LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Phlebitis D010689 1 associated lipids
Pseudoxanthoma Elasticum D011561 2 associated lipids
Common Bile Duct Diseases D003137 3 associated lipids
Cestode Infections D002590 3 associated lipids
Hyperbilirubinemia, Hereditary D006933 3 associated lipids
Neointima D058426 3 associated lipids
Eosinophilic Esophagitis D057765 3 associated lipids
Status Asthmaticus D013224 4 associated lipids
Wounds, Nonpenetrating D014949 4 associated lipids
Eosinophilia D004802 4 associated lipids
Insect Bites and Stings D007299 4 associated lipids
Picornaviridae Infections D010850 4 associated lipids
Mesenteric Vascular Occlusion D008641 4 associated lipids
Rhinitis, Allergic, Perennial D012221 6 associated lipids
Periapical Periodontitis D010485 6 associated lipids
Rhinitis, Allergic, Seasonal D006255 7 associated lipids
Pneumococcal Infections D011008 7 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Ear Diseases D004427 7 associated lipids
Asbestosis D001195 8 associated lipids
Carotid Artery Injuries D020212 8 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Myocardial Ischemia D017202 11 associated lipids
Hyperbilirubinemia D006932 11 associated lipids
Acute-Phase Reaction D000210 12 associated lipids
Airway Obstruction D000402 13 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
Uveitis D014605 14 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Pulmonary Disease, Chronic Obstructive D029424 16 associated lipids
Ulcer D014456 16 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Cough D003371 19 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Carcinoma, Small Cell D018288 21 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Nasal Polyps D009298 26 associated lipids
Angina Pectoris D000787 27 associated lipids
Gastritis D005756 27 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Drug Eruptions D003875 30 associated lipids
Burns D002056 34 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Glomerulonephritis D005921 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Peritonitis D010538 38 associated lipids
Arthritis D001168 41 associated lipids
Hypotension D007022 41 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Osteosarcoma D012516 50 associated lipids
Asthma D001249 52 associated lipids
Reperfusion Injury D015427 65 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Colitis D003092 69 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Leukemia D007938 74 associated lipids
Stomach Ulcer D013276 75 associated lipids
Atherosclerosis D050197 85 associated lipids
Brain Ischemia D002545 89 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Glioma D005910 112 associated lipids
Inflammation D007249 119 associated lipids
Edema D004487 152 associated lipids
Lung Neoplasms D008175 171 associated lipids
Body Weight D001835 333 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

Download all related citations
Per page 10 20 50 100 | Total 1173
Authors Title Published Journal PubMed Link
Diven WF et al. Expression of acute otitis media after receptor blockade of platelet activating factor, thromboxane, and leukotrienes in the chinchilla. 1998 Ann. Otol. Rhinol. Laryngol. pmid:9525240
Black P et al. Chemotherapy in experimental brain tumor, part 2: pretreatment with leukotriene C4 prolongs survival. 1998 J. Neurooncol. pmid:9525821
Capra V et al. Identification and characterization of two cysteinyl-leukotriene high affinity binding sites with receptor characteristics in human lung parenchyma. 1998 Mol. Pharmacol. pmid:9547367
Brady HR et al. Transcellular pathways and cell adhesion as potential contributors to leukotriene and lipoxin biosynthesis in acute glomerulonephritis. 1997 Adv. Exp. Med. Biol. pmid:9547614
