LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Abnormalities, Multiple D000015 13 associated lipids
Acute-Phase Reaction D000210 12 associated lipids
Airway Obstruction D000402 13 associated lipids
Anaphylaxis D000707 35 associated lipids
Angina Pectoris D000787 27 associated lipids
Arthritis D001168 41 associated lipids
Asbestosis D001195 8 associated lipids
Asthma D001249 52 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Body Weight D001835 333 associated lipids
Burns D002056 34 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Cestode Infections D002590 3 associated lipids
Colitis D003092 69 associated lipids
Common Bile Duct Diseases D003137 3 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Cough D003371 19 associated lipids
Drug Eruptions D003875 30 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Ear Diseases D004427 7 associated lipids
Edema D004487 152 associated lipids
Eosinophilia D004802 4 associated lipids
Gastritis D005756 27 associated lipids
Glioma D005910 112 associated lipids
Glomerulonephritis D005921 35 associated lipids
Rhinitis, Allergic, Seasonal D006255 7 associated lipids
Hyperbilirubinemia D006932 11 associated lipids
Hyperbilirubinemia, Hereditary D006933 3 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypotension D007022 41 associated lipids
Inflammation D007249 119 associated lipids
Insect Bites and Stings D007299 4 associated lipids
Leukemia D007938 74 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Lung Neoplasms D008175 171 associated lipids
Mesenteric Vascular Occlusion D008641 4 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Nasal Polyps D009298 26 associated lipids
Periapical Periodontitis D010485 6 associated lipids
Peritonitis D010538 38 associated lipids
Phlebitis D010689 1 associated lipids
Picornaviridae Infections D010850 4 associated lipids
Pneumococcal Infections D011008 7 associated lipids
Pseudoxanthoma Elasticum D011561 2 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Rhinitis, Allergic, Perennial D012221 6 associated lipids
Osteosarcoma D012516 50 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Status Asthmaticus D013224 4 associated lipids
Stomach Ulcer D013276 75 associated lipids
Ulcer D014456 16 associated lipids
Uveitis D014605 14 associated lipids
Wounds, Nonpenetrating D014949 4 associated lipids
Reperfusion Injury D015427 65 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Myocardial Ischemia D017202 11 associated lipids
Carcinoma, Small Cell D018288 21 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Carotid Artery Injuries D020212 8 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Pulmonary Disease, Chronic Obstructive D029424 16 associated lipids
Atherosclerosis D050197 85 associated lipids
Eosinophilic Esophagitis D057765 3 associated lipids
Neointima D058426 3 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

Download all related citations
Per page 10 20 50 100 | Total 1173
Authors Title Published Journal PubMed Link
Romanelli F et al. Arachidonic acid and its metabolites effects on testosterone production by rat Leydig cells. 1995 J. Endocrinol. Invest. pmid:7615904
Sun J and Herman CA The American bullfrog (Rana catesbeiana) exhibits differential cardiovascular responses to LTC4 after short- and long-term cold exposure. 1995 Gen. Comp. Endocrinol. pmid:7622015
Janssen-Timmen U et al. Expression of 5-lipoxygenase in differentiating human skin keratinocytes. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7624354
Szarek JL and Valentovic MA Release of prostaglandin E2 and leukotriene C4/D4 from airway segments isolated from rats after exposure to ozone for 20 months. 1995 Toxicology pmid:7624868
