LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Phlebitis D010689 1 associated lipids
Pseudoxanthoma Elasticum D011561 2 associated lipids
Cestode Infections D002590 3 associated lipids
Hyperbilirubinemia, Hereditary D006933 3 associated lipids
Neointima D058426 3 associated lipids
Eosinophilic Esophagitis D057765 3 associated lipids
Common Bile Duct Diseases D003137 3 associated lipids
Status Asthmaticus D013224 4 associated lipids
Wounds, Nonpenetrating D014949 4 associated lipids
Eosinophilia D004802 4 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

Download all related citations
Per page 10 20 50 100 | Total 1173
Authors Title Published Journal PubMed Link
Kusuhara H et al. Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line. 1998 J. Pharmacol. Exp. Ther. pmid:9618431
Pedersen KE et al. Cysteinyl leukotrienes induce P-selectin expression in human endothelial cells via a non-CysLT1 receptor-mediated mechanism. 1997 J. Pharmacol. Exp. Ther. pmid:9152370
Hundley TR et al. Characteristics of arachidonic acid generation in human basophils: relationship between the effects of inhibitors of secretory phospholipase A2 activity and leukotriene C4 release. 1998 J. Pharmacol. Exp. Ther. pmid:9495842
McAlexander MA et al. Inhibition of 5-lipoxygenase diminishes neurally evoked tachykinergic contraction of guinea pig isolated airway. 1998 J. Pharmacol. Exp. Ther. pmid:9580604
Tominaga M et al. ONO-1078 antagonizes diarrhea-causing changes in ion transport and smooth muscle contraction induced by peptidoleukotrienes in rat and human colon in vitro. 1996 J. Pharmacol. Exp. Ther. pmid:8819486
Aoki M et al. Studies on mechanisms of low emetogenicity of YM976, a novel phosphodiesterase type 4 inhibitor. 2001 J. Pharmacol. Exp. Ther. pmid:11504812
Dantzig AH et al. Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities. 1999 J. Pharmacol. Exp. Ther. pmid:10411602
Casolaro V et al. Nimesulide, a sulfonanilide nonsteroidal anti-inflammatory drug, inhibits mediator release from human basophils and mast cells. 1993 J. Pharmacol. Exp. Ther. pmid:7505332
Prié S et al. Leukotriene C4 receptors on guinea pig tracheocytes. 1995 J. Pharmacol. Exp. Ther. pmid:7562565
Malaviya R et al. Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3', 5'-dibromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97). 2000 J. Pharmacol. Exp. Ther. pmid:11082424
Capper EA et al. Modulation of human monocyte activities by tranilast, SB 252218, a compound demonstrating efficacy in restenosis. 2000 J. Pharmacol. Exp. Ther. pmid:11082441
Suzuki Y and Ra C Analysis of the mechanism for the development of allergic skin inflammation and the application for its treatment: aspirin modulation of IgE-dependent mast cell activation: role of aspirin-induced exacerbation of immediate allergy. 2009 J. Pharmacol. Sci. pmid:19609060
Foller M et al. Participation of leukotriene C(4) in the regulation of suicidal erythrocyte death. 2009 J. Physiol. Pharmacol. pmid:19826192
Lukaszyk A et al. The role of epidermal growth factor in platelet-endothelium interactions. 1998 J. Physiol. Pharmacol. pmid:9670106
Hong F and Yang S Ischemic preconditioning decreased leukotriene C4 formation by depressing leukotriene C4 synthase expression and activity during hepatic I/R injury in rats. 2012 J. Surg. Res. pmid:22921920
Yang SL et al. Increased leukotriene c4 synthesis accompanied enhanced leukotriene c4 synthase expression and activities of ischemia-reperfusion-injured liver in rats. 2007 J. Surg. Res. pmid:17397868
Bacha EA et al. Gastric antigen challenge releases gastrin and eicosanoids and protects against ethanol. 1997 J. Surg. Res. pmid:9228931
O'Neil GS et al. Effect of surgical preparation and arterialization on vasomotion of human saphenous vein. 1994 J. Thorac. Cardiovasc. Surg. pmid:8127099
Utoh J et al. Is an increase in neutrophil leukotriene-generating capacity a specific phenomenon for cardiopulmonary bypass? 1995 J. Thorac. Cardiovasc. Surg. pmid:7609558
Bouchelouche K et al. The cysteinyl-leukotriene D4 induces cytosolic Ca2+ elevation and contraction of the human detrusor muscle. 2003 J. Urol. pmid:12853847
Shichinohe K et al. Effect of M-711 on experimental skin reactions induced by chemical mediators in rats. 1996 J. Vet. Med. Sci. pmid:8741601
