Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Murakami M et al. | The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase. | 1995 | J. Exp. Med. | pmid:7540649 |
Gimpel JA et al. | Reduction of reperfusion injury of human myocardium by allopurinol: a clinical study. | 1995 | Free Radic. Biol. Med. | pmid:7649495 |
Porreca E et al. | Modulation of rat vascular smooth muscle cell (VSMC) proliferation by cysteinyl leukotriene D4: a role for mediation of interleukin 1. | 1995 | Atherosclerosis | pmid:7755646 |
Lam BK et al. | Expression cloning of human LTC4 synthase. | 1995 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:7732869 |
Cruz JR et al. | Fecal excretion of leukotriene C4 during human disease due to Shigella dysenteriae. | 1995 | J. Pediatr. Gastroenterol. Nutr. | pmid:7714683 |
Nishikawa M et al. | Effect of leukotriene C4D4 antagonist on colonic damage induced by intracolonic administration of trinitrobenzene sulfonic acid in rats. | 1995 | J. Gastroenterol. | pmid:7719412 |
Kita H et al. | Eosinophil major basic protein induces degranulation and IL-8 production by human eosinophils. | 1995 | J. Immunol. | pmid:7722326 |
Iwamoto I et al. | Effect of a selective thromboxane A2 receptor antagonist BAY u3405 on antigen-, leukotriene C4- and leukotriene D4-induced bronchoconstriction in guinea pigs. | 1995 | Int. Arch. Allergy Immunol. | pmid:7647588 |
Sun J and Herman CA | Cardiovascular effects of N-methyl leukotriene C4, a nonmetabolizable leukotriene C4 analogue, and the antagonism of leukotriene-induced hypotension by Ro 23-3544, in the American bullfrog, Rana catesbeiana. | 1995 | Can. J. Physiol. Pharmacol. | pmid:7648518 |
Laviolette M et al. | Blood eosinophil leukotriene C4 production in asthma of different severities. | 1995 | Eur. Respir. J. | pmid:8575570 |
Hong JT et al. | Effect of phenobarbital and the peroxisome proliferator ciprofibrate on gamma-Glutamyltranspeptidase activity and leukotriene C4 concentration in cultured rat hepatocytes. | 1995 | J. Biochem. Toxicol. | pmid:8847705 |
Schäfer S and Walland A | Staurosporine inhibits the effects of leukotrienes C4 and D4 in isolated guinea pig heart and trachea. | 1995 | Methods Find Exp Clin Pharmacol | pmid:8577209 |
Shimizu T et al. | Leukotriene B4 and C4 metabolism in small intestine mucosa of children with celiac disease. | 1995 | J. Pediatr. Gastroenterol. Nutr. | pmid:8583294 |
Wang H et al. | Regulation of anti-SRBC antibody production by opioids and their mechanisms. | 1995 | Chin. Med. Sci. J. | pmid:8580479 |
Sato H et al. | Biological characteristics of chronic eosinophilic leukemia cells with a t(2;5)(p23;q35) translocation. | 1995 | Leuk. Lymphoma | pmid:8590853 |
Petric R et al. | Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis. | 1995 | Biochim. Biophys. Acta | pmid:7827126 |
Ju HR et al. | Systemic release of mucosal mast-cell protease in primed brown Norway rats after feeding with beta-lactoglobulin. | 1995 | Biosci. Biotechnol. Biochem. | pmid:7787291 |
RodrÃguez-Ortigosa CM et al. | Taurocholate-stimulated leukotriene C4 biosynthesis and leukotriene C4-stimulated choleresis in isolated rat liver. | 1995 | Gastroenterology | pmid:7768385 |
Tschugguel W et al. | High precision measurement of electrical resistance across endothelial cell monolayers. | 1995 | Pflugers Arch. | pmid:7667075 |
Miadonna A et al. | Antiallergic activity of loratadine: inhibition of leukotriene C4 release from human leucocytes. | 1995 | Clin. Exp. Allergy | pmid:7541309 |
Kristjánsson S et al. | Leukotriene B4 and C4 generation by human leukocytes after ex vivo stimulation with Ca-ionophore and opsonized zymosan in children with atopic asthma. | 1995 | Pediatr Allergy Immunol | pmid:8750311 |
Tornhamre S et al. | Receptor-mediated regulation of leukotriene C4 synthase activity in human platelets. | 1995 | Eur. J. Biochem. | pmid:8536697 |
Brandenburg K et al. | Conformation and fluidity of endotoxins as determinants of biological activity. | 1995 | Prog. Clin. Biol. Res. | pmid:8524923 |
Fiore S and Serhan CN | Lipoxin A4 receptor activation is distinct from that of the formyl peptide receptor in myeloid cells: inhibition of CD11/18 expression by lipoxin A4-lipoxin A4 receptor interaction. | 1995 | Biochemistry | pmid:8527441 |