Enomoto F et al. [Evaluation of arachidonic acid metabolites in experimental rat otitis media with effusion]. 1995 Nippon Jibiinkoka Gakkai Kaiho pmid:7629649
Juergens UR et al. Inhibition of monocyte leukotriene B4 production after aspirin desensitization. 1995 J. Allergy Clin. Immunol. pmid:7636051
Iwamoto I et al. Effect of a selective thromboxane A2 receptor antagonist BAY u3405 on antigen-, leukotriene C4- and leukotriene D4-induced bronchoconstriction in guinea pigs. 1995 Int. Arch. Allergy Immunol. pmid:7647588
Sun J and Herman CA Cardiovascular effects of N-methyl leukotriene C4, a nonmetabolizable leukotriene C4 analogue, and the antagonism of leukotriene-induced hypotension by Ro 23-3544, in the American bullfrog, Rana catesbeiana. 1995 Can. J. Physiol. Pharmacol. pmid:7648518
Gimpel JA et al. Reduction of reperfusion injury of human myocardium by allopurinol: a clinical study. 1995 Free Radic. Biol. Med. pmid:7649495
Van Dijk JP et al. Nicotine inhibits cytokine synthesis by mouse colonic mucosa. 1995 Eur. J. Pharmacol. pmid:7664807
Tschugguel W et al. High precision measurement of electrical resistance across endothelial cell monolayers. 1995 Pflugers Arch. pmid:7667075
Katori M et al. Interaction of substance P and leukotriene C4 in ethanol-induced mucosal injury of rat stomach. 1993 Regul. Pept. pmid:7692504
Westcott JY et al. Inactivation of peptidoleukotrienes in the isolated perfused rat lung. 1993 Arch. Biochem. Biophys. pmid:7692821
Patella V et al. Protein Fv produced during vital hepatitis is a novel activator of human basophils and mast cells. 1993 J. Immunol. pmid:7693815
Westcott JY et al. Inactivation of leukotriene C4 in the airways and subsequent urinary leukotriene E4 excretion in normal and asthmatic subjects. 1993 Am. Rev. Respir. Dis. pmid:7694531
Zuany-Amorim C et al. Characterization and pharmacological modulation of antigen-induced peritonitis in actively sensitized mice. 1993 Br. J. Pharmacol. pmid:7694762
Tudhope SR et al. BAY u9773, a novel antagonist of cysteinyl-leukotrienes with activity against two receptor subtypes. 1994 Eur. J. Pharmacol. pmid:7698171
Cruz JR et al. Fecal excretion of leukotriene C4 during human disease due to Shigella dysenteriae. 1995 J. Pediatr. Gastroenterol. Nutr. pmid:7714683
Georgitis JW et al. Chronic sinusitis: characterization of cellular influx and inflammatory mediators in sinus lavage fluid. 1995 Int. Arch. Allergy Immunol. pmid:7719157
Nishikawa M et al. Effect of leukotriene C4D4 antagonist on colonic damage induced by intracolonic administration of trinitrobenzene sulfonic acid in rats. 1995 J. Gastroenterol. pmid:7719412
Kita H et al. Eosinophil major basic protein induces degranulation and IL-8 production by human eosinophils. 1995 J. Immunol. pmid:7722326
Schauer U et al. Blood eosinophils, leukotriene C4 generation, and bronchial hyperreactivity in formerly preterm infants. 1994 Arch. Dis. Child. pmid:7726609
Lam BK et al. Expression cloning of human LTC4 synthase. 1995 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:7732869
Porreca E et al. Modulation of rat vascular smooth muscle cell (VSMC) proliferation by cysteinyl leukotriene D4: a role for mediation of interleukin 1. 1995 Atherosclerosis pmid:7755646
Rodríguez-Ortigosa CM et al. Taurocholate-stimulated leukotriene C4 biosynthesis and leukotriene C4-stimulated choleresis in isolated rat liver. 1995 Gastroenterology pmid:7768385
Busse WW and Sedgwick JB Eosinophil eicosanoid relations in allergic inflammation of the airways. 1994 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:7771338
Gardiner PJ et al. Leukotriene receptors and their selective antagonists. 1994 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:7771349
Keppler D et al. Transport and metabolism of leukotrienes. 1994 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:7771352
