Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Chang WC et al. | Ca2+ influx through CRAC channels activates cytosolic phospholipase A2, leukotriene C4 secretion, and expression of c-fos through ERK-dependent and -independent pathways in mast cells. | 2006 | FASEB J. | pmid:17023391 |
Olynych TJ et al. | Fungal zymosan induces leukotriene production by human mast cells through a dectin-1-dependent mechanism. | 2006 | J. Allergy Clin. Immunol. | pmid:17030235 |
Medrala W et al. | [Efficacy and safety of specific immunotherapy of upper airways allergic diseases caused by allergy to mites]. | 2006 | Pol. Merkur. Lekarski | pmid:16875150 |
Zhang DW et al. | Mutational analysis of polar amino acid residues within predicted transmembrane helices 10 and 16 of multidrug resistance protein 1 (ABCC1): effect on substrate specificity. | 2006 | Drug Metab. Dispos. | pmid:16415113 |
Chavez J et al. | Interactions between leukotriene C4 and interleukin 13 signaling pathways in a mouse model of airway disease. | 2006 | Arch. Pathol. Lab. Med. | pmid:16594735 |
Deng JM and Shi HZ | Interleukin-16 in asthma. | 2006 | Chin. Med. J. | pmid:16805986 |
Muñoz NM et al. | Transcellular secretion of group V phospholipase A2 from epithelium induces beta 2-integrin-mediated adhesion and synthesis of leukotriene C4 in eosinophils. | 2006 | J. Immunol. | pmid:16785555 |
Tschopp CM et al. | Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma. | 2006 | Blood | pmid:16794249 |
Engin A et al. | Regulation of fibrogenesis during the early phase of common bile duct obstruction. | 2006 | ANZ J Surg | pmid:16813633 |
Son MJ et al. | Naturally occurring biflavonoid, ochnaflavone, inhibits cyclooxygenases-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. | 2006 | Arch. Pharm. Res. | pmid:16681032 |
Zaitsu M et al. | Interleukin-18 primes human basophilic KU812 cells for higher leukotriene synthesis. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16280246 |
Dahlén SE | Treatment of asthma with antileukotrienes: first line or last resort therapy? | 2006 | Eur. J. Pharmacol. | pmid:16510137 |
Wijewickrama GT et al. | Systematic evaluation of transcellular activities of secretory phospholipases A2. High activity of group V phospholipases A2 to induce eicosanoid biosynthesis in neighboring inflammatory cells. | 2006 | J. Biol. Chem. | pmid:16476735 |
Li GQ et al. | Effects of cyclooxygenase-1 and -2 gene disruption on Helicobacter pylori-induced gastric inflammation. | 2006 | J. Infect. Dis. | pmid:16518767 |
Seres I et al. | The association between angiotensin II-induced free radical generation and membrane fluidity in neutrophils of patients with metabolic syndrome. | 2006 | J. Membr. Biol. | pmid:17546512 |
Cao D et al. | Chronic administration of ethyl docosahexaenoate reduces gerbil brain eicosanoid productions following ischemia and reperfusion. | 2006 | J. Nutr. Biochem. | pmid:16098734 |
Conseil G et al. | Functional importance of three basic residues clustered at the cytosolic interface of transmembrane helix 15 in the multidrug and organic anion transporter MRP1 (ABCC1). | 2006 | J. Biol. Chem. | pmid:16230346 |
Niide O et al. | Fungal metabolite gliotoxin blocks mast cell activation by a calcium- and superoxide-dependent mechanism: implications for immunosuppressive activities. | 2006 | Clin. Immunol. | pmid:16213796 |
Raghavenra H et al. | Eugenol--the active principle from cloves inhibits 5-lipoxygenase activity and leukotriene-C4 in human PMNL cells. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16216483 |
Kulka M and Metcalfe DD | TLR3 activation inhibits human mast cell attachment to fibronectin and vitronectin. | 2006 | Mol. Immunol. | pmid:16280166 |