Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Wang M et al. | The Responses of Pulmonary and Systemic Circulation and Airway to Allergic Mediators in Anesthetized Rats. | 2016 | Biol. Pharm. Bull. | pmid:27040628 |
Kar P et al. | Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca2+ Signals. | 2016 | Mol. Cell | pmid:27863227 |
Neprasova M et al. | Toward Noninvasive Diagnosis of IgA Nephropathy: A Pilot Urinary Metabolomic and Proteomic Study. | 2016 | Dis. Markers | pmid:27799660 |
Lukic A et al. | Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4 to leukotriene D4. | 2016 | J. Lipid Res. | pmid:27436590 |
Russell RL et al. | Arachidonic acid pathway alterations in cerebrospinal fluid of dogs with naturally occurring spinal cord injury. | 2016 | BMC Neurosci | pmid:27287721 |
Guo T et al. | Protective Effect of an Antibody against Specific Extracellular Domain of TLR2 on Agonists-Driven Inflammatory and Allergic Response. | 2016 | Biomed Res Int | pmid:27213155 |
Wang M et al. | The responses of pulmonary and systemic circulation and airway to anaphylactic mediators in anesthetized BALB/c mice. | 2016 | Life Sci. | pmid:26808090 |
Piotrowska-Tomala KK et al. | Lipopolysaccharides, cytokines, and nitric oxide affect secretion of prostaglandins and leukotrienes by bovine mammary gland during experimentally induced mastitis in vivo and in vitro. | 2015 | Domest. Anim. Endocrinol. | pmid:25935895 |
Xiao J et al. | Cyclooxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury. | 2015 | Toxicol. Sci. | pmid:25432964 |
Dvash E et al. | Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage. | 2015 | Nat Commun | pmid:26656251 |