Kawana S and Nishiyama S | Pustular psoriasis and aseptic purulent arthritis: possible role of leukotrienes B4 and C4 in a flare of synovitis. | 1995 | Dermatology (Basel) | pmid:7894093 |
Wang D et al. | Correlations between complaints, inflammatory cells and mediator concentrations in nasal secretions after nasal allergen challenge and during natural allergen exposure. | 1995 | Int. Arch. Allergy Immunol. | pmid:7888790 |
Egger D et al. | IL-4 renders mast cells functionally responsive to endothelin-1. | 1995 | J. Immunol. | pmid:7530742 |
Grønbech JE and Lacy ER | Role of gastric blood flow in impaired defense and repair of aged rat stomachs. | 1995 | Am. J. Physiol. | pmid:7491966 |
Ochensberger B et al. | IgE-independent interleukin-4 expression and induction of a late phase of leukotriene C4 formation in human blood basophils. | 1995 | Blood | pmid:7492759 |
Culo F et al. | Ketoconazole inhibits acetaminophen-induced hepatotoxicity in mice. | 1995 | Eur J Gastroenterol Hepatol | pmid:7496865 |
Sjölinder M et al. | Phorbol ester-induced suppression of leukotriene C4 synthase activity in human granulocytes. | 1995 | FEBS Lett. | pmid:8543026 |
Miyamasu M et al. | Chemotactic agonists induce cytokine generation in eosinophils. | 1995 | J. Immunol. | pmid:7529800 |
Horikawa T et al. | Melanocyte mitogens induce both melanocyte chemokinesis and chemotaxis. | 1995 | J. Invest. Dermatol. | pmid:7530272 |
Murakami M et al. | Interleukin-3 regulates development of the 5-lipoxygenase/leukotriene C4 synthase pathway in mouse mast cells. | 1995 | J. Biol. Chem. | pmid:7559381 |
Kurokawa H et al. | Gamma-glutamylcysteine synthetase gene overexpression results in increased activity of the ATP-dependent glutathione S-conjugate export pump and cisplatin resistance. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7488097 |
Low J et al. | Cytoprotective effects of CI-959 in the rat gastric mucosa: modulation of leukocyte adhesion. | 1995 | Gastroenterology | pmid:7557089 |
Sampson AP et al. | Persistent increase in plasma and urinary leukotrienes after acute asthma. | 1995 | Arch. Dis. Child. | pmid:7492159 |
Restrick LJ et al. | Reduction in leukotriene B4 generation by bronchoalveolar lavage cells in asthma. | 1995 | Thorax | pmid:7886653 |
Tsai JJ et al. | Relationship between nasal resistance and airway hyperreactivity following nasal provocation with Dermatophagoides pteronyssinus in allergic rhinitis. | 1995 | Int. Arch. Allergy Immunol. | pmid:7888791 |
De Castro CM et al. | Modulation by dexamethasone of phospholipase A2 activities in endotoxemic guinea pigs. | 1995 | J. Appl. Physiol. | pmid:8567572 |
Datta YH et al. | Peptido-leukotrienes are potent agonists of von Willebrand factor secretion and P-selectin surface expression in human umbilical vein endothelial cells. | 1995 | Circulation | pmid:7586318 |
Sengör T et al. | Tear LTC4 levels in patients with subclinical contact lens related giant papillary conjunctivitis. | 1995 | CLAO J | pmid:7586473 |
Sala A and Folco G | LTC4 in normal urine. | 1995 | Eur. J. Clin. Invest. | pmid:7589021 |
Schauer U et al. | Blood eosinophils, eosinophil-derived proteins, and leukotriene C4 generation in relation to bronchial hyperreactivity in children with atopic dermatitis. | 1995 | Allergy | pmid:7604934 |
Herron DK et al. | Visualization and comparison of molecular dynamics simulations of leukotriene C4, leukotriene D4, and leukotriene E4. | 1995 | J Mol Graph | pmid:8820302 |
Juergens UR et al. | Inhibition of monocyte leukotriene B4 production after aspirin desensitization. | 1995 | J. Allergy Clin. Immunol. | pmid:7636051 |
Gorenne I et al. | Effects of beta 2-adrenoceptor agonists on anti-IgE-induced contraction and smooth muscle reactivity in human airways. | 1995 | Br. J. Pharmacol. | pmid:7780648 |
Karmeli F et al. | A stable nitroxide radical effectively decreases mucosal damage in experimental colitis. | 1995 | Gut | pmid:7590435 |
Utoh J et al. | Is an increase in neutrophil leukotriene-generating capacity a specific phenomenon for cardiopulmonary bypass? | 1995 | J. Thorac. Cardiovasc. Surg. | pmid:7609558 |
Janssen-Timmen U et al. | Expression of 5-lipoxygenase in differentiating human skin keratinocytes. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7624354 |