LTC4

Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.

Cross Reference

Introduction

To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with LTC4?

LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with LTC4

MeSH term MeSH ID Detail
Neointima D058426 3 associated lipids
Eosinophilic Esophagitis D057765 3 associated lipids
Atherosclerosis D050197 85 associated lipids
Pulmonary Disease, Chronic Obstructive D029424 16 associated lipids
Brain Diseases, Metabolic, Inborn D020739 10 associated lipids
Ventricular Remodeling D020257 28 associated lipids
Carotid Artery Injuries D020212 8 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Carcinoma, Small Cell D018288 21 associated lipids
Myocardial Ischemia D017202 11 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Reperfusion Injury D015427 65 associated lipids
Wounds, Nonpenetrating D014949 4 associated lipids
Uveitis D014605 14 associated lipids
Ulcer D014456 16 associated lipids
Stomach Ulcer D013276 75 associated lipids
Status Asthmaticus D013224 4 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Osteosarcoma D012516 50 associated lipids
Rhinitis, Allergic, Perennial D012221 6 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Pseudoxanthoma Elasticum D011561 2 associated lipids
Pneumococcal Infections D011008 7 associated lipids
Picornaviridae Infections D010850 4 associated lipids
Phlebitis D010689 1 associated lipids
Peritonitis D010538 38 associated lipids
Periapical Periodontitis D010485 6 associated lipids
Nasal Polyps D009298 26 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Mesenteric Vascular Occlusion D008641 4 associated lipids
Lung Neoplasms D008175 171 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Leukemia D007938 74 associated lipids
Insect Bites and Stings D007299 4 associated lipids
Inflammation D007249 119 associated lipids
Hypotension D007022 41 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperbilirubinemia, Hereditary D006933 3 associated lipids
Hyperbilirubinemia D006932 11 associated lipids
Rhinitis, Allergic, Seasonal D006255 7 associated lipids
Glomerulonephritis D005921 35 associated lipids
Glioma D005910 112 associated lipids
Gastritis D005756 27 associated lipids
Eosinophilia D004802 4 associated lipids
Edema D004487 152 associated lipids
Ear Diseases D004427 7 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Drug Eruptions D003875 30 associated lipids
Cough D003371 19 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Common Bile Duct Diseases D003137 3 associated lipids
Colitis D003092 69 associated lipids
Cestode Infections D002590 3 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Brain Ischemia D002545 89 associated lipids
Carcinoma, Non-Small-Cell Lung D002289 72 associated lipids
Burns D002056 34 associated lipids
Body Weight D001835 333 associated lipids
Cholestasis, Extrahepatic D001651 7 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Asthma D001249 52 associated lipids
Asbestosis D001195 8 associated lipids
Arthritis D001168 41 associated lipids
Angina Pectoris D000787 27 associated lipids
Anaphylaxis D000707 35 associated lipids
Airway Obstruction D000402 13 associated lipids
Acute-Phase Reaction D000210 12 associated lipids
Abnormalities, Multiple D000015 13 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with LTC4

Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with LTC4?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with LTC4?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with LTC4?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with LTC4?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with LTC4?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with LTC4

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Per page 10 20 50 100 | Total 1173
Authors Title Published Journal PubMed Link
Miura K et al. Differences in functional consequences and signal transduction induced by IL-3, IL-5, and nerve growth factor in human basophils. 2001 J. Immunol. pmid:11490016