Sperber K et al. Mucin secretion in inflammatory bowel disease: comparison of a macrophage-derived mucin secretagogue (MMS-68) to conventional secretagogues. 1998 Inflamm. Bowel Dis. pmid:9552223
Gao M et al. Multidrug resistance protein. Identification of regions required for active transport of leukotriene C4. 1998 J. Biol. Chem. pmid:9553138
Scheidegger C et al. Effects of extracts and of individual components from Petasites on prostaglandin synthesis in cultured skin fibroblasts and on leucotriene synthesis in isolated human peripheral leucocytes. 1998 Pharm Acta Helv pmid:9556438
Sabbah A et al. [Testing basophil activation by flow cytometry in the diagnosis of allergy to hymenopteran venom]. 1998 Allerg Immunol (Paris) pmid:9559061
Cyrus CB et al. Leukotrienes C4 and D4 increase the ciliary beat frequency in human upper airway mucosa in vitro. 1998 Otolaryngol Head Neck Surg pmid:9560097
Herman CA et al. Synthesis and action of eicosanoids in warm and cold-acclimated amphibians. 1997 Adv. Exp. Med. Biol. pmid:9561172
Sporn PH et al. Keratinocyte growth factor increases LTC4 synthesis and expression of flap in cultured rat alveolar type II cells. 1997 Adv. Exp. Med. Biol. pmid:9561179
Shindo K et al. Prednisolone inhibits synthesis of 5-H(P)ETE in eosinophils from asthmatic patients during a wheezing attack but not during remission. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9578148
Kobayashi H et al. Urinary trypsin inhibitor reduces the release of histamine from rat peritoneal mast cells. 1998 J. Lab. Clin. Med. pmid:9579392
McAlexander MA et al. Inhibition of 5-lipoxygenase diminishes neurally evoked tachykinergic contraction of guinea pig isolated airway. 1998 J. Pharmacol. Exp. Ther. pmid:9580604
Jonsson EW Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle. 1998 Acta Physiol Scand Suppl pmid:9597121
Obukowicz MG et al. Identification and characterization of a novel delta6/delta5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent. 1998 Biochem. Pharmacol. pmid:9605428
Sato E et al. Acetylcholine stimulates alveolar macrophages to release inflammatory cell chemotactic activity. 1998 Am. J. Physiol. pmid:9609736
van Aubel RA et al. Adenosine triphosphate-dependent transport of anionic conjugates by the rabbit multidrug resistance-associated protein Mrp2 expressed in insect cells. 1998 Mol. Pharmacol. pmid:9614209
Kusuhara H et al. Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line. 1998 J. Pharmacol. Exp. Ther. pmid:9618431
Li L et al. Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter. 1998 J. Biol. Chem. pmid:9632674
Allen S et al. Differential leukotriene constrictor responses in human atherosclerotic coronary arteries. 1998 Circulation pmid:9641692
Koshino T et al. Expression of 5-lipoxygenase and 5-lipoxygenase-activating protein mRNAs in the peripheral blood leukocytes of asthmatics. 1998 Biochem. Biophys. Res. Commun. pmid:9642160
Peters-Golden M Cell biology of the 5-lipoxygenase pathway. 1998 Am. J. Respir. Crit. Care Med. pmid:9647604
Priebe W et al. Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump. 1998 Biochem. Biophys. Res. Commun. pmid:9647783
Nagata M et al. Granulocyte macrophage colony-stimulating factor augments ICAM-1 and VCAM-1 activation of eosinophil function. 1998 Am. J. Respir. Cell Mol. Biol. pmid:9651192
Hamasaki Y et al. Inhibition of leukotriene synthesis by terfenadine in vitro. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9654399
Schuligoi R et al. Effects of the cyclooxygenase-2 inhibitor NS-398 on thromboxane and leukotriene synthesis in rat peritoneal cells. 1998 Inflamm. Res. pmid:9657255
Pfau JC et al. A comparison of the effects of lipopolysaccharide and ceramide on arachidonic acid metabolism in THP-1 monocytic cells. 1998 Cell. Immunol. pmid:9665757
