aorta endothelial cells by anisodamine]. | 1989 | Zhongguo Yao Li Xue Bao | pmid:2558499 |
| Du ZY and Huang YH | Effects of tetrandrine on production of leukotriene B4 and thromboxane B2 in rabbit blood. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8249626 |
| Hong JL et al. | [Effects of tetrandrine on cytoplasmic free calcium in rat neutrophils]. | 1989 | Zhongguo Yao Li Xue Bao | pmid:2561935 |
| Zhang M et al. | Effects of tetrandrine on functions and ultrastructure of alveolar macrophages in smoke inhalation-injured rabbits. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8010052 |
| Wang ZY et al. | Differential effects of new breviscapine on arachidonic acid metabolisms in blood cells and endothelial cells. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8394637 |
| Wang ZY et al. | Effect of leukotriene B4 on arachidonate metabolism and activation of blood cells and endothelial cells. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8394638 |
| Gao XL et al. | [Effect of tolmetin on responsiveness of isolated guinea pig tracheal smooth muscles]. | 1989 | Zhongguo Yao Li Xue Bao | pmid:2554671 |
| Chen JL et al. | [Determination and clinical implication of leukotriene B(4) and tumor necrosis factor-alpha in condensate of exhaled breath of chronic obstructive pulmonary disease patients]. | 2008 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:18549718 |
| Tang H et al. | [Study on the changes in serum leukotrienes B4 and p38 mitogen activated protein kinase in multiple organ dysfunction syndrome]. | 2005 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:15836829 |
| Liao PY and Wu SH | [Serum levels of IL-5 and LTB4 in children with Henoch-Schonlein purpura]. | 2006 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:16787590 |
| Li J and Pan JH | [Clinical efficacy of montelukast for the treatment of bronchiolitis in infants]. | 2015 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:26483224 |
| Liu Y et al. | [Experimental study on anti-inflammatory effects of mahuang decoction and its compositions]. | 2005 | Zhong Yao Cai | pmid:16131036 |
| HAN R et al. | [Determination of Th1/Th2 cytokines and chemokines in patients with allergic diseases and its significance]. | 2009 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:19693971 |
| Jin SH et al. | [Inhibition of Cryptoporus volvatus ferment substance on release of leukotriene B4, C4 and D4 from neutrophils in rats in vitro]. | 2003 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:12970928 |
| Deng YM et al. | [Increase of LTB4 level and expression of LTA4-hydrolase mRNA in lung tissue and cerebral cortex in asthmatic rats]. | 2003 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:12970929 |
| Wang YN et al. | [Inhibitory effects of mizolastine on substance P-induced production of leukotriene B4 and interleukin 5 in mouse skin]. | 2006 | Zhejiang Da Xue Xue Bao Yi Xue Ban | pmid:16610094 |
| Rose DM et al. | The combined use of lipoxygenase and cyclooxygenase inhibitors in Klebsiella pneumoniae-induced bovine mastitis. | 1991 | Zentralbl Veterinarmed A | pmid:1649514 |
| Bremm KD et al. | Generation of leukotrienes and lipoxygenase factors from human polymorphonuclear granulocytes during bacterial phagocytosis and interaction with bacterial exotoxins. | 1983 | Zentralbl Bakteriol Mikrobiol Hyg A | pmid:6326424 |
| Beck-Speier I et al. | Sulfite induces release of lipid mediators by alveolar macrophages. | 1998 Mar-Apr | Z. Naturforsch., C, J. Biosci. | pmid:9618940 |
| Scheick C et al. | Human neutrophil chemotaxis in response to diepoxides of linolenic acid. | 1996 Nov-Dec | Z. Naturforsch., C, J. Biosci. | pmid:9031528 |
| Deicher HR et al. | Identification of an LtB4-protein complex as evidence of endothelial cell cytotoxic activity (ECA) in progressive systemic sclerosis (PSS). | 1987 Jul-Aug | Z Rheumatol | pmid:2823504 |