Cunningham FM et al. Pharmacology of the 5-lipoxygenase inhibitors BAY Y 1015 and BAY X 1005 in the horse. 1997 J. Vet. Pharmacol. Ther. pmid:9280370
Fujita M et al. Cysteinyl leukotrienes induce nasal symptoms of allergic rhinitis via a receptor-mediated mechanism in guinea pigs. 1997 Jpn. J. Pharmacol. pmid:9469641
Matsushita N et al. Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antiasthmatic effects. 1998 Jpn. J. Pharmacol. pmid:9804057
Ishii K et al. A useful method for differential evaluation of anti-inflammatory effects due to cyclooxygenase and 5-lipoxygenase inhibitions in mice. 1994 Jpn. J. Pharmacol. pmid:7990266
Petric R and Ford-Hutchinson AW Elevated cysteinyl leukotriene excretion in experimental glomerulonephritis. 1994 Kidney Int. pmid:7853790
Mayatepek E and Flock B Leukotriene C4-synthesis deficiency: a new inborn error of metabolism linked to a fatal developmental syndrome. 1998 Lancet pmid:9820300
Jordan TR et al. [Clinical symptoms and mediators in the allergic early and late phase reaction]. 2006 Laryngorhinootologie pmid:16498540
Arango P and Kountakis SE Presence of cysteinyl leukotrienes in asthmatic patients with chronic sinusitis. 2002 Laryngoscope pmid:12169896
Sato H et al. Biological characteristics of chronic eosinophilic leukemia cells with a t(2;5)(p23;q35) translocation. 1995 Leuk. Lymphoma pmid:8590853
Ramanujam D et al. Dramatic resolution of respiratory symptoms with imatinib mesylate in patients with chronic myeloid leukemia presenting with lower airway symptoms resembling asthma. 2009 Leuk. Lymphoma pmid:19757309
Bermejo Benito P et al. In vivo and in vitro antiinflammatory activity of saikosaponins. 1998 Life Sci. pmid:9763210
Huang SC Leukotriene-induced contraction is mediated by cysteinyl leukotriene receptor CysLT1 in guinea pig fundus but by CysLT1 and CysLT2 in antrum. 2011 Life Sci. pmid:21396378
Zhu X et al. Structural determinants of blockade of eosinophil activation, adhesion and secretion by synthetic analogs of phomactin. 2003 Life Sci. pmid:14519449
de las Heras B et al. Effects of six diterpenes on macrophage eicosanoid biosynthesis. 2001 Life Sci. pmid:12005260
Yakubu MA and Leffler CW Enhanced pial arteriolar sensitivity to bioactive agents following exposure to endothelin-1. 2000 Life Sci. pmid:10665982
Hisamatsu K and Nakajima M Pranlukast protects leukotriene C4- and D4-induced epithelial cell impairment of the nasal mucosa in vitro. 2000 Life Sci. pmid:11105993
Díaz AM et al. Phenylpropanoid glycosides from Scrophularia scorodonia: in vitro anti-inflammatory activity. 2004 Life Sci. pmid:15010262
Wang M et al. The responses of pulmonary and systemic circulation and airway to anaphylactic mediators in anesthetized BALB/c mice. 2016 Life Sci. pmid:26808090
Lopes LR et al. Reduced inflammatory response in rats fed fat-rich diets: role of leukotrienes. 2000 Life Sci. pmid:10896024
Ito K et al. Mrp2/Abcc2 transport activity is stimulated by protein kinase Calpha in a baculo virus co-expression system. 2005 Life Sci. pmid:15904671
Yoo JM et al. Inhibitory effect of N-Acyl dopamines on IgE-mediated allergic response in RBL-2H3 cells. 2013 Lipids pmid:23377981
Aiso M et al. Biliary excretion of bile acids and organic anions in zone 1- and zone 3-injured rats. 2000 Liver pmid:10726959
Mullol J et al. [Eosinophil activation by epithelial cells of the respiratory mucosa. Comparative study of normal mucosa and inflammatory mucosa]. 1997 Med Clin (Barc) pmid:9303983
Capra V et al. Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends. 2007 Med Res Rev pmid:16894531
Tang F et al. Inhibitory effect of methyleugenol on IgE-mediated allergic inflammation in RBL-2H3 cells. 2015 Mediators Inflamm. pmid:25960618
Desplat V et al. Incorporation and effect of arachidonic acid on the growth of human myeloma cell lines. 1999 Mediators Inflamm. pmid:10704149
Haberl C et al. Release of prostaglandin D2 by murine mast cells: importance of metabolite formation for antiproliferative activity. 1998 Mediators Inflamm. pmid:9836493
Ribeiro LR et al. Lipoxin Inhibits Fungal Uptake by Macrophages and Reduces the Severity of Acute Pulmonary Infection Caused by Paracoccidioides brasiliensis. 2015 Mediators Inflamm. pmid:26635449
Seres I et al. Angiotensin II-induced oxidative burst is fluvastatin sensitive in neutrophils of patients with hypercholesterolemia. 2005 Metab. Clin. Exp. pmid:16125525