| MeSH term | MeSH ID | Detail |
|---|---|---|
| Airway Obstruction | D000402 | 13 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Autoimmune Diseases | D001327 | 27 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Reperfusion Injury | D015427 | 65 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Alvarenga PH et al. | The function and three-dimensional structure of a thromboxane A2/cysteinyl leukotriene-binding protein from the saliva of a mosquito vector of the malaria parasite. | 2010 | PLoS Biol. | pmid:21152418 |
| Kawamura F et al. | Effects of menadione, a reactive oxygen generator, on leukotriene secretion from RBL-2H3 cells. | 2010 | Biol. Pharm. Bull. | pmid:20460770 |
| Houssen ME et al. | Natural anti-inflammatory products and leukotriene inhibitors as complementary therapy for bronchial asthma. | 2010 | Clin. Biochem. | pmid:20430018 |
| Kitahata Y et al. | Prolonged culture of mast cells with high-glucose medium enhances the Fc epsilon RI-mediated degranulation response and leukotriene C4 production. | 2010 | Int. Arch. Allergy Immunol. | pmid:20523060 |
| Borrelli I et al. | Benzene metabolites inhibit the release of proinflammatory mediators and cytokines from human basophils. | 2010 Jul-Sep | Int J Immunopathol Pharmacol | pmid:20943043 |
| Huang SC | Leukotriene-induced contraction is mediated by cysteinyl leukotriene receptor CysLT1 in guinea pig fundus but by CysLT1 and CysLT2 in antrum. | 2011 | Life Sci. | pmid:21396378 |
| Hung ND et al. | Oral administration of 2-docosahexaenoyl lysophosphatidylcholine displayed anti-inflammatory effects on zymosan A-induced peritonitis. | 2011 | Inflammation | pmid:20490641 |
| Mackay GA and Stewart AG | R2D(2) for C(4)Eo: an 'alliance' of PGD(2) receptors is required for LTC(4) production by human eosinophils. | 2011 | Br. J. Pharmacol. | pmid:21426314 |
| Shaari K et al. | Bioassay-guided identification of an anti-inflammatory prenylated acylphloroglucinol from Melicope ptelefolia and molecular insights into its interaction with 5-lipoxygenase. | 2011 | Bioorg. Med. Chem. | pmid:21958738 |
| Mesquita-Santos FP et al. | Co-operative signalling through DP(1) and DP(2) prostanoid receptors is required to enhance leukotriene C(4) synthesis induced by prostaglandin D(2) in eosinophils. | 2011 | Br. J. Pharmacol. | pmid:20973774 |
| Lu Y et al. | Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation. | 2011 | Biochem. Pharmacol. | pmid:21907188 |
| He P et al. | Oxidative stress suppresses cysteinyl leukotriene generation by mouse bone marrow-derived mast cells. | 2011 | J. Biol. Chem. | pmid:21233206 |
| Aung G et al. | Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines. | 2011 | Immunology | pmid:21214543 |
| Oh YC et al. | Anti-allergic effects of sinomenine by inhibition of prostaglandin Dâ‚‚ and leukotriene Câ‚„ in mouse bone marrow-derived mast cells. | 2011 | Immunopharmacol Immunotoxicol | pmid:21080779 |
| Hung ND et al. | Mechanisms for anti-inflammatory effects of 1-[15(S)-hydroxyeicosapentaenoyl] lysophosphatidylcholine, administered intraperitoneally, in zymosan A-induced peritonitis. | 2011 | Br. J. Pharmacol. | pmid:21091644 |
| Kim SJ et al. | Manassantin A isolated from Saururus chinensis inhibits 5-lipoxygenase-dependent leukotriene C4 generation by blocking mitogen-activated protein kinase activation in mast cells. | 2011 | Biol. Pharm. Bull. | pmid:22040894 |
| Carnini C et al. | Synthesis of cysteinyl leukotrienes in human endothelial cells: subcellular localization and autocrine signaling through the CysLT2 receptor. | 2011 | FASEB J. | pmid:21753081 |
| Al-Amran FG et al. | Leukotriene biosynthesis inhibition ameliorates acute lung injury following hemorrhagic shock in rats. | 2011 | J Cardiothorac Surg | pmid:21649921 |
| Jin M et al. | Anti-inflammatory activity of 6-hydroxy-2,7-dimethoxy-1,4-henanthraquinone from tuberous roots of yam (Dioscorea batatas) through inhibition of prostaglandin Dâ‚‚ and leukotriene Câ‚„ production in mouse bone marrow-derived mast cells. | 2011 | Arch. Pharm. Res. | pmid:21975811 |
| Dartt DA et al. | Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation. | 2011 | J. Immunol. | pmid:21357260 |