Ltc4 is a lipid of Fatty Acyls (FA) class. Ltc4 is associated with abnormalities such as Asthma, Eosinophilia, Pulmonary Eosinophilia, Pneumonia and Cardiovascular Diseases. The involved functions are known as Signal, Gene Expression, Stimulus, Signal Transduction and Metabolic Inhibition. Ltc4 often locates in Plasma membrane, Cytoplasm, Back, Cytoplasmic and Tissue membrane. The associated genes with LTC4 are STIM1 gene, ABCC2 gene, CD9 gene, Mutant Proteins and Amino Acids, Aromatic. The related lipids are glycolithocholate.
To understand associated biological information of LTC4, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
LTC4 is suspected in Pneumonia, Asthma, Pulmonary Eosinophilia, Eosinophilia, Cardiovascular Diseases, Disintegration and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with LTC4
Lipid pathways are not clear in current pathway databases. We organized associated pathways with LTC4 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Rao AM et al. | Arachidonic acid and leukotriene C4: role in transient cerebral ischemia of gerbils. | 1999 | Neurochem. Res. | pmid:10492517 |
Nakasato H et al. | Prevention of severe premenstrual asthma attacks by leukotriene receptor antagonist. | 1999 | J. Allergy Clin. Immunol. | pmid:10482831 |
O'Connor BJ et al. | Selective airway responsiveness in asthma. | 1999 | Trends Pharmacol. Sci. | pmid:10101956 |
Akpek EA et al. | A study of adenosine treatment in experimental acute spinal cord injury. Effect on arachidonic acid metabolites. | 1999 | Spine | pmid:9926381 |
Niinuma K et al. | Primary active transport of organic anions on bile canalicular membrane in humans. | 1999 | Am. J. Physiol. | pmid:10330006 |
Lärfars G et al. | Activation of nitric oxide release and oxidative metabolism by leukotrienes B4, C4, and D4 in human polymorphonuclear leukocytes. | 1999 | Blood | pmid:9949184 |
Hamasaki Y et al. | Magnolol inhibits leukotriene synthesis in rat basophilic leukemia-2H3 cells. | 1999 | Planta Med. | pmid:10232065 |
Lankisch TO et al. | High-affinity cholecystokinin type A receptor/cytosolic phospholipase A2 pathways mediate Ca2+ oscillations via a positive feedback regulation by calmodulin kinase in pancreatic acini. | 1999 | Eur. J. Cell Biol. | pmid:10535305 |
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Cordoba-Rodriguez R et al. | Calcium regulation of a slow post-spike hyperpolarization in vagal afferent neurons. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393875 |
Bischoff SC et al. | IL-4 enhances proliferation and mediator release in mature human mast cells. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393951 |
Clish CB et al. | Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10393980 |
Sano A et al. | Inhibition of cPLA2 translocation and leukotriene C4 secretion by fluticasone propionate in exogenously activated human eosinophils. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10351938 |
Kita H et al. | Does IgE bind to and activate eosinophils from patients with allergy? | 1999 | J. Immunol. | pmid:10352312 |
Chen ZS et al. | An enhanced active efflux of CPT-11 and SN-38 in cisplatin-resistant human KB carcinoma cells. | 1999 | Cancer Lett. | pmid:10378768 |
Bannenberg G et al. | Leukotriene C4 is a tight-binding inhibitor of microsomal glutathione transferase-1. Effects of leukotriene pathway modifiers. | 1999 | J. Biol. Chem. | pmid:9890956 |
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Irkeç MT et al. | Role of tear inflammatory mediators in contact lens-associated giant papillary conjunctivitis in soft contact lens wearers. | 1999 | Ocul. Immunol. Inflamm. | pmid:10410873 |
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Mayatepek E et al. | A severely affected infant with absence of cysteinyl leukotrienes in cerebrospinal fluid: further evidence that leukotriene C4-synthesis deficiency is a new neurometabolic disorder. | 1999 | Neuropediatrics | pmid:10222453 |
Takao A et al. | Inhibitory effects of azelastine hydrochloride in alcohol-induced asthma. | 1999 | Ann. Allergy Asthma Immunol. | pmid:10227338 |
Denizot Y et al. | Are lipid mediators implicated in the production of pro- and anti-inflammatory cytokines during cardiopulmonary bypass graft with extracorporeal circulation? | 1999 | Cytokine | pmid:10328869 |
