Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Leier I et al. | ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump. | 1996 | Biochem. J. | pmid:8670053 |
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Ibe BO et al. | Leukotriene synthesis by isolated perinatal ovine intrapulmonary vessels correlates with age-related changes in 5-lipoxygenase protein. | 1997 | Biochem. Mol. Med. | pmid:9232199 |
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Sala A et al. | Pharmacological modulation of human platelet leukotriene C4-synthase. | 1997 | Biochem. Pharmacol. | pmid:9113110 |
Yang SL and Lou YJ | Sodium nitroprusside decreased leukotriene C4 generation by inhibiting leukotriene C4 synthase expression and activity in hepatic ischemia-reperfusion injured rats. | 2007 | Biochem. Pharmacol. | pmid:17194456 |
Ravasi S et al. | Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma. | 2002 | Biochem. Pharmacol. | pmid:11996896 |
Folco G et al. | Leukotriene C4 stimulates TXA2 formation in isolated sensitized guinea pig lungs. | 1981 | Biochem. Pharmacol. | pmid:21043253 |
Lu Y et al. | Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation. | 2011 | Biochem. Pharmacol. | pmid:21907188 |
Martin V et al. | Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors. | 2001 | Biochem. Pharmacol. | pmid:11705452 |
Rappa G et al. | New insights into the biology and pharmacology of the multidrug resistance protein (MRP) from gene knockout models. | 1999 | Biochem. Pharmacol. | pmid:10413292 |
Obukowicz MG et al. | Identification and characterization of a novel delta6/delta5 fatty acid desaturase inhibitor as a potential anti-inflammatory agent. | 1998 | Biochem. Pharmacol. | pmid:9605428 |
Létourneau IJ et al. | Role of proline 1150 in functional interactions between the membrane spanning domains and nucleotide binding domains of the MRP1 (ABCC1) transporter. | 2008 | Biochem. Pharmacol. | pmid:18336795 |
Agarwal R et al. | Glutathione S-transferase-dependent conjugation of leukotriene A4-methyl ester to leukotriene C4-methyl ester in mammalian skin. | 1992 | Biochem. Pharmacol. | pmid:1449522 |
Enderle GJ et al. | Different pathomechanisms of altered biliary leukotriene C4 elimination in isolated perfused rat livers. | 1995 | Biochem. Pharmacol. | pmid:7857316 |
Noguchi T et al. | MRP1 mutated in the L0 region transports SN-38 but not leukotriene C4 or estradiol-17 (beta-D-glucuronate). | 2005 | Biochem. Pharmacol. | pmid:16098482 |
Conseil G et al. | Role of two adjacent cytoplasmic tyrosine residues in MRP1 (ABCC1) transport activity and sensitivity to sulfonylureas. | 2005 | Biochem. Pharmacol. | pmid:15652236 |