Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Herman CA et al. | Leukotriene C4-stimulated contractions in bullfrog lung are affected by cold acclimation and calcium antagonists. | 1995 | Prostaglandins | pmid:7480797 |
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Petric R et al. | Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis. | 1995 | Biochim. Biophys. Acta | pmid:7827126 |
Ju HR et al. | Systemic release of mucosal mast-cell protease in primed brown Norway rats after feeding with beta-lactoglobulin. | 1995 | Biosci. Biotechnol. Biochem. | pmid:7787291 |
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Kristjánsson S et al. | Leukotriene B4 and C4 generation by human leukocytes after ex vivo stimulation with Ca-ionophore and opsonized zymosan in children with atopic asthma. | 1995 | Pediatr Allergy Immunol | pmid:8750311 |
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Kawana S and Nishiyama S | Pustular psoriasis and aseptic purulent arthritis: possible role of leukotrienes B4 and C4 in a flare of synovitis. | 1995 | Dermatology (Basel) | pmid:7894093 |
Wang D et al. | Correlations between complaints, inflammatory cells and mediator concentrations in nasal secretions after nasal allergen challenge and during natural allergen exposure. | 1995 | Int. Arch. Allergy Immunol. | pmid:7888790 |
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Patella V et al. | The antineoplastic bryostatins affect human basophils and mast cells differently. | 1995 | Blood | pmid:7532037 |
Weber M et al. | Monocyte chemotactic protein MCP-2 activates human basophil and eosinophil leukocytes similar to MCP-3. | 1995 | J. Immunol. | pmid:7535823 |
Romanelli F et al. | Arachidonic acid and its metabolites effects on testosterone production by rat Leydig cells. | 1995 | J. Endocrinol. Invest. | pmid:7615904 |
Patella V et al. | Human heart mast cells: a definitive case of mast cell heterogeneity. | 1995 | Int. Arch. Allergy Immunol. | pmid:7536502 |
Patella V et al. | Human heart mast cells. Isolation, purification, ultrastructure, and immunologic characterization. | 1995 | J. Immunol. | pmid:7533185 |
Thomas JW et al. | Potent interleukin 3 receptor agonist with selectively enhanced hematopoietic activity relative to recombinant human interleukin 3. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7537376 |
Smit NP et al. | Stimulation of cultured melanocytes in medium containing a serum substitute: Ultroser-G. | 1995 | Pigment Cell Res. | pmid:7540755 |
Malaviya R and Abraham SN | Interaction of bacteria with mast cells. | 1995 | Meth. Enzymol. | pmid:7476393 |
Yakubu MA et al. | Hematoma-induced enhanced cerebral vasoconstrictions to leukotriene C4 and endothelin-1 in piglets: role of prostanoids. | 1995 | Pediatr. Res. | pmid:7478789 |
Buyukgebiz O et al. | Allopurinol inhibits endothelin release after mesenteric ischemia-reperfusion injury. | 1995 | Transplant. Proc. | pmid:7482880 |
Grønbech JE and Lacy ER | Role of gastric blood flow in impaired defense and repair of aged rat stomachs. | 1995 | Am. J. Physiol. | pmid:7491966 |
Ochensberger B et al. | IgE-independent interleukin-4 expression and induction of a late phase of leukotriene C4 formation in human blood basophils. | 1995 | Blood | pmid:7492759 |
Culo F et al. | Ketoconazole inhibits acetaminophen-induced hepatotoxicity in mice. | 1995 | Eur J Gastroenterol Hepatol | pmid:7496865 |
Sjölinder M et al. | Phorbol ester-induced suppression of leukotriene C4 synthase activity in human granulocytes. | 1995 | FEBS Lett. | pmid:8543026 |
Brady HR et al. | Lipoxygenase product formation and cell adhesion during neutrophil-glomerular endothelial cell interaction. | 1995 | Am. J. Physiol. | pmid:7840235 |
Miyamasu M et al. | Chemotactic agonists induce cytokine generation in eosinophils. | 1995 | J. Immunol. | pmid:7529800 |
Rachmilewitz D et al. | Sulfhydryl blocker-induced rat colonic inflammation is ameliorated by inhibition of nitric oxide synthase. | 1995 | Gastroenterology | pmid:7541005 |
Murakami M et al. | Interleukin-3 regulates development of the 5-lipoxygenase/leukotriene C4 synthase pathway in mouse mast cells. | 1995 | J. Biol. Chem. | pmid:7559381 |
Kurokawa H et al. | Gamma-glutamylcysteine synthetase gene overexpression results in increased activity of the ATP-dependent glutathione S-conjugate export pump and cisplatin resistance. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7488097 |
Ganbo T et al. | Inhibition of mucociliary clearance of the eustachian tube by leukotrienes C4 and D4. | 1995 | Ann. Otol. Rhinol. Laryngol. | pmid:7872607 |
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Sun J and Herman CA | The American bullfrog (Rana catesbeiana) exhibits differential cardiovascular responses to LTC4 after short- and long-term cold exposure. | 1995 | Gen. Comp. Endocrinol. | pmid:7622015 |