Muñoz NM et al. Transcellular secretion of group V phospholipase A2 from epithelium induces beta 2-integrin-mediated adhesion and synthesis of leukotriene C4 in eosinophils. 2006 J. Immunol. pmid:16785555
Malaviya R and Uckun FM Role of STAT6 in IgE receptor/FcepsilonRI-mediated late phase allergic responses of mast cells. 2002 J. Immunol. pmid:11751988
Miura K et al. Localizing a control region in the pathway to leukotriene C(4) secretion following stimulation of human basophils with anti-IgE antibody. 2001 J. Immunol. pmid:11739523
Myou S et al. Activation of group IV cytosolic phospholipase A2 in human eosinophils by phosphoinositide 3-kinase through a mitogen-activated protein kinase-independent pathway. 2003 J. Immunol. pmid:14530366
Patella V et al. Protein Fv produced during vital hepatitis is a novel activator of human basophils and mast cells. 1993 J. Immunol. pmid:7693815
Nguyen T and Gupta S Leukotriene C4 secretion from normal murine mast cells by a probenecid-sensitive and multidrug resistance-associated protein-independent mechanism. 1997 J. Immunol. pmid:9144509
Mishra NC et al. Nicotine primarily suppresses lung Th2 but not goblet cell and muscle cell responses to allergens. 2008 J. Immunol. pmid:18490768
Kita H et al. Eosinophil major basic protein induces degranulation and IL-8 production by human eosinophils. 1995 J. Immunol. pmid:7722326
Zhu X et al. Role of mitogen-activated protein kinase-mediated cytosolic phospholipase A2 activation in arachidonic acid metabolism in human eosinophils. 2001 J. Immunol. pmid:11418683
Bandeira-Melo C et al. IL-16 promotes leukotriene C(4) and IL-4 release from human eosinophils via CD4- and autocrine CCR3-chemokine-mediated signaling. 2002 J. Immunol. pmid:11971026
Zhu Y and Bertics PJ Chemoattractant-induced signaling via the Ras-ERK and PI3K-Akt networks, along with leukotriene C4 release, is dependent on the tyrosine kinase Lyn in IL-5- and IL-3-primed human blood eosinophils. 2011 J. Immunol. pmid:21106848
Brock TG et al. Effects of granulocyte-macrophage colony-stimulating factor on eicosanoid production by mononuclear phagocytes. 1996 J. Immunol. pmid:8786314
Nunomura S et al. The FcRβ- and γ-ITAMs play crucial but distinct roles in the full activation of mast cells induced by IgEκ and Protein L. 2012 J. Immunol. pmid:22430736
Monahan J et al. Attenuation of IL-5-mediated signal transduction, eosinophil survival, and inflammatory mediator release by a soluble human IL-5 receptor. 1997 J. Immunol. pmid:9378992
Triggiani M et al. Secretory phospholipases A2 activate selective functions in human eosinophils. 2003 J. Immunol. pmid:12626587
Strait RT et al. IL-4 exacerbates anaphylaxis. 2003 J. Immunol. pmid:12646651
Serio KJ et al. Lipopolysaccharide down-regulates the leukotriene C4 synthase gene in the monocyte-like cell line, THP-1. 2003 J. Immunol. pmid:12574384
MacGlashan DW and Hubbard WC IL-3 alters free arachidonic acid generation in C5a-stimulated human basophils. 1993 J. Immunol. pmid:8245471
Egger D et al. IL-4 renders mast cells functionally responsive to endothelin-1. 1995 J. Immunol. pmid:7530742
Weber M et al. Monocyte chemotactic protein MCP-2 activates human basophil and eosinophil leukocytes similar to MCP-3. 1995 J. Immunol. pmid:7535823
Patella V et al. Human heart mast cells. Isolation, purification, ultrastructure, and immunologic characterization. 1995 J. Immunol. pmid:7533185
Papayianni A et al. Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells. 1996 J. Immunol. pmid:8690917
Kuehn HS et al. The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells. 2008 J. Immunol. pmid:19017959
Bandeira-Melo C et al. Cyclooxygenase-2-derived prostaglandin E2 and lipoxin A4 accelerate resolution of allergic edema in Angiostrongylus costaricensis-infected rats: relationship with concurrent eosinophilia. 2000 J. Immunol. pmid:10623853
Miura K et al. Extracellular signal-regulated kinases regulate leukotriene C4 generation, but not histamine release or IL-4 production from human basophils. 1999 J. Immunol. pmid:10201947
