Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Dichlberger A et al. | Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells. | 2014 | J. Lipid Res. | pmid:25114172 |
Xiang Y et al. | Anti-inflammatory effect of acetylpuerarin on eicosanoid signaling pathway in primary rat astrocytes. | 2014 | J. Mol. Neurosci. | pmid:24026619 |
Bertin J et al. | Exposure of human astrocytes to leukotriene C4 promotes a CX3CL1/fractalkine-mediated transmigration of HIV-1-infected CD4⺠T cells across an in vitro blood-brain barrier model. | 2014 | Virology | pmid:24725939 |
Zhang X et al. | Complex role of STIM1 in the activation of store-independent Orai1/3 channels. | 2014 | J. Gen. Physiol. | pmid:24567509 |
Pinho BR et al. | Modulation of basophils' degranulation and allergy-related enzymes by monomeric and dimeric naphthoquinones. | 2014 | PLoS ONE | pmid:24587235 |
Linares Segovia B et al. | Parameters of lung inflammation in asthmatic as compared to healthy children in a contaminated city. | 2014 | BMC Pulm Med | pmid:25000942 |
Cole SP | Multidrug resistance protein 1 (MRP1, ABCC1), a "multitasking" ATP-binding cassette (ABC) transporter. | 2014 | J. Biol. Chem. | pmid:25281745 |
Lee JF et al. | Lipoxygenase pathway mediates increases of airway resistance and lung inflation induced by exposure to nanotitanium dioxide in rats. | 2014 | Oxid Med Cell Longev | pmid:24693335 |
Piotrowska-Tomala KK et al. | Lipopolysaccharides, cytokines, and nitric oxide affect secretion of prostaglandins and leukotrienes by bovine mammary gland during experimentally induced mastitis in vivo and in vitro. | 2015 | Domest. Anim. Endocrinol. | pmid:25935895 |
Dvash E et al. | Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage. | 2015 | Nat Commun | pmid:26656251 |