| MeSH term | MeSH ID | Detail |
|---|---|---|
| Phlebitis | D010689 | 1 associated lipids |
| Pseudoxanthoma Elasticum | D011561 | 2 associated lipids |
| Eosinophilic Esophagitis | D057765 | 3 associated lipids |
| Common Bile Duct Diseases | D003137 | 3 associated lipids |
| Hyperbilirubinemia, Hereditary | D006933 | 3 associated lipids |
| Cestode Infections | D002590 | 3 associated lipids |
| Neointima | D058426 | 3 associated lipids |
| Picornaviridae Infections | D010850 | 4 associated lipids |
| Mesenteric Vascular Occlusion | D008641 | 4 associated lipids |
| Eosinophilia | D004802 | 4 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Borrelli I et al. | Benzene metabolites inhibit the release of proinflammatory mediators and cytokines from human basophils. | 2010 Jul-Sep | Int J Immunopathol Pharmacol | pmid:20943043 |
| Oh YC et al. | Anti-allergic activity of a platycodon root ethanol extract. | 2010 | Int J Mol Sci | pmid:20717534 |
| Kloprogge E et al. | Cellular communication in leukotriene C4 production between eosinophils and neutrophils. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2509375 |
| Schauer U et al. | Enhanced leukotriene C4 production by peripheral eosinophilic granulocytes from children with asthma. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2512259 |
| Georgitis JW et al. | Chronic sinusitis: characterization of cellular influx and inflammatory mediators in sinus lavage fluid. | 1995 | Int. Arch. Allergy Immunol. | pmid:7719157 |
| Genovese A et al. | Protein Fv produced during viral hepatitis is an endogenous immunoglobulin superantigen activating human heart mast cells. | 2003 | Int. Arch. Allergy Immunol. | pmid:14707465 |
| Genovese A et al. | Role of mast cells, basophils and their mediators in adverse reactions to general anesthetics and radiocontrast media. | 1996 | Int. Arch. Allergy Immunol. | pmid:8645973 |
| Davoine F et al. | Interleukin-12 inhibits eosinophil degranulation and migration but does not promote eosinophil apoptosis. | 2006 | Int. Arch. Allergy Immunol. | pmid:16735797 |
| Patella V et al. | Oxatomide inhibits the release of proinflammatory mediators from human basophils and mast cells. | 1996 | Int. Arch. Allergy Immunol. | pmid:8753840 |
| Hirano T et al. | Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils. | 2004 | Int. Arch. Allergy Immunol. | pmid:15153793 |
| Iwamoto I et al. | Effect of a selective thromboxane A2 receptor antagonist BAY u3405 on antigen-, leukotriene C4- and leukotriene D4-induced bronchoconstriction in guinea pigs. | 1995 | Int. Arch. Allergy Immunol. | pmid:7647588 |
| Ilarraza R et al. | Montelukast inhibits leukotriene stimulation of human dendritic cells in vitro. | 2012 | Int. Arch. Allergy Immunol. | pmid:22846852 |
| Hashimoto K et al. | Cysteinyl leukotrienes induce monocyte chemoattractant protein-1 in human monocyte/macrophages via mitogen-activated protein kinase and nuclear factor-kappaB pathways. | 2009 | Int. Arch. Allergy Immunol. | pmid:19218821 |
| Koketsu R et al. | Pretreatment with low levels of FcεRI-crosslinking stimulation enhances basophil mediator release. | 2013 | Int. Arch. Allergy Immunol. | pmid:23711850 |
| James A et al. | The influence of aspirin on release of eoxin C4, leukotriene C4 and 15-HETE, in eosinophilic granulocytes isolated from patients with asthma. | 2013 | Int. Arch. Allergy Immunol. | pmid:23921438 |
| Itoh K et al. | Relationship between airway eosinophilia and airway hyperresponsiveness in a late asthmatic model of guinea pigs. | 1996 | Int. Arch. Allergy Immunol. | pmid:8527956 |
| Kawashima T et al. | Inhibitory effect of pemirolast, a novel antiallergic drug, on leukotriene C4 and granule protein release from human eosinophils. | 1994 | Int. Arch. Allergy Immunol. | pmid:8130655 |
