Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Perng DW et al. | Leukotriene C4 induces TGF-beta1 production in airway epithelium via p38 kinase pathway. | 2006 | Am. J. Respir. Cell Mol. Biol. | pmid:16179583 |
Sanchez Mejia RO et al. | Matrix-associated transforming growth factor-beta1 primes mouse bone marrow-derived mast cells for increased high-affinity Fc receptor for immunoglobulin E-dependent eicosanoid biosynthesis. | 2000 | Am. J. Respir. Cell Mol. Biol. | pmid:10783127 |
Lay JC et al. | Cellular and biochemical response of the human lung after intrapulmonary instillation of ferric oxide particles. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10100994 |
Vieira-de-Abreu A et al. | Cross-talk between macrophage migration inhibitory factor and eotaxin in allergic eosinophil activation forms leukotriene Câ‚„-synthesizing lipid bodies. | 2011 | Am. J. Respir. Cell Mol. Biol. | pmid:20539011 |
Dent G et al. | Protein kinase C inhibition enhances platelet-activating factor-induced eicosanoid production in human eosinophils. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9448055 |
Funayama T et al. | Role of Leukotriene-degrading enzymes in pulmonary response to antigen infusion in sensitized guinea pigs in vivo. | 1996 | Am. J. Respir. Cell Mol. Biol. | pmid:8703483 |
Suzuki R and Freed AN | Heparin inhibits hyperventilation-induced late-phase hyperreactivity in dogs. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11779726 |
Macfarlane AJ et al. | Sputum cysteinyl leukotrienes increase 24 hours after allergen inhalation in atopic asthmatics. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10806153 |
Meltzer SS et al. | Inhibition of exercise-induced bronchospasm by zileuton: a 5-lipoxygenase inhibitor. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8630575 |
Burghardt JS et al. | Lipid mediators in oxygen-induced airway remodeling and hyperresponsiveness in newborn rats. | 1996 | Am. J. Respir. Crit. Care Med. | pmid:8887572 |
Chen CR et al. | Platelet-activating factor potentiates protamine-induced lung edema. Role of eicosanoids. | 1994 | Am. J. Respir. Crit. Care Med. | pmid:8111595 |
Sano A et al. | Inhibition of cPLA2 translocation and leukotriene C4 secretion by fluticasone propionate in exogenously activated human eosinophils. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10351938 |
Hasday JD et al. | Anti-inflammatory effects of zileuton in a subpopulation of allergic asthmatics. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10764316 |
Yamaya M et al. | Epithelial modulation of leukotriene-C4-induced human tracheal smooth muscle contraction. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7881688 |
Peters-Golden M | Cell biology of the 5-lipoxygenase pathway. | 1998 | Am. J. Respir. Crit. Care Med. | pmid:9647604 |
Myers SI and Hernandez R | Leukotriene C4 regulation of splanchnic blood flow during ischemia. | 1994 | Am. J. Surg. | pmid:8209929 |
Lester GD and Rice BL | Effects of leukotriene C4 on the bioelectric properties and ion transport of equine tracheal epithelium. | 2012 | Am. J. Vet. Res. | pmid:23176432 |
Westcott JY et al. | Inactivation of leukotriene C4 in the airways and subsequent urinary leukotriene E4 excretion in normal and asthmatic subjects. | 1993 | Am. Rev. Respir. Dis. | pmid:7694531 |
Tsikas D et al. | Catalytic hydrogenation of leukotriene B4 enhances sensitivity and specificity of gas chromatography-tandem mass spectrometry techniques and enables simultaneous analysis with cysteinyl leukotrienes in biological fluids. | 1996 | Anal. Biochem. | pmid:8619486 |
Wickham S et al. | Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes. | 2011 | Anal. Biochem. | pmid:21447318 |