Kimura Y et al. Effects of stilbenes isolated from medicinal plants on arachidonate metabolism and degranulation in human polymorphonuclear leukocytes. 1995 J Ethnopharmacol pmid:7776662
Gorenne I et al. Effects of beta 2-adrenoceptor agonists on anti-IgE-induced contraction and smooth muscle reactivity in human airways. 1995 Br. J. Pharmacol. pmid:7780648
Ju HR et al. Systemic release of mucosal mast-cell protease in primed brown Norway rats after feeding with beta-lactoglobulin. 1995 Biosci. Biotechnol. Biochem. pmid:7787291
Ramondt J et al. Sensitivity of ovine myometrial tissue to various eicosanoids in vitro. 1995 Prostaglandins pmid:7792392
Gorenne I et al. Antagonism of leukotriene responses in human airways by BAY x7195. 1995 Eur. J. Pharmacol. pmid:7796856
Shimizu T et al. Inhibitory effects of theophylline, terbutaline, and hydrocortisone on leukotriene B4 and C4 generation by human leukocytes in vitro. 1994 Pediatr. Pulmonol. pmid:7800427
Goulet JL et al. Altered inflammatory responses in leukotriene-deficient mice. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:7809134
Müller M et al. Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:7809167
Currie S et al. Phosphorylation and activation of Ca(2+)-sensitive cytosolic phospholipase A2 in MCII mast cells mediated by high-affinity Fc receptor for IgE. 1994 Biochem. J. pmid:7818499
Willburger RE and Wittenberg RH Prostaglandin release from lumbar disc and facet joint tissue. 1994 Spine pmid:7825047
Wang D et al. Concentrations of chemical mediators in nasal secretions of patients with hay fever during natural allergen exposure. 1994 Acta Otolaryngol. pmid:7825440
Petric R et al. Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis. 1995 Biochim. Biophys. Acta pmid:7827126
Brady HR et al. Lipoxygenase product formation and cell adhesion during neutrophil-glomerular endothelial cell interaction. 1995 Am. J. Physiol. pmid:7840235
Kurosawa M et al. Inhibition by a novel peptide leukotriene receptor antagonist ONO-1078 of airway wall thickening and airway hyperresponsiveness to histamine induced by leukotriene C4 or leukotriene D4 in guinea-pigs. 1994 Clin. Exp. Allergy pmid:7842366
Hubbard NE and Erickson KL Role of 5'-lipoxygenase metabolites in the activation of peritoneal macrophages for tumoricidal function. 1995 Cell. Immunol. pmid:7842477
HasanoÄŸlu E et al. The role of prostanoids in the complications of extracorporeal shock wave lithotripsy (ESWL) in children. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7846111
Liu L et al. Impairment of macrophage eicosanoid and nitric oxide production by an alkaloid from Sinomenium acutum. 1994 Arzneimittelforschung pmid:7848335
Schuil PJ et al. Histamine and leukotriene C4 effects on in vitro ciliary beat frequency of human upper respiratory cilia. 1994 Eur Arch Otorhinolaryngol pmid:7848641
Petric R and Ford-Hutchinson AW Elevated cysteinyl leukotriene excretion in experimental glomerulonephritis. 1994 Kidney Int. pmid:7853790
Enderle GJ et al. Different pathomechanisms of altered biliary leukotriene C4 elimination in isolated perfused rat livers. 1995 Biochem. Pharmacol. pmid:7857316
Ganbo T et al. Inhibition of mucociliary clearance of the eustachian tube by leukotrienes C4 and D4. 1995 Ann. Otol. Rhinol. Laryngol. pmid:7872607
Pintos-Morell G et al. Altered leukotriene generation in leukocytes from cystinotic children. 1994 Pediatr. Res. pmid:7877883
Yamaya M et al. Epithelial modulation of leukotriene-C4-induced human tracheal smooth muscle contraction. 1995 Am. J. Respir. Crit. Care Med. pmid:7881688
Restrick LJ et al. Reduction in leukotriene B4 generation by bronchoalveolar lavage cells in asthma. 1995 Thorax pmid:7886653