| Partsch G et al. | Modulation of the migration and chemotaxis of PMN cells by hyaluronic acid. | 1989 May-Jun | Z Rheumatol | pmid:2551105 |
| Kolb E | [Biochemistry and significance of prostaglandins, prostacyclins, thromboxanes and leukotrienes and the modification of their biosynthesis by essential fatty acids]. | 1985 | Z Gesamte Inn Med | pmid:2988221 |
| Miller B | [Is pathogenetically-founded therapy of chronic inflammatory bowel disease in sight?]. | 1993 | Z Gastroenterol | pmid:8197797 |
| Biondo GA et al. | Production of leukotriene B4 by Paracoccidioides brasiliensis. | 2012 | Yeast | pmid:22628121 |
| Stenson WF | Pathogenesis of inflammatory bowel disease. | 1985 | Year Immunol. | pmid:3033942 |
| Zeng GQ et al. | Effects of dauricine and anisodamine on LTs and PAF induced DNA synthesis in bovine anterior cerebral arterial smooth muscle cells. | 1992 | Yao Xue Xue Bao | pmid:1336297 |
| Wang WJ et al. | [The antiinflammatory activity of shikonin and its inhibitory effect on leukotriene B4 biosynthesis]. | 1994 | Yao Xue Xue Bao | pmid:8079645 |
| Zhou LE et al. | [Effects of ginkgolide B on arachidonic acid metabolizing enzymes and level of intracellular calcium in rat polymorphonuclear leukocytes]. | 2001 | Yao Xue Xue Bao | pmid:12579871 |
| Liu DP et al. | [Effect of seleno-organic compounds on leukotriene B4 biosynthesis]. | 1993 | Yao Xue Xue Bao | pmid:8249607 |
| Li NY and Zhu XY | [Effect of some anti-inflammatory drugs on the biosynthesis of leukotriene B4]. | 1988 | Yao Xue Xue Bao | pmid:2847484 |
| Zhong M et al. | [Effects of leukotrienes on production of interleukin 6 from mouse peritoneal macrophages]. | 1998 | Yao Xue Xue Bao | pmid:12016997 |
| Inagaki M | [Studies on the new antiarthritic drug candidate S-2474]. | 2003 | Yakugaku Zasshi | pmid:12772588 |
| Andoh T | [Importance of epidermal keratinocytes in itching]. | 2006 | Yakugaku Zasshi | pmid:16755126 |
| Kobayashi Y and Taguchi T | [Studies on organofluorine compounds: an overview of our 30 years]. | 2000 | Yakugaku Zasshi | pmid:11082706 |
| Mukhtar H et al. | Hepatic microsomal metabolism of leukotriene B4 in rats: biochemical characterization, effect of inducers, and age- and sex-dependent differences. | 1989 | Xenobiotica | pmid:2543147 |
| Spilker ME et al. | Leveraging model-based study designs and serial micro-sampling techniques to understand the oral pharmacokinetics of the potent LTB4 inhibitor, CP-105696, for mouse pharmacology studies. | 2017 | Xenobiotica | pmid:27435693 |
| Eizayaga FX et al. | Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension. | 2007 | World J. Gastroenterol. | pmid:17876871 |
| Rahimi R et al. | A review of the efficacy of traditional Iranian medicine for inflammatory bowel disease. | 2010 | World J. Gastroenterol. | pmid:20857519 |
| Baskin-Bey ES et al. | Constitutive androstane receptor agonist, TCPOBOP, attenuates steatohepatitis in the methionine choline-deficient diet-fed mouse. | 2007 | World J. Gastroenterol. | pmid:17948939 |
| Wang FY et al. | Potential protective effects of Clostridium butyricum on experimental gastric ulcers in mice. | 2015 | World J. Gastroenterol. | pmid:26217085 |
| Ganesh R et al. | Cyclooxygenase/lipoxygenase shunting lowers the anti-cancer effect of cyclooxygenase-2 inhibition in colorectal cancer cells. | 2012 | World J Surg Oncol | pmid:23013454 |
| Thumb N | [Mechanism of action of non-steroidal antirheumatic agents]. | 1982 | Wien Med Wochenschr | pmid:6299014 |
| Toruń B | [Biochemical disorders in psoriasis]. | 1986 | Wiad. Lek. | pmid:3012888 |
| Zipser RD and Laffi G | Prostaglandins, thromboxanes and leukotrienes in clinical medicine. | 1985 | West. J. Med. | pmid:3004043 |
| Burrall BA and Goetzl EJ | Navigating the sea of eicosanoids. | 1985 | West. J. Med. | pmid:3004045 |
| Lipkan GN | [Leukotrienes--a new class of physiologically active compounds (review of the literature)]. | 1987 | Vrach Delo | pmid:3033900 |