Shindo K et al. | In vivo effect of prednisolone on release of leukotriene C4 in eosinophils obtained from asthmatic patients. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7575557 |
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Zuberbier T et al. | Gangliosides enhance IgE receptor-dependent histamine and LTC4 release from human mast cells. | 1995 | Biochim. Biophys. Acta | pmid:7578275 |
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Takagi S et al. | The pathophysiological roles of heterogeneous eosinophils in allergic rhinitis caused by house dust mites. | 1995 | Biochem. Mol. Biol. Int. | pmid:7581000 |
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Tsai JJ et al. | Relationship between nasal resistance and airway hyperreactivity following nasal provocation with Dermatophagoides pteronyssinus in allergic rhinitis. | 1995 | Int. Arch. Allergy Immunol. | pmid:7888791 |
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Kanwar S et al. | Leukotriene C4/D4 induces P-selectin and sialyl Lewis(x)-dependent alterations in leukocyte kinetics in vivo. | 1995 | Circ. Res. | pmid:7554141 |
Mayer R et al. | Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. | 1995 | J. Cell Biol. | pmid:7559771 |
Prié S et al. | Leukotriene C4 receptors on guinea pig tracheocytes. | 1995 | J. Pharmacol. Exp. Ther. | pmid:7562565 |
Hom JT et al. | The amyloidogenic peptide human amylin augments the inflammatory activities of eosinophils. | 1995 | J. Leukoc. Biol. | pmid:7595053 |
Enderle GJ et al. | Different pathomechanisms of altered biliary leukotriene C4 elimination in isolated perfused rat livers. | 1995 | Biochem. Pharmacol. | pmid:7857316 |
Mita H and Shida T | Comparison of anti-allergic activities of the histamine H1 receptor antagonists epinastine, ketotifen and oxatomide in human leukocytes. | 1995 | Arzneimittelforschung | pmid:7893266 |
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Nagata M et al. | Eosinophil adhesion to vascular cell adhesion molecule-1 activates superoxide anion generation. | 1995 | J. Immunol. | pmid:7543540 |
Sarmiento EU et al. | IL-3, IL-5, and granulocyte-macrophage colony-stimulating factor potentiate basophil mediator release stimulated by eosinophil granule major basic protein. | 1995 | J. Immunol. | pmid:7543541 |
De Castro CM et al. | Modulation by dexamethasone of phospholipase A2 activities in endotoxemic guinea pigs. | 1995 | J. Appl. Physiol. | pmid:8567572 |
Ohtsuki T et al. | Reperfusion induces 5-lipoxygenase translocation and leukotriene C4 production in ischemic brain. | 1995 | Am. J. Physiol. | pmid:7900879 |
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Takafuji S et al. | Effects of physiologic soluble agonists on leukotriene C4 production and degranulation by human eosinophils. | 1995 | Int. Arch. Allergy Immunol. | pmid:7549519 |
Yoshida K et al. | Effect of fibronectin on the production of leukotriene C4 by eosinophils. | 1995 | Int. Arch. Allergy Immunol. | pmid:7549524 |
Datta YH et al. | Peptido-leukotrienes are potent agonists of von Willebrand factor secretion and P-selectin surface expression in human umbilical vein endothelial cells. | 1995 | Circulation | pmid:7586318 |
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Schauer U et al. | Blood eosinophils, eosinophil-derived proteins, and leukotriene C4 generation in relation to bronchial hyperreactivity in children with atopic dermatitis. | 1995 | Allergy | pmid:7604934 |
Yamaya M et al. | Epithelial modulation of leukotriene-C4-induced human tracheal smooth muscle contraction. | 1995 | Am. J. Respir. Crit. Care Med. | pmid:7881688 |
Herron DK et al. | Visualization and comparison of molecular dynamics simulations of leukotriene C4, leukotriene D4, and leukotriene E4. | 1995 | J Mol Graph | pmid:8820302 |
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Juergens UR et al. | Inhibition of monocyte leukotriene B4 production after aspirin desensitization. | 1995 | J. Allergy Clin. Immunol. | pmid:7636051 |
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Ganbo T et al. | The effects of leukotrienes C4 and D4 on ciliary activity of human paranasal sinus mucosa in vitro. | 1995 | Rhinology | pmid:8919211 |
Karmeli F et al. | A stable nitroxide radical effectively decreases mucosal damage in experimental colitis. | 1995 | Gut | pmid:7590435 |
Utoh J et al. | Is an increase in neutrophil leukotriene-generating capacity a specific phenomenon for cardiopulmonary bypass? | 1995 | J. Thorac. Cardiovasc. Surg. | pmid:7609558 |
Janssen-Timmen U et al. | Expression of 5-lipoxygenase in differentiating human skin keratinocytes. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7624354 |