Chang WC et al. All-or-none activation of CRAC channels by agonist elicits graded responses in populations of mast cells. 2007 J. Immunol. pmid:17911611
Iikura M et al. Secretory IgA induces degranulation of IL-3-primed basophils. 1998 J. Immunol. pmid:9686618
Goulet JL et al. Genetic factors determine the contribution of leukotrienes to acute inflammatory responses. 2000 J. Immunol. pmid:10779800
Cummings HE et al. Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor. 2013 J. Immunol. pmid:24244016
Nagata M et al. Eosinophil adhesion to vascular cell adhesion molecule-1 activates superoxide anion generation. 1995 J. Immunol. pmid:7543540
Sarmiento EU et al. IL-3, IL-5, and granulocyte-macrophage colony-stimulating factor potentiate basophil mediator release stimulated by eosinophil granule major basic protein. 1995 J. Immunol. pmid:7543541
Campbell EM et al. Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/- mice: the role of mast cells. 1999 J. Immunol. pmid:10438957
Liu T et al. Platelet-driven leukotriene C4-mediated airway inflammation in mice is aspirin-sensitive and depends on T prostanoid receptors. 2015 J. Immunol. pmid:25904552
Brock TG et al. Decreased leukotriene C4 synthesis accompanies adherence-dependent nuclear import of 5-lipoxygenase in human blood eosinophils. 1999 J. Immunol. pmid:9973428
Mesquita-Santos FP et al. Cutting edge: prostaglandin D2 enhances leukotriene C4 synthesis by eosinophils during allergic inflammation: synergistic in vivo role of endogenous eotaxin. 2006 J. Immunol. pmid:16424158
Eglite S et al. Requirements for C5a receptor-mediated IL-4 and IL-13 production and leukotriene C4 generation in human basophils. 2000 J. Immunol. pmid:10925305
Dartt DA et al. Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation. 2011 J. Immunol. pmid:21357260
Vilariño N et al. Acute IL-3 priming up-regulates the stimulus-induced Raf-1-Mek-Erk cascade independently of IL-3-induced activation of Erk. 2005 J. Immunol. pmid:16116188
Miura K and MacGlashan DW Dual phase priming by IL-3 for leukotriene C4 generation in human basophils: difference in characteristics between acute and late priming effects. 2000 J. Immunol. pmid:10706691
Douglas IS et al. CD4+ T cell and eosinophil adhesion is mediated by specific ICAM-3 ligation and results in eosinophil activation. 2000 J. Immunol. pmid:10706734
Sedgwick JB et al. Effect of isolation protocol on eosinophil function: Percoll gradients versus immunomagnetic beads. 1996 J. Immunol. Methods pmid:8914593
Laviolette M et al. Comparison of two modified techniques for purifying blood eosinophils. 1993 J. Immunol. Methods pmid:8228275
Volland H et al. Enzyme immunometric assay for leukotriene C4. 1994 J. Immunol. Methods pmid:7930643
Tsang S et al. Simplified purification of human basophils. 2000 J. Immunol. Methods pmid:10648851
Mayatepek E et al. LTB4 and LTC4 are absent in the cerebrospinal fluid of human immunodeficiency virus type 1-seropositive persons with toxoplasmic encephalitis: evidence for inhibition of 5-lipoxygenase by Toxoplasma gondii. 1999 J. Infect. Dis. pmid:9952384
Li GQ et al. Effects of cyclooxygenase-1 and -2 gene disruption on Helicobacter pylori-induced gastric inflammation. 2006 J. Infect. Dis. pmid:16518767
Mayatepek E et al. Acute metabolic crisis with extreme deficiency of glutathione in combination with decreased levels of leukotriene C4 in a patient with glutathione synthetase deficiency. 2004 J. Inherit. Metab. Dis. pmid:15243994
Mayatepek E et al. Defects in the synthesis of cysteinyl leukotrienes: a new group of inborn errors of metabolism. 2000 J. Inherit. Metab. Dis. pmid:10896305
Sichletidis L et al. Comparative efficacy of salbutamol and salmeterol in exercise-induced asthma. 1993 Mar-Apr J. Int. Med. Res. pmid:8243793
Cederholm T et al. Impaired leukotriene C4 generation in granulocytes from protein-energy malnourished chronically ill elderly. 2000 J. Intern. Med. pmid:10886494
