LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Frieling T et al. | Leukotriene-evoked cyclic chloride secretion is mediated by enteric neuronal modulation in guinea-pig colon. | 1997 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:9151302 |
| Takano T et al. | Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. | 1997 | J. Exp. Med. | pmid:9151906 |
| Pedersen KE et al. | Cysteinyl leukotrienes induce P-selectin expression in human endothelial cells via a non-CysLT1 receptor-mediated mechanism. | 1997 | J. Pharmacol. Exp. Ther. | pmid:9152370 |
| Abe T et al. | [Multidrug resistance protein (MRP)]. | 1997 | Nippon Rinsho | pmid:9155156 |
| Planquois JM et al. | Differential inhibition by selective phosphodiesterase inhibitors of antigen, LTC4 and histamine-induced contraction of guinea-pig isolated trachea. | 1996 | Pulm Pharmacol | pmid:9160414 |
| Hamasaki Y et al. | The Chinese herbal medicine, shinpi-to, inhibits IgE-mediated leukotriene synthesis in rat basophilic leukemia-2H3 cells. | 1997 | J Ethnopharmacol | pmid:9174973 |
| Akagi M et al. | Anti-allergic effect of tea-leaf saponin (TLS) from tea leaves (Camellia sinensis var. sinensis). | 1997 | Biol. Pharm. Bull. | pmid:9178940 |
| Genovese A et al. | Loratadine and desethoxylcarbonyl-loratadine inhibit the immunological release of mediators from human Fc epsilon RI+ cells. | 1997 | Clin. Exp. Allergy | pmid:9179431 |
| Leynadier F | [Drug allergies: value of the leucotriene C4 release test?]. | 1997 | Presse Med | pmid:9180883 |
| Forssmann U et al. | Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes. | 1997 | J. Exp. Med. | pmid:9182688 |
| Chavis C et al. | Leukotriene E4 plasma levels in adult asthmatic patients with variable disease severity. | 1997 | Allergy | pmid:9201374 |
| Patella V et al. | Heterogeneous effects of protamine on human mast cells and basophils. | 1997 | Br J Anaesth | pmid:9215027 |
| Sabbah A et al. | [Anaphylactic or anaphylactoid reactions to paracetamol. Report of 3 cases]. | 1997 | Allerg Immunol (Paris) | pmid:9221011 |
| Bacha EA et al. | Gastric antigen challenge releases gastrin and eicosanoids and protects against ethanol. | 1997 | J. Surg. Res. | pmid:9228931 |
| Ibe BO et al. | Leukotriene synthesis by isolated perinatal ovine intrapulmonary vessels correlates with age-related changes in 5-lipoxygenase protein. | 1997 | Biochem. Mol. Med. | pmid:9232199 |
| Sabbah A et al. | [Allergy to mosquitoes and use of new immunobiological parameters]. | 1997 | Allerg Immunol (Paris) | pmid:9254117 |
| Sainte-Laudy J et al. | [Bioclinical interest in the assay of leukotrienes in four cases of sensitization to trophallergens]. | 1997 | Allerg Immunol (Paris) | pmid:9254120 |
| Cunningham FM et al. | Pharmacology of the 5-lipoxygenase inhibitors BAY Y 1015 and BAY X 1005 in the horse. | 1997 | J. Vet. Pharmacol. Ther. | pmid:9280370 |
| Stride BD et al. | Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. | 1997 | Mol. Pharmacol. | pmid:9281595 |
| Hamasaki Y et al. | Post-transcriptional regulation of LTC4 synthase activity by retinoic acid in rat basophilic leukemia cells. | 1997 | Biochim. Biophys. Acta | pmid:9295165 |
| Jakobsson PJ et al. | Characterization of microsomal GST-II by western blot and identification of a novel LTC4 isomer. | 1997 | J Lipid Mediat Cell Signal | pmid:9302651 |
| Mullol J et al. | [Eosinophil activation by epithelial cells of the respiratory mucosa. Comparative study of normal mucosa and inflammatory mucosa]. | 1997 | Med Clin (Barc) | pmid:9303983 |
| Taichman RS et al. | Human osteosarcomas inhibit hematopoietic colony formation: partial reversal by antibody to transforming growth factor-beta 1. | 1997 | Bone | pmid:9315339 |
| Hsueh W et al. | Injurious and protective mechanisms in the gut. Interaction of PAF, phospholipase A2, eicosanoids, and nitric oxide synthase. | 1997 | Adv. Exp. Med. Biol. | pmid:9321977 |
| Chow JY et al. | The potentiating actions of cigarette smoking on ethanol-induced gastric mucosal damage in rats. | 1997 | Gastroenterology | pmid:9322514 |
