Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Hanjalic-Beck A et al. | Chlormadinone acetate suppresses prostaglandin biosynthesis in human endometrial explants. | 2012 | Fertil. Steril. | pmid:22769735 |
Iram SH and Cole SP | Mutation of Glu521 or Glu535 in cytoplasmic loop 5 causes differential misfolding in multiple domains of multidrug and organic anion transporter MRP1 (ABCC1). | 2012 | J. Biol. Chem. | pmid:22232552 |
Han YS et al. | Macelignan inhibits histamine release and inflammatory mediator production in activated rat basophilic leukemia mast cells. | 2012 | Inflammation | pmid:22729280 |
Dellon ES et al. | Diagnostic utility of major basic protein, eotaxin-3, and leukotriene enzyme staining in eosinophilic esophagitis. | 2012 | Am. J. Gastroenterol. | pmid:22777338 |
Nagy E et al. | Increased transcript level of poly(ADP-ribose) polymerase (PARP-1) in human tricuspid compared with bicuspid aortic valves correlates with the stenosis severity. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22450322 |
Kar P et al. | Different agonists recruit different stromal interaction molecule proteins to support cytoplasmic Ca2+ oscillations and gene expression. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22509043 |
Qin L et al. | Effect of multiple cysteine substitutions on the functionality of human multidrug resistance protein 1 expressed in human embryonic kidney 293 cells: identification of residues essential for function. | 2012 | Drug Metab. Dispos. | pmid:22511347 |
Nunomura S et al. | The FcRβ- and γ-ITAMs play crucial but distinct roles in the full activation of mast cells induced by IgEκ and Protein L. | 2012 | J. Immunol. | pmid:22430736 |
Stolarczyk EI et al. | Casein kinase 2α regulates multidrug resistance-associated protein 1 function via phosphorylation of Thr249. | 2012 | Mol. Pharmacol. | pmid:22695718 |
Lu Y et al. | Citreorosein inhibits degranulation and leukotriene Câ‚„ generation through suppression of Syk pathway in mast cells. | 2012 | Mol. Cell. Biochem. | pmid:22395859 |
Kidron H et al. | Impact of probe compound in MRP2 vesicular transport assays. | 2012 | Eur J Pharm Sci | pmid:22406294 |
Oyoshi MK et al. | Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22416124 |
Jin Y et al. | Pinusolide isolated from Biota orientalis inhibits 5-lipoxygenase dependent leukotriene C4 generation by blocking c-Jun N-terminal kinase pathway in mast cells. | 2012 | Biol. Pharm. Bull. | pmid:22863941 |
Ilarraza R et al. | Montelukast inhibits leukotriene stimulation of human dendritic cells in vitro. | 2012 | Int. Arch. Allergy Immunol. | pmid:22846852 |
Song HH et al. | Anti-inflammatory and anti-allergic effect of Agaricus blazei extract in bone marrow-derived mast cells. | 2012 | Am. J. Chin. Med. | pmid:22928836 |
Pereira-Vega A et al. | Premenstrual asthma and leukotriene variations in the menstrual cycle. | 2012 Nov-Dec | Allergol Immunopathol (Madr) | pmid:22115570 |
Lechowski S et al. | Combined arginine and glutamine decrease release of de novo synthesized leukotrienes and expression of proinflammatory cytokines in activated human intestinal mast cells. | 2013 | Eur J Nutr | pmid:22527286 |
Jung HW et al. | Comparison of the efficacy of KOB03, ketotifen, and montelukast in an experimental mouse model of allergic rhinitis. | 2013 | Int. Immunopharmacol. | pmid:23643816 |
González-Cobos JC et al. | Store-independent Orai1/3 channels activated by intracrine leukotriene C4: role in neointimal hyperplasia. | 2013 | Circ. Res. | pmid:23349245 |
Meszaros P et al. | Long term myriocin treatment increases MRP1 transport activity. | 2013 | Int. J. Biochem. Cell Biol. | pmid:23178537 |