LTC4
Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
Cross Reference
Introduction
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with LTC4?
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with LTC4
PubChem Associated disorders and diseases
What pathways are associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with LTC4?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with LTC4?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with LTC4?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with LTC4?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with LTC4?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with LTC4
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chaung HC et al. | Leukotriene C4 release and gene expressions of IL-8 and MCP-1 in porcine alveolar epithelial type II cells. | 2009 | Res. Vet. Sci. | pmid:18565553 |
| Austen KF et al. | The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications. | 2009 | J. Allergy Clin. Immunol. | pmid:19647860 |
| Theron AJ et al. | Leukotrienes C4 and D4 sensitize human neutrophils for hyperreactivity to chemoattractants. | 2009 | Inflamm. Res. | pmid:19184354 |
| Di Capite J et al. | Intercellular Ca2+ wave propagation involving positive feedback between CRAC channels and cysteinyl leukotrienes. | 2009 | FASEB J. | pmid:18978154 |
| Di Capite J et al. | Decoding of cytoplasmic Ca(2+) oscillations through the spatial signature drives gene expression. | 2009 | Curr. Biol. | pmid:19375314 |
| Farias S et al. | Injury-related production of cysteinyl leukotrienes contributes to brain damage following experimental traumatic brain injury. | 2009 | J. Neurotrauma | pmid:19886806 |
| Westergren VS et al. | Nasal mucosal expression of the leukotriene and prostanoid pathways in seasonal and perennial allergic rhinitis. | 2009 | Clin. Exp. Allergy | pmid:19364335 |
| Zehnpfennig B et al. | Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. | 2009 | Biochemistry | pmid:19334674 |
| Pecaric-Petkovic T et al. | Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33. | 2009 | Blood | pmid:18955562 |
| Togo K et al. | Aspirin and salicylates modulate IgE-mediated leukotriene secretion in mast cells through a dihydropyridine receptor-mediated Ca(2+) influx. | 2009 | Clin. Immunol. | pmid:19144570 |
| Ma K et al. | Protective effects of asiatic acid against D-galactosamine/lipopolysaccharide-induced hepatotoxicity in hepatocytes and kupffer cells co-cultured system via redox-regulated leukotriene C4 synthase expression pathway. | 2009 | Eur. J. Pharmacol. | pmid:19087874 |
| Celik GE et al. | Effect of in vitro aspirin stimulation on basophils in patients with aspirin-exacerbated respiratory disease. | 2009 | Clin. Exp. Allergy | pmid:19486029 |
| Triggiani M et al. | Lung mast cells are a source of secreted phospholipases A2. | 2009 | J. Allergy Clin. Immunol. | pmid:19541351 |
| Suzuki Y and Ra C | Analysis of the mechanism for the development of allergic skin inflammation and the application for its treatment: aspirin modulation of IgE-dependent mast cell activation: role of aspirin-induced exacerbation of immediate allergy. | 2009 | J. Pharmacol. Sci. | pmid:19609060 |
| Ono E et al. | Concentration of 14,15-leukotriene C4 (eoxin C4) in bronchoalveolar lavage fluid. | 2009 | Clin. Exp. Allergy | pmid:19438588 |
| Kupczyk M et al. | Lipoxin A4 generation is decreased in aspirin-sensitive patients in lysine-aspirin nasal challenge in vivo model. | 2009 | Allergy | pmid:19385948 |
| Foller M et al. | Participation of leukotriene C(4) in the regulation of suicidal erythrocyte death. | 2009 | J. Physiol. Pharmacol. | pmid:19826192 |
| Sur R et al. | Role of Janus kinase-2 in IgE receptor-mediated leukotriene C4 production by mast cells. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19835845 |
| Di Capite J et al. | Targeting Ca2+ release-activated Ca2+ channel channels and leukotriene receptors provides a novel combination strategy for treating nasal polyposis. | 2009 | J. Allergy Clin. Immunol. | pmid:19895990 |
| Hung ND et al. | Anti-inflammatory action of arachidonoyl lysophosphatidylcholine or 15-hydroperoxy derivative in zymosan A-induced peritonitis. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19819343 |