| Bell RR et al. | Cadmium and/or selenium effects on guinea pig lung PGE2, TXB2 and LTC4. | 1997 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9344235 |
| Vigorito C et al. | Metabolic and hemodynamic effects of peptide leukotriene C4 and D4 in man. | 1997 | Int. J. Clin. Lab. Res. | pmid:9352380 |
| Jedlitschky G et al. | ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. | 1997 | Biochem. J. | pmid:9355767 |
| Wijnholds J et al. | Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. | 1997 | Nat. Med. | pmid:9359705 |
| Monahan J et al. | Attenuation of IL-5-mediated signal transduction, eosinophil survival, and inflammatory mediator release by a soluble human IL-5 receptor. | 1997 | J. Immunol. | pmid:9378992 |
| Keppler D et al. | The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes. | 1997 | Adv. Enzyme Regul. | pmid:9381978 |
| Hardcastle JE and Bruch RJ | Effect of L-aspartyl-L-phenylalanine methyl ester on leukotriene biosynthesis in macrophage cells. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9384524 |
| Bailey JM et al. | Activation of mitogen-induced T-lymphocyte proliferation by leukotriene C-4. | 1997 | Biochem. Soc. Trans. | pmid:9388724 |
| Zweiman B et al. | Nasal airway changes assessed by acoustic rhinometry and mediator release during immediate and late reactions to allergen challenge. | 1997 | J. Allergy Clin. Immunol. | pmid:9389292 |
| Gomi A et al. | Transient induction of the MRP/GS-X pump and gamma-glutamylcysteine synthetase by 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3- nitrosourea in human glioma cells. | 1997 | Cancer Res. | pmid:9393752 |
| Ohtsuka Y et al. | Reducing cell membrane n-6 fatty acids attenuate mucosal damage in food-sensitive enteropathy in mice. | 1997 | Pediatr. Res. | pmid:9396566 |
| Ito K et al. | Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver. | 1998 | J. Biol. Chem. | pmid:9430713 |
| Medina Avalos MA and Orea Solano M | [Macrophages in asthma]. | 1997 Sep-Oct | Rev Alerg Mex | pmid:9432275 |
| Brock TG et al. | Capacity for repeatable leukotriene generation after transient stimulation of mast cells and macrophages. | 1998 | Biochem. J. | pmid:9445378 |
| Dent G et al. | Protein kinase C inhibition enhances platelet-activating factor-induced eicosanoid production in human eosinophils. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9448055 |
| Cortijo J et al. | Bronchodilator and anti-inflammatory activities of SCA40: studies in human isolated bronchus, human eosinophils, and in the guinea-pig in vivo. | 1997 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:9453467 |
| Barnouin K et al. | Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated to glutathione. | 1998 | Br. J. Cancer | pmid:9460989 |
| Fadok VA et al. | Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. | 1998 | J. Clin. Invest. | pmid:9466984 |
| Fujita M et al. | Cysteinyl leukotrienes induce nasal symptoms of allergic rhinitis via a receptor-mediated mechanism in guinea pigs. | 1997 | Jpn. J. Pharmacol. | pmid:9469641 |
| Kitaura K et al. | Effects of organic anions and bile acid conjugates on biliary excretion of LTC4 in the rat. | 1997 | Prostaglandins | pmid:9491205 |
| Horak F et al. | Effect of continuous allergen challenge on clinical symptoms and mediator release in dust-mite-allergic patients. | 1998 | Allergy | pmid:9491231 |
| Lanas A et al. | Collagen secretion by human gastric and skin fibroblasts: implications for ulcer healing. | 1998 | Eur Surg Res | pmid:9493694 |
| Hundley TR et al. | Characteristics of arachidonic acid generation in human basophils: relationship between the effects of inhibitors of secretory phospholipase A2 activity and leukotriene C4 release. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9495842 |
| Daugschies A and Ruttkowski B | Modulation of migration of Oesophagostomum dentatum larvae by inhibitors and products of eicosanoid metabolism. | 1998 | Int. J. Parasitol. | pmid:9513001 |
| Geuenich S et al. | Induction of leukotriene production by bleomycin and asparaginase in mast cells in vitro and in patients in vivo. | 1998 | Biochem. Pharmacol. | pmid:9514079 |