Leukotriene b4

Leukotriene b4 is a lipid of Fatty Acyls (FA) class. The involved functions are known as Chemotaxis, release of sequestered calcium ion into cytoplasm and Polymerization. Leukotriene b4 often locates in Protoplasm. The associated genes with Leukotriene b4 are phallacidin.

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To understand associated biological information of Leukotriene b4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Leukotriene b4?

There are no associated biomedical information in the current reference collection.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Leukotriene b4

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Airway Obstruction D000402 13 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Hypoxia D000860 23 associated lipids
Adenocarcinoma D000230 166 associated lipids
Enterocolitis D004760 3 associated lipids
Breast Neoplasms D001943 24 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Leukotriene b4

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with Leukotriene b4?

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What functions are associated with Leukotriene b4?

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What lipids are associated with Leukotriene b4?

There are no associated biomedical information in the current reference collection.

What genes are associated with Leukotriene b4?

Related references are published most in these journals:

Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Leukotriene b4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Leukotriene b4

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Per page 10 20 50 100 | Total 5221
Authors Title Published Journal PubMed Link
Bitto A et al. Effects of COX1-2/5-LOX blockade in Alzheimer transgenic 3xTg-AD mice. 2017 Inflamm. Res. pmid:28238167
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Al-Roujayee AS Naringenin improves the healing process of thermally-induced skin damage in rats. 2017 J. Int. Med. Res. pmid:28415935
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Archambault AS et al. Leukotriene B₄ Metabolism and p70S6 Kinase 1 Inhibitors: PF-4708671 but Not LY2584702 Inhibits CYP4F3A and the ω-Oxidation of Leukotriene B₄ In Vitro and In Cellulo. 2017 PLoS ONE pmid:28068410
Min A et al. SNAP23-Dependent Surface Translocation of Leukotriene B4 (LTB4) Receptor 1 Is Essential for NOX2-Mediated Exocytotic Degranulation in Human Mast Cells Induced by Trichomonas vaginalis-Secreted LTB4. 2017 Infect. Immun. pmid:27795355
Spilker ME et al. Leveraging model-based study designs and serial micro-sampling techniques to understand the oral pharmacokinetics of the potent LTB4 inhibitor, CP-105696, for mouse pharmacology studies. 2017 Xenobiotica pmid:27435693
Zhou X et al. Erythromycin attenuates metalloprotease/anti-metalloprotease imbalance in cigarette smoke-induced emphysema in rats via the mitogen-activated protein kinase/nuclear factor-κB activation pathway. 2017 Mol Med Rep pmid:28358431
Singh A et al. Lipoxin A4, a 5-lipoxygenase pathway metabolite, modulates immune response during acute respiratory tularemia. 2017 J. Leukoc. Biol. pmid:27630217
Pallio G et al. Use of a balanced dual cyclooxygenase-1/2 and 5-lypoxygenase inhibitor in experimental colitis. 2016 Eur. J. Pharmacol. pmid:27450484
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Pontes AS et al. p38 MAPK is involved in human neutrophil chemotaxis induced by L-amino acid oxidase from Calloselasma rhodosthoma. 2016 Toxicon pmid:27242041
Pedruzzi G et al. Understanding PGE2, LXA4 and LTB4 balance during Mycobacterium tuberculosis infection through mathematical model. 2016 J. Theor. Biol. pmid:26551160
Jung KH et al. Protective Effects of Intratracheally-Administered Bee Venom Phospholipase A2 on Ovalbumin-Induced Allergic Asthma in Mice. 2016 Toxins (Basel) pmid:27669297
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Chaves MM et al. Crosstalk between purinergic receptors and lipid mediators in leishmaniasis. 2016 Parasit Vectors pmid:27595742
Sun D and Shi M Neutrophil swarming toward Cryptococcus neoformans is mediated by complement and leukotriene B4. 2016 Biochem. Biophys. Res. Commun. pmid:27402276