Horikawa T et al. Melanocyte mitogens induce both melanocyte chemokinesis and chemotaxis. 1995 J. Invest. Dermatol. pmid:7530272
Kobayashi H et al. Urinary trypsin inhibitor reduces the release of histamine from rat peritoneal mast cells. 1998 J. Lab. Clin. Med. pmid:9579392
Gibbs BF et al. Regulation of mediator secretion in human basophils by p38 mitogen-activated protein kinase: phosphorylation is sensitive to the effects of phosphatidylinositol 3-kinase inhibitors and calcium mobilization. 2002 J. Leukoc. Biol. pmid:12149431
Oliveira SH et al. Increased responsiveness of murine eosinophils to MIP-1beta (CCL4) and TCA-3 (CCL1) is mediated by their specific receptors, CCR5 and CCR8. 2002 J. Leukoc. Biol. pmid:12050188
Inoue T et al. Nitric Oxide positively regulates Ag (I)-induced Ca(2+) influx and mast cell activation: role of a Nitric Oxide Synthase-independent pathway. 2009 J. Leukoc. Biol. pmid:19706839
Raible DG Erythrocytes increase leukotriene C4 release from human eosinophils: characterization and examination of possible mechanisms. 1994 J. Leukoc. Biol. pmid:8027672
Gibbs BF and Grabbe J Inhibitors of PI 3-kinase and MEK kinase differentially affect mediator secretion from immunologically activated human basophils. 1999 J. Leukoc. Biol. pmid:10380914
Blanchet MR et al. Modulation of eosinophil activation in vitro by a nicotinic receptor agonist. 2007 J. Leukoc. Biol. pmid:17289799
Hom JT et al. The amyloidogenic peptide human amylin augments the inflammatory activities of eosinophils. 1995 J. Leukoc. Biol. pmid:7595053
Malaviya R and Abraham SN Role of mast cell leukotrienes in neutrophil recruitment and bacterial clearance in infectious peritonitis. 2000 J. Leukoc. Biol. pmid:10857857
Tsuruta R et al. Soluble vascular cell adhesion molecule (VCAM)-Fc fusion protein induces leukotriene C4 secretion in platelet-activating factor-stimulated eosinophils. 1999 J. Leukoc. Biol. pmid:9886248
Rossi A et al. Up-regulation of prostaglandin biosynthesis by leukotriene C4 in elicited mice peritoneal macrophages activated with lipopolysaccharide/interferon-{gamma}. 2005 J. Leukoc. Biol. pmid:16046553
Mayatepek E et al. Synthesis and metabolism of leukotrienes in gamma-glutamyl transpeptidase deficiency. 2004 J. Lipid Res. pmid:14754911
Dichlberger A et al. Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells. 2014 J. Lipid Res. pmid:25114172
Sjölinder M et al. Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1. 1999 J. Lipid Res. pmid:10064732
Lukic A et al. Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4 to leukotriene D4. 2016 J. Lipid Res. pmid:27436590
Seno K et al. Pyrrolidine inhibitors of human cytosolic phospholipase A(2). 2000 J. Med. Chem. pmid:10737736
Seres I et al. The association between angiotensin II-induced free radical generation and membrane fluidity in neutrophils of patients with metabolic syndrome. 2006 J. Membr. Biol. pmid:17546512
Becher UM et al. Inhibition of leukotriene C4 action reduces oxidative stress and apoptosis in cardiomyocytes and impedes remodeling after myocardial injury. 2011 J. Mol. Cell. Cardiol. pmid:21112334
Zhou M et al. In vivo intranasal anti-CD23 treatment inhibits allergic responses in a murine model of allergic rhinitis. 2013 J. Mol. Histol. pmid:23377922
Eaton A et al. Cysteinyl leukotriene signaling through perinuclear CysLT(1) receptors on vascular smooth muscle cells transduces nuclear calcium signaling and alterations of gene expression. 2012 J. Mol. Med. pmid:22527886
Xiang Y et al. Anti-inflammatory effect of acetylpuerarin on eicosanoid signaling pathway in primary rat astrocytes. 2014 J. Mol. Neurosci. pmid:24026619
Wu L et al. Lipoxin A4 inhibits 5-lipoxygenase translocation and leukotrienes biosynthesis to exert a neuroprotective effect in cerebral ischemia/reperfusion injury. 2012 J. Mol. Neurosci. pmid:22661361
Fujii R et al. Adenosine triphosphate-dependent transport of leukotriene C4 by membrane vesicles prepared from cisplatin-resistant human epidermoid carcinoma tumor cells. 1994 J. Natl. Cancer Inst. pmid:7966417