Mitsunobu F et al. Different roles of histamine and leukotriene C4 in the airways between patients with atopic and nonatopic asthma. 1998 J Asthma pmid:9669831
Lukaszyk A et al. The role of epidermal growth factor in platelet-endothelium interactions. 1998 J. Physiol. Pharmacol. pmid:9670106
Stenke L et al. Novel enzymatic abnormalities in AML and CML in blast crisis: elevated leucocyte leukotriene C4 synthase activity paralleled by deficient leukotriene biosynthesis from endogenous substrate. 1998 Br. J. Haematol. pmid:9674747
Akman A et al. Effects of lodoxamide, disodium cromoglycate and fluorometholone on tear leukotriene levels in vernal keratoconjunctivitis. 1998 Eye (Lond) pmid:9683957
Iikura M et al. Secretory IgA induces degranulation of IL-3-primed basophils. 1998 J. Immunol. pmid:9686618
Lebel B et al. Inhibition of mediator release from dispersed nasal polyp cells by cyclosporin A. 1998 Int. Arch. Allergy Immunol. pmid:9693278
Keppler D et al. Transport function and substrate specificity of multidrug resistance protein. 1998 Meth. Enzymol. pmid:9711586
Ishihara K et al. Inhibition of icosanoid production in MC/9 mouse mast cells by n-3 polyunsaturated fatty acids isolated from edible marine algae. 1998 Biosci. Biotechnol. Biochem. pmid:9720225
Miller DS et al. Excretory transport of xenobiotics by dogfish shark rectal gland tubules. 1998 Am. J. Physiol. pmid:9728065
Geirsson A et al. Potentiating effects of pertussis toxin on leukotriene C4 induced formation of inositol phosphate and prostacyclin in human umbilical vein endothelial cells. 1998 J. Cell. Physiol. pmid:9731750
Nishida M et al. Lack of active lung anaphylaxis in congenitally mast cell-deficient Ws/Ws rats sensitized with the nematode Nippostrongylus brasiliensis. 1998 APMIS pmid:9740510
Amat M et al. Leukotriene A4 hydrolase and leukotriene C4 synthase activities in human chondrocytes: transcellular biosynthesis of Leukotrienes during granulocyte-chondrocyte interaction. 1998 Arthritis Rheum. pmid:9751098
Wen FQ et al. Eicosanoid profile in cultured human pulmonary artery smooth muscle cells treated with IL-1 beta and TNF alpha. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9758210
Bermejo Benito P et al. In vivo and in vitro antiinflammatory activity of saikosaponins. 1998 Life Sci. pmid:9763210
Miura K et al. Phosphorylation of cytosolic phospholipase A2 by IL-3 is associated with increased free arachidonic acid generation and leukotriene C4 release in human basophils. 1998 J. Allergy Clin. Immunol. pmid:9768595
Carter BZ et al. gamma-glutamyl leukotrienase, a gamma-glutamyl transpeptidase gene family member, is expressed primarily in spleen. 1998 J. Biol. Chem. pmid:9774450
Nakano R et al. A leukotriene receptor antagonist, ONO-1078, modulates drug sensitivity and leukotriene C4 efflux in lung cancer cells expressing multidrug resistance protein. 1998 Biochem. Biophys. Res. Commun. pmid:9790952
Bartosz G et al. Human mast cells secreting leukotriene C4 express the MRP1 gene-encoded conjugate export pump. 1998 Aug-Sep Biol. Chem. pmid:9792445
Templeton AG et al. Effects of S-salbutamol on human isolated bronchus. 1998 Pulm Pharmacol Ther pmid:9802957
Ohtsuka Y et al. Chronic oral antigen exposure induces lymphocyte migration in anaphylactic mouse intestine. 1998 Pediatr. Res. pmid:9803464
Matsushita N et al. Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antiasthmatic effects. 1998 Jpn. J. Pharmacol. pmid:9804057
Sciuto AM et al. Post-exposure treatment with isoproterenol attenuates pulmonary edema in phosgene-exposed rabbits. 1998 Sep-Oct J Appl Toxicol pmid:9804432
Yatabe T et al. Studies on 5-lipoxygenase inhibitors. II. Discovery, optical resolution and enantioselective synthesis of FR110302, a highly potent non-redox type 5-lipoxygenase inhibitor. 1998 Chem. Pharm. Bull. pmid:9810693
