| MeSH term | MeSH ID | Detail |
|---|---|---|
| Phlebitis | D010689 | 1 associated lipids |
| Pseudoxanthoma Elasticum | D011561 | 2 associated lipids |
| Eosinophilic Esophagitis | D057765 | 3 associated lipids |
| Common Bile Duct Diseases | D003137 | 3 associated lipids |
| Cestode Infections | D002590 | 3 associated lipids |
| Hyperbilirubinemia, Hereditary | D006933 | 3 associated lipids |
| Neointima | D058426 | 3 associated lipids |
| Mesenteric Vascular Occlusion | D008641 | 4 associated lipids |
| Eosinophilia | D004802 | 4 associated lipids |
| Insect Bites and Stings | D007299 | 4 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yamaya M et al. | Epithelial modulation of leukotriene-C4-induced human tracheal smooth muscle contraction. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7881688 |
| Restrick LJ et al. | Reduction in leukotriene B4 generation by bronchoalveolar lavage cells in asthma. | 1995 | Thorax | pmid:7886653 |
| Kawashima T et al. | [Inhibitory effect of AS-35. a novel antiallergic drug, on chemical mediator release from human eosinophils]. | 1994 | Arerugi | pmid:7887808 |
| Wang D et al. | Correlations between complaints, inflammatory cells and mediator concentrations in nasal secretions after nasal allergen challenge and during natural allergen exposure. | 1995 | Int. Arch. Allergy Immunol. | pmid:7888790 |
| Tsai JJ et al. | Relationship between nasal resistance and airway hyperreactivity following nasal provocation with Dermatophagoides pteronyssinus in allergic rhinitis. | 1995 | Int. Arch. Allergy Immunol. | pmid:7888791 |
| Mita H and Shida T | Comparison of anti-allergic activities of the histamine H1 receptor antagonists epinastine, ketotifen and oxatomide in human leukocytes. | 1995 | Arzneimittelforschung | pmid:7893266 |
| Scadding GK et al. | Effect of short-term treatment with fluticasone propionate nasal spray on the response to nasal allergen challenge. | 1994 | Br J Clin Pharmacol | pmid:7893587 |
| Kawana S and Nishiyama S | Pustular psoriasis and aseptic purulent arthritis: possible role of leukotrienes B4 and C4 in a flare of synovitis. | 1995 | Dermatology (Basel) | pmid:7894093 |
| Ohtsuki T et al. | Reperfusion induces 5-lipoxygenase translocation and leukotriene C4 production in ischemic brain. | 1995 | Am. J. Physiol. | pmid:7900879 |
| Thioudellet C et al. | Molecular and functional characterization of recombinant human gamma-glutamyltransferase. Coupling of its activity to glutathione levels in V79 cells. | 1994 | Eur. J. Biochem. | pmid:7913033 |
| Jedlitschky G et al. | ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein. | 1994 | Cancer Res. | pmid:7915193 |
| Kapuściński A | Leukotriene C4 in the rat brain after resuscitation from clinical death. | 1994 | Folia Neuropathol | pmid:7922113 |
| Ohemeng KA et al. | Novel bishydroxamic acids as 5-lipoxygenase inhibitors. | 1994 | Bioorg. Med. Chem. | pmid:7922131 |
| Ducep JB et al. | Synthesis of 5- and 6-fluoro derivatives of 5,8,14-eicosatrienoic and 5,8,11,14-eicosatetraenoic acids. Effects of fluorinated arachidonic acids on leukotriene C4 production by macrophages. | 1994 | Bioorg. Med. Chem. | pmid:7922133 |
| Leff AR | Inflammatory mediation of airway hyperresponsiveness by peripheral blood granulocytes. The case for the eosinophil. | 1994 | Chest | pmid:7924496 |
| Büchler M et al. | Functional reconstitution of ATP-dependent transporters from the solubilized hepatocyte canalicular membrane. | 1994 | Eur. J. Biochem. | pmid:7925347 |
| Matsumoto T et al. | Effects of diet on experimentally induced intestinal ulcers in rats: morphology and tissue leukotrienes. | 1994 | Gut | pmid:7926906 |
| Anwar AR et al. | Adhesion to fibronectin primes eosinophils via alpha 4 beta 1 (VLA-4). | 1994 | Immunology | pmid:7927493 |
| Volland H et al. | Enzyme immunometric assay for leukotriene C4. | 1994 | J. Immunol. Methods | pmid:7930643 |
| Black KL et al. | Enzymatic barrier protects brain capillaries from leukotriene C4. | 1994 | J. Neurosurg. | pmid:7931622 |
| Böhme M et al. | ATP-dependent export pumps and their inhibition by cyclosporins. | 1994 | Adv. Enzyme Regul. | pmid:7942282 |
| Leier I et al. | The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. | 1994 | J. Biol. Chem. | pmid:7961706 |
| Fujii R et al. | Adenosine triphosphate-dependent transport of leukotriene C4 by membrane vesicles prepared from cisplatin-resistant human epidermoid carcinoma tumor cells. | 1994 | J. Natl. Cancer Inst. | pmid:7966417 |