Miura K et al. | Extracellular signal-regulated kinases regulate leukotriene C4 generation, but not histamine release or IL-4 production from human basophils. | 1999 | J. Immunol. | pmid:10201947 |
Mao Q et al. | ATPase activity of purified and reconstituted multidrug resistance protein MRP1 from drug-selected H69AR cells. | 1999 | Biochim. Biophys. Acta | pmid:10556489 |
Held HD et al. | Characterization of airway and vascular responses in murine lungs. | 1999 | Br. J. Pharmacol. | pmid:10205008 |
Rao AM et al. | CDP-choline: neuroprotection in transient forebrain ischemia of gerbils. | 1999 | J. Neurosci. Res. | pmid:10561698 |
Malaviya R and Uckun FM | Genetic and biochemical evidence for a critical role of Janus kinase (JAK)-3 in mast cell-mediated type I hypersensitivity reactions. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10208864 |
Norman BH et al. | Reversal of resistance in multidrug resistance protein (MRP1)-overexpressing cells by LY329146. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10612603 |
Desplat V et al. | Incorporation and effect of arachidonic acid on the growth of human myeloma cell lines. | 1999 | Mediators Inflamm. | pmid:10704149 |
Nilsen A et al. | Short-term exposure of rodents to diesel exhausts: usefulness for studies of genotoxic and immunotoxic effects. | 1999 | Chem. Biol. Interact. | pmid:10227576 |
Constable AL et al. | DMSO induction of the leukotriene LTC4 by Lewis rat Schwann cells. | 1999 | J. Neurol. Sci. | pmid:10202977 |
Miadonna A et al. | Nasal response to a single antigen challenge in patients with allergic rhinitis - inflammatory cell recruitment persists up to 48 hours. | 1999 | Clin. Exp. Allergy | pmid:10383595 |
McWherter CA et al. | Circular permutation of the granulocyte colony-stimulating factor receptor agonist domain of myelopoietin. | 1999 | Biochemistry | pmid:10194378 |
Carvalho-Tavares J et al. | Assessment of the mechanism of juxtacrine activation and adhesion of leukocytes in liver microcirculation. | 1999 | Am. J. Physiol. | pmid:10198324 |
Renes J et al. | ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1. | 1999 | Br. J. Pharmacol. | pmid:10188979 |
Schmidt D et al. | Passive sensitization of human airways increases responsiveness to leukotriene C4. | 1999 | Eur. Respir. J. | pmid:10515407 |
Muñoz NM et al. | Augmentation of eosinophil degranulation and LTC(4) secretion by integrin-mediated endothelial cell adhesion. | 1999 | Am. J. Physiol. | pmid:10516222 |
May A et al. | Means of increasing sensitivity of an in vitro diagnostic test for aspirin intolerance. | 1999 | Clin. Exp. Allergy | pmid:10520062 |
Ko JK and Cho CH | Co-regulation of mucosal nitric oxide and prostaglandin in gastric adaptive cytoprotection. | 1999 | Inflamm. Res. | pmid:10522801 |
Van Aubel RA et al. | Mechanisms and interaction of vinblastine and reduced glutathione transport in membrane vesicles by the rabbit multidrug resistance protein Mrp2 expressed in insect cells. | 1999 | Mol. Pharmacol. | pmid:10496953 |
Hagmann W et al. | Purification of the human apical conjugate export pump MRP2 reconstitution and functional characterization as substrate-stimulated ATPase. | 1999 | Eur. J. Biochem. | pmid:10491184 |
Falcón-Pérez JM et al. | Functional domain analysis of the yeast ABC transporter Ycf1p by site-directed mutagenesis. | 1999 | J. Biol. Chem. | pmid:10438540 |
Campbell EM et al. | Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/- mice: the role of mast cells. | 1999 | J. Immunol. | pmid:10438957 |
Kawabe T et al. | Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2). | 1999 | FEBS Lett. | pmid:10456333 |
Vellenga E et al. | Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1. | 1999 | Br. J. Pharmacol. | pmid:10385244 |
Stride BD et al. | Localization of a substrate specificity domain in the multidrug resistance protein. | 1999 | J. Biol. Chem. | pmid:10428874 |
Lieberman MW et al. | Gamma-glutamyl leukotrienase cleavage of leukotriene C4. | 1999 | Adv. Exp. Med. Biol. | pmid:10667345 |
Schweitzer P et al. | Cannabinoid modulation of neuronal activity in adult rat hippocampus. | 1999 | Adv. Exp. Med. Biol. | pmid:10667381 |
Herman CA and Luczy-Bachman G | Eicosanoids in the brain of warm- and cold-acclimated bullfrogs. | 1999 | Adv. Exp. Med. Biol. | pmid:10667397 |
Amann R et al. | Eicosanoid release in the endotoxin-primed isolated perfused rat lung and its pharmacological modification. | 1999 | Inflamm. Res. | pmid:10669114 |