Wei EQ et al. Effect of ONO-1078, a leukotriene antagonist, on capsaicin- and substance P-induced bronchoconstriction and airway microvascular leakage in guinea pigs. 1996 Zhongguo Yao Li Xue Bao pmid:9812736
Yamane Y et al. Expression of multidrug resistance protein/GS-X pump and gamma-glutamylcysteine synthetase genes is regulated by oxidative stress. 1998 J. Biol. Chem. pmid:9813007
Kjellström S et al. On-line coupling of microdialysis sampling with liquid chromatography for the determination of peptide and non-peptide leukotrienes. 1998 J Chromatogr A pmid:9818423
Mayatepek E and Flock B Leukotriene C4-synthesis deficiency: a new inborn error of metabolism linked to a fatal developmental syndrome. 1998 Lancet pmid:9820300
Takafuji S et al. Release of granule proteins from human eosinophils stimulated with mast-cell mediators. 1998 Allergy pmid:9821474
Bakos E et al. Functional multidrug resistance protein (MRP1) lacking the N-terminal transmembrane domain. 1998 J. Biol. Chem. pmid:9822694
Chu XY et al. Biliary excretion mechanism of CPT-11 and its metabolites in humans: involvement of primary active transporters. 1998 Cancer Res. pmid:9823324
Horizoe T et al. ER-34122, a novel dual 5-lipoxygenase/cyclooxygenase inhibitor with potent anti-inflammatory activity in an arachidonic acid-induced ear inflammation model. 1998 Inflamm. Res. pmid:9831321
Ohashi H et al. Sulochrin inhibits eosinophil activation and chemotaxis. 1998 Inflamm. Res. pmid:9831326
Haberl C et al. Release of prostaglandin D2 by murine mast cells: importance of metabolite formation for antiproliferative activity. 1998 Mediators Inflamm. pmid:9836493
Anadol AZ et al. Role of endogenous endothelin peptides in intestinal ischemia-reperfusion injury in rats. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9849655
Wu RY and Wei EQ [Inhibitory effects of tachykinin receptor antagonists on leukotriene C4-induced cardiovascular responses in guinea pigs]. 1996 Yao Xue Xue Bao pmid:9863223
Suzuki H and Sugiyama Y Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2. 1998 Semin. Liver Dis. pmid:9875554
Tsuruta R et al. Soluble vascular cell adhesion molecule (VCAM)-Fc fusion protein induces leukotriene C4 secretion in platelet-activating factor-stimulated eosinophils. 1999 J. Leukoc. Biol. pmid:9886248
Bannenberg G et al. Leukotriene C4 is a tight-binding inhibitor of microsomal glutathione transferase-1. Effects of leukotriene pathway modifiers. 1999 J. Biol. Chem. pmid:9890956
Akpek EA et al. A study of adenosine treatment in experimental acute spinal cord injury. Effect on arachidonic acid metabolites. 1999 Spine pmid:9926381
Ochensberger B et al. Regulation of cytokine expression and leukotriene formation in human basophils by growth factors, chemokines and chemotactic agonists. 1999 Eur. J. Immunol. pmid:9933081
Lärfars G et al. Activation of nitric oxide release and oxidative metabolism by leukotrienes B4, C4, and D4 in human polymorphonuclear leukocytes. 1999 Blood pmid:9949184
Mayatepek E et al. LTB4 and LTC4 are absent in the cerebrospinal fluid of human immunodeficiency virus type 1-seropositive persons with toxoplasmic encephalitis: evidence for inhibition of 5-lipoxygenase by Toxoplasma gondii. 1999 J. Infect. Dis. pmid:9952384
Brock TG et al. Decreased leukotriene C4 synthesis accompanies adherence-dependent nuclear import of 5-lipoxygenase in human blood eosinophils. 1999 J. Immunol. pmid:9973428
Urasaki T et al. Cytosolic phospholipase A2, increased and activated in the eosinophils of patients with hypereosinophilic syndrome in vivo, is involved in the augmented release of leukotriene C4. 1999 Inflamm. Res. pmid:9987681
Moneret-Vautrin DA et al. Human basophil activation measured by CD63 expression and LTC4 release in IgE-mediated food allergy. 1999 Ann. Allergy Asthma Immunol. pmid:9988204