Ee MT et al. Leukotriene B4 mediates macrophage influx and pulmonary hypertension in bleomycin-induced chronic neonatal lung injury. 2016 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:27317685
Maddipati KR et al. Lipidomic analysis of patients with microbial invasion of the amniotic cavity reveals up-regulation of leukotriene B4. 2016 FASEB J. pmid:27312808
Gall BJ et al. Reduction of GPSM3 expression akin to the arthritis-protective SNP rs204989 differentially affects migration in a neutrophil model. 2016 Genes Immun. pmid:27307211
Marvar PJ et al. Systemic leukotriene B4 receptor antagonism lowers arterial blood pressure and improves autonomic function in the spontaneously hypertensive rat. 2016 J. Physiol. (Lond.) pmid:27230966
Elias I et al. ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance. 2016 Diabetes pmid:27207555
Zoccal KF et al. Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality. 2016 Nat Commun pmid:26907476
Jiang J et al. Effect of Marine-Derived n-3 Polyunsaturated Fatty Acids on Major Eicosanoids: A Systematic Review and Meta-Analysis from 18 Randomized Controlled Trials. 2016 PLoS ONE pmid:26808318
Tavares N et al. Degranulating Neutrophils Promote Leukotriene B4 Production by Infected Macrophages To Kill Leishmania amazonensis Parasites. 2016 J. Immunol. pmid:26800873
Robinson R To Attract Others, Immune Cells Release a Packet Which Releases a Signal. 2016 PLoS Biol. pmid:26742021
Majumdar R et al. Exosomes Mediate LTB4 Release during Neutrophil Chemotaxis. 2016 PLoS Biol. pmid:26741884
Dong R et al. Cigarette smoke-induced lung inflammation in COPD mediated via LTB4/BLT1/SOCS1 pathway. 2016 Int J Chron Obstruct Pulmon Dis pmid:26730186
Havixbeck JJ et al. Neutrophil contributions to the induction and regulation of the acute inflammatory response in teleost fish. 2016 J. Leukoc. Biol. pmid:26292979
Su HH et al. Aryl hydrocarbon receptor-ligand axis mediates pulmonary fibroblast migration and differentiation through increased arachidonic acid metabolism. 2016 Toxicology pmid:27697457
Bellou A et al. 4-Aminopyridine, A Blocker of Voltage-Dependent K+ Channels, Restores Blood Pressure and Improves Survival in the Wistar Rat Model of Anaphylactic Shock. 2016 Crit. Care Med. pmid:27270180
Madrigales-Ahuatzi D and Perez-Gutierrez RM Evaluation of Anti-inflammatory Activity of Seeds of Phalaris canariensis. 2016 Drug Res (Stuttg) pmid:25830684
Siddiqui F et al. Opuntia dillenii cladode: Opuntiol and opuntioside attenuated cytokines and eicosanoids mediated inflammation. 2016 J Ethnopharmacol pmid:26900126
Kim HK et al. Glutamine Prevents Late-Phase Anaphylaxis via MAPK Phosphatase 1-Dependent Cytosolic Phospholipase A2 Deactivation. 2016 Int. Arch. Allergy Immunol. pmid:27838690
Tsen SY et al. Relative Inhibitions of 5-Lipoxygenase and Myeloperoxidase and Free-Radical Scavenging Activities of Daidzein, Dihydrodaidzein, and Equol. 2016 J Med Food pmid:27027338
Rodrigues IA et al. Natural Products: Insights into Leishmaniasis Inflammatory Response. 2015 Mediators Inflamm. pmid:26538837
Jeon WK et al. The proinflammatory LTB4/BLT1 signal axis confers resistance to TGF-β1-induced growth inhibition by targeting Smad3 linker region. 2015 Oncotarget pmid:26497676
Li J and Pan JH [Clinical efficacy of montelukast for the treatment of bronchiolitis in infants]. 2015 Zhongguo Dang Dai Er Ke Za Zhi pmid:26483224
Le Bel M and Gosselin J Leukotriene B4 Enhances NOD2-Dependent Innate Response against Influenza Virus Infection. 2015 PLoS ONE pmid:26444420
Sawada Y et al. Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses. 2015 J. Exp. Med. pmid:26438363
Akthar S et al. Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection. 2015 Nat Commun pmid:26400771
O'Dwyer CA et al. The BLT1 Inhibitory Function of α-1 Antitrypsin Augmentation Therapy Disrupts Leukotriene B4 Neutrophil Signaling. 2015 J. Immunol. pmid:26371243
Alvarellos ML et al. PharmGKB summary: very important pharmacogene information for CYP4F2. 2015 Pharmacogenet. Genomics pmid:25370453
Zhang J et al. Exhaled Hydrogen Sulfide Predicts Airway Inflammation Phenotype in COPD. 2015 Respir Care pmid:25336529