| MeSH term | MeSH ID | Detail |
|---|---|---|
| Phlebitis | D010689 | 1 associated lipids |
| Pseudoxanthoma Elasticum | D011561 | 2 associated lipids |
| Neointima | D058426 | 3 associated lipids |
| Eosinophilic Esophagitis | D057765 | 3 associated lipids |
| Common Bile Duct Diseases | D003137 | 3 associated lipids |
| Hyperbilirubinemia, Hereditary | D006933 | 3 associated lipids |
| Cestode Infections | D002590 | 3 associated lipids |
| Wounds, Nonpenetrating | D014949 | 4 associated lipids |
| Picornaviridae Infections | D010850 | 4 associated lipids |
| Mesenteric Vascular Occlusion | D008641 | 4 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Medrala W et al. | [Efficacy and safety of specific immunotherapy of upper airways allergic diseases caused by allergy to mites]. | 2006 | Pol. Merkur. Lekarski | pmid:16875150 |
| Leynadier F | [Drug allergies: value of the leucotriene C4 release test?]. | 1997 | Presse Med | pmid:9180883 |
| Maekawa A et al. | Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18931305 |
| Uzonyi B et al. | Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16606835 |
| Mandal AK et al. | The membrane organization of leukotriene synthesis. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15084748 |
| Kar P et al. | Different agonists recruit different stromal interaction molecule proteins to support cytoplasmic Ca2+ oscillations and gene expression. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22509043 |
| Oyoshi MK et al. | Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22416124 |
| Paul S et al. | ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8692921 |
| Goulet JL et al. | Altered inflammatory responses in leukotriene-deficient mice. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7809134 |
| Müller M et al. | Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7809167 |
| Basavarajappa D et al. | Roles of coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP) in cellular leukotriene biosynthesis. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25034252 |
| Tedla N et al. | Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12529506 |
| Cordoba-Rodriguez R et al. | Calcium regulation of a slow post-spike hyperpolarization in vagal afferent neurons. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393875 |
| Tang DG et al. | Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8643560 |
| Thomas JW et al. | Potent interleukin 3 receptor agonist with selectively enhanced hematopoietic activity relative to recombinant human interleukin 3. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7537376 |
| Bischoff SC et al. | IL-4 enhances proliferation and mediator release in mature human mast cells. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393951 |
| Clish CB et al. | Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393980 |
| Feltenmark S et al. | Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:18184802 |
| Lam BK et al. | Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8052639 |
| Janssen-Timmen U et al. | Expression of 5-lipoxygenase in differentiating human skin keratinocytes. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7624354 |
| Brandenburg K et al. | Conformation and fluidity of endotoxins as determinants of biological activity. | 1995 | Prog. Clin. Biol. Res. | pmid:8524923 |
| Willburger RE et al. | Inhibition of eicosanoid release from synovial organ culture by incubation with tepoxalin and its acid metabolite. | 1996 | Prostaglandins | pmid:8936587 |
| Hisamatsu K et al. | Effect of leukotriene C4 exposure on ciliated cells of the nasal mucosa. | 1996 | Prostaglandins | pmid:8900445 |
| Herman CA et al. | Leukotriene C4-stimulated contractions in bullfrog lung are affected by cold acclimation and calcium antagonists. | 1995 | Prostaglandins | pmid:7480797 |
| Baker SR et al. | The pharmacology of N-methyl LTC4; a metabolically stable LTC4-mimetic. | 1990 | Prostaglandins | pmid:2255765 |
| Ramondt J et al. | Sensitivity of ovine myometrial tissue to various eicosanoids in vitro. | 1995 | Prostaglandins | pmid:7792392 |
| Kitaura K et al. | Effects of organic anions and bile acid conjugates on biliary excretion of LTC4 in the rat. | 1997 | Prostaglandins | pmid:9491205 |
| Tanaka H et al. | The effect of a novel leukotriene C4/D4 antagonist, BAY-x-7195, on experimental allergic reactions. | 1995 Nov-Dec | Prostaglandins | pmid:8838238 |
| Wen FQ et al. | Eicosanoid profile in cultured human pulmonary artery smooth muscle cells treated with IL-1 beta and TNF alpha. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9758210 |
| Hua Z et al. | Evaluation and interference of serum and skin lesion levels of leukotrienes in patients with eczema. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16757158 |
| Zaitsu M et al. | Effect of dexamethasone on leukotriene synthesis in DMSO-stimulated HL-60 cells. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10102384 |
| KuÅŸtimur S et al. | Effect of nordihydroguaretic acid and fluconazole on the LTC4/PGE2 ratio in the kidney of mice damaged by Candida albicans. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9150373 |
| Hardcastle JE and Bruch RJ | Effect of L-aspartyl-L-phenylalanine methyl ester on leukotriene biosynthesis in macrophage cells. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9384524 |
| Abeywardena MY et al. | Dietary n-3 and n-6 polyunsaturated oils and airway contractility. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418024 |
| Sare M et al. | The effects of indomethacin, NDGA, allopurinol and superoxide dismutase on prostaglandin E2 and leukotriene C4 levels after mesenteric ischemia-reperfusion injury. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9014215 |
| Shindo K et al. | Prednisolone inhibits synthesis of 5-H(P)ETE in eosinophils from asthmatic patients during a wheezing attack but not during remission. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9578148 |
| Hackshaw KV et al. | Environmental influences on fatty acid composition of membranes from autoimmune MRL lpr/lpr mice. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8804129 |
| Shimizu T et al. | Effects of n-3 polyunsaturated fatty acids on indomethacin-induced changes in eicosanoid production and blood flow in the gastric mucosa of rats. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12878448 |
| Damtew B and Spagnuolo PJ | Leukotriene C4 from vascular endothelium enhances neutrophil adhesiveness. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9051719 |
| HasanoÄŸlu E et al. | The role of prostanoids in the complications of extracorporeal shock wave lithotripsy (ESWL) in children. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846111 |
| Abe M et al. | Evaluation of the effects of steroids on experimental septic lung injury. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8848431 |
| Zaitsu M et al. | Interleukin-18 primes human basophilic KU812 cells for higher leukotriene synthesis. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16280246 |
| Anadol AZ et al. | Role of endogenous endothelin peptides in intestinal ischemia-reperfusion injury in rats. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9849655 |
| Lam BK | Leukotriene C(4) synthase. | 2003 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12895593 |
| Bandeira-Melo C and Weller PF | Eosinophils and cysteinyl leukotrienes. | 2003 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12895596 |
| Mita H et al. | Purification of human blood basophils and leukotriene C4 generation following calcium ionophore stimulation. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7505057 |
| Batirel HF et al. | The effect of aqueous garlic extract on the levels of arachidonic acid metabolites (leukotriene C4 and prostaglandin E2) in rat forebrain after ischemia-reperfusion injury. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8804127 |
| Keskil ZA et al. | Changes of arterial arachidonic acid metabolites in hypertensive patients during haemodialysis. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10189068 |
| Raghavenra H et al. | Eugenol--the active principle from cloves inhibits 5-lipoxygenase activity and leukotriene-C4 in human PMNL cells. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16216483 |
| Hamasaki Y et al. | Inhibition of leukotriene synthesis by terfenadine in vitro. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9654399 |