| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neointima | D058426 | 3 associated lipids |
| Eosinophilic Esophagitis | D057765 | 3 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Pulmonary Disease, Chronic Obstructive | D029424 | 16 associated lipids |
| Brain Diseases, Metabolic, Inborn | D020739 | 10 associated lipids |
| Ventricular Remodeling | D020257 | 28 associated lipids |
| Carotid Artery Injuries | D020212 | 8 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
| Carcinoma, Small Cell | D018288 | 21 associated lipids |
| Myocardial Ischemia | D017202 | 11 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Suzuki Y and Ra C | Analysis of the mechanism for the development of allergic skin inflammation and the application for its treatment: aspirin modulation of IgE-dependent mast cell activation: role of aspirin-induced exacerbation of immediate allergy. | 2009 | J. Pharmacol. Sci. | pmid:19609060 |
| Mochizuki Y et al. | Suppressive activity of epinastine hydrochloride on eosinophil activation in vitro. | 2008 Jan-Feb | In Vivo | pmid:18396776 |
| Lecca D et al. | The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. | 2008 | PLoS ONE | pmid:18974869 |
| Mueller CF et al. | Multidrug resistance protein-1 affects oxidative stress, endothelial dysfunction, and atherogenesis via leukotriene C4 export. | 2008 | Circulation | pmid:18506003 |
| Ma KF et al. | Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model. | 2008 | World J. Gastroenterol. | pmid:18461660 |
| Kirshenbaum AS et al. | Effect of lipopolysaccharide (LPS) and peptidoglycan (PGN) on human mast cell numbers, cytokine production, and protease composition. | 2008 | BMC Immunol. | pmid:18687131 |
| Mishra NC et al. | Nicotine primarily suppresses lung Th2 but not goblet cell and muscle cell responses to allergens. | 2008 | J. Immunol. | pmid:18490768 |
| Yang R et al. | Interaction between the bound Mg.ATP and the Walker A serine residue in NBD2 of multidrug resistance-associated protein MRP1 plays a crucial role for the ATP-dependent leukotriene C4 transport. | 2008 | Biochemistry | pmid:18636743 |
| Marchan R et al. | Multidrug resistance-associated protein 1 as a major mediator of basal and apoptotic glutathione release. | 2008 | Biochim. Biophys. Acta | pmid:18621020 |
| Reichel V et al. | Texas Red transport across rat and dogfish shark (Squalus acanthias) choroid plexus. | 2008 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:18650317 |
| Rothnie A et al. | Mechanistic differences between GSH transport by multidrug resistance protein 1 (MRP1/ABCC1) and GSH modulation of MRP1-mediated transport. | 2008 | Mol. Pharmacol. | pmid:18768387 |
| Grant CE et al. | Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3). | 2008 | Drug Metab. Dispos. | pmid:18775981 |
| Tan Y and Lim LH | trans-Resveratrol, an extract of red wine, inhibits human eosinophil activation and degranulation. | 2008 | Br. J. Pharmacol. | pmid:18776917 |
| Chang WC et al. | Local Ca2+ influx through Ca2+ release-activated Ca2+ (CRAC) channels stimulates production of an intracellular messenger and an intercellular pro-inflammatory signal. | 2008 | J. Biol. Chem. | pmid:18156181 |
| Blokzijl H et al. | Up-regulation and cytoprotective role of epithelial multidrug resistance-associated protein 1 in inflammatory bowel disease. | 2008 | J. Biol. Chem. | pmid:18838379 |
| Wang W et al. | Mechanistic study of potentiation of chemotherapy by a haloenol lactone derivative in vitro. | 2008 | Cancer Chemother. Pharmacol. | pmid:17899085 |
| Yang SH and Yu CL | Antiinflammatory effects of Bu-zhong-yi-qi-tang in patients with perennial allergic rhinitis. | 2008 | J Ethnopharmacol | pmid:17980528 |
| Hattori Y et al. | Gastric mucosal protection against ethanol by EP2 and EP4 signaling through the inhibition of leukotriene C4 production. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17947453 |
| Slot AJ et al. | Modulation of human multidrug resistance protein (MRP) 1 (ABCC1) and MRP2 (ABCC2) transport activities by endogenous and exogenous glutathione-conjugated catechol metabolites. | 2008 | Drug Metab. Dispos. | pmid:18079363 |
| Devakumar A et al. | Structural analysis of leukotriene C4 isomers using collisional activation and 157 nm photodissociation. | 2008 | J. Am. Soc. Mass Spectrom. | pmid:18024058 |