| Wang D et al. | Correlations between complaints, inflammatory cells and mediator concentrations in nasal secretions after nasal allergen challenge and during natural allergen exposure. | 1995 | Int. Arch. Allergy Immunol. | pmid:7888790 |
| Kitahata Y et al. | Prolonged culture of mast cells with high-glucose medium enhances the Fc epsilon RI-mediated degranulation response and leukotriene C4 production. | 2010 | Int. Arch. Allergy Immunol. | pmid:20523060 |
| Patella V et al. | Human heart mast cells: a definitive case of mast cell heterogeneity. | 1995 | Int. Arch. Allergy Immunol. | pmid:7536502 |
| Lebel B et al. | Inhibition of mediator release from dispersed nasal polyp cells by cyclosporin A. | 1998 | Int. Arch. Allergy Immunol. | pmid:9693278 |
| Austen KF | The Paul Kallós Memorial Lecture. From slow-reacting substance of anaphylaxis to leukotriene C4 synthase. | 1995 May-Jun | Int. Arch. Allergy Immunol. | pmid:7613129 |
| Tsai JJ et al. | Relationship between nasal resistance and airway hyperreactivity following nasal provocation with Dermatophagoides pteronyssinus in allergic rhinitis. | 1995 | Int. Arch. Allergy Immunol. | pmid:7888791 |
| Weber M and Dahinden CA | Basophil and eosinophil activation by CC chemokines. | 1995 May-Jun | Int. Arch. Allergy Immunol. | pmid:7542061 |
| Kang BC et al. | Experimental asthma developed by room air contamination with cockroach allergen. | 1996 | Int. Arch. Allergy Immunol. | pmid:8917126 |
| Takafuji S et al. | Effects of physiologic soluble agonists on leukotriene C4 production and degranulation by human eosinophils. | 1995 | Int. Arch. Allergy Immunol. | pmid:7549519 |
| Yoshida K et al. | Effect of fibronectin on the production of leukotriene C4 by eosinophils. | 1995 | Int. Arch. Allergy Immunol. | pmid:7549524 |
| Bossé M et al. | Eosinophil activation status and corticosteroid responsiveness in severe asthma. | 2000 | Int. Arch. Allergy Immunol. | pmid:10899764 |
| Marone G et al. | Human heart mast cells in anaphylaxis and cardiovascular disease. | 1995 May-Jun | Int. Arch. Allergy Immunol. | pmid:7542106 |
| Okamoto M et al. | Effects of perilla seed oil supplementation on leukotriene generation by leucocytes in patients with asthma associated with lipometabolism. | 2000 | Int. Arch. Allergy Immunol. | pmid:10878492 |
| Nunomura S et al. | Role of the FcepsilonRI beta-chain ITAM as a signal regulator for mast cell activation with monomeric IgE. | 2005 | Int. Immunol. | pmid:15944196 |
| Jung HW et al. | Comparison of the efficacy of KOB03, ketotifen, and montelukast in an experimental mouse model of allergic rhinitis. | 2013 | Int. Immunopharmacol. | pmid:23643816 |
| Muraki M et al. | Inhaled montelukast inhibits cysteinyl-leukotriene-induced bronchoconstriction in ovalbumin-sensitized guinea-pigs: the potential as a new asthma medication. | 2009 | Int. Immunopharmacol. | pmid:19706339 |
| Fujisaki T et al. | Bestatin selectively suppresses the growth of leukemic stem/progenitor cells with BCR/ABL mRNA transcript in patients with chronic myelogeneous leukemia. | 2003 | Int. Immunopharmacol. | pmid:12781706 |
| Yang SH et al. | The stimulatory effects of nasal discharge from patients with perennial allergic rhinitis on normal human neutrophils are normalized after treatment with a new mixed formula of Chinese herbs. | 2002 | Int. Immunopharmacol. | pmid:12469937 |
| Rossi MI et al. | Long-term exacerbation by interleukin 13 of IgE-mediated eosinophilia in rats. | 2005 | Int. Immunopharmacol. | pmid:15953562 |
| Meszaros P et al. | Long term myriocin treatment increases MRP1 transport activity. | 2013 | Int. J. Biochem. Cell Biol. | pmid:23178537 |
