LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Phlebitis D010689 1 associated lipids
Pseudoxanthoma Elasticum D011561 2 associated lipids
Neointima D058426 3 associated lipids
Eosinophilic Esophagitis D057765 3 associated lipids
Common Bile Duct Diseases D003137 3 associated lipids
Cestode Infections D002590 3 associated lipids
Hyperbilirubinemia, Hereditary D006933 3 associated lipids
Wounds, Nonpenetrating D014949 4 associated lipids
Eosinophilia D004802 4 associated lipids
Insect Bites and Stings D007299 4 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

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Authors Title Published Journal PubMed Link
Dichlberger A et al. Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells. 2014 J. Lipid Res. pmid:25114172
Cole SP Targeting multidrug resistance protein 1 (MRP1, ABCC1): past, present, and future. 2014 Annu. Rev. Pharmacol. Toxicol. pmid:24050699
Basavarajappa D et al. Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25034252
Xiang Y et al. Anti-inflammatory effect of acetylpuerarin on eicosanoid signaling pathway in primary rat astrocytes. 2014 J. Mol. Neurosci. pmid:24026619
Bertin J et al. Exposure of human astrocytes to leukotriene C4 promotes a CX3CL1/fractalkine-mediated transmigration of HIV-1-infected CD4⁺ T cells across an in vitro blood-brain barrier model. 2014 Virology pmid:24725939
Zhang X et al. Complex role of STIM1 in the activation of store-independent Orai1/3 channels. 2014 J. Gen. Physiol. pmid:24567509
Pinho BR et al. Modulation of basophils' degranulation and allergy-related enzymes by monomeric and dimeric naphthoquinones. 2014 PLoS ONE pmid:24587235
Linares Segovia B et al. Parameters of lung inflammation in asthmatic as compared to healthy children in a contaminated city. 2014 BMC Pulm Med pmid:25000942
Cole SP Multidrug resistance protein 1 (MRP1, ABCC1), a "multitasking" ATP-binding cassette (ABC) transporter. 2014 J. Biol. Chem. pmid:25281745
Lee JF et al. Lipoxygenase pathway mediates increases of airway resistance and lung inflation induced by exposure to nanotitanium dioxide in rats. 2014 Oxid Med Cell Longev pmid:24693335