LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Noguchi T et al. | MRP1 mutated in the L0 region transports SN-38 but not leukotriene C4 or estradiol-17 (beta-D-glucuronate). | 2005 | Biochem. Pharmacol. | pmid:16098482 |
| Bailey JM et al. | Activation of mitogen-induced T-lymphocyte proliferation by leukotriene C-4. | 1997 | Biochem. Soc. Trans. | pmid:9388724 |
| Westlake CJ et al. | Identification of the structural and functional boundaries of the multidrug resistance protein 1 cytoplasmic loop 3. | 2003 | Biochemistry | pmid:14640677 |
| Cai J et al. | Functional expression of multidrug resistance protein 1 in Pichia pastoris. | 2001 | Biochemistry | pmid:11444977 |
| Yang R et al. | Interaction between the bound Mg.ATP and the Walker A serine residue in NBD2 of multidrug resistance-associated protein MRP1 plays a crucial role for the ATP-dependent leukotriene C4 transport. | 2008 | Biochemistry | pmid:18636743 |
| Rinaldo-Matthis A et al. | Pre-steady-state kinetic characterization of thiolate anion formation in human leukotriene Câ‚„ synthase. | 2012 | Biochemistry | pmid:22217203 |
| Ahmad S et al. | Catalytic characterization of human microsomal glutathione S-transferase 2: identification of rate-limiting steps. | 2013 | Biochemistry | pmid:23409838 |
| Zehnpfennig B et al. | Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. | 2009 | Biochemistry | pmid:19334674 |
| Qin L et al. | Residues responsible for the asymmetric function of the nucleotide binding domains of multidrug resistance protein 1. | 2008 | Biochemistry | pmid:19063607 |
| Fiore S and Serhan CN | Lipoxin A4 receptor activation is distinct from that of the formyl peptide receptor in myeloid cells: inhibition of CD11/18 expression by lipoxin A4-lipoxin A4 receptor interaction. | 1995 | Biochemistry | pmid:8527441 |
| Leslie EM et al. | Functional and structural consequences of cysteine substitutions in the NH2 proximal region of the human multidrug resistance protein 1 (MRP1/ABCC1). | 2003 | Biochemistry | pmid:12731862 |
| Ren XQ et al. | A positively charged amino acid proximal to the C-terminus of TM17 of MRP1 is indispensable for GSH-dependent binding of substrates and for transport of LTC4. | 2002 | Biochemistry | pmid:12450376 |
| Zhang DW et al. | Characterization of the role of polar amino acid residues within predicted transmembrane helix 17 in determining the substrate specificity of multidrug resistance protein 3. | 2003 | Biochemistry | pmid:12924948 |
| McWherter CA et al. | Circular permutation of the granulocyte colony-stimulating factor receptor agonist domain of myelopoietin. | 1999 | Biochemistry | pmid:10194378 |
| Karwatsky J et al. | The leucotriene C4 binding sites in multidrug resistance protein 1 (ABCC1) include the first membrane multiple spanning domain. | 2005 | Biochemistry | pmid:15628876 |
| Paul S et al. | Structure and in vitro substrate specificity of the murine multidrug resistance-associated protein. | 1996 | Biochemistry | pmid:8885844 |
| Hamasaki Y et al. | Post-transcriptional regulation of LTC4 synthase activity by retinoic acid in rat basophilic leukemia cells. | 1997 | Biochim. Biophys. Acta | pmid:9295165 |
| Westcott JY et al. | Arachidonate-induced eicosanoid synthesis in RBL-2H3 cells: stimulation with antigen or A23187 induces prolonged activation of 5-lipoxygenase. | 1996 | Biochim. Biophys. Acta | pmid:8816855 |
| Petric R et al. | Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis. | 1995 | Biochim. Biophys. Acta | pmid:7827126 |
| Kawakami Y et al. | Neutralization of leukotriene C4 and D4 activity by monoclonal and single-chain antibodies. | 2014 | Biochim. Biophys. Acta | pmid:24361619 |