Kawashima T et al. [Inhibitory effect of AS-35. a novel antiallergic drug, on chemical mediator release from human eosinophils]. 1994 Arerugi pmid:7887808
Wang D et al. Correlations between complaints, inflammatory cells and mediator concentrations in nasal secretions after nasal allergen challenge and during natural allergen exposure. 1995 Int. Arch. Allergy Immunol. pmid:7888790
Tsai JJ et al. Relationship between nasal resistance and airway hyperreactivity following nasal provocation with Dermatophagoides pteronyssinus in allergic rhinitis. 1995 Int. Arch. Allergy Immunol. pmid:7888791
Mita H and Shida T Comparison of anti-allergic activities of the histamine H1 receptor antagonists epinastine, ketotifen and oxatomide in human leukocytes. 1995 Arzneimittelforschung pmid:7893266
Scadding GK et al. Effect of short-term treatment with fluticasone propionate nasal spray on the response to nasal allergen challenge. 1994 Br J Clin Pharmacol pmid:7893587
Kawana S and Nishiyama S Pustular psoriasis and aseptic purulent arthritis: possible role of leukotrienes B4 and C4 in a flare of synovitis. 1995 Dermatology (Basel) pmid:7894093
Ohtsuki T et al. Reperfusion induces 5-lipoxygenase translocation and leukotriene C4 production in ischemic brain. 1995 Am. J. Physiol. pmid:7900879
Thioudellet C et al. Molecular and functional characterization of recombinant human gamma-glutamyltransferase. Coupling of its activity to glutathione levels in V79 cells. 1994 Eur. J. Biochem. pmid:7913033
Jedlitschky G et al. ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein. 1994 Cancer Res. pmid:7915193
Kapuściński A Leukotriene C4 in the rat brain after resuscitation from clinical death. 1994 Folia Neuropathol pmid:7922113
Ohemeng KA et al. Novel bishydroxamic acids as 5-lipoxygenase inhibitors. 1994 Bioorg. Med. Chem. pmid:7922131
Ducep JB et al. Synthesis of 5- and 6-fluoro derivatives of 5,8,14-eicosatrienoic and 5,8,11,14-eicosatetraenoic acids. Effects of fluorinated arachidonic acids on leukotriene C4 production by macrophages. 1994 Bioorg. Med. Chem. pmid:7922133
Leff AR Inflammatory mediation of airway hyperresponsiveness by peripheral blood granulocytes. The case for the eosinophil. 1994 Chest pmid:7924496
Büchler M et al. Functional reconstitution of ATP-dependent transporters from the solubilized hepatocyte canalicular membrane. 1994 Eur. J. Biochem. pmid:7925347
Matsumoto T et al. Effects of diet on experimentally induced intestinal ulcers in rats: morphology and tissue leukotrienes. 1994 Gut pmid:7926906
Anwar AR et al. Adhesion to fibronectin primes eosinophils via alpha 4 beta 1 (VLA-4). 1994 Immunology pmid:7927493
Volland H et al. Enzyme immunometric assay for leukotriene C4. 1994 J. Immunol. Methods pmid:7930643
Black KL et al. Enzymatic barrier protects brain capillaries from leukotriene C4. 1994 J. Neurosurg. pmid:7931622
Böhme M et al. ATP-dependent export pumps and their inhibition by cyclosporins. 1994 Adv. Enzyme Regul. pmid:7942282
Leier I et al. The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. 1994 J. Biol. Chem. pmid:7961706
Fujii R et al. Adenosine triphosphate-dependent transport of leukotriene C4 by membrane vesicles prepared from cisplatin-resistant human epidermoid carcinoma tumor cells. 1994 J. Natl. Cancer Inst. pmid:7966417
Mitsuhashi T et al. Increased production of eicosanoids, TXA2, PGI2 and LTC4 in experimental spinal cord injuries. 1994 Paraplegia pmid:7970857
Wei EQ et al. [Effect of a leukotriene antagonist, ONO-1078, on electric stimulation of vagus (ESV)-induced bronchoconstriction and microvascular leakage in guinea pigs]. 1994 Yao Xue Xue Bao pmid:7976357
Nagashima T et al. The effect of leukotriene C4 on the permeability of brain capillary endothelial cell monolayer. 1994 Acta Neurochir Suppl (Wien) pmid:7976646
