Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Mueller CF et al. | Multidrug resistance protein-1 affects oxidative stress, endothelial dysfunction, and atherogenesis via leukotriene C4 export. | 2008 | Circulation | pmid:18506003 |
Ma KF et al. | Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model. | 2008 | World J. Gastroenterol. | pmid:18461660 |
Kirshenbaum AS et al. | Effect of lipopolysaccharide (LPS) and peptidoglycan (PGN) on human mast cell numbers, cytokine production, and protease composition. | 2008 | BMC Immunol. | pmid:18687131 |
Mishra NC et al. | Nicotine primarily suppresses lung Th2 but not goblet cell and muscle cell responses to allergens. | 2008 | J. Immunol. | pmid:18490768 |
Yang R et al. | Interaction between the bound Mg.ATP and the Walker A serine residue in NBD2 of multidrug resistance-associated protein MRP1 plays a crucial role for the ATP-dependent leukotriene C4 transport. | 2008 | Biochemistry | pmid:18636743 |
Marchan R et al. | Multidrug resistance-associated protein 1 as a major mediator of basal and apoptotic glutathione release. | 2008 | Biochim. Biophys. Acta | pmid:18621020 |
Reichel V et al. | Texas Red transport across rat and dogfish shark (Squalus acanthias) choroid plexus. | 2008 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:18650317 |
Wang W et al. | Mechanistic study of potentiation of chemotherapy by a haloenol lactone derivative in vitro. | 2008 | Cancer Chemother. Pharmacol. | pmid:17899085 |
Yang SH and Yu CL | Antiinflammatory effects of Bu-zhong-yi-qi-tang in patients with perennial allergic rhinitis. | 2008 | J Ethnopharmacol | pmid:17980528 |
Hattori Y et al. | Gastric mucosal protection against ethanol by EP2 and EP4 signaling through the inhibition of leukotriene C4 production. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17947453 |
Rius M et al. | ATP-dependent transport of leukotrienes B4 and C4 by the multidrug resistance protein ABCC4 (MRP4). | 2008 | J. Pharmacol. Exp. Ther. | pmid:17959747 |
Mochizuki Y et al. | Suppressive activity of epinastine hydrochloride on eosinophil activation in vitro. | 2008 Jan-Feb | In Vivo | pmid:18396776 |
Theron AJ et al. | Leukotrienes C4 and D4 sensitize human neutrophils for hyperreactivity to chemoattractants. | 2009 | Inflamm. Res. | pmid:19184354 |
Di Capite J et al. | Intercellular Ca2+ wave propagation involving positive feedback between CRAC channels and cysteinyl leukotrienes. | 2009 | FASEB J. | pmid:18978154 |
Di Capite J et al. | Decoding of cytoplasmic Ca(2+) oscillations through the spatial signature drives gene expression. | 2009 | Curr. Biol. | pmid:19375314 |
Westergren VS et al. | Nasal mucosal expression of the leukotriene and prostanoid pathways in seasonal and perennial allergic rhinitis. | 2009 | Clin. Exp. Allergy | pmid:19364335 |
Zehnpfennig B et al. | Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. | 2009 | Biochemistry | pmid:19334674 |
Athayde LA et al. | Blocking central leukotrienes synthesis affects vasopressin release during sepsis. | 2009 | Neuroscience | pmid:19285113 |
Hashimoto K et al. | Cysteinyl leukotrienes induce monocyte chemoattractant protein-1 in human monocyte/macrophages via mitogen-activated protein kinase and nuclear factor-kappaB pathways. | 2009 | Int. Arch. Allergy Immunol. | pmid:19218821 |
Martinez-Losa M et al. | Taurine chloramine inhibits functional responses of human eosinophils in vitro. | 2009 | Clin. Exp. Allergy | pmid:19222497 |