Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Lechowski S et al. | Combined arginine and glutamine decrease release of de novo synthesized leukotrienes and expression of proinflammatory cytokines in activated human intestinal mast cells. | 2013 | Eur J Nutr | pmid:22527286 |
Macglashan DW and Saini SS | Omalizumab increases the intrinsic sensitivity of human basophils to IgE-mediated stimulation. | 2013 | J. Allergy Clin. Immunol. | pmid:23791510 |
Zhang X et al. | Mechanisms of STIM1 activation of store-independent leukotriene C4-regulated Ca2+ channels. | 2013 | Mol. Cell. Biol. | pmid:23878392 |
Jung HW et al. | Comparison of the efficacy of KOB03, ketotifen, and montelukast in an experimental mouse model of allergic rhinitis. | 2013 | Int. Immunopharmacol. | pmid:23643816 |
González-Cobos JC et al. | Store-independent Orai1/3 channels activated by intracrine leukotriene C4: role in neointimal hyperplasia. | 2013 | Circ. Res. | pmid:23349245 |
Meszaros P et al. | Long term myriocin treatment increases MRP1 transport activity. | 2013 | Int. J. Biochem. Cell Biol. | pmid:23178537 |
Welsh DG | The many faces of Orai. | 2013 | Circ. Res. | pmid:23538273 |
Gurzeler U et al. | In vitro differentiation of near-unlimited numbers of functional mouse basophils using conditional Hoxb8. | 2013 | Allergy | pmid:23590216 |
Milara J et al. | Bafetinib inhibits functional responses of human eosinophils in vitro. | 2013 | Eur. J. Pharmacol. | pmid:23747655 |
Koketsu R et al. | Pretreatment with low levels of FcεRI-crosslinking stimulation enhances basophil mediator release. | 2013 | Int. Arch. Allergy Immunol. | pmid:23711850 |
Zhou M et al. | In vivo intranasal anti-CD23 treatment inhibits allergic responses in a murine model of allergic rhinitis. | 2013 | J. Mol. Histol. | pmid:23377922 |
James A et al. | The influence of aspirin on release of eoxin C4, leukotriene C4 and 15-HETE, in eosinophilic granulocytes isolated from patients with asthma. | 2013 | Int. Arch. Allergy Immunol. | pmid:23921438 |
Seki K et al. | Oxidative stress potentially enhances FcεRI-mediated leukotriene C4 release dependent on the late-phase increase of intracellular glutathione in mast cells. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23998930 |
Long EK et al. | Fatty acids induce leukotriene C4 synthesis in macrophages in a fatty acid binding protein-dependent manner. | 2013 | Biochim. Biophys. Acta | pmid:24046860 |
Suram S et al. | Cytosolic phospholipase A(2)α and eicosanoids regulate expression of genes in macrophages involved in host defense and inflammation. | 2013 | PLoS ONE | pmid:23950842 |
Dong X et al. | Urotensin II promotes the production of LTC4 in rat aortic adventitial fibroblasts through NF-κB-5-LO pathway by p38 MAPK and ERK activations. | 2013 | Heart Vessels | pmid:23053343 |
Kanaoka Y et al. | Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand. | 2013 | J. Biol. Chem. | pmid:23504326 |
Pereira-Vega A et al. | Premenstrual asthma and leukotriene variations in the menstrual cycle. | 2012 Nov-Dec | Allergol Immunopathol (Madr) | pmid:22115570 |
Kidron H et al. | Impact of probe compound in MRP2 vesicular transport assays. | 2012 | Eur J Pharm Sci | pmid:22406294 |
Oyoshi MK et al. | Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22416124 |