Farias SE et al. Transcellular biosynthesis of cysteinyl leukotrienes in rat neuronal and glial cells. 2007 J. Neurochem. pmid:17711426
Constable AL et al. DMSO induction of the leukotriene LTC4 by Lewis rat Schwann cells. 1999 J. Neurol. Sci. pmid:10202977
Black P et al. Chemotherapy in experimental brain tumor, part 2: pretreatment with leukotriene C4 prolongs survival. 1998 J. Neurooncol. pmid:9525821
Hashizume K and Black KL Increased endothelial vesicular transport correlates with increased blood-tumor barrier permeability induced by bradykinin and leukotriene C4. 2002 J. Neuropathol. Exp. Neurol. pmid:12152787
Rao AM et al. CDP-choline: neuroprotection in transient forebrain ischemia of gerbils. 1999 J. Neurosci. Res. pmid:10561698
Paoletti P et al. CSF leukotriene C4 following subarachnoid hemorrhage. 1988 J. Neurosurg. pmid:3418380
Black KL et al. Enzymatic barrier protects brain capillaries from leukotriene C4. 1994 J. Neurosurg. pmid:7931622
Dhillon HS et al. Regional generation of leukotriene C4 after experimental brain injury in anesthetized rats. 1996 J. Neurotrauma pmid:9002063
Farias S et al. Injury-related production of cysteinyl leukotrienes contributes to brain damage following experimental traumatic brain injury. 2009 J. Neurotrauma pmid:19886806
Cao D et al. Chronic administration of ethyl docosahexaenoate reduces gerbil brain eicosanoid productions following ischemia and reperfusion. 2006 J. Nutr. Biochem. pmid:16098734
Cruz JR et al. Fecal excretion of leukotriene C4 during human disease due to Shigella dysenteriae. 1995 J. Pediatr. Gastroenterol. Nutr. pmid:7714683
Shimizu T et al. Leukotriene B4 and C4 metabolism in small intestine mucosa of children with celiac disease. 1995 J. Pediatr. Gastroenterol. Nutr. pmid:8583294
Ebersole JL et al. Inflammatory mediators and immunoglobulins in GCF from healthy, gingivitis and periodontitis sites. 1993 J. Periodont. Res. pmid:8263728
Abad MJ et al. Effects of furocoumarins from Cachrys trifida on some macrophage functions. 2001 J. Pharm. Pharmacol. pmid:11518028
Fernández MA et al. New insights into the mechanism of action of the anti-inflammatory triterpene lupeol. 2001 J. Pharm. Pharmacol. pmid:11732756
Kusuhara H et al. Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line. 1998 J. Pharmacol. Exp. Ther. pmid:9618431
Pedersen KE et al. Cysteinyl leukotrienes induce P-selectin expression in human endothelial cells via a non-CysLT1 receptor-mediated mechanism. 1997 J. Pharmacol. Exp. Ther. pmid:9152370
Hundley TR et al. Characteristics of arachidonic acid generation in human basophils: relationship between the effects of inhibitors of secretory phospholipase A2 activity and leukotriene C4 release. 1998 J. Pharmacol. Exp. Ther. pmid:9495842
McAlexander MA et al. Inhibition of 5-lipoxygenase diminishes neurally evoked tachykinergic contraction of guinea pig isolated airway. 1998 J. Pharmacol. Exp. Ther. pmid:9580604
Aoki M et al. Studies on mechanisms of low emetogenicity of YM976, a novel phosphodiesterase type 4 inhibitor. 2001 J. Pharmacol. Exp. Ther. pmid:11504812
Masereeuw R et al. Active lucifer yellow secretion in renal proximal tubule: evidence for organic anion transport system crossover. 1999 J. Pharmacol. Exp. Ther. pmid:10215693
Dantzig AH et al. Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities. 1999 J. Pharmacol. Exp. Ther. pmid:10411602
Casolaro V et al. Nimesulide, a sulfonanilide nonsteroidal anti-inflammatory drug, inhibits mediator release from human basophils and mast cells. 1993 J. Pharmacol. Exp. Ther. pmid:7505332
Malaviya R et al. Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3', 5'-dibromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97). 2000 J. Pharmacol. Exp. Ther. pmid:11082424
Capper EA et al. Modulation of human monocyte activities by tranilast, SB 252218, a compound demonstrating efficacy in restenosis. 2000 J. Pharmacol. Exp. Ther. pmid:11082441