| Nakajima F et al. | Role of anti-Nak(a) antibody, monocytes and platelets in the development of transfusion-related acute lung injury. | 2008 | Vox Sang. | pmid:19138262 |
| Sieunarine K et al. | Plasma levels of the lipid mediators, leukotriene B4 and lyso platelet-activating factor, in intraoperative salvaged blood. | 1992 | Vox Sang. | pmid:1333134 |
| Nishimura M et al. | Interference with TRALI-causing anti-HLA DR alloantibody induction of human pulmonary microvascular endothelial cell injury by purified soluble HLA DR. | 2007 | Vox Sang. | pmid:17547569 |
| Vel'tishchev IuE and Sviatkina OB | [New mediators of allergy and inflammation of a lipid nature]. | 1984 | Vopr. Med. Khim. | pmid:6098991 |
| Schröder HC et al. | Avarol restores the altered prostaglandin and leukotriene metabolism in monocytes infected with human immunodeficiency virus type 1. | 1991 | Virus Res. | pmid:1662847 |
| Loke WM et al. | Augmentation of 5-lipoxygenase activity and expression during dengue serotype-2 infection. | 2013 | Virol. J. | pmid:24168271 |
| Eberhard J et al. | Leukotriene A(4)-hydrolase expression and leukotriene B(4) levels in chronic inflammation of bacterial origin: immunohistochemistry and reverse-phase high-performance liquid chromatography analysis of oral mucosal epithelium. | 2002 | Virchows Arch. | pmid:12070603 |
| Zetner K et al. | Effect of clindamycin hydrochloride on gingival crevicular fluid and immune mediators in beagles. | 2002 | Vet. Ther. | pmid:19750749 |
| Pietra M et al. | Evaluation of leukotriene B4 in the canine exhaled breath: standardization of a technique of sample collection. | 2003 | Vet. Res. Commun. | pmid:14535445 |
| Lee WD et al. | Tilmicosin-induced bovine neutrophil apoptosis is cell-specific and downregulates spontaneous LTB4 synthesis without increasing Fas expression. | 2004 Mar-Apr | Vet. Res. | pmid:15099497 |
| Barnouin J et al. | [Nutritional factors and mammary inflammatory infection in the dairy cow. Ecopathological approach during the peripartum period]. | 1994 | Vet. Res. | pmid:8038788 |
| Hatt JM et al. | Collection and analysis of breath and breath condensate exhaled by feral pigeons (Columba livia) and chickens (Gallus domesticus). | 2009 | Vet. Rec. | pmid:19850854 |
| Higgins AJ and Lees P | Detection of leukotriene B4 in equine inflammatory exudate. | 1984 | Vet. Rec. | pmid:6093326 |
| Van de Weerdt ML et al. | Ketoprofen and phenylbutazone attenuation of PAF-induced lung inflammation in calves. | 1999 | Vet. J. | pmid:10030127 |
| Breathnach R et al. | Characterization of certain inflammatory variables in the peripheral blood of clinically healthy dogs. | 2006 | Vet. J. | pmid:16427586 |
| Breathnach R et al. | Increased leukotriene B(4) production, complement C3 conversion and acid hydrolase enzyme concentrations in different leucocyte sub-populations of dogs with atopic dermatitis. | 2006 | Vet. J. | pmid:16427587 |
| de Grauw JC et al. | Assessment of synovial fluid biomarkers in healthy foals and in foals with tarsocrural osteochondrosis. | 2011 | Vet. J. | pmid:21216637 |
| Persson K et al. | Effects of certain inflammatory mediators on bovine neutrophil migration in vivo and in vitro. | 1993 | Vet. Immunol. Immunopathol. | pmid:8236797 |
| Lin TY and London CA | Characterization and modulation of canine mast cell derived eicosanoids. | 2010 | Vet. Immunol. Immunopathol. | pmid:20036014 |
| Cook VL et al. | The effect of lidocaine on in vitro adhesion and migration of equine neutrophils. | 2009 | Vet. Immunol. Immunopathol. | pmid:19136156 |
| Eckert RE et al. | p38 mitogen-activated kinase (MAPK) is essential for equine neutrophil migration. | 2009 | Vet. Immunol. Immunopathol. | pmid:19095309 |
| Atluru D and Gudapaty S | Inhibition of bovine mononuclear cell proliferation, interleukin-2 synthesis, protein-tyrosine kinase and leukotriene B4 production by a protein-tyrosine kinase inhibitor, genistein. | 1993 | Vet. Immunol. Immunopathol. | pmid:8256431 |
