Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Wiklund CU et al. | Interactions of volatile anesthetics with cholinergic, tachykinin, and leukotriene mechanisms in isolated Guinea pig bronchial smooth muscle. | 2002 | Anesth. Analg. | pmid:12456432 |
Bölke E et al. | Changes of gut barrier function during anesthesia and cardiac surgery. | 2001 | Angiology | pmid:11515987 |
Gentile DA et al. | Elevations of local leukotriene C4 levels during viral upper respiratory tract infections. | 2003 | Ann. Allergy Asthma Immunol. | pmid:14533659 |
Hamasaki Y et al. | Inhibition of leukotriene synthesis by azelastine. | 1996 | Ann. Allergy Asthma Immunol. | pmid:8630722 |
Takao A et al. | Inhibitory effects of azelastine hydrochloride in alcohol-induced asthma. | 1999 | Ann. Allergy Asthma Immunol. | pmid:10227338 |
Moneret-Vautrin DA et al. | Human basophil activation measured by CD63 expression and LTC4 release in IgE-mediated food allergy. | 1999 | Ann. Allergy Asthma Immunol. | pmid:9988204 |
el-Ahmady O et al. | Elevated concentrations of interleukins and leukotriene in response to Mycobacterium tuberculosis infection. | 1997 | Ann. Clin. Biochem. | pmid:9133249 |
Laviolette M et al. | Effects of inhaled steroids on blood eosinophils in moderate asthma. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8031001 |
Maclouf J et al. | Leukotriene C4 formation by transcellular biosynthesis. | 1994 | Ann. N. Y. Acad. Sci. | pmid:8017763 |
Mayatepek E et al. | A patient with neurological symptoms and abnormal leukotriene metabolism: a new defect in leukotriene biosynthesis. | 2005 | Ann. Neurol. | pmid:16315285 |
Diven WF et al. | Expression of acute otitis media after receptor blockade of platelet activating factor, thromboxane, and leukotrienes in the chinchilla. | 1998 | Ann. Otol. Rhinol. Laryngol. | pmid:9525240 |
Ganbo T et al. | Inhibition of mucociliary clearance of the eustachian tube by leukotrienes C4 and D4. | 1995 | Ann. Otol. Rhinol. Laryngol. | pmid:7872607 |
Abe M et al. | A novel method for preserving human lungs using a super-cooling system. | 2006 | Ann. Thorac. Surg. | pmid:16928543 |
Hoopes C | Invited commentary. | 2006 | Ann. Thorac. Surg. | pmid:16928544 |
Cole SP | Targeting multidrug resistance protein 1 (MRP1, ABCC1): past, present, and future. | 2014 | Annu. Rev. Pharmacol. Toxicol. | pmid:24050699 |
Ding GY et al. | Multidrug resistance-associated protein (MRP) mediated transport of daunomycin and leukotriene C4 (LTC4) in isolated plasma membrane vesicles. | 1999 Jul-Aug | Anticancer Res. | pmid:10652618 |
Wang J et al. | Does leukotriene affect intracellular glutathione redox state in cultured human airway epithelial cells? | 2008 | Antioxid. Redox Signal. | pmid:18199004 |
Engin A et al. | Regulation of fibrogenesis during the early phase of common bile duct obstruction. | 2006 | ANZ J Surg | pmid:16813633 |
Nishida M et al. | Lack of active lung anaphylaxis in congenitally mast cell-deficient Ws/Ws rats sensitized with the nematode Nippostrongylus brasiliensis. | 1998 | APMIS | pmid:9740510 |