| Sharma R et al. | RLIP76 (RALBP1)-mediated transport of leukotriene C4 (LTC4) in cancer cells: implications in drug resistance. | 2004 | Int. J. Cancer | pmid:15386349 |
| Vigorito C et al. | Metabolic and hemodynamic effects of peptide leukotriene C4 and D4 in man. | 1997 | Int. J. Clin. Lab. Res. | pmid:9352380 |
| Meier HL et al. | Simultaneous initiation of degranulation and inhibition of leukotriene release by soman in human basophils. | 1995 | Int. J. Immunopharmacol. | pmid:7545649 |
| Hamasaki Y et al. | (9-[4-acetyl-3-hydroxy-2-n-propylphenoxy) methyl]-3-(1H-tetrazol-5-yl)-4H-pyrido [1,2-a] pyrimidin-4-one), AS-35, inhibits leukotriene synthesis. | 2000 | Int. J. Immunopharmacol. | pmid:10785545 |
| Daugschies A and Ruttkowski B | Modulation of migration of Oesophagostomum dentatum larvae by inhibitors and products of eicosanoid metabolism. | 1998 | Int. J. Parasitol. | pmid:9513001 |
| Okamoto M et al. | Effects of dietary supplementation with n-3 fatty acids compared with n-6 fatty acids on bronchial asthma. | 2000 | Intern. Med. | pmid:10732825 |
| Sciuto AM et al. | Post-exposure treatment with isoproterenol attenuates pulmonary edema in phosgene-exposed rabbits. | 1998 Sep-Oct | J Appl Toxicol | pmid:9804432 |
| Xu R et al. | Novel polyhydroxylated steroids from the East China Sea gorgonian Echinogorgia sassapo reticulata with suppressive activity of leukotriene C4 generation and degranulation in bone marrow-derived mast cells. | 2014 | J Asian Nat Prod Res | pmid:24437431 |
| Mitsunobu F et al. | Different roles of histamine and leukotriene C4 in the airways between patients with atopic and nonatopic asthma. | 1998 | J Asthma | pmid:9669831 |
| Heredi-Szabo K et al. | Characterization of 5(6)-carboxy-2,'7'-dichlorofluorescein transport by MRP2 and utilization of this substrate as a fluorescent surrogate for LTC4. | 2008 | J Biomol Screen | pmid:18349419 |
| Al-Amran FG et al. | Leukotriene biosynthesis inhibition ameliorates acute lung injury following hemorrhagic shock in rats. | 2011 | J Cardiothorac Surg | pmid:21649921 |
| Kjellström S et al. | On-line coupling of microdialysis sampling with liquid chromatography for the determination of peptide and non-peptide leukotrienes. | 1998 | J Chromatogr A | pmid:9818423 |
| Kimura Y et al. | Effects of stilbenes isolated from medicinal plants on arachidonate metabolism and degranulation in human polymorphonuclear leukocytes. | 1995 | J Ethnopharmacol | pmid:7776662 |
| Abad MJ et al. | Anti-inflammatory activity of four Bolivian Baccharis species (Compositae). | 2006 | J Ethnopharmacol | pmid:16202549 |
| Quan Z et al. | Ethanol extracts of Saururus chinensis suppress ovalbumin-sensitization airway inflammation. | 2010 | J Ethnopharmacol | pmid:20699114 |
| Di Sotto A et al. | Pharmacological and phytochemical study on a Sisymbrium officinale Scop. extract. | 2010 | J Ethnopharmacol | pmid:19969059 |
| Yang SH and Yu CL | Antiinflammatory effects of Bu-zhong-yi-qi-tang in patients with perennial allergic rhinitis. | 2008 | J Ethnopharmacol | pmid:17980528 |
| Hamasaki Y et al. | The Chinese herbal medicine, shinpi-to, inhibits IgE-mediated leukotriene synthesis in rat basophilic leukemia-2H3 cells. | 1997 | J Ethnopharmacol | pmid:9174973 |
| Liebhart J et al. | Production of leukotriene C4 by peripheral blood leukocytes stimulated with anti-fcepsilonRI antibody, PMA, and fMLP does not correlate with irreversible airway obstruction in asthmatics. | 2007 | J Investig Allergol Clin Immunol | pmid:17323856 |
| Annila I et al. | Bee venom induces high histamine or high leukotriene C4 release in skin of sensitized beekeepers. | 2000 Jul-Aug | J Investig Allergol Clin Immunol | pmid:11039839 |
| Jakobsson PJ et al. | Characterization of microsomal GST-II by western blot and identification of a novel LTC4 isomer. | 1997 | J Lipid Mediat Cell Signal | pmid:9302651 |