| Thanasak J et al. | Effects of polyunsaturated fatty acids on the proliferation of mitogen stimulated bovine peripheral blood mononuclear cells. | 2005 | Vet. Immunol. Immunopathol. | pmid:15734550 |
| Foster AP et al. | Agonist-induced adherence of equine eosinophils to fibronectin. | 1997 | Vet. Immunol. Immunopathol. | pmid:9223226 |
| Park HJ et al. | Dietary fish oil and flaxseed oil suppress inflammation and immunity in cats. | 2011 | Vet. Immunol. Immunopathol. | pmid:21440312 |
| Brooks AC et al. | CXCL8 attenuates chemoattractant-induced equine neutrophil migration. | 2011 | Vet. Immunol. Immunopathol. | pmid:21040981 |
| Kogut MH et al. | Bacterial toll-like receptor agonists induce sequential NF-κB-mediated leukotriene B4 and prostaglandin E2 production in chicken heterophils. | 2012 | Vet. Immunol. Immunopathol. | pmid:22119018 |
| Wright KA et al. | FeLV-induced immunosuppression through alterations in signal transduction: changes in intracellular free calcium levels. | 1989 | Vet. Immunol. Immunopathol. | pmid:2549693 |
| Krogsgaard Thomsen M and Strøm H | Biological variation in random and leukotriene B4-directed migration of canine neutrophils. | 1989 | Vet. Immunol. Immunopathol. | pmid:2549697 |
| Hall JA et al. | Dietary antioxidants and behavioral enrichment enhance neutrophil phagocytosis in geriatric Beagles. | 2006 | Vet. Immunol. Immunopathol. | pmid:16806493 |
| Atluru D et al. | In vitro inhibition of 5-lipoxygenase metabolite, leukotriene B4, in bovine mononuclear cells by bovine viral diarrhea virus. | 1992 | Vet. Immunol. Immunopathol. | pmid:1315086 |
| Atluru D et al. | Inhibition of bovine lymphocyte response to phytohemagglutinin by a specific 5-lipoxygenase inhibitor. | 1987 | Vet. Immunol. Immunopathol. | pmid:3035781 |
| Higgins AJ | Eicosanoids in health and in disease: an appraisal. | 1985 | Vet Q | pmid:2983485 |
| Higgins AJ et al. | Actions of BW540C in an equine model of acute inflammation: a preliminary study. | 1987 | Vet Q | pmid:3039716 |
| Zollinger E et al. | Collection of exhaled breath and exhaled breath condensate in veterinary medicine. A review. | 2006 | Vet Q | pmid:17052074 |
| Skripkin IuK and Lezvinskaia EM | [Neutrophil chemotaxis and its role in the pathogenesis of dermatoses]. | 1986 | Vestn Dermatol Venerol | pmid:3019036 |
| Peskar BA and Simmet T | [Eicosanoids and lung function]. | 1986 | Verh Dtsch Ges Inn Med | pmid:3028006 |
| Elovsson S et al. | Evaluation of nasal barrier dysfunction at acute- and late-phase reactions in a guinea pig model of allergic rhinitis. | 2005 | Vascul. Pharmacol. | pmid:16257271 |
| Park WH et al. | Anti-inflammatory effects of a traditional Korean herbal formulation, Silsosangami, consisting of seven medicinal herbs: effect on hemolysis, neutrophil function, and gene expressions of iNOS and COX-2. | 2004 | Vascul. Pharmacol. | pmid:15664882 |
| Cockeran R et al. | Characterization of the interactions of the pneumolysoid, Δ6 PLY, with human neutrophils in vitro. | 2011 | Vaccine | pmid:21968446 |
| Luostarinen R et al. | Effects of dietary supplementation with vitamin E on human neutrophil chemotaxis and generation of LTB4. | 1991 | Ups. J. Med. Sci. | pmid:1663672 |
| Borgeat P et al. | [Leukotrienes and inflammation]. | 1985 | Union Med Can | pmid:2997964 |
| Rola-Pleszczynski M | [Regulation of the immune response using leukotrienes]. | 1989 May-Jun | Union Med Can | pmid:2547261 |
| Neubauer B et al. | Leukotriene-B4 concentrations in breathing condensate before and after simulated deep dives. | 2004 | Undersea Hyperb Med | pmid:15485084 |
| Aydin C et al. | Effects of hepatectomy and arginine enriched diet on colonic mucosa originated inflammatory cytokines. | 2003 | Ulus Travma Acil Cerrahi Derg | pmid:14569477 |