| Mitsuhashi T et al. | Increased production of eicosanoids, TXA2, PGI2 and LTC4 in experimental spinal cord injuries. | 1994 | Paraplegia | pmid:7970857 |
| Wei EQ et al. | [Effect of a leukotriene antagonist, ONO-1078, on electric stimulation of vagus (ESV)-induced bronchoconstriction and microvascular leakage in guinea pigs]. | 1994 | Yao Xue Xue Bao | pmid:7976357 |
| Nagashima T et al. | The effect of leukotriene C4 on the permeability of brain capillary endothelial cell monolayer. | 1994 | Acta Neurochir Suppl (Wien) | pmid:7976646 |
| Amon U et al. | Control function of protein kinase C isozymes on leukotriene generation from human basophils? | 1994 | Agents Actions | pmid:7976816 |
| Votta BJ and Bertolini DR | Cytokine suppressive anti-inflammatory compounds inhibit bone resorption in vitro. | 1994 Sep-Oct | Bone | pmid:7980964 |
| Medina L et al. | Leukotriene C4 upregulates collagenase expression and synthesis in human lung fibroblasts. | 1994 | Biochim. Biophys. Acta | pmid:7981229 |
| Ishii K et al. | A useful method for differential evaluation of anti-inflammatory effects due to cyclooxygenase and 5-lipoxygenase inhibitions in mice. | 1994 | Jpn. J. Pharmacol. | pmid:7990266 |
| Fiore S et al. | Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor. | 1994 | J. Exp. Med. | pmid:8006586 |
| Maclouf J et al. | Leukotriene C4 formation by transcellular biosynthesis. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8017763 |
| Hamasaki Y et al. | Inhibition by dexamethasone of retinoic acid-induced enhancement of leukotriene C4 synthesis in rat basophilic leukemia-1 cells. | 1994 | Am. J. Respir. Cell Mol. Biol. | pmid:8018338 |
| Böhme M et al. | Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver. | 1994 | Gastroenterology | pmid:8020669 |
| Raible DG | Erythrocytes increase leukotriene C4 release from human eosinophils: characterization and examination of possible mechanisms. | 1994 | J. Leukoc. Biol. | pmid:8027672 |
| Laviolette M et al. | Effects of inhaled steroids on blood eosinophils in moderate asthma. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8031001 |
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| Cotti E and Torabinejad M | Detection of leukotriene C4 in human periradicular lesions. | 1994 | Int Endod J | pmid:8034369 |
| Christie PE et al. | Increased urinary LTE4 excretion following inhalation of LTC4 and LTE4 in asthmatic subjects. | 1994 | Eur. Respir. J. | pmid:8050548 |
| Lam BK et al. | Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8052639 |
| Yamada N et al. | Pharmacological profile of the novel, potent and selective peptide leukotriene antagonist (E)-2,2-diethyl-3'-[2-[2-(4-isopropyl)thiazolyl]ethenyl]succinanilic acid. | 1994 | Arzneimittelforschung | pmid:8053974 |
| Bando T et al. | Inhibitory effect of aerosol administration of a sulfidopeptide leukotriene antagonist on bronchoconstriction induced by antigen inhalation in guinea pigs. | 1994 | Arzneimittelforschung | pmid:8053975 |
| Shimizu T et al. | Leukotriene B4 and C4 generation by small intestinal mucosa in children with coeliac disease. | 1994 | Digestion | pmid:8063028 |
| Le Poole IC et al. | Organotypic culture of human skin to study melanocyte migration. | 1994 | Pigment Cell Res. | pmid:8072944 |
| Shimizu T et al. | Leukotriene B4 and C4 generation by blood leukocytes after ex vivo stimulation by Ca-ionophore and opsonized zymosan in children with atopic dermatitis. | 1994 | Pediatr Allergy Immunol | pmid:8087194 |
| Shimizu T et al. | Effects of pancreatic and snake venom phospholipase A2 on the generation of leukotriene B4 and C4 by human leukocytes in vitro. | 1994 | Pancreas | pmid:8108369 |
| Chen CR et al. | Platelet-activating factor potentiates protamine-induced lung edema. Role of eicosanoids. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8111595 |
| Weide I et al. | Intravascular cysteinyl-leukotriene formation by clotting whole human blood. Evidence from clamped umbilical vein segments and thrombus specimens. | 1993 | Thromb. Res. | pmid:8122190 |
| Ramis I et al. | Application of totally automated on-line sample clean up system for extraction and high-performance liquid chromatography separation of peptide leukotrienes. | 1993 Nov-Dec | J Pharm Biomed Anal | pmid:8123725 |
| Leier I et al. | Characterization of the ATP-dependent leukotriene C4 export carrier in mastocytoma cells. | 1994 | Eur. J. Biochem. | pmid:8125120 |