| Lam BK et al. | Leukotriene C4 synthase. | 1995 | J Lipid Mediat Cell Signal | pmid:8777577 |
| Herron DK et al. | Visualization and comparison of molecular dynamics simulations of leukotriene C4, leukotriene D4, and leukotriene E4. | 1995 | J Mol Graph | pmid:8820302 |
| Ramis I et al. | Application of totally automated on-line sample clean up system for extraction and high-performance liquid chromatography separation of peptide leukotrienes. | 1993 Nov-Dec | J Pharm Biomed Anal | pmid:8123725 |
| Syslová K et al. | Immunomagnetic molecular probe with UHPLC-MS/MS: a promising way for reliable bronchial asthma diagnostics based on quantification of cysteinyl leukotrienes. | 2013 Jul-Aug | J Pharm Biomed Anal | pmid:23644905 |
| Shilling AD et al. | Use of canalicular membrane vesicles (CMVs) from rats, dogs, monkeys and humans to assess drug transport across the canalicular membrane. | 2006 May-Jun | J Pharmacol Toxicol Methods | pmid:16176877 |
| Olynych TJ et al. | Fungal zymosan induces leukotriene production by human mast cells through a dectin-1-dependent mechanism. | 2006 | J. Allergy Clin. Immunol. | pmid:17030235 |
| Nakasato H et al. | Prevention of severe premenstrual asthma attacks by leukotriene receptor antagonist. | 1999 | J. Allergy Clin. Immunol. | pmid:10482831 |
| Sachs-Olsen C et al. | Eoxins: a new inflammatory pathway in childhood asthma. | 2010 | J. Allergy Clin. Immunol. | pmid:20920774 |
| Akin C et al. | Mast cell activation syndrome: Proposed diagnostic criteria. | 2010 | J. Allergy Clin. Immunol. | pmid:21035176 |
| Thivierge M et al. | Toll-like receptor agonists differentially regulate cysteinyl-leukotriene receptor 1 expression and function in human dendritic cells. | 2006 | J. Allergy Clin. Immunol. | pmid:16675346 |
| Yoshisue H et al. | Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts. | 2007 | J. Allergy Clin. Immunol. | pmid:17208594 |
| Lee KS et al. | Cysteinyl leukotriene upregulates IL-11 expression in allergic airway disease of mice. | 2007 | J. Allergy Clin. Immunol. | pmid:17208595 |
| Hamilton RG and Franklin Adkinson N | In vitro assays for the diagnosis of IgE-mediated disorders. | 2004 | J. Allergy Clin. Immunol. | pmid:15316492 |
| Zaitsu M et al. | A novel pharmacologic action of glucocorticosteroids on leukotriene C4 catabolism. | 2001 | J. Allergy Clin. Immunol. | pmid:11447392 |
| Lee TH et al. | Leukotriene E4: perspective on the forgotten mediator. | 2009 | J. Allergy Clin. Immunol. | pmid:19482346 |
| Austen KF et al. | The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications. | 2009 | J. Allergy Clin. Immunol. | pmid:19647860 |
| Chen YH et al. | IFN-alpha inhibits IL-3 priming of human basophil cytokine secretion but not leukotriene C4 and histamine release. | 2003 | J. Allergy Clin. Immunol. | pmid:14610485 |
| Horsmanheimo L et al. | Histamine and leukotriene C4 release in cutaneous mosquito-bite reactions. | 1996 | J. Allergy Clin. Immunol. | pmid:8757218 |
| de Paulis A et al. | Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine. | 1996 | J. Allergy Clin. Immunol. | pmid:8765829 |
| Macglashan DW and Saini SS | Omalizumab increases the intrinsic sensitivity of human basophils to IgE-mediated stimulation. | 2013 | J. Allergy Clin. Immunol. | pmid:23791510 |
| Kowalski ML et al. | Differential effects of aspirin and misoprostol on 15-hydroxyeicosatetraenoic acid generation by leukocytes from aspirin-sensitive asthmatic patients. | 2003 | J. Allergy Clin. Immunol. | pmid:13679808 |
| Triggiani M et al. | Lung mast cells are a source of secreted phospholipases A2. | 2009 | J. Allergy Clin. Immunol. | pmid:19541351 |