Amon U et al. Control function of protein kinase C isozymes on leukotriene generation from human basophils? 1994 Agents Actions pmid:7976816
Votta BJ and Bertolini DR Cytokine suppressive anti-inflammatory compounds inhibit bone resorption in vitro. 1994 Sep-Oct Bone pmid:7980964
Medina L et al. Leukotriene C4 upregulates collagenase expression and synthesis in human lung fibroblasts. 1994 Biochim. Biophys. Acta pmid:7981229
Ishii K et al. A useful method for differential evaluation of anti-inflammatory effects due to cyclooxygenase and 5-lipoxygenase inhibitions in mice. 1994 Jpn. J. Pharmacol. pmid:7990266
Fiore S et al. Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor. 1994 J. Exp. Med. pmid:8006586
Maclouf J et al. Leukotriene C4 formation by transcellular biosynthesis. 1994 Ann. N. Y. Acad. Sci. pmid:8017763
Hamasaki Y et al. Inhibition by dexamethasone of retinoic acid-induced enhancement of leukotriene C4 synthesis in rat basophilic leukemia-1 cells. 1994 Am. J. Respir. Cell Mol. Biol. pmid:8018338
Böhme M et al. Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver. 1994 Gastroenterology pmid:8020669
Raible DG Erythrocytes increase leukotriene C4 release from human eosinophils: characterization and examination of possible mechanisms. 1994 J. Leukoc. Biol. pmid:8027672
Laviolette M et al. Effects of inhaled steroids on blood eosinophils in moderate asthma. 1994 Ann. N. Y. Acad. Sci. pmid:8031001
Wardle TD and Turnberg LA Potential role for interleukin-1 in the pathophysiology of ulcerative colitis. 1994 Clin. Sci. pmid:8033515
Cotti E and Torabinejad M Detection of leukotriene C4 in human periradicular lesions. 1994 Int Endod J pmid:8034369
Christie PE et al. Increased urinary LTE4 excretion following inhalation of LTC4 and LTE4 in asthmatic subjects. 1994 Eur. Respir. J. pmid:8050548
Lam BK et al. Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:8052639
Yamada N et al. Pharmacological profile of the novel, potent and selective peptide leukotriene antagonist (E)-2,2-diethyl-3'-[2-[2-(4-isopropyl)thiazolyl]ethenyl]succinanilic acid. 1994 Arzneimittelforschung pmid:8053974
Bando T et al. Inhibitory effect of aerosol administration of a sulfidopeptide leukotriene antagonist on bronchoconstriction induced by antigen inhalation in guinea pigs. 1994 Arzneimittelforschung pmid:8053975
Shimizu T et al. Leukotriene B4 and C4 generation by small intestinal mucosa in children with coeliac disease. 1994 Digestion pmid:8063028
Le Poole IC et al. Organotypic culture of human skin to study melanocyte migration. 1994 Pigment Cell Res. pmid:8072944
Shimizu T et al. Leukotriene B4 and C4 generation by blood leukocytes after ex vivo stimulation by Ca-ionophore and opsonized zymosan in children with atopic dermatitis. 1994 Pediatr Allergy Immunol pmid:8087194
Shimizu T et al. Effects of pancreatic and snake venom phospholipase A2 on the generation of leukotriene B4 and C4 by human leukocytes in vitro. 1994 Pancreas pmid:8108369
Chen CR et al. Platelet-activating factor potentiates protamine-induced lung edema. Role of eicosanoids. 1994 Am. J. Respir. Crit. Care Med. pmid:8111595
Weide I et al. Intravascular cysteinyl-leukotriene formation by clotting whole human blood. Evidence from clamped umbilical vein segments and thrombus specimens. 1993 Thromb. Res. pmid:8122190
Ramis I et al. Application of totally automated on-line sample clean up system for extraction and high-performance liquid chromatography separation of peptide leukotrienes. 1993 Nov-Dec J Pharm Biomed Anal pmid:8123725
Leier I et al. Characterization of the ATP-dependent leukotriene C4 export carrier in mastocytoma cells. 1994 Eur. J. Biochem. pmid:8125120