Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Diven WF et al. | Expression of acute otitis media after receptor blockade of platelet activating factor, thromboxane, and leukotrienes in the chinchilla. | 1998 | Ann. Otol. Rhinol. Laryngol. | pmid:9525240 |
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Lanas A et al. | Collagen secretion by human gastric and skin fibroblasts: implications for ulcer healing. | 1998 | Eur Surg Res | pmid:9493694 |
Hundley TR et al. | Characteristics of arachidonic acid generation in human basophils: relationship between the effects of inhibitors of secretory phospholipase A2 activity and leukotriene C4 release. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9495842 |
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Kobayashi H et al. | Urinary trypsin inhibitor reduces the release of histamine from rat peritoneal mast cells. | 1998 | J. Lab. Clin. Med. | pmid:9579392 |
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McAlexander MA et al. | Inhibition of 5-lipoxygenase diminishes neurally evoked tachykinergic contraction of guinea pig isolated airway. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9580604 |
Scheidegger C et al. | Effects of extracts and of individual components from Petasites on prostaglandin synthesis in cultured skin fibroblasts and on leucotriene synthesis in isolated human peripheral leucocytes. | 1998 | Pharm Acta Helv | pmid:9556438 |
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Cyrus CB et al. | Leukotrienes C4 and D4 increase the ciliary beat frequency in human upper airway mucosa in vitro. | 1998 | Otolaryngol Head Neck Surg | pmid:9560097 |
Matsushita N et al. | Pharmacological studies on the novel antiallergic drug HQL-79: II. Elucidation of mechanisms for antiallergic and antiasthmatic effects. | 1998 | Jpn. J. Pharmacol. | pmid:9804057 |
Amat M et al. | Leukotriene A4 hydrolase and leukotriene C4 synthase activities in human chondrocytes: transcellular biosynthesis of Leukotrienes during granulocyte-chondrocyte interaction. | 1998 | Arthritis Rheum. | pmid:9751098 |
Suzuki H and Sugiyama Y | Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2. | 1998 | Semin. Liver Dis. | pmid:9875554 |
Nakano R et al. | A leukotriene receptor antagonist, ONO-1078, modulates drug sensitivity and leukotriene C4 efflux in lung cancer cells expressing multidrug resistance protein. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9790952 |
Yatabe T et al. | Studies on 5-lipoxygenase inhibitors. II. Discovery, optical resolution and enantioselective synthesis of FR110302, a highly potent non-redox type 5-lipoxygenase inhibitor. | 1998 | Chem. Pharm. Bull. | pmid:9810693 |
Yamane Y et al. | Expression of multidrug resistance protein/GS-X pump and gamma-glutamylcysteine synthetase genes is regulated by oxidative stress. | 1998 | J. Biol. Chem. | pmid:9813007 |
Miura K et al. | Phosphorylation of cytosolic phospholipase A2 by IL-3 is associated with increased free arachidonic acid generation and leukotriene C4 release in human basophils. | 1998 | J. Allergy Clin. Immunol. | pmid:9768595 |
Carter BZ et al. | gamma-glutamyl leukotrienase, a gamma-glutamyl transpeptidase gene family member, is expressed primarily in spleen. | 1998 | J. Biol. Chem. | pmid:9774450 |
Miller DS et al. | Excretory transport of xenobiotics by dogfish shark rectal gland tubules. | 1998 | Am. J. Physiol. | pmid:9728065 |
Geirsson A et al. | Potentiating effects of pertussis toxin on leukotriene C4 induced formation of inositol phosphate and prostacyclin in human umbilical vein endothelial cells. | 1998 | J. Cell. Physiol. | pmid:9731750 |
Anadol AZ et al. | Role of endogenous endothelin peptides in intestinal ischemia-reperfusion injury in rats. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9849655 |
Nishida M et al. | Lack of active lung anaphylaxis in congenitally mast cell-deficient Ws/Ws rats sensitized with the nematode Nippostrongylus brasiliensis. | 1998 | APMIS | pmid:9740510 |
Dent G et al. | Protein kinase C inhibition enhances platelet-activating factor-induced eicosanoid production in human eosinophils. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9448055 |
Pfau JC et al. | A comparison of the effects of lipopolysaccharide and ceramide on arachidonic acid metabolism in THP-1 monocytic cells. | 1998 | Cell. Immunol. | pmid:9665757 |
Mitsunobu F et al. | Different roles of histamine and leukotriene C4 in the airways between patients with atopic and nonatopic asthma. | 1998 | J Asthma | pmid:9669831 |
Lukaszyk A et al. | The role of epidermal growth factor in platelet-endothelium interactions. | 1998 | J. Physiol. Pharmacol. | pmid:9670106 |
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Lebel B et al. | Inhibition of mediator release from dispersed nasal polyp cells by cyclosporin A. | 1998 | Int. Arch. Allergy Immunol. | pmid:9693278 |
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