| Di Capite J et al. | Targeting Ca2+ release-activated Ca2+ channel channels and leukotriene receptors provides a novel combination strategy for treating nasal polyposis. | 2009 | J. Allergy Clin. Immunol. | pmid:19895990 |
| Miura K et al. | Phosphorylation of cytosolic phospholipase A2 by IL-3 is associated with increased free arachidonic acid generation and leukotriene C4 release in human basophils. | 1998 | J. Allergy Clin. Immunol. | pmid:9768595 |
| Meliton AY et al. | Blockade of LTC4 synthesis caused by additive inhibition of gIV-PLA2 phosphorylation: Effect of salmeterol and PDE4 inhibition in human eosinophils. | 2003 | J. Allergy Clin. Immunol. | pmid:12897749 |
| Bandeira-Melo C et al. | Cysteinyl leukotrienes induce IL-4 release from cord blood-derived human eosinophils. | 2002 | J. Allergy Clin. Immunol. | pmid:12063527 |
| Juergens UR et al. | Inhibition of monocyte leukotriene B4 production after aspirin desensitization. | 1995 | J. Allergy Clin. Immunol. | pmid:7636051 |
| Zweiman B et al. | Nasal airway changes assessed by acoustic rhinometry and mediator release during immediate and late reactions to allergen challenge. | 1997 | J. Allergy Clin. Immunol. | pmid:9389292 |
| Oskeritzian CA et al. | Surface CD88 functionally distinguishes the MCTC from the MCT type of human lung mast cell. | 2005 | J. Allergy Clin. Immunol. | pmid:15940129 |
| Lane SJ and Lee TH | Mast cell effector mechanisms. | 1996 | J. Allergy Clin. Immunol. | pmid:8939179 |
| De Servi S et al. | Transcardiac release of leukotriene C4 by neutrophils in patients with coronary artery disease. | 1991 | J. Am. Coll. Cardiol. | pmid:2007712 |
| Hevko JM and Murphy RC | Electrospray ionization and tandem mass spectrometry of cysteinyl eicosanoids: leukotriene C4 and FOG7. | 2001 | J. Am. Soc. Mass Spectrom. | pmid:11444597 |
| Devakumar A et al. | Structural analysis of leukotriene C4 isomers using collisional activation and 157 nm photodissociation. | 2008 | J. Am. Soc. Mass Spectrom. | pmid:18024058 |
| De Castro CM et al. | Modulation by dexamethasone of phospholipase A2 activities in endotoxemic guinea pigs. | 1995 | J. Appl. Physiol. | pmid:8567572 |
| Falcón-Pérez JM et al. | Domain interactions in the yeast ATP binding cassette transporter Ycf1p: intragenic suppressor analysis of mutations in the nucleotide binding domains. | 2001 | J. Bacteriol. | pmid:11466279 |
| Ren XQ et al. | A functional role of intracellular loops of human multidrug resistance protein 1. | 2006 | J. Biochem. | pmid:16861249 |
| Hong JT et al. | Effect of phenobarbital and the peroxisome proliferator ciprofibrate on gamma-Glutamyltranspeptidase activity and leukotriene C4 concentration in cultured rat hepatocytes. | 1995 | J. Biochem. Toxicol. | pmid:8847705 |
| Situ D et al. | Mutational analysis of ionizable residues proximal to the cytoplasmic interface of membrane spanning domain 3 of the multidrug resistance protein, MRP1 (ABCC1): glutamate 1204 is important for both the expression and catalytic activity of the transporter. | 2004 | J. Biol. Chem. | pmid:15208328 |
| Iram SH and Cole SP | Expression and function of human MRP1 (ABCC1) is dependent on amino acids in cytoplasmic loop 5 and its interface with nucleotide binding domain 2. | 2011 | J. Biol. Chem. | pmid:21177244 |
| Murakami M et al. | Interleukin-3 regulates development of the 5-lipoxygenase/leukotriene C4 synthase pathway in mouse mast cells. | 1995 | J. Biol. Chem. | pmid:7559381 |
| Conseil G et al. | Functional importance of three basic residues clustered at the cytosolic interface of transmembrane helix 15 in the multidrug and organic anion transporter MRP1 (ABCC1). | 2006 | J. Biol. Chem. | pmid:16230346 |
| Christmas P et al. | Membrane localization and topology of leukotriene C4 synthase. | 2002 | J. Biol. Chem. | pmid:12023288 |